419 results about "Skin wound" patented technology

A compound, as shown in Formula I, is a multi-heterocyclic compound. It has been verified that the compound provided by this invention integrates a novel compound targeting the calcitonin gene-related peptide (CGRP) based on ephedrine. Upon contact with the skin, due to photoactivated cell biological function regulation and the blocking effect of the multi-heterocyclic compound I structure on serotonin receptors, it achieves therapeutic effects on cutaneous vascular malformations and telangiectasia, improves the effectiveness of phototherapy in improving chronic cutaneous vascular diseases, and promotes skin wound healing.

The invention provides application of a turbellarian worm extract in preparation of a product for promoting wound healing, a biological agent for promoting the proliferation activity and / or migration ability of fibroblast NIH3T3, a biological agent for improving the wound healing rate and the decrustation time and a biological agent for improving the collagen fiber deposition type in the wound healing process. The biological preparation is used for promoting regeneration of skin appendage organs in the wound healing process. Wherein the extraction of the turbellarian worm extract comprises the steps of turbellarian worm cleaning, tissue crushing, alcohol extraction, centrifugal separation and concentration drying. The turbellarian worm extract has good capacity of promoting wound healing, and has the effects of effectively improving skin wound healing efficiency, shortening decrustation time, inhibiting scar formation in the wound healing process, promoting regeneration of skin appendage organs in the wound healing process and the like.

The invention relates to a double-layer dressing for promoting wound healing and inhibiting scars and a preparation method and application thereof.The double-layer dressing comprises a hydrogel layer and a piezoelectric film layer compounded on the hydrogel layer, and the piezoelectric film layer is prepared by mixing an organic piezoelectric material, a ferroelectric material and an organic solvent and then conducting an electrostatic spinning technology; the hydrogel layer is formed by curing a methacrylic anhydride acellular extracellular matrix, methacrylic anhydride catechol chitosan and conductive nanoparticles under the action of a curing agent. The lower skin contact layer of the double-layer dressing is the hydrogel layer, so that the directional growth of fibroblasts is favorably induced; the upper dressing is a piezoelectric material composite ferroelectric material, is beneficial to piezoelectric stimulation re-induction function recovery after final skin repair and guidance of directional growth of wound cells, and has good skin wound induction repair and scar inhibition effects.

The invention provides a superfine-diameter PCL / COL nanofiber membrane as well as a preparation method and application thereof, and relates to the technical field of skin wound repair materials. The PCL / COL nanofiber membrane material is prepared from PCL and I-type collagen as raw materials through electrostatic spinning and vacuum drying. According to the preparation method disclosed by the invention, an electrostatic spinning technology is combined with strict regulation and control on parameters, so that the stable and superfine 40-nanoscale PCL / COL nanofiber membrane material is prepared. The diameter of the superfine PCL / COL nanofiber membrane material reaches the bionic scale of the minimum natural collagen of an extracellular matrix, and meanwhile, the superfine PCL / COL nanofiber membrane material shows more excellent hydrophilicity and lower surface roughness, has good biological safety and mechanical stability, not only realizes high matching with a natural ECM hierarchical structure, but also has good application prospects. By enhancing the cell-material interface interaction, the adhesion, proliferation and migration capacities of fibroblasts are remarkably improved, the wound healing period can be effectively shortened, an excellent repair promoting effect is shown, and a solid foundation is laid for clinical transformation of materials.

The invention belongs to the technical field of bioengineering medicines, and particularly relates to a gel dressing for repairing skin wounds and a preparation method of the gel dressing. The anti-fouling coating is prepared from the following raw materials in parts by weight: 65 to 75 parts of polyvinyl alcohol, 14 to 20 parts of sodium alginate, 4 to 8 parts of sodium carboxymethyl cellulose, 1 to 3 parts of sodium hyaluronate, 12 to 22 parts of glycerol, 1 to 3 parts of surface anti-fouling additive, 6 to 10 parts of antibacterial microcapsule and 2 to 2.8 parts of compound ion. According to the invention, a PVA freeze-thaw physical network and an alginic acid Ca / Zn composite ion network cooperate to limit a pore channel, so that stable forming is realized; a chitosan / sodium tripolyphosphate microcapsule is prepared from polyhexamethylene biguanide hydrochloride and covered with sodium alginate, release sensitive to pH / ionic strength, acceleration in an inflammation stage and self-limiting in a later stage are constructed, and long-acting bacteriostasis is formed by SA-Zn site slow release; the stability and staged adaptation are highlighted through processes such as encapsulation, low-shear doping and the like and raw material synergy.

The invention relates to a skin wound repairing material and a preparation method thereof, and belongs to the technical field of biological medicines. The repair material disclosed by the invention contains palmitoyl tripeptide-1, methacrylated collagen, cuttlebone extract, recombinant human epidermal growth factor lipidosome, polydopamine nanoparticles, hyaluronic acid, sodium alginate modified silk fibroin and the like in a specific proportion. Wherein the cuttlebone extract is a product which is obtained by carrying out common enzymolysis on cuttlebone through chitinase and nattokinase and then carrying out step-by-step enzymolysis on the cuttlebone through gelatinase and lumbrukinase and is less than 5kDa. The components are prepared into an efficient product by adopting a special method, the stability of the components is improved, the problem that the activity is difficult to maintain is solved, and the skin wound repairing effect is good through reasonable compatibility.

The present invention discloses the preparation of an anti-inflammatory peptide derived from the hydrolysis of shell nacre protein and its application in skin repair. The peptide PDFDNGF provided by the invention can effectively promote the proliferation of RAW264.7 macrophage cells and inhibit the excessive production of nitric oxide and cytokines in RAW264.7 cells induced by lipopolysaccharide, while increasing the levels of anti-inflammatory cytokines, demonstrating significant anti-inflammatory activity. Furthermore, the active peptide has a significant proliferative effect on L929 cells, indicating its potential to promote skin wound healing. This invention provides a theoretical basis for the high-value utilization of shell nacre.

The invention discloses a bi-crosslinking gelatin-based hydrogel wound dressing as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method disclosed by the invention comprises the following steps: mixing a gelatin solution and an oxidized konjac glucomannan solution, heating and stirring to obtain a hydrogel precursor solution; and mixing the hydrogel precursor solution with a borax solution to obtain the bi-crosslinked gelatin-based hydrogel wound dressing. According to the method, oxidized konjac glucomannan and gelatin are subjected to Schiff base and Schiff base crosslinking, borax is further added to introduce a dynamic boric acid ester bond effect to enhance a three-dimensional network of the hydrogel, and the dynamic reversible Schiff base effect and the boric acid ester bond effect are enhanced, so that the pore diameter and the swelling ratio of the hydrogel are increased, and the gel strength of the hydrogel is enhanced; due to the good self-healing injectable performance, biodegradability and mechanical property of the hydrogel, the hydrogel can be used as a wound dressing for irregular deep skin wounds, and the technical problem that existing hydrogel is insufficient in treatment of irregular wounds is solved.

The invention belongs to the technical field of medical gel, and particularly relates to modified hydrogel for skin wound healing and a preparation method thereof.The modified hydrogel is prepared from, by weight, 2-5 parts of drug-loaded GDVLNs, 1-2 parts of chitosan, 0.6-1.5 parts of antioxidant, 0.2 part of LAP, 1.5 parts of MA, 18 parts of gel matrix and 100 parts of buffer solution, the drug-loaded GDVLNs prepared from the traditional Chinese medicine active ingredients and the ginseng vesicles have the functions of resisting oxidative stress, promoting angiogenesis, promoting cell proliferation and the like, and the MA modified hydrogel system can realize slow release and controlled release of the drug-loaded GDVLNs and play a long-acting healing promoting role.

The embodiment of the invention provides nano-enzyme hydrogel for promoting scar-free wound repair through inflammation regulation and c-Jun gene silencing and a preparation method of the nano-enzyme hydrogel. The nano-enzyme hydrogel is prepared from the following components in parts by mass: synthesized epsilon-polylysine modified CeO2 nano-enzyme particles and aldehyde hyaluronic acid, an instant Schiff base reaction between epsilon PL-CeO2 surface amino groups and HA-CHO molecule aldehyde groups is utilized, in-situ mixing is performed to form a hydrogel network, in addition, bFGF and siRNA are loaded into PLGA microspheres, and the hydrogel network is formed through in-situ mixing. And further embedding into the hydrogel to obtain the nano-enzyme hydrogel. The obtained nano-enzyme hydrogel has the functions of inflammation regulation, cell proliferation promotion, vascular regeneration promotion, c-Jun gene silencing and the like, and scar-free healing of skin wounds is remarkably promoted.

The invention discloses a skin tension reducing device and method based on full-period adjustment, and belongs to the technical field of medical cosmetology. The skin tension reducing device comprises a left auxiliary pasting film, a right auxiliary pasting film, a plurality of tension adjusting devices and a tension detecting device. The adjusting device comprises fixed guide blocks, a traction belt and a conical spiral tightener; the two guide blocks are respectively fixed at the same height of the left auxiliary film and the right auxiliary film; the two guide blocks are respectively provided with a conical internal thread and a guide hole, and the conical spiral tightener is in threaded fit with the conical guide hole; one end of a traction belt is connected with a conical spiral tightener positioned on the left auxiliary film, and the other end of the traction belt is fixed on a fixed guide block positioned on the right auxiliary film through a guide hole; the tension detection device comprises strain gauges, a tension acquisition plate and a handheld display, and the strain gauges are attached to the traction belts and used for detecting the tension of the traction belts. Dynamic tension reduction management can be carried out on the whole cycle of skin wound healing, and the purpose of tension reduction is achieved in a high-quality mode.

Provided are a new polypeptide for repairing mucosal damage or a skin wound, and the use thereof. The polypeptide is not homologous with known polypeptides, can be stably present in vivo and in vitro, and has the effect of regulating stem cell proliferation and differentiation to repair mucosal damage or a skin wound. The present invention further relates to the use of the new polypeptide in the repairing of mucosal damage or a skin wound by means of regulating stem cell proliferation and differentiation, and the use thereof in the prevention, alleviation or treatment of gastrointestinal diseases.

The invention discloses a preparation method and application of a gynostemma pentaphylla exosome. According to the method, a high-activity callus is obtained by optimizing a callus induction culture medium, and a suspension culture system is established to realize biomass accumulation with the dry cell weight of 19.8 + / -0.7 g / L. A sequential progressive composite induction strategy (methyl jasmonate is added after chitosan is pre-induced for 24 hours) is innovatively adopted, so that the saponin content is remarkably increased to 102.6 + / -4.8 mg / g DW. Exosomes (P-Exos) are extracted from induced cells through an enzymolysis-magnetic bead affinity purification technology (WGA modified magnetic bead affinity capture after mild enzymolysis of a cracking buffer solution), the yield reaches 1.45 + / -0.08 mg / g cells, and the extraction efficiency is remarkably improved compared with that of a traditional gradient centrifugation method (C-Exos). Moreover, the gynostemma pentaphyllum exosome prepared by the invention can effectively improve the synthesis of skin collagen, has a better effect, can be applied to medicines for promoting skin wound repair or can be added into anti-aging cosmetics as a functional component, and has a very high application value.

The invention discloses stem cell freeze-dried powder for promoting skin healing and a preparation method of the stem cell freeze-dried powder. The freeze-dried powder comprises an effective component, a freeze-drying protective agent group and a polymer protective agent group, the effective component is umbilical cord mesenchymal stem cell conditioned medium freeze-dried supernatant, the protective agent group is selected from one or more of cane sugar, trehalose, lactose and mannitol, and the polymer protective agent group is selected from one or more of polyvinylpyrrolidone (PVP) and glucan. The preparation method comprises the following steps: collection of a conditioned culture medium, preparation of a freeze-drying protective agent solution, mixing treatment, low-temperature pre-freezing and freeze-drying, collection and packaging of freeze-dried powder and the like. The method can effectively retain stem cell-derived active factors and enhance the stability and redissolvability of the freeze-dried powder, and is suitable for skin wound repair, regenerative medicine and other scenes.

The invention provides a hydrogel dressing for synergistically promoting chronic wound healing through near-infrared controlled release of ROS (reactive oxygen species) and NO (nitric oxide) as well as a preparation method and application of the hydrogel dressing. Belongs to the technical field of biomedical materials. The hydrogel is prepared from the following components: upconversion nanoparticles as a core, silicon dioxide wrapping, carbon dot and L-arginine loading, maltotriose modification, and mixing and gelling with 2-amino-2-fluoro-2-deoxyadenosine as a hydrogel carrier, so as to obtain the hydrogel dressing. The obtained hydrogel dressing has the functions of inhibiting bacteria, promoting cell proliferation, promoting revascularization and the like, and remarkably promotes skin wound healing.

The invention discloses a temperature-controlled anti-inflammatory and antibacterial skin wound dressing capable of promoting revascularization and a preparation method and application thereof, and relates to the technical field of medical materials, the preparation method comprises the following steps: S1, preparing calcium peroxide microspheres; s2, the poloxamer 407, the chitosan and the forsythiaside A are jointly dissolved in an acetic acid solution, and mixed gel is obtained; s3, dispersing calcium peroxide microspheres into the mixed gel to obtain the skin wound dressing capable of controlling temperature, resisting inflammation and bacteria and promoting revascularization. The traditional Chinese medicine active ingredient forsythiaside A is loaded, so that the healing efficiency of diabetic wounds is improved; due to the temperature-sensitive property of the gel, the gel can be better attached to the wound, the antibacterial property can inhibit microorganism breeding at the wound surface, the oxygen release capacity can improve the anoxic environment at the wound, and the loaded traditional Chinese medicine active ingredient forsythiaside A has the anti-inflammatory capacity, promotes cell regeneration at the wound and accelerates the repair process.

The invention discloses a biomedical polymer-based wound infection indicating dressing material as well as a preparation method and application thereof, and the dressing material is obtained by modifying a pH responsive dye, performing graft polymerization on the modified pH responsive dye, a cross-linking agent and hydrophilic monomer free radicals to form a hydrogel coating, and then wrapping the hydrogel coating on a biomedical polymer material. The material has a pH responsive infection indication function, can amplify a wound infection condition which is not easy to detect into a color change which is intuitive and distinguishable by naked eyes, can meet the requirement of monitoring the skin wound infection condition in actual clinical application, is beneficial to early detection of wound infection, and has a wide application prospect. And the preparation method can maintain the original texture of the biomedical polymer material to the greatest extent and reduce the risk of dye exudation, and the preparation process is conventional and easy to operate and has wide engineering prospects.

The invention relates to the technical field of biological active peptides, in particular to a method for rapidly and effectively screening light protection active peptides from collagen hydrolysate. The invention relates to an application of a photoprotective polypeptide in preparation of a product. The product has at least one of the following purposes: (1) maintaining or increasing the water content of skin; (2) preventing and / or slowing down skin aging; (3) prevention and / or alleviation of skin UVB injury; and (4) promoting healing of skin wounds or wound surfaces. Two key signal factors (NF-kB, AP-1) and a key matrix metalloproteinase (MMP-9) are screened from a mitogen-activated protein kinase (MAPK) and nuclear factor-kB (NF-kB) pathway to be used as docking targets, and a mimic peptide and the three targets act synergistically to make up for the defect that a single target screening peptide is difficult to comprehensively cope with a light damage multivariate pathway, so that the application of the mimic peptide to the light damage multivariate pathway is realized, and the application of the mimic peptide to the light damage multivariate pathway is realized. And the collagen peptide with excellent light protection activity is obtained through screening.

The present invention relates to an advanced dressing characterized by a powder of polymeric material based on poly(lactic-co-glycolic) acid, functionalized with dextran, maltodextrin, collagen, citric acid, chitosan, polyphenols, colloidal silver, hyaluronic acid and / or salts thereof, polyethylene glycol and alginate. The present invention further relates to a process for producing the powder and the use of the powder in treating non-necrotic skin wounds.

The invention discloses a preparation method and application of an endothelium corneum gigeriae galli and angelica sinensis ointment, and relates to the technical field of traditional Chinese medicine, the endothelium corneum gigeriae galli and angelica sinensis ointment comprises the following raw materials in parts by weight: a medicine solution: 1-3g of angelica sinensis extract and 30-35 parts of endothelium corneum gigeriae An oil phase: 1-5 g of white vaseline, 1-5 g of glycerin monostearate, 10-14 g of stearic acid, 5-8 g of liquid paraffin and 3-6 g of wool fat; a water phase: 0.2 to 0.5 g of triethanolamine, 0.5 to 1 g of glycerin, and 0.1 to 0.5 g of ethylparaben; according to the endothelium corneum gigeriae galli and angelica sinensis ointment, endothelium corneum gigeriae galli and angelica sinensis materials are adopted, endothelium corneum gigeriae galli has the effects of healing sore, promoting tissue regeneration, removing blood stasis and the like, angelica sinensis has the effects of replenishing qi, enriching blood and promoting blood circulation to remove blood stasis, and skin wound healing and capillary regeneration can be effectively promoted, local blood circulation is improved, and inflammatory response is inhibited; meanwhile, the ointment is soft in texture and can absorb percolate and inhibit microbial infection; the method is convenient, economical, practical, good in stability and suitable for application and popularization.

Disclosed herein is a method for treating skin wounds in a patient in need of such treatment, comprising applying a foamed composition comprising nitric oxide to the area of skin requiring such treatment. The wound may be selected from the group consisting of skin ulcers, including diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), arterial ulcers, decubitus (pressure) ulcers or other pressure injuries, deep tissue injuries (DTIs), burns, abrasions, skin tears, or bruises.

The invention provides application of pitaya peel polysaccharide in preparation of a medicine for repairing skin wounds. The monosaccharide components of the pitaya peel polysaccharide comprise rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid. Research finds that the dragon fruit peel polysaccharide remarkably accelerates the wound healing process and promotes granulation tissue formation and collagen deposition. Meanwhile, the pitaya peel polysaccharide can also promote cell proliferation and neovascularization at the skin wound part, exert an anti-inflammatory effect, remodel skin microbiota and provide a more suitable microenvironment for skin wound healing. The invention provides a new drug choice for clinically repairing skin wounds, and can be used for developing new skin wound dressings.

The invention relates to the technical field of biomedical engineering and pharmacology and relates to, but is not limited to, a method for the composition and production of a wound dressing for the healing of complete and chronic skin wounds.

The invention discloses organic zinc antibacterial gel and a preparation method thereof. The organic zinc antibacterial gel consists of water, chitosan and a zinc antibacterial agent, wherein the zinc antibacterial agent is zinc dehydroacetate as shown in the following formula. The preparation method of the organic zinc antibacterial gel comprises the following steps: uniformly stirring and mixing chitosan, water, organic acid and sodium dehydroacetate for reaction, then adding a salt solution of zinc ions, fully stirring, and finally cooling to obtain the organic zinc antibacterial hydrogel. The antibacterial property of the hydrogel can be remarkably improved, and the hydrogel is beneficial to promoting skin wound healing. # imgabs0 #

The invention discloses double-crosslinking personalized hydrogel for promoting wound healing and a preparation process thereof, and relates to the technical field of biomedical materials. The hydrogel comprises sodium alginate, modified chitosan, calcium carbonate, glucolactone, acrylamide, methylene diacrylamide, ammonium persulfate and tetramethylethylenediamine, and the hydrogel can also carry drugs in the preparation process, including but not limited to drugs with the functions of diminishing inflammation, resisting bacteria, stopping bleeding and the like. The hydrogel is prepared in a double-crosslinking mode of physical crosslinking and chemical crosslinking. The hydrogel provided by the invention has the advantages of high biocompatibility, adjustable viscosity, easy replacement, adjustable water absorbability and temperature responsiveness, has a loose porous structure, has better water content, cell proliferation and migration performance, swelling performance, drug sustained release performance and the like, can effectively promote wound healing, and has a good application prospect. The method has potential application prospects in skin wound treatment and repair.

The present application relates to a kind of carboxymethylated gellan gum composite hydrogel that can promote the preparation method of infectious skin wound healing, the present application will be a certain concentration of carboxymethylated gellan gum with the solution of active ion (Ca 2+ 、Cu 2+ 、Zn 2+ ) of proper proportion, using ion crosslinking method to prepare carboxymethylated gellan gum hydrogel.The prepared hydrogel has fast gelation, good injectability, self-healing, tissue adhesion performance and excellent bacteriostatic effect, and can effectively promote the healing of infected wound, has potential application prospect in the treatment of wound infection.

A composite membrane comprises a membrane matrix formed by the stable cross-linking of silk fibroin with β-sheets, and baicalin uniformly dispersed between the segments of the silk fibroin molecular chain, wherein the mass ratio of silk fibroin to baicalin is 100:3-4. The preparation method includes the following steps: 1) taking silkworm cocoons, boiling them several times with sodium carbonate solution, washing them, and drying them to 60°C; 2) dissolving them in a ternary solution, centrifuging and filtering to obtain a clear silk fibroin solution, and drying it to obtain silk fibroin; 3) preparing a silk fibroin solution with a concentration of 1-30 mg / ml, and adjusting the pH to 7.4; 4) adding baicalin to the silk fibroin solution, forming a film, drying it, and annealing it to obtain the composite membrane. The composite membrane of this invention has superior biocompatibility, hemostatic properties, and controllable biodegradability, and can promote M2 polarization of macrophages, shorten the inflammatory period, and effectively promote skin wound healing.

The invention relates to the technical field of medical apparatus and instruments, in particular to a plasma electrode device which comprises at least one electrode plate. The plurality of connecting electrodes are connected to the edge of the central electrode in a surrounding manner; the first connecting parts are arranged on the connecting electrodes, and the first connecting part of one electrode plate is correspondingly connected with the first connecting part of the adjacent electrode plate, so that the electrode parts of all the electrode plates are electrically connected. The modularized and splicable plasma electrode device provided by the invention realizes the splicing of a plurality of electrode plates by innovating the electrode component and the first connecting component, has the advantages of good skin wound surface fitting property, flexible treatment area expansion, reliable multi-unit connection and the like, and can adapt to various irregular wound surfaces and different sizes of wound surfaces.

The invention belongs to the technical field of liquid medicine extraction, discloses an extraction system and extraction equipment of liquid medicine for treating skin wounds, and particularly relates to an extraction system of liquid medicine for treating skin wounds, which comprises a pretreatment module, a multi-stage solvent extraction module, a separation and purification module, a liquid medicine preparation module and an intelligent control system, the pretreatment module is used for cleaning and smashing raw materials, through the arranged extraction system, mutual cooperation and cooperation of the raw materials are promoted in the process of extracting liquid medicine for treating skin wounds, the intelligent level in the extraction process is improved, it is ensured that the quality and components of the liquid medicine in each batch are consistent, and the quality of the liquid medicine is improved. According to the technical scheme, personalized treatment requirements in different clinical application scenes are met, and when equipment is abnormal or parameters exceed a set range, an alarm can be given immediately and corresponding protection measures can be taken, so that the safety of the equipment and personnel is guaranteed, and the use safety of the equipment is improved.

According to the application of the arcangelisia loureiri extract in preparing the burn and scald wound healing medicine, the arcangelisia loureiri crude extract is obtained through extraction and concentration with a decoction method, and wound healing can be promoted by reducing the area of a rat skin wound, shortening the healing time of the rat skin wound, reducing the hyperplasia speed of the skin corium layer and promoting healing of the wound; the effects of remarkably promoting wound healing of burns and scalds and reducing scars are achieved.