299 results about "Skin wound" patented technology

A compound, as shown in Formula I, is a multi-heterocyclic compound. It has been verified that the compound provided by this invention integrates a novel compound targeting the calcitonin gene-related peptide (CGRP) based on ephedrine. Upon contact with the skin, due to photoactivated cell biological function regulation and the blocking effect of the multi-heterocyclic compound I structure on serotonin receptors, it achieves therapeutic effects on cutaneous vascular malformations and telangiectasia, improves the effectiveness of phototherapy in improving chronic cutaneous vascular diseases, and promotes skin wound healing.

The invention belongs to the technical field of medical gel, and particularly relates to modified hydrogel for skin wound healing and a preparation method thereof.The modified hydrogel is prepared from, by weight, 2-5 parts of drug-loaded GDVLNs, 1-2 parts of chitosan, 0.6-1.5 parts of antioxidant, 0.2 part of LAP, 1.5 parts of MA, 18 parts of gel matrix and 100 parts of buffer solution, the drug-loaded GDVLNs prepared from the traditional Chinese medicine active ingredients and the ginseng vesicles have the functions of resisting oxidative stress, promoting angiogenesis, promoting cell proliferation and the like, and the MA modified hydrogel system can realize slow release and controlled release of the drug-loaded GDVLNs and play a long-acting healing promoting role.

The invention discloses stem cell freeze-dried powder for promoting skin healing and a preparation method of the stem cell freeze-dried powder. The freeze-dried powder comprises an effective component, a freeze-drying protective agent group and a polymer protective agent group, the effective component is umbilical cord mesenchymal stem cell conditioned medium freeze-dried supernatant, the protective agent group is selected from one or more of cane sugar, trehalose, lactose and mannitol, and the polymer protective agent group is selected from one or more of polyvinylpyrrolidone (PVP) and glucan. The preparation method comprises the following steps: collection of a conditioned culture medium, preparation of a freeze-drying protective agent solution, mixing treatment, low-temperature pre-freezing and freeze-drying, collection and packaging of freeze-dried powder and the like. The method can effectively retain stem cell-derived active factors and enhance the stability and redissolvability of the freeze-dried powder, and is suitable for skin wound repair, regenerative medicine and other scenes.

The invention provides a hydrogel dressing for synergistically promoting chronic wound healing through near-infrared controlled release of ROS (reactive oxygen species) and NO (nitric oxide) as well as a preparation method and application of the hydrogel dressing. Belongs to the technical field of biomedical materials. The hydrogel is prepared from the following components: upconversion nanoparticles as a core, silicon dioxide wrapping, carbon dot and L-arginine loading, maltotriose modification, and mixing and gelling with 2-amino-2-fluoro-2-deoxyadenosine as a hydrogel carrier, so as to obtain the hydrogel dressing. The obtained hydrogel dressing has the functions of inhibiting bacteria, promoting cell proliferation, promoting revascularization and the like, and remarkably promotes skin wound healing.

The invention provides application of pitaya peel polysaccharide in preparation of a medicine for repairing skin wounds. The monosaccharide components of the pitaya peel polysaccharide comprise rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid. Research finds that the dragon fruit peel polysaccharide remarkably accelerates the wound healing process and promotes granulation tissue formation and collagen deposition. Meanwhile, the pitaya peel polysaccharide can also promote cell proliferation and neovascularization at the skin wound part, exert an anti-inflammatory effect, remodel skin microbiota and provide a more suitable microenvironment for skin wound healing. The invention provides a new drug choice for clinically repairing skin wounds, and can be used for developing new skin wound dressings.

The invention relates to the technical field of biomedical engineering and pharmacology and relates to, but is not limited to, a method for the composition and production of a wound dressing for the healing of complete and chronic skin wounds.

A composite membrane comprises a membrane matrix formed by the stable cross-linking of silk fibroin with β-sheets, and baicalin uniformly dispersed between the segments of the silk fibroin molecular chain, wherein the mass ratio of silk fibroin to baicalin is 100:3-4. The preparation method includes the following steps: 1) taking silkworm cocoons, boiling them several times with sodium carbonate solution, washing them, and drying them to 60°C; 2) dissolving them in a ternary solution, centrifuging and filtering to obtain a clear silk fibroin solution, and drying it to obtain silk fibroin; 3) preparing a silk fibroin solution with a concentration of 1-30 mg / ml, and adjusting the pH to 7.4; 4) adding baicalin to the silk fibroin solution, forming a film, drying it, and annealing it to obtain the composite membrane. The composite membrane of this invention has superior biocompatibility, hemostatic properties, and controllable biodegradability, and can promote M2 polarization of macrophages, shorten the inflammatory period, and effectively promote skin wound healing.

The invention relates to the technical field of medical apparatus and instruments, in particular to a plasma electrode device which comprises at least one electrode plate. The plurality of connecting electrodes are connected to the edge of the central electrode in a surrounding manner; the first connecting parts are arranged on the connecting electrodes, and the first connecting part of one electrode plate is correspondingly connected with the first connecting part of the adjacent electrode plate, so that the electrode parts of all the electrode plates are electrically connected. The modularized and splicable plasma electrode device provided by the invention realizes the splicing of a plurality of electrode plates by innovating the electrode component and the first connecting component, has the advantages of good skin wound surface fitting property, flexible treatment area expansion, reliable multi-unit connection and the like, and can adapt to various irregular wound surfaces and different sizes of wound surfaces.

According to the application of the arcangelisia loureiri extract in preparing the burn and scald wound healing medicine, the arcangelisia loureiri crude extract is obtained through extraction and concentration with a decoction method, and wound healing can be promoted by reducing the area of a rat skin wound, shortening the healing time of the rat skin wound, reducing the hyperplasia speed of the skin corium layer and promoting healing of the wound; the effects of remarkably promoting wound healing of burns and scalds and reducing scars are achieved.

Provided herein are cell-free compositions containing the secretome / exosomes of dsRNA primed cells ("herein dsRNA-primed secretome / exosome). The dsRNA-primed secretome is obtained from conditioned media following cell culture (for an effective amount of time) of cells treated with dsRNA, either by transfecting the cells with dsRNA or incubating the cells with dsRNA. The dsRNA-primed secretome / / exosome can be administered to a subject in need thereof, by administering an effective amount of the dsRNA-primed secretome / exosomes to a subject in need thereof. Exemplary subjects / sites of treatment include subjects include, but are not limited to in need of wound healing such as skin wound healing, burn sites, subjects in need of bone repair such as osteochondral bone repair, bone fracture sites, corneal wound sites. Other subjects include osteoporotic subjects and subjects with intervertebral disc degeneration.

The utility model relates to the technical field of medical instruments, and discloses a wound protection device for the cardiothoracic surgery department, which comprises a protection suite, a mounting insertion cylinder, a fitting pad, an abutting ring piece, a sterile cotton layer, a nursing cotton layer, a ventilation groove and a filter cotton layer. The attaching pad is attached and fixed to the skin, then the installation insertion cylinder is inserted and limited through the limiting clamping piece corresponding to the limiting groove, after the installation insertion cylinder and the protection sleeve are installed in a butt joint mode, the protection sleeve and the installation insertion cylinder can be fixed in a magnetic attraction mode through the magnetic attraction piece and the fixing magnetic ring, and after the installation insertion cylinder is inserted into the protection sleeve, the protection sleeve can be fixed through the fixing magnetic ring. The bottom of the nursing cotton layer can be attached to the wound of a patient for protection, antibacterial treatment is conducted through the disinfection cotton layer, when dressing change is conducted, the installation insertion cylinder is directly pulled out upwards, in this way, the protective sleeve and the installation insertion cylinder can be rapidly disassembled and assembled, use is convenient, redundant complex structural elements are reduced, and therefore the effects of reducing cost and improving practicability are achieved.

The invention relates to the technical field of skin medicines, in particular to a pharmaceutical composition for preventing or treating inflammatory skin diseases and application. The invention discloses a pharmaceutical composition for preventing or treating inflammatory skin diseases and application. The composition comprises active ingredients of astacin and derivatives thereof, p-toluene sulfonamide and derivatives thereof, and pharmaceutically or cosmetically acceptable excipients. Through the synergistic effect of the two active components, the composition can effectively inhibit skin inflammatory response, relieve pruritus and erythema and promote skin barrier repair and wound healing. The composition can be prepared into multiple external dosage forms such as cream, gel and spray, is suitable for preventing or treating multiple inflammatory skin diseases such as atopic dermatitis, eczema and psoriasis, and can also be used for repairing and nursing skin wounds. The external formula provided by the invention has both curative effect and safety, and provides a new choice for the treatment of inflammatory dermatosis.

The application provides a Guizhou Rhamnus skin wound healing ointment and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compositions. The ointment comprises Guizhou Rhamnus concentrated extract and base excipients. The ointment has the functions of promoting skin wound healing, preventing swelling and pain, preventing infection and scar, reducing swelling and pain, removing blood stasis and promoting tissue regeneration, dredging channels and activating collaterals, and healthy skin tissue. The active ingredients of traditional Chinese medicine have the advantages of rapid healing and repair, obvious swelling and pain relief, delicate ointment texture, easy absorption by the skin, high safety, good stability, wide source of raw materials, easy collection, simple preparation process, batch processing, no toxic side effects on the health of production personnel, and no adverse effects on the environment.

The application discloses a kind of by polydopamine mesoporous nanoparticles crosslinked sulfhydrylated hyaluronic acid hydrogel and its preparation method and application, with dopamine and 4-formylphenylboronic acid as monomer, with trimethylbenzene as and poloxamer as template agent, in weak alkaline (pH=8.4), oxygen exists in the environment, by the oxidation self-polymerization reaction between monomer Preparation of polydopamine nanoparticles with mesoporous structure.Then the water dispersion of polydopamine nanoparticles is mixed with sulfhydrylated hyaluronic acid solution according to certain proportion, and the hydrogel dressing with injectable property is prepared.The hydrogel is expected to be used as skin wound dressing for the treatment of diabetic wounds.

The invention relates to the technical field of medical supplies, in particular to a wound repair medical dressing containing glycosylglycerol, and a dressing solution for the wound repair medical dressing comprises the following raw materials: carbomer 940, medical glycerol, glycosylglycerol, sodium hyaluronate, purified water, 1, 2-hexanediol, 1, 3-butanediol and a pharmaceutical adjuvant sodium hydroxide. The dressing is extruded to a skin wound surface or an affected part to form a thin film structure, a physical barrier is formed, the wound surface or the affected part is isolated from the external environment, the wound surface is protected from being polluted by the external environment, a microenvironment is provided for non-chronic wound surface healing, a protective layer is formed on the surface of the wound surface, the physical barrier effect is achieved, and the wound surface is protected. The dressing is used for nursing superficial wounds such as small wounds, scratches and incisions and surrounding skin; the contained components do not have pharmacological effects and cannot be absorbed by a human body.

The invention belongs to the field of medicines, and particularly relates to an in-vitro evaluation model for promoting skin wound healing based on a VPA-Exo drug-loaded exosome as well as a construction method and application of the in-vitro evaluation model. The construction method of the in-vitro evaluation model for promoting skin wound healing comprises the following steps: S1, after passage of resuscitated HSF cells and HUVEC cells, taking HSF cells or HUVEC cell suspension in a logarithmic phase, inoculating the HSF cells or HUVEC cell suspension on a culture plate, and culturing on a real-time label-free cell analyzer for 20-28 hours; and S2, then adding VPA-EXO with the concentration of 12.5 mu g / mL-400 mu g / mL to act on the HSF cells or the HUVEC cells.

This invention discloses an exovesicle from *Ashitsubaki* (Tomorrow's Leaf), its preparation method, and its application in the preparation of skin wound repair products, belonging to the field of plant exovesicle technology. The method uses fresh *Ashitsubaki* leaf stems and leaves as raw materials. After crushing, the material is filtered through a filter bag. The filtrate is then enzymatically hydrolyzed, centrifuged, and finally filtered through a tangential flow filtration system and further filtered to remove impurities and bacteria, yielding uniformly sized *Ashitsubaki* exovesicles. The preparation method of this invention is simple, and the obtained *Ashitsubaki* exovesicles exhibit excellent cell migration and skin healing promotion abilities, showing broad application prospects in the preparation of skin wound repair products.

The present invention relates to a composition for wound treatment or skin regeneration, comprising an extract from one or more selected from the group consisting of Trichosanthes kirilowii (T. kirilowii), Pueraria lobata (P. lobata), Liriope platyphylla (L. platyphylla), Poria cocos (P. cocos), Prunus mume (P. mume), Astragalus membranaceus (A. membranaceus), Panax ginseng (P. ginseng), and Glycyrrhiza uralensis (G. uralensis). The composition has low cytotoxicity and exhibits wound-healing effects, particularly therapeutic effects on extensive skin ulcers such as diabetic skin ulcers.

The utility model relates to the technical field of medical instruments, in particular to an elastic pull-fit patch for skin wounds, which comprises two elastic patches, a centering structure is arranged between the two elastic patches, and the centering structure comprises a fixing groove frame and two pull-fit belts. The two pulling belts are fixedly connected with the two elastic stickers respectively; by means of the centering structure, when the device is fixed to the wound of a patient, a cotton ball covers the middle of the wound, then a rotating button is rotated, a rotating rod drives a small gear to rotate, due to the fact that the outer surface of the small gear is meshed with gear racks on the two sides, pulling-closing belts on the two sides can slide in a fixing groove frame, and therefore elastic stickers on the two sides are driven to symmetrically cover the two sides of the wound; when the elastic pastes on the two sides reach proper positions, the elastic pastes stop rotating, the covering films on the two sides are torn down, the elastic pastes on the two sides are pasted on the skin of a patient, and therefore the purpose that the pulling pastes can be symmetrically pasted on the two sides of a wound and skin flaps on the two sides can be aligned when the pulling pastes are tensioned is achieved.

The application discloses a skin wound nursing device, belonging to the technical field of wound nursing, which comprises a nursing and cleaning seat, a wound nursing cover body connected to the nursing and cleaning seat through a sliding connecting piece, a cleaning groove arranged in the nursing and cleaning seat, a circulating flushing assembly arranged in the cleaning groove, conveying side seats arranged on the two sides of the wound nursing cover body, a spraying and moving inner ring connected to the conveying side seats through an electric sliding rail assembly, and a plurality of mist sprayers arranged in the spraying and moving inner ring. When a large-area wound is cleaned, the nursing and cleaning seat and the wound nursing cover body arranged in sliding mode can achieve the effect of automatic cleaning and disinfection, and the wound can be automatically smeared with medicinal liquid through the wound nursing cover body above the nursing and cleaning seat after cleaning, so that the sanitary safety during the whole wound nursing process is ensured, the wound is prevented from being infected, the work intensity of medical staff is remarkably reduced, and the wound nursing efficiency is improved.

This invention discloses the application of ferrous ions in the preparation of products for treating bacterial infections, belonging to the field of pharmaceutical technology. Antibacterial activity tests of ferrous ions against Staphylococcus aureus showed strong bactericidal effects, with a survival rate of less than 0.001% against Staphylococcus aureus and less than 0.01% against methicillin-resistant Staphylococcus aureus (MRSA). The use of ferrous ion-containing hydrogels in the treatment of keratitis and skin wound infections significantly reduced the risk of MRSA infection in the lungs and effectively prevented the proliferation and spread of microorganisms in the body, revealing that drugs containing ferrous compounds can be used to treat Staphylococcus aureus infections, including MRSA.

Provided herein are solid forms, e.g., polymorphs, of 2-(3-((7R,8aS)-7-fluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)azetidin-3-yl)acetonitrile, which are useful for treating kinase-related diseases or disorders. The solid forms, and compositions thereof, are useful for treating diseases in a subject, including, but not limited to, ocular diseases such as glaucoma, ocular hypertension, ocular wound repair, neurodegenerative ocular diseases, retinal detachment, and non-ocular diseases such as nerve injury, or skin wound repair, or inflammatory diseases, among others. (Compound 1) TIFF2026501674000028.tif4839

The utility model relates to a kind of scar paste with temperature control memory effect and tension reduction function, the scar paste includes layer by layer arranged silica gel layer, shape memory metal layer, temperature control layer and waterproof layer;The silica gel layer includes the adhesive part of symmetrical adhesion in the two sides of skin wound when using, the two ends of the shape memory metal layer are connected with the adhesive part of corresponding side respectively, temperature control layer and waterproof layer are sequentially arranged on shape memory metal layer;The shape memory metal layer is used to change into preset contraction mode under skin temperature and / or the heating of temperature control layer and drive adhesive part shrink in tension reduction direction.It can drive the adhesive part of silica gel layer shrink in tension reduction direction under skin temperature compared with prior art, so as to achieve the effect of tension reduction and inhibiting scar hyperplasia, finally realize the effect of "scarless healing".

This invention provides a plant-based gel patch and its preparation method. The plant-based gel patch is prepared by mixing and freezing the following components, including modified polyvinyl alcohol, modified chitosan, functionalized borate ester, and distilled water; the preparation method is as follows: (1) modification of chitosan; (2) synthesis of functionalized borate ester; (3) preparation of allyl dihydrocaffeic acid; (4) graft modification of polyvinyl alcohol; (5) molding of the plant-based gel patch; the plant-based gel patch prepared by this invention can be used as a dressing for skin wound healing, and has antibacterial, good adhesion and self-healing ability.

The application discloses an adjustable skin wound suture device for livestock pathological sampling and relates to the technical field of medical suture devices.The slide hole plate is symmetrically installed at the axial center position of the end cover, and the inner wall of the slide hole plate is in threaded connection with the outer side of the screw rod.A stop rod is slidably installed on the inner wall of the slide hole plate, and the end of the stop rod, which is far away from the slide hole plate, is an inclined surface that is inclined from top to bottom to one side of the slide hole plate.The adjustable skin wound suture device for livestock pathological sampling is characterized in that the threaded connection of the screw rod and the slide hole plate can adjust the position of the stop rod according to the skin thickness of the suture position, adjust the bending depth of both sides when the skin nail is driven into the skin, and adjust the suture depth.When the device is lifted after the skin nail is driven into the suture position, the movement of the stop rod during resetting is matched with the inclined surface to press down the top of the skin nail, so that the skin nail cannot be separated after resetting, the stop rod still blocks the skin nail, and the suture position is pulled when the device is lifted.

This invention relates to a skin cell dispersion for autologous treatment of skin wounds. Specifically, this invention provides a skin cell dispersion containing skin cells, epidermal growth factor, and transforming growth factor-β1. The skin cell dispersion of this invention exhibits excellent therapeutic effects on skin wounds.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition for topical application containing sucralfate wet gel. The invention relates to a local application composition containing sucralfate wet gel, which is prepared from the following components in percentage by mass: 15 to 25 percent of sucralfate wet gel, 10 to 18 percent of polyethylene glycol, 0.2 to 0.5 percent of polyethylene glycol stearate, 0.1 to 0.21 percent of sodium methyl p-hydroxybenzoate, 0.01 to 0.023 percent of sodium propyl p-hydroxybenzoate and the balance of purified water. The sucralfate wet gel dressing is smeared on a non-infected and carefully disinfected skin wound surface and dried, a solid barrier is formed on the part, the wound surface can be covered, damaged tissues below the wound surface can be protected against external stimulation, and the sucralfate wet gel dressing is used for treating non-infectious wound surfaces and ulcers, especially vascular ulcers, diabetic ulcers, bedsores and radiodermatitis, and has a good application prospect. A layer of protective barrier is formed on the broken or damaged surface, so that physiological healing is promoted.

The invention discloses a high-efficiency anti-infection double-layer artificial skin and a preparation method thereof. The high-efficiency anti-infection double-layer artificial skin has an excellent antibacterial effect and can reduce the occurrence of mucous membrane and instrument related infections. The collagen scaffold is a recombinant collagen scaffold with a three-dimensional pore structure, provides a suitable physical structure for cells, is beneficial to adhesion and proliferation of fibroblasts, vascular endothelial cells and the like, and has a remarkable skin wound repair effect. According to the invention, mTGase is mainly used for cross-linking glutamine and lysine sites to form protein-protein cross-linking; the Bis-PEG6-Acid can be used for cross-linking the Lys (Lys-NH2) and another protein, so as to form PEG (Polyethylene Glycol)-protein cross-linking; the mTGase and the Bis-PEG6-Acid do not directly and synergistically catalyze the same reaction site, a primary protein network is firstly constructed by the mTGase, the crosslinking density is further enhanced by the Bis-PEG6-Acid, a double-network structure is realized, and the mechanical strength, the degradation resistance and the hydrophilicity of the stent material are enhanced. And the hydrogel also has good tensile elasticity and biocompatibility, and is free of cytotoxicity and sensitization.

This invention discloses a skin tension reducer and method based on full-cycle regulation, belonging to the field of medical aesthetics technology. The skin tension reducer includes a left auxiliary film, a right auxiliary film, multiple tension adjustment devices, and a tension detection device. The adjustment device includes a fixed guide block, a traction belt, and a conical spiral tensioner. Two guide blocks are fixed at the same height on the left and right auxiliary films, respectively. Each guide block has a conical internal thread and a guide hole, and the conical spiral tensioner is threaded into the conical guide hole. One end of a traction belt is connected to the conical spiral tensioner on the left auxiliary film, and the other end is fixed to the fixed guide block on the right auxiliary film via the guide hole. The tension detection device includes strain gauges, a tension acquisition plate, and a handheld display. Each traction belt has a strain gauge attached to it for detecting the tension of the traction belt. This invention can dynamically manage tension reduction throughout the entire healing cycle of skin wounds, achieving high-quality tension reduction.

To provide compositions and methods for treating skin wounds, disorders and diseases.SOLUTION: The disclosure relates, in part, to a pharmaceutical composition comprising one or more polynucleotide species suitable for enhancing, increasing, augmenting, and / or supplementing the levels of Collagen alpha-1 (VII) chain polypeptide and / or lysyl hydroxylase 3 polypeptide and / or Keratin type I cytoskeletal 17 polypeptide in a subject. The disclosure also relates, in part, to pharmaceutical compositions and methods of use for providing prophylactic, palliative, or therapeutic relief of a wound, disorder, or disease of the skin in a subject, including a subject having, or at risk of developing, one or more symptoms of epidermolysis bullosa.SELECTED DRAWING: Figure 3