44 results about "Skin wound" patented technology

The application discloses a kind of by polydopamine mesoporous nanoparticles crosslinked sulfhydrylated hyaluronic acid hydrogel and its preparation method and application, with dopamine and 4-formylphenylboronic acid as monomer, with trimethylbenzene as and poloxamer as template agent, in weak alkaline (pH=8.4), oxygen exists in the environment, by the oxidation self-polymerization reaction between monomer Preparation of polydopamine nanoparticles with mesoporous structure.Then the water dispersion of polydopamine nanoparticles is mixed with sulfhydrylated hyaluronic acid solution according to certain proportion, and the hydrogel dressing with injectable property is prepared.The hydrogel is expected to be used as skin wound dressing for the treatment of diabetic wounds.

This invention discloses an exovesicle from *Ashitsubaki* (Tomorrow's Leaf), its preparation method, and its application in the preparation of skin wound repair products, belonging to the field of plant exovesicle technology. The method uses fresh *Ashitsubaki* leaf stems and leaves as raw materials. After crushing, the material is filtered through a filter bag. The filtrate is then enzymatically hydrolyzed, centrifuged, and finally filtered through a tangential flow filtration system and further filtered to remove impurities and bacteria, yielding uniformly sized *Ashitsubaki* exovesicles. The preparation method of this invention is simple, and the obtained *Ashitsubaki* exovesicles exhibit excellent cell migration and skin healing promotion abilities, showing broad application prospects in the preparation of skin wound repair products.

The utility model relates to a kind of scar paste with temperature control memory effect and tension reduction function, the scar paste includes layer by layer arranged silica gel layer, shape memory metal layer, temperature control layer and waterproof layer;The silica gel layer includes the adhesive part of symmetrical adhesion in the two sides of skin wound when using, the two ends of the shape memory metal layer are connected with the adhesive part of corresponding side respectively, temperature control layer and waterproof layer are sequentially arranged on shape memory metal layer;The shape memory metal layer is used to change into preset contraction mode under skin temperature and / or the heating of temperature control layer and drive adhesive part shrink in tension reduction direction.It can drive the adhesive part of silica gel layer shrink in tension reduction direction under skin temperature compared with prior art, so as to achieve the effect of tension reduction and inhibiting scar hyperplasia, finally realize the effect of "scarless healing".

This invention provides a plant-based gel patch and its preparation method. The plant-based gel patch is prepared by mixing and freezing the following components, including modified polyvinyl alcohol, modified chitosan, functionalized borate ester, and distilled water; the preparation method is as follows: (1) modification of chitosan; (2) synthesis of functionalized borate ester; (3) preparation of allyl dihydrocaffeic acid; (4) graft modification of polyvinyl alcohol; (5) molding of the plant-based gel patch; the plant-based gel patch prepared by this invention can be used as a dressing for skin wound healing, and has antibacterial, good adhesion and self-healing ability.

The application discloses an adjustable skin wound suture device for livestock pathological sampling and relates to the technical field of medical suture devices.The slide hole plate is symmetrically installed at the axial center position of the end cover, and the inner wall of the slide hole plate is in threaded connection with the outer side of the screw rod.A stop rod is slidably installed on the inner wall of the slide hole plate, and the end of the stop rod, which is far away from the slide hole plate, is an inclined surface that is inclined from top to bottom to one side of the slide hole plate.The adjustable skin wound suture device for livestock pathological sampling is characterized in that the threaded connection of the screw rod and the slide hole plate can adjust the position of the stop rod according to the skin thickness of the suture position, adjust the bending depth of both sides when the skin nail is driven into the skin, and adjust the suture depth.When the device is lifted after the skin nail is driven into the suture position, the movement of the stop rod during resetting is matched with the inclined surface to press down the top of the skin nail, so that the skin nail cannot be separated after resetting, the stop rod still blocks the skin nail, and the suture position is pulled when the device is lifted.

A reusable bandage apparatus for covering a wound is disclosed. The reusable bandage apparatus comprises a dome configured to cover and protect a skin wound. The reusable bandage apparatus also comprises a flange extending around the base of the dome, wherein the flange is configured to rest on non-injured skin surrounding the skin wound. The reusable bandage apparatus further comprises a plurality of protrusions located on the underside of the flange, wherein the plurality of protrusions is configured to create a gap between the flange and the non-injured skin.

The application discloses a kind of wound repair composite preparation based on FGF2 variant and its application, it is related to the technical field of skin wound repair biological preparation, the composite preparation is composed of active ingredient and matrix, the active ingredient is FGF2 mutant, the matrix is cream.The FGF2 mutant is NGF2 protein, the NGF2 protein is obtained by protein engineering technology to natural FGF2 is reformed;The NGF2 protein has high thermal stability and extended normal temperature half-life.The cream is preferably water cream (Basic Aquacream).In the application, NGF2 and water cream synergistically, extend the local action time of protein, realize the effect of reducing the frequency of smearing, enhance repair durability.Preparation can effectively promote wound granulation tissue formation, angiogenesis and collagen remodeling, improve healing quality and reduce scar, provide reliable scheme for the development of new generation wound repair biological preparation.

This invention provides a polypeptide and its application in the preparation of products that promote skin wound repair. The polypeptide of this invention, with the amino acid sequence shown in SEQ ID NO:1, not only possesses excellent anti-inflammatory and antioxidant activities, making it suitable for the preparation of anti-inflammatory and antioxidant products, but also effectively promotes the migration of skin fibroblasts and accelerates wound healing, making it suitable for the preparation of products that promote skin wound repair.

The present application relates to the technical field of medical devices, and discloses a wound treatment patch for a high flow rate humidification therapeutic instrument, which comprises a gas-permeable transparent film, an adhesive layer, a connection base and a connecting member, and a plurality of air holes are formed in the gas-permeable transparent film; the adhesive layer is arranged along the peripheral edge of the gas-permeable transparent film; the connection base is installed on one side wall of the adhesive layer and has a hollow channel; one end of the connecting member is connected with the connection base, and the other end of the connecting member is used for being connected with the interface of the high flow rate humidification therapeutic instrument. In this way, the gas chamber formed by the gas-permeable transparent film, the adhesive layer and the skin wound can accommodate gas, the plurality of air holes on the gas-permeable transparent film can be used for discharging gas outward, so that the high flow rate humidification gas entering through the connection base can be filled in the gas chamber, the growth of anaerobic bacteria is inhibited, and the skin wound healing is accelerated.

The application provides a preparation method of oxygen-releasing gelatin for wound healing and application thereof, and relates to the technical field of gelatin preparation.The preparation method comprises the following steps: mixing gelatin with water, adding a mixture of neutral protease and chymotrypsin, carrying out enzymolysis at pH 5.5-6.5 and a temperature of 45-55 DEG C for 10-15 min, inactivating, and obtaining pretreated gelatin by using a dialysis bag with a molecular weight cut-off of 10-15 kDa; mixing the pretreated gelatin with water, adding 30wt%-32wt% hydrogen peroxide solution, stirring, adding 32wt%-34wt% hydrogen peroxide solution, and stirring; continuously adding 30wt%-32wt% hydrogen peroxide solution and stirring; obtaining a crude product; and purifying.The application combines specific enzymolysis pretreatment, an oxidation process and purification to prepare gelatin with better oxygen-releasing capacity, bacteriostatic capacity and significant promotion of skin wound healing, and the gelatin is safe and effective.

The present application provides a kind of synthetic polypeptide and its application in promoting skin healing, the amino acid sequence of the provided synthetic polypeptide is SEQ ID NO:1.The present application also provides the derivative polypeptide of the above-mentioned synthetic polypeptide.The synthetic polypeptide of the present application has obvious wound healing promoting activity, can be used to accelerate the healing of body surface skin wound, reduce scar production.Therefore, the synthetic polypeptide of the present application has excellent wound healing promoting activity, can be used as production raw material or dressing for drug, postoperative medical device, health care product, cosmetic and the like with skin repair function, has broad application prospect.

The application provides application of a carrot-derived extracellular vesicle-like particle in preparation of a skin wound repair product, and belongs to the technical field of biological medicine. The extracellular vesicle-like particle has good water dispersibility and low-temperature storage stability; can be taken by dermal fibroblasts, vascular endothelial cells and the like, can reduce cell apoptosis, improve cell activity, promote proliferation, migration and blood vessel formation related functions under high-sugar high-fat and the like damage conditions, thereby synergistically improving the functions of dermal fibroblasts and vascular endothelial cells, and has certain antibacterial capacity, thereby being beneficial to skin wound healing, and providing a scheme and a clinical conversion idea for wound treatment.

This invention discloses a dressing for treating atopic dermatitis, its preparation method, and its application, relating to the field of medical materials technology. The dressing for treating atopic dermatitis is composed of PH powder and Que@CD nanoparticles. The technical solution provided by this invention utilizes amino-rich ε-polylysine and NHS ester-modified hyaluronic acid for rapid cross-linking via an amidation reaction in a moist environment, forming a three-dimensional gel network encapsulating Que@CD nanoparticles. Utilizing the water solubility of Que@CD, quercetin can be rapidly released to relieve itching. Simultaneously, it exerts anti-inflammatory and antioxidant effects by scavenging excess reactive oxygen species, alleviating oxidative stress, regulating the immune microenvironment, and inhibiting the release of inflammatory factors. Therefore, the dressing proposed in this invention possesses in-situ gelling properties and drug burst release capability, enabling it to closely adhere to irregular skin wounds and comprehensively exert antioxidant, anti-inflammatory, and immunomodulatory effects.

The application discloses a kind of skin wound closure dressing aerosol and preparation method.The aerosol is composed of effective drug, film-forming dressing matrix, propellant;Among them, the effective drug includes sanqi extract, radix lithospermi extract, coptis extract, D-panthenol, oltipraz, pain reliever;The film-forming dressing matrix includes fish scale collagen, polyvinyl alcohol, nanocellulose, carbomer, deionized water.The present application is water-based aerosol medical dressing, utilizes the initial rapid film-forming characteristics of polyvinyl alcohol and the characteristics of fish scale collagen powder and skin tight bonding, synergistic nanocellulose, carbomer is made into film-forming dressing matrix.Further, in dressing, the effective drug with hemostasis, sterilization, analgesic efficacy is added, and the wound is promptly hemostatic, sterilization, swelling, pain relief, promotes healing.The aerosol can be conveniently sprayed to form a protective barrier for the quick film-forming closure of superficial skin minor abrasions, scratches, bedsores, etc.

This invention provides a hydrogel for treating atopic dermatitis and its applications, relating to the field of biomedical technology. The hydrogel comprises SA, plasma water, L-G2, and / or FLA. Preliminary evaluation of the hydrogel was conducted through in vitro cytotoxicity and antibacterial performance tests, confirming its ability to inhibit Staphylococcus aureus and Escherichia coli. Simultaneously, the hydrogel exhibits low cytotoxicity, meeting the basic requirements for biomedical dressings. In animal experiments, by comparing skin lesions before and after treatment in AD mice, the hydrogel was observed to significantly improve skin lesions on the back of mice, demonstrating good anti-inflammatory effects. Pathological histological analysis showed that the hydrogel can reduce epidermal thickness, inhibit the increase in TNF-α levels induced by DNCB, and promote inflammation relief. Simultaneously, SA can provide a moist healing environment for skin wounds, helping to promote wound repair. Therefore, this hydrogel provides a new strategy for the treatment and management of AD and is expected to become a novel topical drug for AD treatment.

This invention relates to a temperature-responsive injectable hydrogel, its preparation method, and its application, belonging to the field of dual-network hydrogel construction and application technology. The hydrogel method includes: (1) reacting chitosan oligosaccharide with an allyl reagent to obtain allyl chitosan oligosaccharide; (2) crosslinking and copolymerizing allyl chitosan oligosaccharide with N-isopropylacrylamide under the action of a polymerization initiator to obtain a temperature-sensitive microgel; (3) loading genipin onto the temperature-sensitive microgel to obtain component A; (4) loading β-glycerophosphate onto the temperature-sensitive microgel to obtain component B; (5) mixing component A, component B, and chitosan solution to obtain a temperature-responsive injectable dual-network hydrogel for drug delivery. The temperature-responsive injectable hydrogel provided by this invention satisfies both injectability and strength stability requirements, and can be applied to, but is not limited to, long-term drug delivery via skin wounds or implantation, possessing high application value.

The application relates to the field of biomaterials and regenerative medicine, in particular to a preparation method and application of fibronectin and collagen protein-loaded PLGA nanoparticles, wherein the preparation method adopts a complex emulsion solvent evaporation method, a buffer solution containing fibronectin, collagen protein and trehalose is used as an inner water phase, a dichloromethane solution of PLGA is used as an oil phase, and a polyvinyl alcohol and trehalose-containing aqueous solution is used as an outer water phase; and the nanoparticles are prepared through emulsification, high-pressure homogenization, dialysis and freeze-drying. The method has the beneficial effects of stable process and effective protection of protein activity. The obtained nanoparticles have uniform particle sizes (100-200 nm), and can realize synergistic controllable release of double proteins. The product organically combines the physical filling support function of PLGA and the biological repair function of active factors, realizes the integration of "filling-regeneration", can significantly reduce the risk of inflammation, and can be safely applied to soft tissue filling, wrinkle improvement and skin wound repair in the field of medical cosmetology.

This invention discloses a gellizable, dynamically adhesive, moist wound healing dressing and its preparation method and application. The dressing is constructed from water-soluble cellulose derivatives, chitosan derivatives, and silk fibroin through physical cross-linking and freeze-induced phase separation, achieving dry-state stability without the need for chemical cross-linking agents. Upon contact with wound exudate, a gel layer forms. With prolonged contact, the carboxyl, amino, and hydroxyl functional groups form a dynamic, reversible hydrogen bond and electrostatic interaction network with skin surface proteins, resulting in an adhesion interface strength lower than the external force required for peeling, thus achieving non-damaging peeling. Furthermore, the dressing possesses antibacterial properties and acts as a nutrient substrate to promote cell proliferation and tissue regeneration. This invention's dressing integrates gelation, moisturizing, dynamic adhesion, antibacterial, and nutritional healing functions, making it suitable for moist wound healing treatment of various skin wounds and providing a novel dressing for clinical wound care.

The application provides a nanoscale photothermal electric coupling energy platform and a preparation method and application thereof, and belongs to the technical field of nanobiomedical materials. The method comprises the following steps: dispersing ZIF-8 particles in an alcohol solvent of silver nitrate, introducing metal silver ions through ion exchange and / or adsorption; dispersing the ZIF-8 material loaded with metal silver ions in an alcohol solvent, dropping a selenium precursor solution prepared by dissolving a sulfide and elemental selenium powder in an organic solvent together, and generating uniformly distributed metal silver selenide nanoparticles in the confined space of ZIF-8 in situ. The obtained product is composed of a ZIF-8 carrier and uniformly dispersed metal silver selenide semiconductor nanoparticles, has a particle size of 300+ / -20 nm, and has a photothermal electric effect. The energy platform can be combined with a biocompatible matrix to form a flexible patch, a film or a coating, can promote cell proliferation, migration, collagen deposition or recovery of mitochondrial function, and is particularly suitable for treating diabetic skin wounds.

The application belongs to the field of biomedical materials, and discloses a multifunctional hydrogel suitable for diabetic wound healing. The hydrogel is compounded by HA-Tris, EPL-Cpb and MXene / Mn composite nanoparticles in a mass ratio of 2:1:(0-0.2), and is rapidly crosslinked in 1 min through a triple mechanism, with a crosslinking efficiency increased by more than 80% compared with traditional methods and a yield of more than 99.5%. The application realizes chemical-photothermal dual-mode antibiosis through precise optimization of the ratio and reaction conditions and the function synergy of the components, with an inhibition rate of 96.86% and 97.23% for Escherichia coli and Staphylococcus aureus, which is increased by more than 62% compared with traditional silver-containing dressings; the hydrogel has a ROS clearance rate of 92.5% and an in-situ oxygen production rate increased by 58% compared with traditional methods, and can efficiently stop bleeding within 30 s, with a blood loss reduced by 90.3% compared with the blank group. The hydrogel has excellent biocompatibility and can comprehensively improve the pathological microenvironment of diabetic wounds, shortening the healing period of full-thickness skin wounds of diabetic rats from 21 days to 10 days, and providing a new and efficient biomedical material for the treatment of diabetic wounds.

The utility model provides a skin wound slide bar type expansion fixator for animal experiments. The skin wound slide bar type expansion fixator is mainly composed of a main shaft body, a fixed suture plate, a sliding suture plate, a spring retention bolt and a spring. The main shaft body is of a cylindrical rod body structure, the fixed sewing plate is fixedly connected to the end of one end of the main shaft body, the spring retention bolt is fixedly connected to the other end of the main shaft body, and the sliding sewing plate is provided with a sliding hole and penetrates through the sliding hole based on the main shaft body to form sliding connection. The two ends of the spring are fixedly connected to the spring retaining bolt and the sliding suture plate respectively, so that the sliding suture plate is limited on the main shaft body to slide based on the elastic force of the spring. The slide bar type expansion fixer has the characteristics of greatly simplified mechanical structure, lower cost and suitability for parallel arrangement and rectangular wound surfaces, and is particularly suitable for being applied to related experimental researches that small experimental animals are induced to form skin fibrosis in the wound surface healing process.

The application discloses arginase 2 inhibiting peptides and application thereof in wound healing. The arginase 2 inhibiting peptide has an amino acid sequence as shown in SEQ ID No. 1 or a mutant sequence thereof. It is found through research of the application at a cell level and in a mouse skin wound model that MUT4-short peptide and MUT5-short peptide can effectively improve the viability and migration ability of keratinocytes under high-sugar conditions in vitro and in a metabolic abnormality model in vivo, reduce the intracellular reactive oxygen level, and promote the repair process of skin wounds, wherein the MUT4-short peptide shows more significant in promoting the recovery of cell functions and accelerating wound healing, and has a good application prospect in promoting skin wound healing, especially in the treatment of difficult-to-heal wounds related to metabolic diseases such as diabetes.

The application discloses a kind of for skin wound patient's suspension bed nursing pad and method for treating urination and defecation.It relates to the technical field of medical devices for suspension bed, comprising: the base stabilizing layer is detachably connected with the suspension bed by microsuction cup, and one end of the base stabilizing layer is provided with a limiting portion;The dynamic shaping layer is arranged on the limiting portion of the base stabilizing layer, and the dynamic shaping layer is composed of a plurality of independent sealed microcapsules arranged in an array, and each microcapsule is provided with a thixotropic non-newtonian fluid material;The absorption and flow guide layer is arranged above the base stabilizing layer and the dynamic shaping layer.The excrement collecting assembly is arranged on the base stabilizing layer.The application discloses a kind of for skin wound patient's suspension bed nursing pad and method for treating urination and defecation, which prevents sliding on the base stabilizing layer, sets up dynamic shaping layer to actively cooperate with the suspension bed to form a recess at the root of patient's leg for defecation, avoids the movement of patients with large-area burns, and can effectively improve the comfort of patients.

This invention relates to a composite hydrogel with hemostatic and antibacterial functions, its preparation method, and its application. The nanocomposite hydrogel is prepared by copolymerizing graphene oxide loaded with silver nanoparticles and chitosan grafted with dihydroporphyrin E6 during the preparation of thermosensitive poly(N-isopropylacrylamide) hydrogel. This composite hydrogel integrates multiple functions such as antibacterial, hemostatic, and cell proliferation and migration promotion. It possesses excellent thermosensitivity, injectability, swelling properties, tissue adhesion, and biodegradability. It achieves highly efficient antibacterial activity through photothermal-photodynamic synergy and multiple antibacterial components. Furthermore, it effectively controls bleeding by utilizing the sealing effect of the hydrogel and the hemostatic properties of chitosan, while simultaneously promoting fibroblast proliferation and migration. It plays a positive role in all stages of wound healing and is suitable for use as a dressing for infected skin wounds.

This invention belongs to the field of biomedical materials technology, specifically relating to a photocrosslinked dual-network hydrogel that promotes skin wound healing and its preparation method. Glycidyl methacrylate is added dropwise to an aqueous solution of ε-polylysine to obtain methacrylated polylysine. An aqueous solution of hyaluronic acid and an aqueous solution of sodium periodate are mixed under light-protected conditions and stirred to obtain oxidized hyaluronic acid. The methacrylated polylysine solution and the oxidized hyaluronic acid solution are mixed and vortexed until homogeneous to obtain a mixed solution. This mixed solution is injected into a mold and cured under ultraviolet light to obtain the photocrosslinked dual-network hydrogel. The dual-network hydrogel of this invention not only effectively solves the contradiction between mechanical strength and biocompatibility that is difficult to achieve simultaneously in traditional single-network hydrogels, but also integrates multiple healing mechanisms through functional complementarity between components.

This invention discloses a core-shell microneedle loaded with silver nanoparticles and growth factors, its preparation method, and its application, belonging to the field of biomedical technology. The core-shell microneedle includes a backing layer and an array of needle tips disposed on the backing layer; the needle tips in the needle tip array have a core-shell structure, with the shell layer of the needle tip loaded with protein-Ag2O2 composite nanoparticles and the core layer of the needle tip loaded with growth factors. The preparation method of the protein-Ag2O2 composite nanoparticles is as follows: a protein aqueous solution is mixed with a silver nitrate solution, and under alkaline conditions, it is reacted with a hydrogen peroxide solution to obtain the protein-Ag2O2 composite nanoparticles. The core-shell microneedles prepared by this invention, through hierarchical loading of silver peroxide nanoparticles and growth factors, respond to the microenvironment of infected skin wounds and perform programmed release, effectively preventing bacterial infection, promoting cell proliferation and angiogenesis, and driving tissue repair, effectively solving the problem of stagnant healing of infected wounds.

The application discloses a method for culturing sweat gland cells to obtain a sweat gland organoid and application thereof, and belongs to the technical field of bioengineering, wherein the sweat gland cells can be cultured by using a three-dimensional culture medium provided by the application, and a sweat gland organoid with high cell activity and bidirectional differentiation potential is obtained; after being transplanted into a full-thickness injury mouse on the sole and back, the sweat gland organoid not only can promote the regeneration and function recovery of the sweat gland, but also can promote the healing of the skin wound, and can be used for preparing a cell product for repairing skin injury and recovering the function of an accessory organ, and has a wide application prospect.

The utility model relates to medical instrument technical field discloses a kind of wound pressure device based on plasticity gauze bag, including the pressure package of polygon and multiple patch blocks, each side upper edge of pressure package outer perimeter is equipped with tensile belt, the two sides of pressure package are equipped with multiple self-adhesive bandage;Each self-adhesive bandage is attached to skin by its rear end face;The rear end face of each patch block is attached to skin by being equipped with second surface, each tensile belt is connected with each patch block one-to-one, each tensile belt is used to exert elastic tension to pressure package to make pressure package pressurization cover wound area.The utility model is covered skin wound area by multiple self-adhesive bandage to pressure package, and pressure package is designed as the mode of having interlayer outside opening to facilitate replacing sterile gauze block in it, in addition, tensile belt and patch block cooperate, which is provided at each side of pressure package, can provide elastic tension outward to each side of pressure package, so that pressure package generates more deformation that adapts to the shape of wound.

This invention discloses a multifunctional medical repair ozone oil composition and its preparation method, belonging to the technical field of medical external care preparations. The composition uses 1%–60% ozonated oil and animal repair oils as its core components, and can selectively add petrolatum, vitamin E, chitosan, and natural plant fragrance essential oils. The surgical skin-specific formula can add peppermint and borneol to enhance penetration, while the gynecological formula is gentle and non-irritating. This product has multiple effects, including antibacterial and anti-inflammatory properties, antipruritic and analgesic effects, moisturizing and repairing properties, and promoting the healing of mucous membranes and skin wounds. It is suitable for gynecological intimate care, surgical skin repair, and can also be applied externally to the back to soothe respiratory discomfort and to the abdomen to relieve abdominal pain and bloating. It has a wide range of applications, high clinical value, and is suitable for large-scale production and clinical promotion.

The application provides a preparation method of platelet exosomes and application thereof in wound healing, and belongs to the technical field of biological medicine. The application provides a complete method for preparing animal platelet exosomes PDEs by freezing and thawing, and provides application of the animal platelet exosomes PDEs in drugs for treating skin wound healing across species. Researches of the application prove that sheep-derived PDEs treated by activation can effectively promote skin wound healing of mice, and can significantly promote formation of new blood vessels in skin tissue; the application fills the research blank of heterogenous PDEs in the field of wound healing treatment, provides a new drug selection and treatment approach for skin wound treatment, and has a wide application prospect in the field of clinical skin burn treatment.