221 results about "Methacrylic anhydride" patented technology

The invention discloses injectable hydrogel with redox activity and electroactivity as well as a preparation method and application of the injectable hydrogel, and belongs to the technical field of medical materials. The preparation method comprises the following steps: reacting methacrylic anhydride and polysaccharide molecules in a solvent to prepare a double-bond functional polymer; the preparation method comprises the following steps: firstly, pre-polymerizing dopamine in a solvent, and then adding MOF (Metal Organic Framework) to carry out polymerization reaction, so as to prepare dopamine modified MOF; reacting the dopamine modified MOF, EDOT and ferric salt in a solvent, and collecting the precipitate to prepare a nano filler; the preparation method comprises the following steps: jointly dispersing the double-bond functional polymer, active polypeptide, a photoinitiator and nano filler into a solvent, and carrying out photocuring cross-linking. The preparation condition is mild, gel forming is rapid, the method is simple, the prepared hydrogel has injectable performance and conductive performance, catalytic activity of natural enzyme can be simulated, active oxygen removal can be achieved in the early stage of myocardial ischemia, electrical conduction of infarction parts can be enhanced, and effective recovery of cardiac functions can be achieved.

The invention relates to a double-layer dressing for promoting wound healing and inhibiting scars and a preparation method and application thereof.The double-layer dressing comprises a hydrogel layer and a piezoelectric film layer compounded on the hydrogel layer, and the piezoelectric film layer is prepared by mixing an organic piezoelectric material, a ferroelectric material and an organic solvent and then conducting an electrostatic spinning technology; the hydrogel layer is formed by curing a methacrylic anhydride acellular extracellular matrix, methacrylic anhydride catechol chitosan and conductive nanoparticles under the action of a curing agent. The lower skin contact layer of the double-layer dressing is the hydrogel layer, so that the directional growth of fibroblasts is favorably induced; the upper dressing is a piezoelectric material composite ferroelectric material, is beneficial to piezoelectric stimulation re-induction function recovery after final skin repair and guidance of directional growth of wound cells, and has good skin wound induction repair and scar inhibition effects.

The invention provides a methacrylic anhydride modified sclera extracellular matrix repair material and a curing method thereof, and belongs to the technical field of medical repair materials. The methacrylic anhydride modified sclera extracellular matrix repair material provided by the invention is prepared from the following raw materials: a methacrylic anhydride modified sclera extracellular matrix, methacrylated gelatin, a photoinitiator and a solvent. The sclera extracellular matrix modified by methacrylic anhydride is adopted, methacrylic anhydride contains methacrylic acid, double bonds can be introduced, the sclera extracellular matrix has the photo-initiation polymerization capacity, and in-situ gelling can be carried out at sclera and cornea damage positions under the action of a photoinitiator; the sclera extracellular matrix has good biocompatibility and histocompatibility, so that sclera matrix cells and corneal epithelial cells are adhered and proliferated, and the sutureless repair is realized; the methacrylated gelatin can provide a photo-crosslinking gelatin network under the action of a photoinitiator, so that cell adhesion and proliferation can be promoted, and repair is realized.

The invention discloses a preparation method of a 32P-loaded ultrathin flaky chitosan hydrogel applicator. The preparation method comprises the following steps: (1) preparing a chitosan aqueous solution; (2) dropwise adding methacrylic anhydride into the chitosan aqueous solution for reaction to obtain methylacryloylated chitosan; (3) preparing a methylacryloyl chitosan aqueous solution; (4) adding 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone into the methylacryloylated chitosan aqueous solution to obtain a chitosan hydrogel precursor solution, and (5) coating the inner wall of a mold made of a polytetrafluoroethylene material with a super-hydrophilic coating; (6) adding the Na2H32PO4 aqueous solution and the chitosan hydrogel precursor solution into a mold, stirring, and carrying out illumination curing; and (7) taking out the cured hydrogel and packaging the hydrogel between two layers of transparent adhesive tapes. According to the application, the ultrathin hydrogel applicator can be prepared, so that the blocking of the hydrogel material to rays is reduced, and the curative effect of the applicator is enhanced.

The invention discloses polysaccharide-based double-network hydrogel as well as a preparation method and application thereof. The polysaccharide-based double-network hydrogel comprises a first gel network and a second gel network interwoven with the first gel network, the first gel network is formed by crosslinking modified chitosan and modified hyaluronic acid through a Schiff base reaction, and the second gel network is formed by crosslinking modified chitosan and modified hyaluronic acid through a photopolymerization reaction; wherein the modified chitosan is chitosan modified by glycidyl methacrylate or chitosan which is coupled with a cartilage regeneration promoting substance and is modified by glycidyl methacrylate, and the modified hyaluronic acid is formylated hyaluronic acid modified by methacrylic anhydride. The hydrogel prepared by the invention has controllable aperture, proper swelling property and long-term stable drug sustained release effect, can effectively maintain the activity of mesenchymal stem cells, has good in-vivo biocompatibility, and can significantly promote cartilage regeneration.

The present invention pertains to the technical field of materials. Disclosed are a polymer composite hydrogel and a preparation method therefor, and a tooth desensitization material. The polymer composite hydrogel consists of a GelMA hydrogel and BP nanosheets composited inside the GelMA hydrogel, wherein the GelMA hydrogel is prepared by crosslinking gelatin methacryloyl via double bonds under the action of a photoinitiator. Under the photothermal effect, the polymer composite hydrogel of the present invention can enhance the resistance of dentin to external stimuli and promote the formation of stable and effective occlusion of dentinal tubules. Moreover, the occlusion effect on the dentinal tubules exhibits acid resistance, corrosion resistance, and stability, preventing the possibility of short-term reopening of the occluded dentinal tubules. This is of great significance for the treatment of occluded dentin hypersensitivity (DH).

The invention relates to the technical field of medical interventional therapy materials, and particularly discloses a preparation method of sodium hyaluronate embolism microspheres and the prepared embolism microspheres. The preparation method of the sodium hyaluronate embolization microspheres comprises the following steps: S1, adding methacrylic anhydride, N, N-dimethylformamide and sodium hydroxide into a sodium hyaluronate aqueous solution, reacting, adding sodium chloride, reacting, adding absolute ethyl alcohol, precipitating, filtering to remove filtrate, cleaning and drying; s2, preparing a mixture of methacrylated sodium hyaluronate, a monomer with negative charges, an initiator and water into a water phase; a mixture of oil soluble liquid and a dispersing agent is used as an oil phase; and under the protection of nitrogen, carrying out reverse suspension polymerization. According to the preparation method of the sodium hyaluronate embolization microspheres, the methylacryloylated sodium hyaluronate and the negatively charged monomer are copolymerized to introduce the negatively charged group, so that the microspheres can effectively load chemotherapeutic drugs, and the compression elasticity is high.

The invention relates to the technical field of bone tissue materials, and discloses a metal-doped biomimetic mineralized dECM cryogel and a preparation method and application thereof.The preparation method of the cryogel comprises the steps that firstly, hyaluronic acid and methacrylic anhydride are mixed in a solvent, the pH value is adjusted, a reaction is conducted, and methacrylic acid hyaluronic acid is obtained; then under the condition of a photoinitiator, mixing the methacrylic acid hyaluronic acid with an acellular extracellular matrix, and performing freezing and crosslinking treatment to obtain the cryogel, and finally, soaking the cryogel in a mineralization solution containing Ca < 2 + > and / or Mg < 2 + >, adding a buffer solution containing phosphite ions, incubating, and washing to obtain the crystal gel. The biomimetic mineralized dECM cryogel prepared by the method disclosed by the invention is good in ion release stability, can significantly improve the migration ability of HUVECs, contributes to promoting proliferation of rMSCs and improving the osteogenic differentiation potential of the rMSCs, and can be used for regeneration and repair of bone defects.

The invention provides a GelMA microneedle patch loaded with chromogenic gold nano bipyramids and a preparation method thereof.The method comprises the steps that citric acid, chloroauric acid and a CTAC solution are mixed, then sodium borohydride is added, and a seed solution is obtained through stirring and standing; mixing chloroauric acid, silver nitrate, hydrochloric acid and CTAB (cetyltrimethyl ammonium bromide), and sequentially adding ascorbic acid and the seed solution to obtain a growth solution; carrying out centrifugation, morphology regulation and chemical etching purification to obtain a chromogenic gold nano bipyramid solution; the preparation method comprises the following steps: reacting gelatin with methacrylic anhydride in PBS, dialyzing and freeze-drying to obtain GelMA; dissolving GelMA in the gold nanoparticle bipyramid solution, and adding a photoinitiator LAP to obtain a mixed precursor solution; and the GelMA microneedle patch loaded with the gold nano bipyramid is prepared through mold casting, centrifugation, ultraviolet light crosslinking and drying demolding. The microneedle extraction and gold nano bipyramid color development integrated scheme is initiated, blood sampling is not needed, the dermis interstitial fluid is extracted in a minimally invasive mode through the microneedle, detection pain and trauma are reduced, the cross infection risk of blood treatment is avoided, and the microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle

The invention discloses a conductive hydrogel for promoting bone growth and a preparation method and application thereof.The preparation method comprises the steps that 1, a methacrylic anhydride gelatin hydrogel prepolymer solution is prepared, a photoinitiator is dissolved in deionized water, and a solution with the mass-volume concentration of 0.003-0.005 g / mL is prepared; methylacrylic anhydride gelatin Gelma is dissolved in the solution, and a methylacrylic anhydride gelatin hydrogel prepolymerization solution is prepared; (2) preparing a CuNPs dispersion liquid; (3) preparation of photo-crosslinking hydrogel: mixing the methylacrylic anhydride gelatin prepolymerization liquid and the CuNPs dispersion liquid to prepare a methylacrylic anhydride gelatin copper nanoparticle conductive hydrogel mixed liquid; in the mixed solution, the massic volume concentration of the methacrylic anhydride gelatin is kept at 0.05 g / mL, the concentration of the copper nanoparticles is 10 mmol / L-40 mmol / L, bubbles are removed, the mixed solution is added into a mold, ultraviolet irradiation is performed, and the photo-crosslinking hydrogel can be prepared. The gel has good conductivity, pore structure, biocompatibility and mechanical property, and has a good osteogenesis promoting effect. The preparation process is simple, and the repeatability is high.

The invention discloses a high-adhesion enzymatic hydrogel for promoting vascular intima repair and a preparation method of the high-adhesion enzymatic hydrogel, and belongs to the technical field of hydrogel preparation. The preparation method comprises the following steps: S1, carrying out double-bond modification on hyaluronic acid by utilizing methacrylic anhydride, and then cross-linking with dopamine to prepare dopamine modified double-bond hyaluronic acid; s2, deoxidizing the hyaluronic acid solution, adding a cross-linking agent and tyramine hydrochloride, and reacting in an acidic environment to prepare tyramine modified hyaluronic acid; s3, mixing the dopamine modified double-bond hyaluronic acid, the tyramine modified hyaluronic acid and deionized water to prepare a hydrogel precursor liquid; and S4, carrying out enzymatic reaction to obtain the hydrogel. The method designed by the invention is simple in process, no extra photocuring equipment needs to be added, and the constructed hydrogel is similar to an extracellular matrix. And the coating can be coated into different shapes to adapt to different environments. The gel is formed through enzymatic reaction, and the gel is rapid in gel forming, good in tissue adhesion, good in biocompatibility and suitable for being applied to vascular repair.

The invention discloses a plant-based deodorant and a preparation method thereof, and relates to the technical field of high polymer materials. When the plant-based deodorant is prepared, beta-cyclodextrin reacts with paratoluensulfonyl chloride and then reacts with ethylenediamine, and amino modified cyclodextrin is prepared; the plant-based extract is subjected to inclusion with amino modified cyclodextrin, and a cyclodextrin inclusion compound is prepared; the preparation method comprises the following steps: reacting hydroxyethyl cellulose with methacrylic anhydride to prepare double-bond modified cellulose; carrying out hydrothermal reaction on titanium sulfate, the carboxylated multi-walled carbon nanotube, ammonium fluoride and cerous nitrate to prepare a co-doped titanium dioxide / carbon nanotube; coating the co-doped titanium dioxide / carbon nano-tubes with oleic acid to prepare modified nano-particles; and reacting the double-bond modified cellulose with the cyclodextrin inclusion compound, and then copolymerizing with the modified nanoparticles and the comonomer to obtain the plant-based deodorant. The prepared plant-based deodorant has the advantages of good deodorization effect, slow release and photocatalytic degradation.

The invention discloses injectable hydrogel with a myocardial tissue repairing function as well as a preparation method and application of the injectable hydrogel, and relates to the technical field of medical materials. The preparation method of the injectable hydrogel comprises the following steps: carrying out a reaction on deferoxamine and DSPE-PEG-NHS, so as to obtain DSPE-PEG-DFO; the preparation method comprises the following steps: wrapping carvedilol with DSPE-PEG-DFO under the hydrophilic and hydrophobic action, so as to obtain a drug-loaded nano-micelle; the preparation method comprises the following steps: reacting a polymer containing amino or hydroxyl with methacrylic anhydride to obtain a methylacryloyl modified polymer; reacting the carboxyl-containing polymer with cysteamine hydrochloride to obtain a sulfydryl modified polymer; mixing the drug-loaded nano-micelle, the methylacryloyl modified polymer and the sulfydryl modified polymer, and reacting under ultraviolet radiation to obtain the injectable hydrogel. The hydrogel disclosed by the invention is good in biocompatibility, can release deferoxamine and carvedilol in a ladder manner, is matched with a myocardial repair process, and realizes a function of repairing damaged myocardial tissues.

The invention provides antibacterial silk fibroin hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The antibacterial silk fibroin hydrogel provided by the invention is prepared from the following components: modified silk fibroin and copper montmorillonite, the modified silk fibroin is at least one of glycidyl methacrylate modified silk fibroin, methacrylic anhydride modified silk fibroin, isocyanate ethyl methacrylate modified silk fibroin and norbornene anhydride modified silk fibroin, and chemical crosslinking is formed among molecules of the modified silk fibroin. The copper montmorillonite and the modified silk fibroin form physical crosslinking through hydrogen bonds, and the mass ratio of the modified silk fibroin to the copper montmorillonite is 100: (1-10). The antibacterial silk fibroin hydrogel provided by the invention has good biological safety, long-acting antibacterial property, electrical conductivity and good mechanical property.

The invention discloses a decellularized amniotic membrane matrix composite scaffold, a preparation method thereof and application of the decellularized amniotic membrane matrix composite scaffold in orbital bone defect repair, and relates to the technical field of biomedical engineering and biomedical materials. In order to solve the limitation of an existing orbit implant material, methacrylic anhydride (MA) is grafted to HAM, methacrylate HAMMA hydrogel is synthesized, and then the decellularized amnion matrix composite scaffold (HAMMA / HAP / BMP-2) is prepared by combining a simulated body fluid biomimetic mineralization method with 3D printing and ultraviolet curing. The composite scaffold material prepared by the invention can regulate the release of BMP-2 and maintain the effective drug concentration of a bone defect area so as to regulate the immune microenvironment of an early bone defect repair area, collect osteoblasts and accelerate the repair of bone defects.

The invention provides an analgesic microneedle patch based on 3D printing and a preparation method and application thereof, and belongs to the technical field of biomedical materials.The preparation method of the hydrogel microneedle patch based on 3D printing comprises the following steps that 1, cold water fish skin gelatin is dissolved in DPBS, and a gelatin solution is obtained; (2) mixing methacrylic anhydride and gelatin liquid to generate polymerization reaction, so as to obtain a hydrogel material; and 3) loading an anesthetic and analgesic drug on the hydrogel material, and printing by a photocuring 3D printing method to obtain the hydrogel microneedle patch. The 3D printing technology is combined with a microneedle which is a dysmenorrhea-free skin drug delivery system, local anesthetics are loaded into the microneedle patch, on the basis of painless drug delivery, the drug delivery efficiency is improved, the drug onset time is shortened, and then the effect of effectively, rapidly and safely playing a local anesthesia role is achieved.

The invention belongs to the technical field of biomedical materials, and particularly relates to a hydrogel dressing based on traditional Chinese medicine polysaccharide and a preparation method of the hydrogel dressing. The hydrogel dressing based on the traditional Chinese medicine polysaccharide is prepared from the following raw materials in parts by weight: 10 to 15 parts of gastrodia elata polysaccharide, 8 to 12 parts of rhizoma bletillae polysaccharide, 5 to 8 parts of astragalus polysaccharide, 1 to 3 parts of a nano-silver-baicalin compound, 2 to 3 parts of methacrylic anhydride, 0.02 to 0.05 part of VEGF, 0.4 to 1 part of PLGA, 0.1 to 0.3 part of Irgacure 2959, 20 to 30 parts of a 5% calcium chloride solution, 0.1 part of polyvinyl alcohol and 100 to 170 parts of PBS. A triple gel network structure is constructed through photocuring, ionic crosslinking and an emulsification-solvent evaporation method, so that the function integration of controlled release, antibiosis and vascular regeneration promotion is realized, and the clinical treatment requirements of complex wounds are effectively met.

The invention relates to an intumescent efficient hemostatic sponge and a preparation method thereof, the preparation method comprises the following steps: preparation of HAMA: utilizing hyaluronic acid to react with methacrylic anhydride, and grafting double bonds on a hyaluronic acid macromolecular skeleton; preparing HAMA hydrogel: pouring the HAMA solution dissolved with the photoinitiator into a mold, and initiating crosslinking in an ultraviolet radiation manner to obtain the HAMA hydrogel; the HAMA hydrogel is taken out of the mold and dried, and the hemostatic sponge is formed. The expansion type efficient hemostatic sponge can be prepared by adopting the preparation method. The hemostatic sponge disclosed by the invention shows remarkable advantages in the aspects of expansion ratio, hemostatic effect, biocompatibility and the like, and has a wide application prospect and an important clinical value. The preparation method disclosed by the invention is easy to operate in process flow and suitable for large-scale production.

The invention relates to the technical field of lithium ion battery diaphragms, in particular to a high-temperature-resistant modified acrylic acid composite material and a preparation method thereof. The high-temperature-resistant modified acrylic acid composite material comprises a polypropylene diaphragm and coating slurry coated on at least one side of the polypropylene diaphragm, the coating slurry is prepared from the following raw materials: n-butyl acrylate, methyl methacrylate, ethyl acrylate, toluene diisocynate, methacrylic anhydride, graphene oxide, nanoscale ceramic powder, polyvinylidene fluoride, vinyltriethoxysilane, polysiloxane, a dispersing agent, a catalyst and a solvent. According to the invention, high safety can be brought to the battery, high temperature resistance is realized, the diaphragm can tolerate high temperature, the service life of the battery is obviously prolonged, and the safety is greatly improved.

The invention discloses a polycarbonate-based non-isocyanate polyurethane ultraviolet curing coating and a preparation method of the polycarbonate-based non-isocyanate polyurethane ultraviolet curing coating. The photocureable coating is prepared from the following components: 10 to 60 percent of polycarbonate acrylate, 5 to 20 percent of urethane acrylate, 10 to 60 percent of reactive diluent, 1 to 5 percent of photoinitiator and 0 to 60 percent of solvent. Comprising the following steps: (1) reacting polycarbonate diol with methacrylic anhydride to obtain polycarbonate acrylate; (2) carbonating the allyl glycidyl ether by using carbon dioxide to obtain corresponding five-membered cyclic carbonate, and reacting with diamine to obtain urethane acrylate; and (3) uniformly mixing the obtained product with a reactive diluent and a photoinitiator to obtain the ultraviolet curing coating. The polycarbonate-based non-isocyanate polyurethane ultraviolet curing coating obtained by the invention is a biodegradable environment-friendly coating, a non-isocyanate polyurethane synthesis route is adopted, the use of isocyanate is avoided, and the coating shows excellent flexibility and pencil hardness on a PC (polycarbonate) base material.

The invention belongs to the technical field of anticorrosive paint, and discloses intelligent corrosion inhibition hydrogel with double functions of pH sensitivity and corrosion self-early warning, preparation of the intelligent corrosion inhibition hydrogel and application of the intelligent corrosion inhibition hydrogel in modified epoxy resin anticorrosive paint. The preparation method comprises the following steps: preparing a water phase from quaternary ammonium salt chitosan, methacrylic anhydride, a photoinitiator and a corrosion inhibitor, taking a Span emulsifier and paraffin as an oil phase, dropwise adding the water phase into the oil phase, rapidly stirring to form a water-in-oil emulsion system, and rapidly preparing the pH-sensitive hydrogel microspheres coated with the corrosion inhibitor through photo-crosslinking. And finally, forming the corrosion self-early-warning shell by using the tannic acid modified hydrogel microspheres by adopting an electrostatic adsorption layer-by-layer assembly method. The intelligent corrosion inhibitor hydrogel and the modified anticorrosive paint prepared by the invention have double functions of pH sensitivity and corrosion self-early warning. And meanwhile, the material is green and environment-friendly, the preparation process is simple, the cost is low, the corrosion resistance is effectively improved, the corrosion resistance is enriched, and long-acting corrosion prevention is realized.

The invention provides an acrylic polyurethane coating and a preparation method thereof, and belongs to the technical field of coating compositions.The preparation method comprises the following steps that hexylpolyurethane based on non-isocyanate sorbitol, methacrylic anhydride, p-toluenesulfonic acid and hydroquinone monomethyl ether are mixed and heated for a reaction, ethyl acetate is added for mixing, washing, drying, filtering and vacuum concentration are performed, and the acrylic polyurethane coating is obtained. The bio-based polyurethane acrylate is obtained; the preparation method comprises the following steps: mixing ZG nanoparticles, methylbenzene, 3-(methacryloyloxy) propyltrimethoxysilane and hydroquinone monomethyl ether, heating, stirring, centrifuging and washing to obtain functionalized ZG; and fully mixing the bio-based polyurethane acrylate, the photoinitiator, the acrylate-based single-terminated reactive polysiloxane, the reactive diluent and the functionalized ZG to obtain the acrylic polyurethane coating. The coating can improve the curing speed, and has hydrophobic and oleophobic properties and corrosion resistance at the same time.

The invention belongs to the technical field of biomedical materials, and particularly relates to astragaloside-loaded conductive hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: uniformly mixing a methylacrylic anhydride gelatin aqueous solution with an organic solvent solution of astragaloside, and carrying out ultraviolet light cross-linking curing to form methylacrylic anhydride gelatin / astragaloside hydrogel; soaking the obtained hydrogel in hydrochloric acid containing a free radical initiator; then soaking and polymerizing in an aniline ethanol solution; and soaking and purifying to obtain the methylacrylic anhydride gelatin-polyaniline conductive hydrogel loaded with astragaloside. In-vitro experiments prove that the compound has a certain anti-inflammatory effect, can induce neural stem cells to be directionally differentiated into neurons and oligodendrocytes, and is beneficial to promoting nerve regeneration and myelin sheath formation; finally, in-vivo experiments prove that the composition can improve the athletic ability and tissue function recovery of SCI rats, and has a good application prospect.

The invention provides 3D printing bio-ink as well as a preparation method and application thereof. The 3D printing bio-ink is prepared from the following components: methacrylic anhydride gelatin, oxidized hyaluronic acid, carboxymethyl chitosan and 2-methacryloyloxyethyl phosphorylcholine. By designing the specific composition of the 3D printing bio-ink, the 3D printing bio-ink which is good in printing performance, mechanical strength and electrical conductivity and high in cell survival rate after printing is prepared, and then a 3D printing stent with high cell-stent interaction is prepared and can be used for preparing a skin injury repair material.

The application discloses a kind of high adhesion enzymatic hydrogel for promoting vascular intimal repair and a preparation method thereof, and belongs to the technical field of hydrogel preparation.The preparation method is as follows: S1, using methacrylic anhydride to modify the double bond of hyaluronic acid, then crosslinking with dopamine to obtain dopamine-modified double-bonded hyaluronic acid;S2, after removing oxygen from the hyaluronic acid solution, add a crosslinking agent and tyramine hydrochloride, and react in an acidic environment to obtain tyramine-modified hyaluronic acid;S3, mix the dopamine-modified double-bonded hyaluronic acid, tyramine-modified hyaluronic acid and deionized water to obtain a hydrogel precursor solution;S4, then use enzymatic reaction to obtain the hydrogel.The method designed by the application is simple, does not require additional light curing equipment, and the constructed hydrogel is similar to the extracellular matrix.The hydrogel can be coated into different shapes to adapt to different environments.The hydrogel is formed by enzymatic reaction, which is rapid, well adhered to the tissue, biocompatible, and suitable for application in vascular repair.

The present invention discloses a method for preparing a photocrosslinked hyaluronic acid / ε-polylysine antibacterial adhesive hydrogel, the method comprising first modifying hyaluronic acid with methacrylic anhydride, introducing dopamine to modify the methacrylic anhydride-modified hyaluronic acid and mixing it evenly with ε-polylysine, then adding a photoinitiator solution and mixing evenly, and irradiating it with ultraviolet light for more than ten seconds to obtain the result. The hydrogel prepared by dopamine-modified hyaluronic acid has significantly improved adhesion to tissues compared to unmodified hyaluronic acid hydrogels, and ε-polylysine can further improve the adhesion of the hydrogel by virtue of its synergistic effect with dopamine.

The invention relates to the technical field of biological materials, and discloses electrical stimulation LDH hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a zinc salt, a vanadium salt and urea in water in a nitrogen atmosphere to obtain a precursor solution; the precursor solution is subjected to a hydrothermal reaction, and ZnV-LDH is obtained; under stirring, gradually dropwise adding methacrylic anhydride into the gelatin solution, and heating for reaction; adding preheated water into the reaction liquid to stop the reaction; dialyzing and purifying the reaction liquid, pre-freezing, and freeze-drying to obtain hydrogel; and adding ZnV-LDH into the hydrogel, and carrying out ultrasonic mixing, so as to obtain the electrical stimulation LDH hydrogel. Through the synergistic effect of the ZnV-LDH and the hydrogel, the electrical stimulation LDH hydrogel disclosed by the invention has electrical activity and can generate potential change in response to external stimulation; under ultrasonic stimulation, concentration-dependent electrical response can be generated, the response has periodicity and stability, and osteogenic differentiation and cell mechanical properties can be promoted to the maximum extent.

The invention relates to the technical field of synthesis of photoresist monomer compounds, and particularly discloses a synthesis method of 1, 3-adamantanediol monomethacrylate. The synthesis method of the 1, 3-adamantane diol monomethacrylate comprises the following steps: by taking 1, 3-dihydroxy adamantane and methacrylic anhydride / methacryloyl chloride as reaction raw materials and a two-phase solvent as a reaction solvent, under the action of a catalyst and a polymerization inhibitor, carrying out esterification reaction and post-treatment to obtain the 1, 3-adamantane diol monomethacrylate. The component A is 1, 3-adamantanediol monomethacrylate; the catalyst is ethyl magnesium chloride; the temperature of the esterification reaction is 10-20 DEG C, and the time is 6-8 hours. The synthesis method of 1, 3-adamantanediol monomethacrylate provided by the invention has the advantages of mild reaction conditions, simple operation, cheap and easily available raw materials and the like, and the yield of the obtained 1, 3-adamantanediol monomethacrylate is greater than or equal to 80.0%, and the purity is greater than or equal to 99.00%.

The present invention discloses a method for preparing a starch-based 3D printing ink suitable for high printability, and belongs to the technical field of green printing materials. The present invention selects natural starch as raw material, and modifies the starch by methacrylic anhydride. The modified methacrylated starch can undergo self-crosslinking under ultraviolet light to form a network structure, and then compounded with natural starch and high-amylose starch to prepare a starch-based 3D printing ink with high printability. The ink has the characteristics of controllable photosensitivity, easy extrusion, and high formability, can be printed with high precision, is biodegradable, and uses non-toxic and pollution-free crosslinking agents and adhesives in the preparation process. It is a green material and can be safely used in biological tissue engineering. The present invention uses 3D printing technology, and can print the shape and size of printed products according to needs, which is convenient for personalized production. The printed products have high mechanical strength, high porosity and high biological stability, and have high application prospects.

The invention discloses a preparation method of silver-loaded nano-cluster-adriamycin composite hydrogel. The method comprises the following steps: preparing a silver nano-cluster from an AgNO3 solution and a gallic acid solution; preparing a prepolymer from chitosan, hyaluronic acid, an acetic acid solution and methacrylic anhydride; mixing silver nanoclusters, a doxorubicin hydrochloride solution and the prepolymer, and adding a photoinitiator to obtain preliminarily formed hydrogel; and immersing the primarily formed hydrogel into a sodium citrate solution to obtain the silver-loaded nano-cluster-adriamycin composite hydrogel. The composite hydrogel prepared by the invention has a pH-responsive drug release characteristic, the drug release is accelerated in an acidic environment, and the drug release is slow in a neutral environment; the antibacterial agent has an inhibiting effect on bacteria such as escherichia coli and staphylococcus aureus, and shows good antibacterial performance; the toxicity to cancer cells is obviously higher than that of normal cells, and certain tumor targeting is achieved; and the polymer has good mechanical strength and good swelling performance in different pH environments, and has a wide application prospect.