18 results about "Methacrylic anhydride" patented technology

Provided is a method for producing a high-purity ethylenic isocyanate compound, in which (meth)acrylic anhydride is suppressed.　Provided is a method for producing a purified ethylenic isocyanate composition from a crude ethylenic isocyanate composition, wherein an alcohol is added to the crude ethylenic isocyanate composition, and the purified ethylenic isocyanate composition contains a (meth)acrylic acid ester compound which has an isocyanate group, and 0.2 mass% or less of an acid anhydride.　Also provided is an ethylenic isocyanate composition which contains an ethylenic isocyanate compound and 0.2 mass% or less of an acid anhydride.

This invention discloses a method for maintaining the triple helix structure during the preparation of methacrylated recombinant collagen hydrogels, belonging to the field of genetic engineering technology. This invention optimizes the reaction parameters of the methacrylic anhydride (MA) chemical cross-linking process of recombinant collagen. Through screening, the titration method with an addition rate of 2 μL / min for MA was selected. The reaction temperature and the amount of MA added were optimized, and it was found that a MA:Col ratio of 1:2 and a reaction temperature of 35℃ resulted in good triple helix maintenance. This invention, through the titration method of adding methacrylic anhydride, greatly maintains the triple helix structure of recombinant collagen during the preparation of hydrogels, preserving excellent biocompatibility and showing broad application prospects in the field of biomaterials.

The application provides a kind of targeting drug-loaded liposome combined functional hydrogel and its preparation method and application, including active targeting liposome and functional gelatin hydrogel, make the active targeting liposome disperse in functional gelatin hydrogel, under the photo initiator, ultraviolet crosslinking solidification obtains the targeting drug-loaded liposome combined functional hydrogel;The functional gelatin hydrogel includes methacrylic anhydride grafting gelatin hydrogel and gallic acid grafting gelatin hydrogel, and the active targeting liposome is RGD peptide modified drug-loaded liposome.The application overcomes the defects of poor targeting, large systemic toxic side effects and insufficient regulation of joint immune microenvironment in the existing methotrexate single drug therapy for rheumatoid arthritis.

There is provided microparticles crosslinked with disulfide bonds and methods of producing the same. The microparticles are particularly useful for the cryopreservation of cells. The disulfide bonds are provided from a functionalization of methacrylic anhydride based microparticles with cystamine or from using methacrylic anhydride based monomers containing a cystamine link core with the disulfide bond, and beneficially by combining both modes of disulfide crosslinking. Other uses for these microspheres include as printing support materials (jammed gels) for 3D printing hydrogels, optionally containing therapeutic cells.

A water dispersible acrylic modified polyester, which is the free-radical reaction product of: I. 45 to 90 wt.% of a saturated polyester, based on the total weight of (I) and (II), wherein said saturated polyester is free of an α,β-unsaturated monomer, and wherein the polyester has an acid number of 0 to 30 mg KOH / g, hydroxyl number of 5 to 50 mg KOH / g, a number average molecular weight of 2,000 to 30,000 g / mol, and a weight average molecular weight of 10,000 to 200,000 g / mol; and II. 10 to 55 wt.% of one or more ethylenically unsaturated monomers, based on the total weight of (I) and (II), wherein the one or more ethylenically unsaturated monomers comprises: i. methacrylic anhydride, acrylic anhydride or a combination thereof; and ii. optionally, one or more ethylenically unsaturated monomers other than (Il)(i).

This invention relates to the field of biomaterials technology, specifically to a method for preparing and applying a soluble bifunctional conductive microneedle patch. The preparation method includes the following steps: (1) adding low molecular weight hyaluronic acid and catalase to deionized water to obtain an HA-CAT solution; (2) adding N,N-dimethylformamide and methacrylic anhydride to the low molecular weight hyaluronic acid solution to obtain methacryloyl hyaluronic acid (HAMA); (3) dissolving a photoinitiator and methacryloyl hyaluronic acid in deionized water, adding black phosphorus nanosheets (BP) to obtain an HAMA-BP solution, filling the needle tip with the HAMA-BP solution, and filling the base with the HA-CAT solution. This conductive microneedle patch possesses excellent mechanical properties and biocompatibility. The black phosphorus nanosheets respond to changes in pH and continuously release reactive oxygen species in hypoxic environments.

This invention discloses a method for preparing a ternary dynamic glycopeptide hydrogel bio-ink, comprising the following steps: dissolving methacrylamide gelatin, aldehyde-modified hyaluronic acid, hydrazide-modified gelatin, and a photoinitiator together in a solvent and mixing them evenly to obtain the bio-ink. This bio-ink constructs a dynamic covalent cross-linking network through reversible acylhydrazone bonds formed between aldehyde-modified hyaluronic acid and hydrazide-modified gelatin, providing a remodelable three-dimensional microenvironment for cells. Simultaneously, the photocrosslinking properties of methacrylic anhydride-modified gelatin are introduced to rapidly solidify and maintain overall shape stability during the printing stage, providing a remodelable cellular microenvironment during subsequent in vitro culture. This establishes an organoid culture platform with both good printability and excellent cell compatibility, providing a reliable material basis for subsequent drug screening and functional studies.

The application relates to the technical field of biological materials, and discloses an electrically stimulated LDH hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a zinc salt, a vanadium salt and urea in water under a nitrogen atmosphere to obtain a precursor solution; performing a hydrothermal reaction on the precursor solution to obtain ZnV-LDH; gradually adding methacrylic anhydride into a gelatin solution under stirring, heating and reacting; adding preheated water into the reaction solution to stop the reaction; performing dialysis purification, pre-freezing and freeze-drying on the reaction solution to obtain a hydrogel; and adding the ZnV-LDH into the hydrogel, ultrasonic mixing, and obtaining the electrically stimulated LDH hydrogel. Through the synergistic effect of the ZnV-LDH and the hydrogel, the electrically stimulated LDH hydrogel has electric activity, can respond to external stimulation to generate a potential change, can generate a concentration-dependent electric response under ultrasonic stimulation, and the response has periodicity and stability, so that the osteogenic differentiation and the cell mechanical properties can be promoted to the maximum extent.

This invention discloses a smart, responsive comb-shaped gelatin-based hydrogel and its applications, belonging to the field of biomedical materials technology. The preparation method of the hydrogel is as follows: S1, Prussian blue is modified with tannic acid to obtain TA-coated Prussian blue core-shell nanoparticles, referred to as the PB-TA complex; S2, gelatin is dissolved in PBS solution, then methacrylic anhydride is added dropwise, and the reaction is carried out at 50-60℃ for 90-120 min, followed by dialyzing and freeze-drying to obtain acylated gelatin; S3, an initiator and NIPAM solution are added to the acylated gelatin solution, and the reaction is stirred for 10-14 h to obtain a comb-shaped gelatin solution; S4, zein solution and PB-TA complex solution are added to the comb-shaped gelatin solution to prepare a smart hydrogel exhibiting both temperature and near-infrared photothermal response. This hydrogel can be used for drug delivery, enabling controlled drug release.

This invention discloses an injectable photocurable hydrogel with anti-inflammatory and pro-angiogenic tissue regeneration properties, belonging to the field of biomedical materials technology. The hydrogel is a methacrylic anhydride-modified gelatin hydrogel loaded with calcium phosphate oligomers and sulfur quantum dots. Its preparation method involves dissolving methacrylic anhydride-modified gelatin in a phosphate buffer solution, then adding calcium phosphate oligomers and sulfur quantum dots, followed by adding a photoinitiator and mixing thoroughly. Finally, it is cured under ultraviolet or blue light irradiation. This invention also discloses the application of the injectable photocurable hydrogel with anti-inflammatory and pro-angiogenic tissue regeneration properties in the preparation of products for treating infected bone defects. This hydrogel can release the bioactive components of sulfur quantum dots and calcium phosphate oligomers in situ, synergistically promoting the healing of infected bone defects through multiple effects including antibacterial, immunomodulatory, angiogenesis, and osteoproliferative effects.

This invention belongs to the field of biomaterial preparation technology, specifically disclosing a double-crosslinked AlgMA gel scaffold, its construction method, and its application. The construction method includes the following steps: S1, esterifying sodium alginate with methacrylic anhydride, dialyzing, and freeze-drying to obtain methacryloylated sodium alginate (AlgMA); S2, mixing the AlgMA obtained in S1 with a photoinitiator and performing photo-responsive crosslinking to obtain a photocrosslinked gel scaffold; S3, subjecting the photocrosslinked gel scaffold obtained in S2 to secondary ion-curing crosslinking to obtain a double-crosslinked AlgMA gel scaffold. This invention discloses a double-crosslinked AlgMA gel scaffold, its construction method, and its application. This double-crosslinked AlgMA gel scaffold exhibits high morphological fidelity, excellent mechanical properties, and controllable pore size distribution and porosity, meeting the requirements of biomimetic muscle tissue for scaffold mechanical adaptability.

The application provides a gelatin-based bio-ink for digital light processing, which comprises a gelatin-ureidopyrimidinone polymer GelMA-UPy, a photoinitiator, a light absorber and a solvent; wherein the GelMA-UPy is prepared by reacting methylacrylic anhydride gelatin GelMA with 2-(6-isocyanohexylaminocarbonylamino)-6-methyl-4[1H]pyrimidine UPy-NCO; the application introduces the UPy group into the methylacrylic anhydride gelatin in the form of a group, so that the gelatin-based bio-ink has reversible quadruple hydrogen bonds, that is, a dynamic bond; and due to the fact that the UPy is easy to form a dimer, a dynamic network structure is formed at a micro level; the introduction of the dynamic network makes the gelatin-based bio-ink change from the original pure chemical crosslinking structure to a structure in which the chemical crosslinking and the dynamic network coexist, which is of great help to solve the defects of the gelatin-based bio-ink in the application of the digital light processing technology.

The present invention belongs to the technical field of cosmetics. Provided is a photoprotective composition, comprising soluble collagen and a Phyllanthus emblica fruit extract. A mass ratio of the soluble collagen to the Phyllanthus emblica fruit extract is 75:1 to 25:1, the soluble collagen comprises photocurable collagen and a photoinitiator, and the photocurable collagen is collagen modified by acylation of 2-methacrylic anhydride.

This invention discloses a method for preparing a photothermal controlled-release hydrogel contact lens material. The method involves chemically bonding ganciclovir with hydroxypropyltrimethylammonium chloride chitosan, then adding methacrylic anhydride to introduce double bonds. The resulting product is used as a crosslinking agent to crosslink and copolymerize with hydroxyethyl methacrylate (MXene) nanosheets to prepare the hydrogel material. The prepared photothermal controlled-release hydrogel contact lens material can bond drugs to the polymer chains of the hydrogel contact lens for drug loading, avoiding drug loss due to tear rinsing, thereby improving drug storage stability. Furthermore, it can be modulated with near-infrared light to generate a photothermal effect, raising the hydrogel temperature and triggering the breakage of thermosensitive azo bonds, releasing the drug into the contact lens matrix. When the lens is worn, the drug can be slowly released from the contact lens into the eye, potentially making it a multifunctional contact lens material for treating eye diseases.