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Dopamine-mediated polypyrrole conductive hydrogel and preparation method thereof

A conductive hydrogel, polypyrrole technology, applied in the field of biomedical materials, can solve the problems of reduced electrical properties, uneven dispersion, insolubility, etc., and achieve the effects of improving mechanical properties, improving electrical properties, and good biocompatibility

Active Publication Date: 2019-04-05
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when nanomaterials are randomly dispersed in the hydrogel substrate, there are disadvantages such as easy agglomeration and uneven dispersion, which lead to the discontinuity of the conductive polymer part of the prepared conductive hydrogel, which in turn leads to a decrease in its electrical properties and mechanical properties. Unstable performance
[0004] Polypyrrole, as one of the conductive polymers, has attracted much attention for its good biocompatibility and stable electrical properties. However, as a rigid polymer chain, it is insoluble and difficult to process, which limits its application.

Method used

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  • Dopamine-mediated polypyrrole conductive hydrogel and preparation method thereof
  • Dopamine-mediated polypyrrole conductive hydrogel and preparation method thereof
  • Dopamine-mediated polypyrrole conductive hydrogel and preparation method thereof

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Embodiment 1

[0034] The preparation method of a dopamine-mediated polypyrrole conductive hydrogel of the present embodiment, the specific preparation steps are as follows:

[0035] (1) Weigh 5g of gelatin and dissolve it in 50mL of phosphate buffer solution, stir at 50°C until the gelatin is completely dissolved; add 3mL of methacrylic anhydride dropwise to the above solution, continue to react for 3 hours, and transfer to the phosphate buffer solution The reaction was terminated in the medium; the above solution was placed in a dialysis bag for 5 days, the dialyzed solution was poured into a centrifuge tube, centrifuged at 2000r / min, and freeze-dried to obtain modified gelatin.

[0036] (2) Weigh 0.1g of modified gelatin sample, 0.05g of acrylamide monomer, dissolve in 2mL of phosphate buffer solution at 45°C, add 0.01g of photoinitiator Irgacure2959, and transfer it to a PDMS mold after it is completely dissolved , Initiate polymerization under ultraviolet light, the polymerization time ...

Embodiment 2

[0041] The preparation method of a dopamine-mediated polypyrrole conductive hydrogel of the present embodiment, the specific preparation steps are as follows:

[0042] (1) Weigh 5g of gelatin and dissolve it in 50mL of phosphate buffer solution, stir at 50°C until the gelatin is completely dissolved; add 5mL of methacrylic anhydride dropwise to the above solution, continue to react for 6h, and transfer to the phosphate buffer solution The reaction was terminated in the medium; the above solution was placed in a dialysis bag for 7 days, the dialyzed solution was poured into a centrifuge tube, centrifuged at 3000r / min, freeze-dried, and modified gelatin was obtained.

[0043] (2) Weigh 0.1g modified gelatin sample, 0.1g acrylamide monomer, dissolve in 2mL phosphate buffer solution at 50°C, add 0.015g photoinitiator Irgacure2959, and transfer to PDMS mold after it is completely dissolved , Initiate polymerization under ultraviolet light, the polymerization time is 90s, then demol...

Embodiment 3

[0048] The preparation method of a dopamine-mediated polypyrrole conductive hydrogel of the present embodiment, the specific preparation steps are as follows:

[0049] (1) Weigh 5g of gelatin and dissolve it in 50mL of phosphate buffer solution, stir at 50°C until the gelatin is completely dissolved; add 6mL of methacrylic anhydride dropwise to the above solution, continue to react for 12h, and transfer to the phosphate buffer solution The reaction was terminated in the medium; the above solution was placed in a dialysis bag for 8 days, the dialyzed solution was poured into a centrifuge tube, centrifuged at 4000r / min, freeze-dried, and modified gelatin was obtained.

[0050] (2) Weigh 0.1g modified gelatin sample, 0.2g acrylamide monomer, dissolve in 2mL phosphate buffer solution at 60°C, add 0.02g photoinitiator Irgacure2959, after it is completely dissolved, transfer it to a PDMS mold , Initiate polymerization under ultraviolet light, the polymerization time is 120s, then de...

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Abstract

The invention belongs to the field of biomedical materials and discloses dopamine-mediated polypyrrole conductive hydrogel and a preparation method thereof. The preparation method includes: dissolvingmethacrylic acid-modified gelatin and an acrylamide monomer in a phosphate buffered solution, adding a photoinitiator, triggering polymerization in ultraviolet to obtain modified gelatin-polyacrylamide hybrid hydrogel, soaking the modified gelatin-polyacrylamide hybrid hydrogel in a water solution containing a pyrrole monomer and dopamine hydrochloride, dropwise adding a peroxidant, and stirringto allow reacting to obtain the dopamine-mediated polypyrrole conductive hydrogel. The dopamine-mediated polypyrrole conductive hydrogel provided herein is prepared by growing pyrrole in situ on hydrogel through dopamine mediation, has the characteristics of both hydrogels and conductive polymers, has the advantages of good biocompatibility and excellent and stable electrical properties, and is expectedly applicable to the tissue engineering repair fields, such as neural restoration, cardiac muscular tissue regeneration, and skin restoration.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a dopamine-mediated polypyrrole conductive hydrogel and a preparation method thereof. Background technique [0002] Conductive hydrogels are widely used in research fields such as tissue engineering materials, biosensors, supercapacitors, dyes, and batteries. It combines the dual characteristics of hydrogel and conductive substances, and has excellent electrical properties and good biocompatibility. It is expected to be an ideal biomedical material and become a research hotspot in the field of tissue engineering materials, especially in the field of electrical No. Sensitive tissue repair and regeneration, such as skin, myocardial tissue, nerves. [0003] Conductive hydrogels are usually prepared by dispersing conductive components such as carbon nanotubes, conductive polymers, and metal nanoparticles in a hydrogel matrix. Among them, conductive polymers have attra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L51/08C08L79/04C08K5/18C08F289/00C08F220/56C08F2/48C08G73/06
CPCC08F2/48C08F289/00C08G73/0611C08J3/075C08J2351/08C08J2479/04C08K5/18C08F220/56
Inventor 宁成云胡诗迁周蕾陈俊祺姚甜甜王珍高于鹏
Owner SOUTH CHINA UNIV OF TECH
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