308 results about "Myocardial tissue" patented technology

The invention discloses application of an RNF130 activator in preparation of a medicine for preventing and / or treating ischemic heart disease, and belongs to the technical field of biological medicine. Research results show that when an RNF130 activator is given in a mouse of a myocardial ischemia reperfusion injury model, the left ventricular ejection fraction and the left ventricular short-axis shortening rate of the mouse can be improved, myocardial tissue pathological injury can be relieved, the protein expression levels of NOX-2, BAX and TNF-alpha are reduced, the myocardial infarction area is reduced, and myocardial cell apoptosis is reduced; therefore, the RNF130 activator has prevention and treatment effects on the myocardial ischemia-reperfusion injury, that is, the RNF130 activator can be used as an effective component of the medicine for preventing or treating diabetes complicated by myocardial ischemia-reperfusion injury, and a new strategy is provided for preparation of the medicine for preventing and treating myocardial ischemia-reperfusion injury.

The disclosure provides various embodiments of systems to facilitate the cutting of myocardial tissue structures percutaneously.

The wire comprises an insulating layer, an electrode tip assembly and an anchoring component, the electrode tip assembly comprises an operating part and an electrode tip, the electrode tip is arranged at the far end of the operating part, and the electrode tip assembly can move between a first position and a second position relative to the insulating layer; the electrode tip assembly at the first position is located in the insulating layer, the electrode tip of the electrode tip assembly at the second position extends out of the insulating layer, the surface of the electrode tip is not smooth, and the area of the minimum cross section of the electrode tip is 4.0 mm < 2 >. According to the lead for pace-making, the electrode tip is provided with the non-smooth surface, so that the electrode tip can be slowly inserted into ventricular septal myocardial tissue even if a conical structure is not adopted, and is easy to screw in. The arrangement can ensure that the cross section is not similar to a conical structure and has a small-area cross section, the cross section is not easy to break when being inserted into heart tissue, and the cross section area is small, so that the damage to normal myocardium when the lead is pulled out is small.

A mechanical continuous myocardial tissue resection system, comprising: a housing, a resection cavity component, a pull lever component, an axial rotary resection knife component, a tissue locking component, a locking triggering component and an excitation component. The tissue locking component in the system is movably inserted into the resection cavity component and can lock a resection target tissue entering the internal cavity of the resection cavity component from a resection window. The locking triggering component is configured to be capable of locking the tissue locking component and can be triggered to release the locked tissue locking component. The pull lever component is configured to be capable of driving the tissue locking component and locking same with the locking triggering component. The excitation component is configured to be in linkage with the axial rotary resection knife component and the locking triggering component. The system can realize one-time puncture and continuous rotary resection in the state of a minimally invasive incision, thereby achieving precise resection of myocardial tissue.

The invention belongs to the field of compositions of biomedical materials and high-molecular compounds, and provides hydrogel capable of regulating and controlling the redox steady state of a microenvironment as well as a preparation method and application of the hydrogel. A macromolecular network of the hydrogel capable of regulating and controlling the redox steady state of the microenvironment is formed by catechol modified hyaluronic acid, carboxylated chitosan, oxidized dextran and iron ions through a hybridization cross-linking reaction; under physiological conditions, catechol groups in the hydrogel can be subjected to an autoxidation reaction to generate H2O2, and meanwhile, iron ions coordinated on the catechol groups in the hydrogel can catalytically decompose H2O2 into water and oxygen, so that the level of active oxygen in a microenvironment is adjusted. The hydrogel disclosed by the invention can realize bidirectional regulation and control on active oxygen in a pathological microenvironment after myocardial infarction, so that the redox steady state of the pathological microenvironment after myocardial infarction is maintained, and the regeneration and repair capacity of an existing hydrogel material with antioxidant capacity on myocardial tissues after myocardial infarction is improved.

The invention discloses an irreversible electroporation damage assessment system and method based on myocardial dielectric properties, solves the problem of how to assess damage in a pulsed electric field ablation process, and belongs to the technical field of medical equipment. The system comprises an acquisition module and a workstation, wherein the acquisition module acquires an intracardiac ECG signal, a global electric field voltage signal of a target cardiac cavity, and impedance and temperature between ablation electrode pairs in real time; the work station processes the collected signals to obtain electrocardio characteristics, ablation parameters, temperature between the ablation electrode pairs, impedance drop, contact force and contact state between the ablation electrode pairs and myocardial tissue and ablation electrode position stability, the obtained signals are input into the evaluation model, and the evaluation model outputs IRE injury evaluation classification results. The evaluation model is realized based on a neural network. And real-time measurement and evaluation are carried out on PF ablation injury so as to assist a user to complete comprehensive, objective and accurate evaluation of the ablation effect.

The invention discloses a preparation method and application of yak blood peptide with anti-hypoxia and anti-fatigue functions. The method comprises the steps of raw material pretreatment, composite enzymolysis (adopting a mixture of enzyme digestion modified lumbrukinase and nattokinase), enzyme deactivation, separation and purification, ferrous chelation, Maillard reaction, concentration and drying and the like. The enzymolysis efficiency and the active peptide yield are remarkably improved through ultrasonic treatment and a composite enzymolysis technology, the stability and the anti-hypoxia capacity of peptide fragments are enhanced through ferrous chelation, and the antioxidant activity and the anti-fatigue activity are further improved through the Maillard reaction. Experiments show that the yak blood peptide prepared by the method can significantly improve the antioxidant enzyme activity, prolong the normal-pressure hypoxia survival time, prolong the swimming exhaustion time and significantly reduce the MDA content of brain tissue and myocardial tissue. The obtained product can be applied to anti-hypoxia and anti-fatigue medicines or health-care foods, and has the advantages of high process efficiency, remarkable activity, high safety and the like.

The invention discloses a cardiac ultrasound image optimization enhancement method based on image filtering, and belongs to the technical field of cardiac ultrasound images. The invention discloses a cardiac ultrasound image optimization enhancement method based on image filtering. The method comprises the following steps: S1, obtaining a cardiac ultrasound binary image; s2, obtaining a to-be-processed cardiac ultrasound image; s3, highlighting the edge characteristics of the vascular wall and the myocardial tissue; s4, obtaining an enhanced cardiac ultrasound image; and S5, obtaining an optimized and enhanced cardiac ultrasound image. According to the method, the problem that the overall consistency judgment of structures such as heart chambers and valves is easily affected in the prior art is solved, the heart disease change area can be displayed more visually, misjudgment caused by noise or low contrast of medical staff is reduced, texture information of different levels can be effectively captured, the recognition capacity of a complex heart structure is enhanced, and the recognition efficiency is improved. Furthermore, the myocardial strain rate, the ventricular volume and other parameters are more accurately quantified, and a reliable basis is provided for evaluating the cardiac function.

The invention relates to the field of medical image examination, and discloses a one-stop heart magnetic resonance examination technology which comprises the following steps: S1, high-integration-degree nuclear magnetic resonance scanning technology: acquiring original data of various heart magnetic resonance examinations through one-time scanning by adopting a high-integration-degree imaging sequence, the original data comprises images with different contrast ratios for measuring myocardial tissues T1, T2 and T2 * and film images for evaluating heart and ventricular functions; s2, expansion type deep learning reconstruction: reconstructing all different T1, T2 and T2 * weighted images and movie images in quantitative imaging and movie imaging data by adopting a reconstruction technology based on deep learning; and S3, quantitative image reconstruction: adopting a quantitative image reconstruction technology based on deep learning to reconstruct T1, T2 and T2 * quantitative images. According to the method, movie imaging for heart function examination and T1 quantitative imaging, T2 quantitative imaging and T2 * quantitative imaging for myocardial tissue characterization are completed in one-time scanning.

The invention relates to the technical field of medical health, in particular to a cardiac muscle tissue electrophysiology unmarked optical detection method based on deep learning. The method comprises the following steps: acquiring optical detection image data and electrophysiological signal data of myocardial tissue; the optical detection image data and the electrophysiological signal data are subjected to image preprocessing, so that optical-physiological signal mapping data are obtained, and image preprocessing comprises image registration, image cutting, periodic enhancement, time difference enhancement, spatial filtering, intensity normalization and data smoothing; and according to the optical-physiological signal mapping data, carrying out feature signal extraction based on a mechanical contraction curve and an electrophysiological curve so as to obtain mechanical contraction curve data and electrophysiological curve data. According to the method, unmarked optical detection is adopted, so that direct interference on myocardial tissues is avoided, and the physiological state of the tissues is better maintained.

The invention discloses an application of isorhamnetin in preparation of an anti-myocardial fibrosis medicine, and belongs to the technical field of medicines. The invention proposes that the isorhamnetin can effectively reduce myocardial tissue collagen deposition for the first time, and the medical application of the isorhamnetin is expanded. The isorhamnetin is used as the anti-myocardial fibrosis medicine, can effectively relieve the increase of mRNA expression levels of alpha-SMA, COL-1, COL-3, p53, PAI-1, IL-1beta and IL-6, and has the function of retarding myocardial fibrosis. The isorhamnetin is used as the active component of the anti-myocardial fibrosis medicine, the safety is high, the side effect is small, a novel anti-myocardial fibrosis treatment strategy is provided, and the application blank of the isorhamnetin in the field is filled.

A system is described for generating a revascularization score for a blockage of a coronary artery in a heart. The system accesses indications of viability of myocardial tissue in the heart, a blockage state of the blockage that includes a blockage location and a blockage amount, and the perfusion territory of the myocardial tissue. Based on the myocardial tissue state, blockage state, and perfusion territory, the system generates a revascularization score for the blockage. The system generates a graphic of the heart that illustrates coronary arteries, myocardial tissue state, blockage state, and the revascularization score. The system displays the graphic to provide a visual representation of the revascularization score for the blockage of the coronary artery.

The invention relates to a breast cancer chemotherapy myocardial stress quantitative evaluation method, which comprises the following steps of: acquiring an electromechanical response signal of a myocardial tissue of a chemotherapy patient in a pulsation period, extracting an electromechanical coupling delay parameter of a local tissue, and identifying an initial region of a chemotherapy-induced myocardial stress reaction; for the identified stress starting region and the adjacent cardiac muscle tissue, acquiring the transcellular membrane response time difference, and calculating a stress conduction lag difference index for characterizing the chemotherapy-induced asymmetric stress conduction characteristic; controllable micro-load intervention is carried out on a patient, and a strain reaction curve of a stress starting area and peripheral tissues after the load is applied is monitored; based on the response lag time, the strain peak change rate and the dynamic trend of recovering to the baseline in the load response process, the stress response elastic coefficient of the myocardial tissue is obtained through inversion and is used for quantifying the stress level of the myocardial after breast cancer chemotherapy; tiny changes of myocardial functions are quantified, and a trend judgment basis is provided.

The invention discloses injectable hydrogel with a myocardial tissue repairing function as well as a preparation method and application of the injectable hydrogel, and relates to the technical field of medical materials. The preparation method of the injectable hydrogel comprises the following steps: carrying out a reaction on deferoxamine and DSPE-PEG-NHS, so as to obtain DSPE-PEG-DFO; the preparation method comprises the following steps: wrapping carvedilol with DSPE-PEG-DFO under the hydrophilic and hydrophobic action, so as to obtain a drug-loaded nano-micelle; the preparation method comprises the following steps: reacting a polymer containing amino or hydroxyl with methacrylic anhydride to obtain a methylacryloyl modified polymer; reacting the carboxyl-containing polymer with cysteamine hydrochloride to obtain a sulfydryl modified polymer; mixing the drug-loaded nano-micelle, the methylacryloyl modified polymer and the sulfydryl modified polymer, and reacting under ultraviolet radiation to obtain the injectable hydrogel. The hydrogel disclosed by the invention is good in biocompatibility, can release deferoxamine and carvedilol in a ladder manner, is matched with a myocardial repair process, and realizes a function of repairing damaged myocardial tissues.

An injectable hydrogel for heart failure treatment with myocardial tissue repair function and its preparation method and use are disclosed. The hydrogel is prepared by chelating alginic acid and multivalent cations. The hydrogel is loaded with an active substance for repairing cardiac injury. The active substance is recombinant humanized collagen type III. The hydrogel is administrated into the left ventricle free wall by transendocardial injection. Implanting the hydrogel in the myocardium can increase the thickness of the left ventricular wall, adjust the stress of the ventricular wall, affect the morphology of the left ventricle, and prevent or reverse left ventricular enlargement. Further, the hydrogel is loaded with a new recombinant humanized collagen material that has the function of repairing cardiac tissue injury to further improve cardiac function and promote cardiac repair.

The invention relates to a myocardial tissue construct with a bionic structure and a function as well as a preparation method and application of the myocardial tissue construct. The myocardial tissue construct with both the bionic structure and the function comprises the following components: a hydrogel matrix suitable for 3D printing rheological properties, a cross-linking agent dispersed in the hydrogel matrix, inorganic biological material particles with myocardial protection and vascularization biological activity promotion, myocardial cells and vascularization related cells, the myocardial cells and the vascularization-related cells are regularly arranged in a three-dimensional space by simulating a cell distribution mode in a natural myocardial tissue; preferably, the regularly arranged structure comprises at least one of spatial arrangement of myocardial cell-angiogenesis related cells in a left-right / up-down side-by-side mode and spatial arrangement of myocardial cell-angiogenesis related cells in a core-shell / shell-core coaxial mode.

An apparatus and methods for performing ablation of myocardial tissues are disclosed. The apparatus includes a plurality of ablation electrode configurations to which nanosecond pulsed electric fields are applied. The methods relate to therapies to treat cardiac arrhythmias, such as, atrial fibrillation and scar-related ventricular tachycardia, amongst others. The affected myocardial tissues are ablated creating a plurality of lesions enabled by the nanosecond pulsed electric fields applied to either penetrating electrodes, endo-endo electrodes, or endo-epi electrodes. Different electrophysiological tests are performed to assess the application of nanosecond pulsed electric field ablation to specific desired tissue location within the heart. Test results show the potential to overcome limitations of current ablation therapies, thereby providing patients and doctors a superior treatment for cardiac arrhythmias.

The invention belongs to the technical field of heart organ chips, and provides a heart organ chip optimization method based on mechanical matching, which is used for optimizing a double-layer substrate in a heart organ chip, a strain sensor and an electrophysiological electrode. A double-layer substrate in a heart organ chip, a strain sensor and an electrophysiological electrode are optimized, and the method comprises the steps that for the double-layer substrate simulating an extracellular matrix and an epicardium, the Young modulus is reduced by controlling phase change of tetradecane, introducing pores into polydimethylsiloxane and improving the cross-linking ratio of the polydimethylsiloxane; a strain sensor and an electrophysiological electrode based on carbon nanotube-polydimethylsiloxane are integrated into a double-layer substrate, and the Young modulus of the strain sensor and the Young modulus of the electrophysiological electrode are matched with the Young modulus of the double-layer substrate. The problem that the Young modulus of the substrate and the sensor material is too high is avoided, and mechanical matching among the soft myocardial tissue, the sensor and the substrate is achieved.

A delivery system and method are described that include a catheter and an active wire. The catheter has a catheter body that defines a primary lumen and a secondary lumen therethrough, which are spaced apart from each other. A distal end of the catheter body is configured to be located within a chamber of a heart proximate to myocardial tissue at a site of interest (SOI). The primary lumen has a greater cross-sectional size than the secondary lumen. The primary lumen is configured to receive at least a portion of an IMD therein and to permit the portion of the IMD to move relative to the catheter. The active wire is configured to extend through the secondary lumen so that a distal end of the active wire projects beyond the distal end of the catheter body to pierce the myocardial tissue at the SOI.

The application relates to a rotary cutting type myocardial biopsy forceps, which comprises a sleeve assembly, a catheter and a handle assembly, the distal end of the handle assembly is connected with the proximal end of the catheter, and the distal end of the catheter is connected with the sleeve assembly; the sleeve assembly comprises a sleeve body, the proximal end of the sleeve body is connected with the catheter, the distal end of the sleeve body is provided with an open port, the inside of the sleeve body is slidably provided with a rotary cutting knife, the inside of the catheter is provided with a first driving member, the handle assembly is drivingly connected with the rotary cutting knife through the first driving member, so as to drive the rotary cutting knife to extend out of the sleeve body and cut myocardial tissue; the distal end of the sleeve body is movably provided with a closing assembly, the inside of the catheter is provided with a second driving member, the handle assembly is drivingly connected with the closing assembly through the second driving member, so as to control the closing assembly to selectively open or close the open port at the distal end of the sleeve body. The rotary cutting type myocardial biopsy forceps can accurately control the sampling depth, and the open port at the distal end of the sleeve body can be closed after sampling, so that myocardial cells are prevented from falling off.

The invention discloses a cardiovascular disease detection method based on image analysis, and particularly relates to the technical field of cardiovascular disease detection. Whether further detection is needed or not is judged by evaluating the distribution uniformity of microbubbles at the vascular branches and the development degree of myocardial tissue lesions. If further detection is needed, the photoacoustic imaging technology is adopted, the saturation degree of photoacoustic signals is analyzed, and a nonlinear signal demodulation algorithm is combined, so that the detection accuracy of the tiny calcification in the cardiovascular system is evaluated. By analyzing the influence of the cardiovascular tissue fiber arrangement direction on the optical signal propagation path, the abnormal degree of the lesion area fiber structure is evaluated. The cardiac muscle tissue lesion degree, the micro calcification detection accuracy and the abnormal degree of the fiber structure are comprehensively analyzed, the severity of the cardiovascular disease is evaluated, whether clinical intervention measures are needed or not is judged, early diagnosis and accurate evaluation of the cardiovascular disease are achieved, and the diagnosis efficiency and accuracy are improved.

The rotary cutting type myocardial biopsy forceps comprise a sleeve assembly, a catheter and a handle assembly, the far end of the handle assembly is connected with the near end of the catheter, and the far end of the catheter is connected with the sleeve assembly; the sleeve assembly comprises a sleeve body, the near end of the sleeve body is connected with the catheter, the far end of the sleeve body is provided with an opening, a rotary cutter is slidably arranged in the sleeve body, a first driving part is arranged in the catheter, and the handle assembly is in driving connection with the rotary cutter through the first driving part and used for driving the rotary cutter to stretch out of the sleeve body. The cardiac muscle tissue is subjected to rotary cutting; a closing assembly is movably arranged at the far end of the sleeve body, a second driving part is arranged in the catheter, and the handle assembly is in driving connection with the closing assembly through the second driving part and used for controlling the closing assembly to selectively open or close an opening in the far end of the sleeve body. The rotary cutting type myocardial biopsy forceps can accurately control the sampling depth, and the opening in the far end of the sleeve body can be closed after sampling, so that myocardial cells are prevented from falling off.

The invention discloses a myocardial rotary cutting system with an inverted puncture needle. The myocardial rotary cutting system comprises a shell, and a rotary cutting device assembly and a negative pressure device assembly are arranged in the shell; the rotary cutting device assembly extends out of the shell, and an inner cavity of the rotary cutting device assembly communicates with an inner cavity of the shell. The side face, away from the shell, of the rotary cutting device assembly is provided with an excision window and a tissue storage chamber, the excision window communicates with an inner cavity of the rotary cutting device assembly, a rotary cutting pipe is arranged in the rotary cutting device assembly, one end of the rotary cutting pipe is connected with a first bevel gear, and a rotary cutting blade is formed at the other end of the rotary cutting pipe. The rotary cutting blade can form continuous axial cutting action relative to the cutting window based on axial rotation; when the rotary cutting pipe shields the cutting window, the cutting window is in a closed state; a puncture needle is arranged in the rotary cutting pipe, and a boss-shaped barb structure is arranged on the puncture needle in a sleeving manner; according to the invention, in a minimally invasive incision state, tissue locking, continuous mechanical rotary cutting and accurate cardiac muscle tissue excision can be realized.

The invention discloses a myocardial damage information analysis method and device based on multi-sequence magnetic resonance imaging, and the method comprises the steps: obtaining historical multi-sequence magnetic resonance imaging data generated by a myocardial tissue of a to-be-recognized object based on nuclear magnetic resonance, the historical multi-sequence magnetic resonance imaging data comprising an MTT sequence, a VNE image, a CEST sequence and an OS-BOLD sequence; inputting the historical multi-sequence magnetic resonance imaging data into a pre-trained myocardial injury information analysis model so as to analyze the historical multi-sequence magnetic resonance imaging data; and outputting multiple types of myocardial tissue regions corresponding to the historical multi-sequence magnetic resonance imaging data, and respectively calculating quantitative parameters of the MTT sequence, the VNE image, the CEST sequence and the OS-BOLD sequence in the multiple types of myocardial tissue regions to obtain myocardial damage information of the to-be-identified object. Therefore, by adopting the embodiment of the invention, the accuracy of the myocardial injury information is improved.

The invention provides a multi-mode ultrasonic monitoring method for degradation of a PFO degradable plugging device, and relates to the technical field of cardiovascular ultrasonic medical treatment. The multi-mode ultrasonic monitoring method for degradation of the PFO degradable occluder aims to overcome the technical defects that in the prior art, a single ultrasonic mode cannot achieve degradation progress quantification of the occluder, precise identification of residual shunt and evaluation of the integration degree of surrounding myocardial tissue at the same time. According to the method, three modalities of real-time three-dimensional transthoracic ultrasound (RT-3D TTE), ultrasonic contrast (CEUS) and shear wave elastography (SWE) are cooperatively applied, the form, hemodynamics and tissue elasticity data of the occluder are collected in stages, non-invasive, dynamic and accurate monitoring of the whole degradation process of the occluder is achieved in combination with preset quantitative indexes, and a reliable basis is provided for clinically adjusting a treatment scheme.

The invention relates to the technical field of medical image processing and three-dimensional reconstruction, and particularly discloses a reconstruction and analogue simulation method based on a cardiac image. The method comprises the following steps: firstly, preprocessing an input CT or MRI medical image, and automatically segmenting a heart multi-tissue structure by using an nnUNetv2 model, including a plurality of anatomical regions such as atrium, ventricle, myocardial tissue and blood pool; and then performing topology repair, smoothing processing and label resampling on the segmentation result to obtain a three-dimensional label body with a continuous structure and a complete boundary. And based on the optimized tag body, constructing a heart three-dimensional surface model by adopting a Marching Cubes algorithm, and generating a multi-material volume grid suitable for finite element analysis. According to an electrode position and a radio frequency parameter set by a user, a radio frequency ablation simulation model based on a Pennes biological heat conduction equation and an Arrhenius model is established, a temperature field and a tissue thermal damage range are calculated, and a simulation result is displayed in a three-dimensional mode in an overlapping mode. According to the method, the integrated process from medical image automatic segmentation to heart three-dimensional reconstruction and thermal simulation is realized, the segmentation precision, the modeling efficiency and the simulation reliability are improved, and the method can be applied to application scenes such as surgical planning, preoperative evaluation and medical teaching.

The invention discloses an application of a non-contact electrical stimulation assembly in preparation of a myocardial infarction repair system, and the non-contact electrical stimulation assembly is a PLLA film, potassium sodium niobate nanoparticles or a PLLA film doped with the potassium sodium niobate nanoparticles. The non-contact electrical stimulation assembly generates an electric field through ultrasonic wireless driving so as to electrically stimulate infarction myocardial tissue. The PLLA film and the potassium sodium niobate nanoparticles in the non-contact electrical stimulation assembly are piezoelectric materials which do not contain lead, are good in biocompatibility and are degradable, and have higher clinical conversion value; an electric field is generated through ultrasonic wireless driving, then infarction myocardial tissue is electrically stimulated, myocardial infarction repair is promoted, ventricular remodeling is inhibited, and the problem that traditional electrical stimulation depends on invasive electrode implantation, a patient needs to carry the electrode for a long time, and then the life quality of the patient is affected is solved. Different modes of electrical stimulation can be given to cardiac muscle tissues according to requirements, and application is flexible.

The invention relates to the technical field of model construction, in particular to a heart model construction method based on multiple physical fields and geometric multiple scales, which comprises the following steps of: performing segmentation processing and three-dimensional model reconstruction on a heart image to generate an initial heart geometric model; performing anisotropic attribute assignment on the initial heart geometric model based on a regularization algorithm to obtain a myocardial tissue structure; embedding a cell electrophysiological model into the computational grid of the myocardial tissue structure through parameter mapping to output a heart model with multi-scale geometric characteristics; an electrophysiological field equation, a mechanical field equation and a heart fluid dynamic field equation are constructed respectively, and coupling among multiple physical fields is achieved; determining whether the feature weight of the myocardial tissue structure texture needs to be increased or not; determining whether the transition function width of cell electrophysiological model parameter mapping needs to be increased or not; and determining a pressure feedback relaxation factor in the coupling iteration. The stability of heart model construction is improved.

The invention provides application of a CTSL inhibitor in preparation of a medicine for treating fulminant myocarditis, and particularly belongs to the technical field of biological medicine. It is found that CTSL in cardiac muscle tissue of a mouse with the fulminant myocarditis is remarkably increased, and the CTSL inhibitor can be used for preparing the medicine for treating the fulminant myocarditis. Results show that the CTSL inhibitor can improve myocardial cell injury, cardiac inflammation, rational reconstitution and functions of heart diseases, increase survival rate and realize treatment of fulminating myocarditis.

The present application relates to the technical field of model construction, and particularly relates to a heart model construction method based on multi-physical field and geometric multi-scale, comprising: carrying out segmentation processing and three-dimensional model reconstruction on a heart image to generate an initial heart geometric model, carrying out anisotropic attribute assignment on the initial heart geometric model based on a regularization algorithm to obtain a myocardial tissue structure; embedding a cell electrophysiology model into a calculation grid of the myocardial tissue structure through parameter mapping to output a heart model with multi-scale geometric characteristics; respectively constructing an electrophysiology field equation, a mechanics field equation and a heart fluid dynamics field equation to realize coupling between the multi-physical fields; determining whether the feature weight of the myocardial tissue structure texture needs to be increased; determining whether the transition function width of the cell electrophysiology model parameter mapping needs to be increased; and determining a pressure feedback relaxation factor in the coupling iteration. The present application improves the stability of heart model construction.