157 results about "Electrophysiology" patented technology

At least some embodiments of the present disclosure is directed to a method of processing cardiac information. The method includes the steps of: receiving an activation waveform comprising a set of activation waveform data; receiving a range of window size. For each of the plurality of window sizes, the method further includes the steps of: selecting a position of a central window; calculating a set of backward correlations; calculating a set of forward correlations; determining a backward confidence value based on the set of backward correlations; and determining a forward confidence value based on the set of forward correlations. Additionally, the method includes the steps of: comparing the set of confidence values to select a designated confidence value and a selected window size corresponding to the designated confidence value; and determining a local cycle length based on the selected window size.

Systems and methods for high-bandwidth, minimally invasive brain-computer interfaces (BCIs) are disclosed. The BCIs are configured for deployment and operation in conjunction with a comprehensive interventional electrophysiology procedural suite. Three primary methods of minimally invasive electrode array delivery are disclosed: (1) cortical surface delivery, (2) ventricular delivery, and (3) endovascular delivery. Additionally, systems and methods for interacting with such high-bandwidth electrode arrays are discussed, including real-time imaging, signal processing, and neural decoding. Systems and methods for architectures for accelerating the underlying computational processes (such as graphics processing units or tensor processing units) are also discussed. Multiple applications of BCIs are discussed, with emphasis on restoration, rehabilitation, and augmentation of neurologic function.

The invention relates to the technical field of biomedical engineering, in particular to an implantable neural electrode capable of performing dual-mode detection of electrode electrophysiology and electrochemical signals, carbon fibers are used as a skeleton, and the surfaces of the carbon fibers are modified with an insulating layer and a modified gel layer with biocompatibility. According to the invention, the carbon fiber is used as a skeleton, and the surface of the carbon fiber is modified with the insulating layer and the modified gel layer with biocompatibility, so that the excellent mechanical properties and electrochemical properties of the carbon fiber are retained, and meanwhile, the direct contact between a rigid material and tissues is avoided; the modified gel layer has good biocompatibility and conductivity, the biocompatibility of the contact surface of the electrode and the tissue can be effectively improved, the inflammatory reaction caused by electrode implantation and the mechanical mismatch between the electrode and the tissue are reduced, and the long-term stable effect is achieved.

A system for testing different regions of the retina of a subject for retinal function, said system comprising: a monitor configured to display a visual electrophysiology stimulus to the subject, wherein the visual electrophysiology stimulus comprises a four ring visual electrophysiology stimulus; at least one active electrode; at least one reference electrode; and a computer configured to receive electrical signals from said at least one active electrode and said at least one reference electrode, and process the electrical signals.

The present disclosure is related to a device for gripping catheters that are used in interventional cardiac procedures without causing internal catheter damage. The present disclosure will allow the operator to maintain improved stability and maneuverability compared with current approaches, including, primarily, digital manipulation, which can lead to fatigue, instability and inappropriate catheter movement. Specifically in the pediatric population where small movements can lead to severe and permanent complications, the present disclosure has the potential to increase the safety profile of already high-risk interventional catheterization and electrophysiology procedures.

The invention discloses a sensing and storage calculation integration method of an electrophysiological sensing device and an artificial synaptic storage calculation device, relates to the technical field of neuromorphic calculation, and aims to solve the problem of separation of wearable health monitoring sensing and storage calculation. The method comprises the following steps: S1, precisely preparing two-dimensional MXene by a liquid phase etching method; s2, constructing an MXene electrophysiological sensing device; s3, constructing an MXene artificial synaptic device; s4, the MXene electrophysiological sensing device in the step S2 and the MXene artificial synapse device in the step S3 are integrated; wherein the step S4 specifically comprises the following steps: S4-1, leading out a source electrode, a grid electrode and a drain electrode of the MXene artificial synapse device through a bonding machine instrument, connecting the grid electrode with the MXene electrophysiological sensor, applying a voltage of 100mV to the source electrode of the MXene artificial synapse device, testing a current change value of a channel material of the MXene artificial synapse device by the drain electrode, and presenting a curve through a mobile terminal, therefore, the human body electrophysiology compression signal can be presented.

Systems and methods for clustering wavefront signals in an electrophysiology map of cardiac tissue are provided. The systems and methods include receiving an electrophysiology map of the cardiac tissue, displaying propagation of the wavefront signals as a plurality of velocity vectors, discretizing the received electrophysiology map into a plurality of segments, clustering the velocity vectors into at least one group within each segment based on predefined criteria, and generating a trend line representing each group of clustered velocity vectors within each segment in the electrophysiology map.

The invention belongs to the technical field of vocal music training, and provides a singing expiration strength stability training system for breath flow control, comprising: a hardware sensing module for collecting airflow dynamic data, respiratory muscle group electrophysiological data and respiratory kinematics data of a user; the data processing control center is used for receiving and processing the airflow dynamic data, the respiratory muscle group electrophysiological data and the respiratory kinematics data to obtain a processing result; the multi-mode feedback module outputs real-time feedback to the user through visual, auditory and tactile multiple channels based on the processing result; according to the method, heterogeneous data of airflow dynamics, electromyography and respiratory kinematics are synchronously collected and fused, song audios are analyzed in combination with an artificial intelligence algorithm to generate a scene-based target curve, and a personalized training baseline is established based on accurate decision and multi-modal sensory collaborative feedback of a fuzzy logic algorithm; the efficient, accurate and personalized improvement of the stability of the exhaling force of singing is realized.

This disclosure relates generally to methods of screening and preparing cardiac cell therapies for potency (e.g., cardiac cell function).

The invention discloses an intraoperative nerve electrophysiology monitoring electrode array fixing system, and relates to the field of electrophysiology monitoring electrode fixing.The intraoperative nerve electrophysiology monitoring electrode array fixing system comprises a mounting rack, a first telescopic driving part is fixedly connected into the mounting rack, and the output end of the first telescopic driving part is fixedly connected with a mounting plate; according to the intraoperative nerve electrophysiology monitoring electrode array fixing system, the electrode is placed in the electrode fixing frame, and after the electrode is fixed through the clamping mechanism, the position is determined through the laser positioner. The transmission mechanism drives the corresponding threaded rod to rotate, so that the electrode fixing frame accurately moves to the required position, and then the second telescopic driving piece drives the electrode to be inserted into the skin of the patient. The whole process is high in automation degree, medical staff can accurately insert each electrode into a monitored part only through simple operation, the stability of the inserted electrodes is guaranteed through the design of fixing of the clamping mechanism and the threaded rod, operation of the medical staff is greatly facilitated, and the electrode insertion efficiency is improved.

The invention discloses an animal olfactory behavior training experiment device, relates to the technical field of animal behavioristics experiment devices, can be cooperatively used with an external nerve recording system and a behavior detection analysis system, and aims to explore a correlation mechanism among smell stimulation, behavior response and nerve activity. The device adopts a radial single-starting-point and multi-terminal-point space structure, and is combined with a multi-odor channel system with physical isolation, so that approaching or avoiding behaviors of animals can be accurately induced. The system is integrated with an intelligent closed-loop control module based on an STM32 single-chip microcomputer, and a graded gas path cleaning mechanism is designed and comprises the functions of countercurrent purging, ultraviolet photolysis, electronic nose cleaning verification and the like, so that the purity of odor stimulation and the reliability of the experimental process are ensured. Meanwhile, the device supports TTL synchronization signal output with millisecond-level precision, can be seamlessly connected with commercially available electrophysiology and behavioristics equipment, and is suitable for multi-mode animal behavior training, recording and regulation scenes.

The invention provides a method for predicting intracardiac abnormal electrophysiological distribution based on an electrocardiogram. The method comprises the steps that body surface multi-lead electrocardiogram data are obtained and preprocessed, and high-quality data fragments are obtained; constructing a lead specific multi-expert network, and extracting lead specific spatio-temporal characteristics; designing a lead weight gating module, and dynamically calculating the attention weight of each lead by adopting a multi-layer perceptron to realize sample self-adaptive lead importance evaluation; performing weighted calibration on each lead feature by using the attention weight, and inputting the reweighted features into a feature fusion and semantic enhancement network to obtain a global feature vector; end-to-end training is completed, and predicted values of the intracardiac abnormal electrophysiology distribution in all the anatomical areas are output. Through lead specific modeling and cross-lead interaction fusion, intracardiac abnormal electrophysiological distribution prediction is achieved, and a noninvasive auxiliary tool is provided for preoperative evaluation and personalized treatment scheme formulation of cardiovascular diseases such as arrhythmia.

To provide an image-guided variable spot light stimulation electrophysiology device applicable to structural / functional imaging and evaluation.SOLUTION: To provide an application of a device for performing image-guided functional assessment based on variable spot light stimulation of a light-activated biological sample to determine changes in functional health during disease progression and treatment. More specifically, the invention relates to the application of the device in the diagnosis of vision and neurological disorders.SELECTED DRAWING: Figure 1

A catheter system for use with a catheter with a distal assembly supporting a plurality of electrodes adapted to sense electrical signal in heart tissue and a force sensor configured to generate first contact signals representative of a contact force acting on the distal assembly. The system includes an ablation power generator configured to energize the plurality of electrodes, an impedance circuitry configured to generate second contact signals representative of the electrodes in contact with tissue, a processor configured to receive the first and second contact signals and generate switch signals in response thereto, and a switch circuitry configured to connect in response to the switch signals solely selected electrodes in contact with tissue to the ablation power generator in forming one or more composite electrodes.

The invention belongs to the technical field of medical instruments, and particularly discloses a lead-free electrophysiological pacemaker device for cardiology department, which comprises a pacemaker main body, one end of the pacemaker main body is provided with an adjusting mechanism, one end of the adjusting mechanism is provided with a pasting mechanism, the adjusting mechanism comprises a connecting frame fixedly arranged at one end of the pacemaker main body, and the connecting frame is fixedly connected with the pacemaker main body. A connecting block is movably arranged on the inner side of the connecting frame, a supporting block is fixedly arranged at one end of the connecting block, a limiting ring is fixedly arranged at the other end of the supporting block, a limiting block is fixedly arranged on the inner wall of the inner side of the limiting ring, and a limiting shaft is movably arranged on the inner side of the limiting ring. Through cooperation of the adjusting mechanism and the pasting mechanism, the pacemaker body can be conveniently pasted to the chest of a patient, winding of adhesive tape is reduced, and the whole device is easy to operate.

The present application relates to the field of electrophysiology, and particularly relates to an ablation state evaluation system. The system comprises an impedance acquisition device and a control unit. The impedance acquisition device is configured to acquire impedance information of tissue at an ablation site in real time before and after energy delivery at different frequencies. The control unit is configured to calculate a frequency response index based on the received impedance information, obtain an energy delivery difference index at a current position, and obtain an energy delivery difference index of an ablation path in combination with a spatial position of an energy delivery electrode. The impedance information of tissue at the ablation site before and after energy delivery is acquired in real time at different frequencies. The frequency response index of tissue at the ablation site before and after energy delivery is calculated based on the impedance information, an energy delivery difference index at a current position is obtained, and an energy delivery difference index of an ablation path is obtained in combination with a spatial position of an energy delivery electrode. The present application realizes rapid evaluation of the effectiveness of energy delivery on an ablation path during an ablation process.

The utility model relates to the technical field of bioengineering, and provides an array chip integrating impedance measurement and microscopic observation, which comprises a transparent substrate, a circuit board, a 3D printing board and an electrode unit, and one side of the transparent substrate is provided with a conductive film; the circuit board is arranged on the conductive film, and a plurality of micro-channels are arranged on the circuit board in an array manner; the 3D printing plate is arranged on the side, away from the conductive film, of the circuit board, a plurality of micro-cavities are arranged on the 3D printing plate in an array mode, and the positions of the micro-cavities correspond to the positions of the micro-channels one to one; the electrode unit comprises a first electrode plate and a second electrode plate, the 3D printing plate is covered with the first electrode plate, the circuit board is surrounded by the second electrode plate, and the second electrode plate and the first electrode plate form a closed loop through a conductive film. Through innovative fusion of micromachining and bioelectrochemistry, synchronization of electrophysiology (impedance) and morphology (microscopy) is realized, and the dynamic growth process of organisms is conveniently and continuously monitored.

The invention discloses a bladder function improvement system and method for urethral dilation. The system identifies tissue viscoelasticity and calculates mechanical resonance frequency on the basis of a Kelvin-VoIP model, and a dynamic pulsating expansion pressure field fitting tissue characteristics is generated through a dynamic rheology driving unit. According to the method, a mechanical electrophysiology double-frequency phase locking technology is adopted, nerve electrical stimulation is accurately anchored to the wave crest phase of mechanical pressure waves, and the synergistic interaction of tissue physical remodeling and nerve reflex arc repairing is achieved. Meanwhile, a spasm-induced fluid impedance instantaneous damping feedback mechanism is introduced into the system, and when abnormal myoelectricity is monitored, the rigidity of the system is instantaneously reduced so as to actively defend damage caused by spasm. Closed-loop control is established through quantified rheological indexes, the problems that traditional rigid expansion is large in blindness and prone to tearing are solved, and precise, intelligent and safe rehabilitation treatment of urethrostenosis is achieved.

Apparatuses for making electrical connections in electrophysiological measurements and monitoring are disclosed. One such apparatus includes a first side having an electrical contact; a second side opposing the first side and having an electrode disposed over the second side; and a layer disposed between the first side and the second side. The layer is adapted to remove moisture from a region around the electrode. The apparatus also has an electrode line in electrical contact with the electrode disposed over the layer on the first side and extending over the layer on the second side. The electrode line is electrically connected to the electrical contact.

The present application relates to the field of electrophysiology catheters, and in particular to a balloon catheter, a catheter electrode assembly, and a flexible circuit board of the catheter electrode assembly. The flexible circuit board of the catheter electrode assembly comprises: an insulating substrate, the insulating substrate being used for being attached to the surface of a balloon of the balloon catheter; an electrode sheet, the electrode sheet being fixed on the insulating substrate, and the electrode sheet being used for transmitting electrical energy; a conductive trace, the conductive trace being attached to the surface of the insulating substrate, and the conductive trace being connected to the electrode sheet to achieve electrical energy transmission; and a trace insulating layer provided corresponding to the conductive trace, the trace insulating layer covering the conductive trace, and the insulating substrate having an exposed region not covered by the trace insulating layer. The present application mainly solves the technical problems that a flexible circuit board of a catheter electrode assembly is prone to separation from a balloon, and the flexible circuit board restricts the balloon from contracting to a small diameter.

At least some embodiments of the present disclosure are directed to a system for processing cardiac information. The system includes a processing unit configured to: receive one or more cardiac electrical signals from one or more electrodes disposed within a cardiac chamber, wherein the cardiac electrical signals are acquired during a cardiac beat; receive an indication of a measurement location corresponding to each of the cardiac electrical signals; analyze the one or more cardiac electrical signals to compute a plurality of duty cycle values, the computed duty cycle values corresponding to a plurality of preselected cycle length windows; and compute an average duty cycle value of the computed duty cycle values over the plurality of preselected cycle length windows.

Systems and methods for high-bandwidth, minimally invasive brain-computer interfaces (BCIs) are disclosed. The BCIs are configured for deployment and operation in conjunction with a comprehensive interventional electrophysiology procedural suite. Three primary methods of minimally invasive electrode array delivery are disclosed: (1) cortical surface delivery, (2) ventricular delivery, and (3) endovascular delivery. Additionally, systems and methods for interacting with such high-bandwidth electrode arrays are discussed, including real-time imaging, signal processing, and neural decoding. Systems and methods for architectures for accelerating the underlying computational processes (such as graphics processing units or tensor processing units) are also discussed. Multiple applications of BCIs are discussed, with emphasis on restoration, rehabilitation, and augmentation of neurologic function.

An electrophysiological medical device includes a catheter, a magnetic positioning system, and a processing unit. The catheter is inserted into the human body. The magnetic positioning system includes a magnetic field generator and a magnetic sensor. The magnetic field generator generates a magnetic field, and the magnetic sensor moves with the catheter to detect first magnetic field information indicating the catheter's position within the body. The processing unit acquires the first magnetic field information from the magnetic positioning system and generates the catheter's original position information based on this information. The processing unit also acquires relevant information from a digital subtraction angiography (DSA) device that causes magnetic interference to the magnetic positioning system, corrects the catheter's original position information based on this information, and obtains and outputs the corrected position information of the catheter. This electrophysiological medical device can specifically address the impact of DSA equipment on the positioning accuracy of the magnetic positioning system, thereby improving positioning accuracy, avoiding the impact of low positioning accuracy on diagnosis and operation, and ultimately improving medical outcomes.

The present invention generally relates to an image guided variable spot stimulation-based electrophysiology assessment device for different biomedical applications. Specifically, the invention relates to application of the device to perform image-guided functional assessment upon variable spot optical stimulation of light-activatable biological specimens to determine changes in the functional health during disease progression and therapy. More specifically, the invention relates to the application of the device in the diagnosis of visual and neurological disorders.

Systems and methods for high-bandwidth, minimally invasive brain-computer interfaces (BCIs) are disclosed. The BCIs are configured for deployment and operation in conjunction with a comprehensive interventional electrophysiology procedural suite. Three primary methods of minimally invasive electrode array delivery are disclosed: (1) cortical surface delivery, (2) ventricular delivery, and (3) endovascular delivery. Additionally, systems and methods for interacting with such high-bandwidth electrode arrays are discussed, including real-time imaging, signal processing, and neural decoding. Systems and methods for architectures for accelerating the underlying computational processes (such as graphics processing units or tensor processing units) are also discussed. Multiple applications of BCIs are discussed, with emphasis on restoration, rehabilitation, and augmentation of neurologic function.

The invention relates to an electrophysiology catheter. The electrophysiology catheter comprises an inner tube and an outer tube which are connected in a sleeved mode, an annular containing channel is formed between the inner tube and the outer tube, at least part of the electrode assembly extends into the containing channel, the electrode assembly comprises a base body, the base body can deform, the two ends of the base body in the length direction are connected with the inner tube and the outer tube respectively, and the base body at least comprises a plurality of first base bodies and a plurality of second base bodies; on the cross section of the electrophysiology catheter, the multiple first base bodies are arranged in the circumferential direction of the containing channel with the first diameter, the multiple second base bodies are arranged in the circumferential direction of the containing channel with the second diameter, the second diameter is smaller than the first diameter, and in the radial direction, the second base bodies are at least partially located between every two adjacent first base bodies; the at least one electrode is connected to the base body, and the multiple electrodes are arranged in the length direction of the base body. According to the scheme, more electrodes can be additionally arranged on the basis that the size of the catheter is not increased, and the use efficiency is improved.

The application relates to an electrophysiological catheter. The electrophysiological catheter comprises a sleeved inner tube and outer tube, the inner tube and the outer tube can move relatively, an electrode assembly connects the inner tube and the outer tube, the electrode assembly comprises: a plurality of groups of matrix groups, the plurality of groups of matrix groups are arranged along the circumference of the inner tube, and the matrix groups connect the inner tube and the outer tube, the matrix groups comprise two or more than two matrixes arranged sequentially along the circumference of the inner tube, the matrixes can be deformed, the matrixes at least comprise connected first segments and second segments, the first segments and the second segments have a first connecting point therebetween, the first connecting points in the same matrix group are connected in contact to form a joint; and an electrode, the electrode is arranged at least at the joint. The electrophysiological catheter provided by the application can improve the stability of the electrode at an ablation position, improve ablation efficiency, and obtain better ablation effect.

High-density flat balloon catheter The present invention relates in general to an expandable catheter used in electrophysiology, and more specifically to a high-density balloon catheter used for the diagnosis and / or treatment of cardiac arrhythmias. The catheter includes an elongated catheter shaft having a proximal end and a distal end. The elongated catheter shaft defines a longitudinal axis. The catheter includes an expandable assembly having a first delivery configuration and a second deployment configuration. The balloon member includes at least one flexible framework positioned between outward and inward layers on the upper and / or lower surfaces of the balloon member, and at least one plurality of electrodes patterned on the flexible framework. In some embodiments, a flat balloon member includes electrodes on both sides of the planar balloon member. The balloon member may include a flexible structural element positioned within an internal cavity.

Provided are multi-layer bioreactors for growing, maintaining, stimulating, monitoring and testing organoids and tissues derived from or representing hollow organs in organoid chambers. Also provided are uses of those bioreactors in modeling a disease process for monitoring disease progress and / or for assessing a biological effect, such as therapeutic efficacy and / or toxicity, e.g., organotoxicity. Also disclosed are bioreactors comprising organoid chambers that are useful as systems for measuring the volume, pressure, contractility, pump function, or electrophysiology of an organoid chamber as well as systems for controlling the pressure experienced by an organoid or tissue in an organoid chamber.