367 results about "Electrophysiology" patented technology

The invention relates to a brain function evaluation system for a patient with disturbance of consciousness based on a neural multi-modal monitoring technology, and belongs to the technical field of biomedicine, and the system comprises a multi-modal data acquisition module which is used for acquiring multi-modal data of an evaluated person, the multi-modal data comprises clinical behavioral data, cerebral blood flow data, brain image data and neural electrophysiological data, the neural electrophysiological data comprises electroencephalogram and evoked potential data, and the brain image data comprises brain structure images and brain function images; the multi-modal data evaluation module is used for evaluating the clinical behavioral data, the cerebral blood flow data, the brain image data and the neural electrophysiological data to obtain an evaluation value of each modal data; and the comprehensive evaluation module is used for processing the plurality of evaluation values by using a disturbance of consciousness awakening prediction model to obtain an evaluation result. The method has the effects that the brain function of the patient with the disturbance of consciousness is evaluated by using a multi-mode neural function monitoring technology, and the evaluation accuracy is improved.

A system for determining electrophysiological data comprising an electronic control unit configured to acquire electrophysiology signals from a plurality of electrodes (130) of one or more catheters, select at least one clique of electrodes from the plurality of electrodes (136) to determine a plurality of local E field data points, determine the location and orientation of the plurality of electrodes, process the electrophysiology signals from the at least one clique from a full set of bipole subcliques to derive the local E field data points associated with the at least one clique of electrodes, derive at least one orientation independent signal from the at least one clique of electrodes (138) from the information content corresponding to weighted parts of electrogram signals, and display or output catheter orientation independent electrophysiologic information to a user or process.

The invention provides an electromagnetic photoacoustic synchronous integrated brain function imaging method and device, and relates to the field of multi-mode brain function imaging research. According to the invention, electroencephalogram, magnetoencephalogram, functional near infrared spectrum and functional ultrasonic imaging technologies are fused, important advantage complementation is formed in signal specificity and temporal-spatial resolution, and neural activity can be described from the angle of human cranial nerve electrophysiology and neural metabolism can be observed from hemodynamic information at the same time. And electrophysiology and hemodynamic activities of the brain can be synchronously recorded.

The invention discloses an electrophysiology and hemodynamics multi-mode intelligent wearable system and a data evaluation method, and belongs to the technical field of biomedical engineering, the system comprises an optical module, a flexible stretchable electric signal module and a central module; the optical module is used for collecting hemodynamic signals including an oxyhemoglobin change signal, a deoxygenated hemoglobin change signal and a pulse wave signal by combining a near-infrared light signal with hemodynamics; the flexible stretchable electric signal module collects electric signals, including electroencephalogram signals, electromyographic signals, electrocardiosignals and electro-oculogram signals, of all parts through electrodes; the central module is used for digitalizing and preprocessing the hemodynamic signal and the electric signal of each part, fusing multi-modal data, evaluating data quality and predicting a dominant external event influencing the data quality; and meanwhile, data quality and dominant external events are output to the terminal to feed back and adjust acquisition parameters of the optical module and the flexible stretchable electric signal module, so that the effectiveness and practicability of monitoring are remarkably improved.

A catheter for electrophysiology applications is disclosed herein that includes a tubular member and an end effector. The end effector is coupled to a distal portion of the tubular member which as a cross-section intersecting first and second orthogonal planes extending along a longitudinal axis. The end effector includes first, second, and third loop members and has an unconstrained configuration in which the first and second loop members respectively define planar surfaces which each intersect the first and second orthogonal planes and the third loop member defines a planar surface that intersects only one of the first and second orthogonal planes.

The invention provides an Alzheimer disease auxiliary accurate identification method and system based on a multi-omics marker network and an adaptive support vector machine. Accurate identification of Alzheimer's disease and other types of dementia is realized through a marker network based on five modal data and an adaptive support vector machine model. According to the method, multi-source heterogeneous data such as blood, urine, neuroimaging, electrophysiology and clinical evaluation are fused, specific markers are analyzed and screened by adopting a weighted gene co-expression network, and cross-modal feature interactive learning is realized through a self-attention mechanism. An online learning mechanism is introduced to enable the model to adapt to new data distribution, and the contribution degree of each marker to diagnosis is output in combination with an interpretability module. Finally, multi-center data synchronization and model optimization are realized by means of a cloud platform, the accuracy, specificity and early diagnosis capability of AD diagnosis and identification and the adaptability of the model are remarkably improved, the limitation of the prior art is overcome, and doctors are assisted to diagnose and treat the Alzheimer's disease.

Devices, methods, and systems related to ultrasound imaging or modulating of the nervous system are described. The devices may comprise, for example, one or more ultrasound transducers, wherein an ultrasound transducer from the one or more ultrasound transducers can comprise an implantable ultrasound transducer, wherein the implantable ultrasound transducer can comprise a sonolucent window. The methods and systems may also comprise, for example, a method of imaging and / or modulating the nervous system of a subject using the one or more ultrasound transducers. The method of imaging and / or modulating the nervous system of the subject can be based on a closed-loop operation, wherein an iteration of the imaging and / or the modulating of the nervous system is based on a prior iteration. The closed-loop operation can comprise ultrasound imaging and ultrasound-based modulating or electrophysiological modulating. The methods can further comprise methods of analyzing ultrasound data, such as via an artificial neural network.

The invention relates to the field of ulcerative colitis, and discloses a multi-parameter monitoring system for evaluating the intestinal barrier function of ulcerative colitis, which is used for realizing the goal of automatically adjusting a treatment scheme according to a monitoring result by constructing a closed-loop feedback treatment system. According to the invention, by designing the nanoprobe of which the surface is modified with a specific binding element and combining with a swallowing capsule endoscopy, real-time imaging and molecular level dynamic tracking of the intestinal barrier are realized, genetically engineered bacteria are constructed to quantify intestinal permeability abnormality and local inflammation level, and an intestinal barrier function damage score and a disease progress prediction result are output; individual monitoring is achieved through transfer learning, ultrasonic elastography, optical coherence tomography, wearable equipment for measuring intestinal electric field impedance spectroscopy and other technologies are adopted, an intestinal wall mechanics-electrophysiology composite parameter set is obtained, and the evaluation accuracy is improved.

Aspects of the present disclosure are directed to intravascular electrophysiology catheters which utilize electrodes on flexible electronic circuit(s) to facilitate reduced assembly complexity and cost. In one example embodiment, a distal tip assembly of an electrophysiology catheter is disclosed. The distal tip assembly including a catheter shaft, flexible circuitry, and a distal tip coupled to a distal end of the catheter shaft. The catheter shaft includes an outer surface with a trench extending into the outer surface, and the flexible circuitry is inserted into the trench and coupled to the catheter shaft. The flexible circuitry includes one or more electrodes configured and arranged to sense electrophysiological characteristics of tissue.

Aspects of the present disclosure are directed to intravascular electrophysiology catheters which utilize electrodes on flexible electronic circuit(s) to facilitate reduced assembly complexity and cost. In one example embodiment, a distal tip assembly of an electrophysiology catheter is disclosed. The distal tip assembly including a catheter shaft, flexible circuitry, and a distal tip coupled to a distal end of the catheter shaft. The catheter shaft includes an outer surface with a trench extending into the outer surface, and the flexible circuitry is inserted into the trench and coupled to the catheter shaft. The flexible circuitry includes one or more electrodes configured and arranged to sense electrophysiological characteristics of tissue.

The invention relates to a chest pain classification method and system based on multi-modal data fusion and a deep learning model, and belongs to the technical field of intelligent medical auxiliary diagnosis. The method comprises the following steps: firstly, carrying out heart region segmentation and pathological feature enhancement preprocessing on a chest radiograph image, extracting anatomical features by adopting a multi-scale visual model which is optimized and improved aiming at the chest radiograph, meanwhile, carrying out multi-lead time sequence calibration and ST-segment waveform marking on an electrocardiogram signal, and capturing electrophysiological time sequence features through a multi-scale one-dimensional convolutional network; then, a dynamic gating hybrid expert system is constructed, an anatomy expert, an electrophysiology expert, a multi-modal association expert and a critical value expert process specific modal features respectively, and a gating network dynamically calculates expert weights based on real-time vital signs and pathological features; according to the method, by integrating multi-modal data and combining a deep learning technology, rapid and accurate chest pain classification support and report generation can be provided for clinicians, and the method has a wide application prospect.

The invention relates to the technical field of biological consciousness state monitoring, in particular to an emergency patient consciousness state monitoring system based on a bio-electricity signal, and the system obtains a theta rhythm signal, an alpha wave signal and a gamma wave oscillation signal through an electroencephalogram signal acquisition module and a signal extraction module; obtaining an effective phase amplitude coupling event and an occurrence time position thereof through a phase amplitude coupling event time position positioning module; based on a patient consciousness state monitoring module, obtaining a patient consciousness state monitoring index, and fitting the patient consciousness state monitoring index with the time sequence to complete patient consciousness state monitoring. By means of the method, the theta-gamma cross-brain region phase amplitude coupling (PAC) event can be accurately positioned, the limitation that space-time positioning of the PAC event is fuzzy and dynamic tracking lags in the traditional technology is broken through, millisecond-level high-resolution monitoring of the consciousness state of an emergency patient is achieved, and a quantifiable neural electrophysiology basis is provided for real-time intervention of disturbance of consciousness.

The invention relates to the technical field of electrophysiology catheters, in particular to a spherical ablation catheter which comprises a balloon arranged at the head end, a plurality of electrodes are arranged on the balloon, and the balloon comprises a first spherical form and a second spherical form after being expanded; the volume of the second spherical form is greater than that of the first spherical form; the adjacent electrodes are spaced in the first spherical form or the second spherical form; the first spherical form is used for mapping and ablation; the second spherical morphology is used for mapping and ablation. According to the spherical ablation catheter, the balloon is arranged and can be configured into the first spherical form and the second spherical form which are different in size, the multiple electrodes are arranged on the balloon, and therefore the ablation catheter does not need to be replaced, mapping and ablation of different parts can be completed through one spherical ablation catheter which is implanted into a body at a time, and the ablation efficiency is improved. The second spherical form can be used for large-area annular ablation of pulmonary vein isolation, the first spherical form can also be used for point ablation or large-area ablation, and meanwhile precise mapping and high-efficiency ablation are achieved.

The invention relates to the field of electrophysiological catheters, in particular to a mapping and ablation system capable of detecting injury depth, which is characterized in that a tail end functional area is arranged at the far end of a catheter, and an electrode, a positioning sensor and an optical probe are arranged in the tail end functional area; the electrode is used for mapping and ablation; the positioning sensor comprises a coil structure; the optical probe is used for performing optical scanning on the contacted tissue. The ablation unit is communicated with the electrode and provides ablation energy for the electrode; the positioning unit is communicated with the catheter and is used for displaying the position and form of the tail end functional area and recognizing the deviation and rotation direction of the tail end functional area; the electrophysiology mapping unit is communicated with the electrode and acquires an electrophysiology signal through the electrode; the optical detection unit is connected with the optical probe through an optical fiber and used for optical coherence tomography; the impedance detection unit is communicated with the electrodes, impedance information of surrounding tissue under different frequencies is collected through the electrodes, and then the frequency response coefficient of the position where each electrode is located is solved and used for recognizing whether the electrodes make contact with the tissue or not.

The invention relates to the field of medical electrophysiology mapping and ablation catheters, in particular to a net-shaped head end with a variable shape and an electrode catheter of the net-shaped head end. The net-shaped head end is formed by combining adjacent electrode arms at a far-end combining section or a near-end combining section, arranging a near-end electrode and a far-end electrode at the combining position of the adjacent electrode arms, and conducting electrode connection on the near-end electrode and the far-end electrode. The near-end electrode and the far-end electrode are distributed in a staggered mode in space, the net-shaped head end generates overall deformation in a stress state, the net-shaped head end can be used in different positions in a shape-adaptive mode by changing the shape of the net-shaped head end structure, and when a flower-shaped structure is formed at the net-shaped head end, the near-end electrode and the far-end electrode can complement each other to form a complete and uniform ablation band. When the net-shaped head end shrinks, the sheath entering size is controlled to the maximum extent; according to the electrode catheter, the net-shaped head end is adopted, the electrode catheter can be adapted to electrophysiological signal collection or ablation at different positions, the integrity of an ablation band can be ensured, the recurrence probability of atrial fibrillation can be reduced, and the hemolysis risk can be reduced.

The invention relates to the technical field of neurology department electromyography room nursing, in particular to a patient postoperative rehabilitation guidance system based on neuroelectrophysiology monitoring, which is established on the basis of collecting and analyzing data on the basis of implementing neuroelectrophysiology monitoring on a patient. And a strategy policy of a rehabilitation guidance model is reasonably provided for monitored real-time data. According to the system, on the premise that neuroelectricity monitoring is carried out on a patient to obtain electromyogram data, the electromyogram data are analyzed and screened, and therefore it is guaranteed that a doctor can put forward scientific and effective targeted rehabilitation guidance policies according to comprehensive analysis of all the data; and after an expert makes a rehabilitation guidance policy for the electromyogram data of the patient in a targeted manner according to the system, the rehabilitation guidance policy is stored for a long time through a storage system in the system, so that the working efficiency of nursing is improved.

The invention discloses a controllable windmill-shaped PFA catheter and a remote catheter ablation device, and relates to the technical field of catheter ablation and medical instruments, the controllable windmill-shaped PFA catheter comprises a catheter, the catheter is led out of a catheter body, the head end of the catheter is of a windmill structure, a magnetic sensor and a plurality of electrodes are arranged on a framework of the windmill structure, and the windmill structure can be contained in a sheath tube; one end of the catheter body is led out of the catheter, and the catheter body is arranged in the sheath tube; one end of the catheter handle is led out of the catheter body, the catheter handle is matched with a gear assembly of an electrophysiology interventional instrument, and the gear assembly at least comprises three sets of gears used for achieving corresponding operation actions. According to the windmill-shaped PFA ablation catheter, the electrodes are evenly distributed on the windmill-shaped framework, even electrode distribution is formed on the target pulmonary vein, and an operator can conduct ablation without replacing the catheter while completing three-dimensional point mapping dissection.

The invention discloses an irregular action recognition method, system and device for short-time sequence electroencephalogram and electromyography fusion, and the method comprises the steps: collecting electroencephalogram and electromyography signals from motor imagery to execution in an incomplete asynchronous manner through a wireless electroencephalogram signal collection device and a distributed wireless surface electromyography signal collection device; processing noise in the electroencephalogram signals and the surface electromyogram signals; in combination with electroencephalogram signals in a motor imagery period, extracting electroencephalogram signal space domain features in a motor execution period, extracting time domain features of surface electromyogram signals, and in combination with a mixed fusion mode of feature layer fusion and decision-making layer fusion, fusing short-time sequence electroencephalogram and electromyogram signals in the motor execution period; according to the method, the motion imagination period recognition result and the motion execution period recognition result are subjected to confidence analysis, irregular actions of the user are quickly and accurately recognized and serve as control instructions to be input into the exoskeleton robot, the exoskeleton robot is controlled to assist the user in completing the target actions, and the initiative of the user is effectively improved.

The invention relates to the technical field of medical health, in particular to a cardiac muscle tissue electrophysiology unmarked optical detection method based on deep learning. The method comprises the following steps: acquiring optical detection image data and electrophysiological signal data of myocardial tissue; the optical detection image data and the electrophysiological signal data are subjected to image preprocessing, so that optical-physiological signal mapping data are obtained, and image preprocessing comprises image registration, image cutting, periodic enhancement, time difference enhancement, spatial filtering, intensity normalization and data smoothing; and according to the optical-physiological signal mapping data, carrying out feature signal extraction based on a mechanical contraction curve and an electrophysiological curve so as to obtain mechanical contraction curve data and electrophysiological curve data. According to the method, unmarked optical detection is adopted, so that direct interference on myocardial tissues is avoided, and the physiological state of the tissues is better maintained.

An electrophysiology catheter with a distal electrode assembly having covered spine carrying a plurality of microelectrodes. One or more spines have preformed configurations including at least a first portion with a first curvature and a second portion with a second curvature, and may include a linear portion. The linear portion may be between the first and second portions. The linear portion may be distal of the first and second portions. One or more spines have a narrower portion so that different portions of the spine can have different flexibility with a degree of independence in flexibility from adjacent portions.

Deep brain stimulation (DBS) can be used to treat many neurological conditions beyond traditional movement disorders. When patients do not suffer from traditional movement disorders, medical professionals cannot use traditional observation-based methods to configure the DBS system. A new method for selecting stimulation configurations can include recording internal data and external data as the patient performs (or attempts to perform) a motor task. The internal data is electrophysiology data recorded by a plurality of DBS electrodes, used to identify at least one of the plurality of electrodes closest to a neuronal population involved in control of the at least one motor task. The external data is electroencephalogram (EEG) data recorded by scalp electrodes, which is used to select at least one of the potential stimulation electrodes to deliver the DBS. When the electrode(s) delivering the DBS are selected, optimal parameters for the DBS are then chosen.

The utility model provides a bite block device for nerve electrophysiology monitoring in an operation, which comprises a lower bite block and an upper bite block, a channel groove for installing a trachea channel is arranged in the lower bite block, and lining plates are oppositely arranged on two sides of the channel groove in the lower bite block; the lower surface of the lower bite block is provided with a lower tooth groove, and the upper surface of the upper bite block is provided with an upper tooth groove. Through the arrangement of the base plate, the upper tooth cushion and the lower tooth cushion can be in full contact with molar teeth in the cavity, so that the pressure borne by incisor teeth is reduced, and the incisor teeth of a patient are prevented from being damaged; the trachea channel is arranged in the middle of the bite block, the inner lining plate is arranged on the outer side of the trachea channel, under protection of the inner lining plate, the trachea can be prevented from being bitten by a patient to be flat, normal use of the trachea is guaranteed, the trachea channel has a certain length and is arranged in the middle of the bite block, and after the whole bite block is arranged in the oral cavity of the patient, the inner trachea channel can press the tongue. The tongue is prevented from entering the space between the upper teeth and the lower teeth and is prevented from being bitten.

Devices, methods, and systems related to ultrasound imaging or modulating of the nervous system are described. The devices may comprise, for example, one or more ultrasound transducers, wherein an ultrasound transducer from the one or more ultrasound transducers can comprise an implantable ultrasound transducer, wherein the implantable ultrasound transducer can comprise a sonolucent window. The methods and systems may also comprise, for example, a method of imaging and / or modulating the nervous system of a subject using the one or more ultrasound transducers. The method of imaging and / or modulating the nervous system of the subject can be based on a closed-loop operation, wherein an iteration of the imaging and / or the modulating of the nervous system is based on a prior iteration. The closed-loop operation can comprise ultrasound imaging and ultrasound-based modulating or electrophysiological modulating. The methods can further comprise methods of analyzing ultrasound data, such as via an artificial neural network.

One or more non-transitory machine-readable media to store data and instructions executable by one or more processors. The instructions are programmed to analyze workflow data for a given phase of a plurality of phases of an ongoing electrophysiology (EP) workflow implemented using a first computing apparatus. The instructions can also determine at least one support event based on the analysis of the workflow data and send a request to at least one remote support specialist responsive to determining the at least one support event. The instructions further can establish a communication link between the first computing apparatus and a second computing apparatus, which is associated with a respective remote support specialist, and enable user interaction with and control of the machine-readable EP workflow instructions on the first computing apparatus responsive to a user input by the respective remote support specialist at the second computing apparatus.

The invention discloses a flexible electrode and a preparation method and application thereof, and relates to the technical field of medical instruments. The flexible electrode comprises a flexible substrate layer, a conductive electrode layer, a packaging layer and an electrode contact which are arranged in a stacked mode. The conductive electrode layer comprises a wire and a conductive contact which are communicated with each other; the packaging layer is provided with a through hole structure, and the through hole structure exposes the conductive contact; and the electrode contact is arranged on the conductive contact. The electrophysiology mapping and electroporation functions are integrated, switching and operation complexity among multiple devices is reduced, and organic combination of real-time monitoring and accurate treatment is achieved.

The invention relates to the field of electrophysiology catheters, in particular to a mapping and ablation catheter capable of detecting injury depth, which comprises a head end, and at least one electrode for mapping and ablation is arranged on the head end; the positioning sensor assembly comprises at least two positioning sensors, each positioning sensor comprises a coil structure, the at least two coil structures are arranged at a certain included angle, and the positioning sensor assembly is used for displaying the position and form of the head end and recognizing the deviation and rotation direction of the head end; the pressure sensing assembly comprises strain gauges and an elastic body, the strain gauges are arranged on the periphery of the elastic body, and the pressure sensing assembly is used for detecting the pressure magnitude and direction of the head end; the at least one optical probe is used for performing optical scanning on the contacted tissue, and the optical probe, the positioning sensor assembly and the electrode have a fixed position relationship. Through the mutual cooperation of the optical probe, the positioning sensor assembly and the pressure sensing assembly, the detection result is more accurate, the detection depth is deeper, the range is larger, and the use is more convenient.

The present invention relates to the technical field of medical electrophysiology catheters, and in particular to a detection system for indicating the degree of contact between catheter electrodes. The system comprises a magnetic field positioning module, a data acquisition module, and an contact detection module. The magnetic field positioning module is used to obtain the relative distance of an electrode relative to a reference point; the data acquisition module is used to obtain the impedance of the electrode relative to the reference point; and the contact detection module locates cells in the total target area based on the relative distance and impedance, and calculates the electrode contact index based on a pre-fitted relationship curve between electrode distance and impedance in the located cells. The contact degree between multiple electrodes and tissue can be obtained in real time. When the electrodes are installed on a catheter, the contact degree between each catheter electrode and tissue is displayed in real time.

The present invention generally relates to expandable catheters for use in electrophysiology, and more specifically to high-density balloon catheters for use in diagnosing and / or treating cardiac arrhythmias. A catheter includes an elongate catheter shaft comprising a proximal end and a distal end. The elongate catheter shaft defines a longitudinal axis. The catheter includes an expandable assembly having a first delivery configuration and a second deployed configuration. The balloon member includes at least one flexible framework disposed between an outer facing layer and an inner facing layer of the top surface and / or the bottom surface of the balloon member and at least one plurality of electrodes patterned onto the flexible framework. In some embodiments, a flat balloon member includes electrodes on both sides of the planar balloon member. The balloon member may include a flexible structural element disposed within the interior cavity.

A system includes a magnetocardiography (MCG) subsystem having a plurality of magnetometers. The system measures, via the MCG subsystem using the plurality of magnetometers, MCG data comprising biomagnetic field signals from a human subject. the system receives, from one or more ECG electrodes that are physically coupled to the human subject, ECG data comprising cardiac electrical activity of a heart of the human subject. The system determines location information of the one or more electrodes that are mounted on the human subject. In some embodiments, the system enhances the measured MCG data and / or the received ECG data according to determined location information of the one or more electrodes.