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72results about How to "Reduce clinical risk" patented technology

Systems and methods for determining location of an access needle in a subject

Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND

In-vitro intervention embolism therapy simulation system

The invention discloses an in-vitro intervention embolism therapy simulation system which comprises a micro-vessel simulation area, a blood flow simulation area and a pressure monitoring area. The micro-vessel simulation area is placed in a constant temperature device and communicated with the blood flow simulation area through a pipeline, the pressure monitoring area is used for monitoring a pressure value in the pipeline, and the micro-vessel simulation area comprises a micro-fluidic chip. According to the in-vitro intervention embolism therapy simulation system, the difference of terminal embolism performances is quantified by observing pipeline classification in the chip plugged by different embolism agents, so that the terminal embolism performances of the different embolism agents can be more visually evaluated, and a simpler and more convenient data accumulation program is provided for research and development persons. Besides, the performances of the embolism agents are more effectively understood, clinical risk is reduced, blood flow washing resistance effects of the different embolism agents can be accurately analyzed in the pressure monitoring area under different conditions, so that embolism strength is evaluated in vitro, and blood vessel recanalization time can be monitored.
Owner:广东广纳安疗科技有限公司

Systems and methods for determining location of an access needle in a subject

Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND

Ginseng aconite injection liquid and its preparation method

A Chinese medicine in the form of injection, freeze-dried powder injection, or perfusion is prepared from ginseng and prepared aconite root. It can decrease the toxin of aconite root.
Owner:北京天新园医药科技开发有限公司

Culture solution and method for inducing mesenchymal stem cells to differentiate into glomerular mesangial cells

The invention discloses culture solution for inducing mesenchymal stem cells to differentiate into glomerular mesangial cells and an inducing method. The culture solution comprises a human platelet-derived growth factor-BB, all-trans-retinoic acid, collagen-IV and a basic medium, wherein the basic medium is a low-sugar DMEM (Dulbecco's modified eagle medium) containing 2% of horse serum and 5ng / ml of bFGF (basic fibroblast growth factor). The inducing method includes the steps: preparing the inducing culture solution; preparing the mesenchymal stem cells; coating a culture plate by the collagen-IV with the concentration of 5ug / cm<2>; inoculating the mesenchymal stem cells with the cell density of 5*103 / cm<2> into the coated culture plate and adding the inducing culture solution; changing the solution once every three days and performing inducing culture for seven days. The mesenchymal stem cells are jointly induced to differentiate into the glomerular mesangial cells by the aid of the human platelet-derived growth factor-BB, the all-trans-retinoic acid and the collagen-IV, inducing period is short, inducing efficiency is high, the glomerular mesangial cells formed by differentiation are high in functional activity, and transplantation therapy of kidney diseases such as kidney failure is facilitated.
Owner:HARBIN YIJIAYI REGENERATIVE MEDICINE TECH

Indigo carmine colorant as well as preparation method and applications thereof

The invention discloses an indigo carmine colorant as well as a preparation method and applications thereof. A mixed solution of indigo carmine and antioxidants contains 0.1%-1%(weight / volume percent concentration, g / 100ml) of indigo carmine, the antioxidants are selected from one or combinations of ascorbic acid, tea polyphenols and phytic acid, and the amount of addition is 0.05%-0.5%(weight / volume percent concentration, g / 100ml). The indigo carmine colorant has advantages as follows: a product is greatly improved in stability, is easy to use and store, and has a good clinical effect; the safety performance is high, and the clinical risk is low; the operation is simple. A prepared indigo carmine solution can be directly used in clinical treatment, dilution and other additional operations are not required, a clinical operation process is greatly simplified, and defects of a colorant obtained with an immediate preparation and use method in the prior art are solved.
Owner:沈伟

Application of fusion polypeptide of ziconotide and TAT peptide in drug preparation

The invention provides application of fusion polypeptide of ziconotide and TAT peptide in drug preparation. According to the application provided by the invention, the terminal C of ziconotide is connected with the terminal N of cell penetrating peptide to obtain fusion peptide, and the defects that intramuscular injection cannot be realized and the like are overcome. The fusion polypeptide can pass through the blood brain barrier and is suitable for the administration through vein, abdominal cavity or nasal cavity while the operation is convenient and the clinical risk is low; after being applied through the vein, abdominal cavity or nasal cavity, the fusion polypeptide has the advantages of long acting time in vivo, good analgesic effect and few peptide side effects and thus is suitablefor large-scale clinical application. The fusion polypeptide provided by the invention is easy to prepare, the preparation technology and the preparation process are controllable in quality, and the fusion polypeptide is suitable for large-scale industrial production.
Owner:SHENZHEN RUIJIAN BIOSCI TECH LTD

Apnea awakening device and method

The invention relates to an apnea awakening device, which comprises a setting terminal, a respiration sensor, a flow rate control device, a pressure generator, a pressure sensor, a microcontroller and a nose pipe, wherein the setting terminal is used for setting the apnea time threshold value and the wakening pressure threshold value, the respiration sensor is attached onto the body of a patient, and is used for detecting whether the patient has the breathe or not in the apnea time, the flow rate control device is used for outputting gas with the preset oxygen concentration, the pressure generator is used for generating the corresponding awakening pressure according to the flow rate of the gas output by the flow rate control device, the pressure sensor is used for collecting the awakening pressure generated by the pressure sensor in real time, the microcontroller is used for controlling the flow rate of the gas output by the flow rate control device according to the detection result of the respiration sensor and the awakening pressure threshold value, and the noise pipe is connected to the naris part of the patient and is used for conveying the wakening pressure generated by the pressure generator into the respiratory tract of the patient. The invention also provides an apnea awakening method. The device and the method have the advantage that the clinic risk and the cost can be simultaneously reduced.
Owner:SHENZHEN COMEN MEDICAL INSTR

Systems and methods for determining pressure frequency changes in a subject

ActiveUS20170238823A1Reduce clinical riskImproving reliability and safety and efficacyElectrocardiographySurgical needlesCell electrophysiologyBiomedical engineering
Systems and methods for epicardial electrophysiology and other procedures are provided in which conditions at the location of an access needle may be determined according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject, and the pressure frequency information may be segmented based on the cardiac waveform information. Conditions at the current location of the needle may be determined based on an algorithm including the segmented pressure frequency information and the cardiac waveform information.
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND

Application of polypeptide capable of passing through hemato encephalic barrier in preparing drug

The invention relates to application of a polypeptide capable of passing through a hemato encephalic barrier in preparing a drug. An end C of ziconotide is connected with an end N of a cell penetrating peptide by virtue of one glycine to obtain the polypeptide capable of passing through the hemato encephalic barrier. The polypeptide provided by the invention is suitable for the vein, abdominal cavity or nasal cavity drug administration way, convenient in operation, low in clinical risk, capable of being applied by virtue of veins, abdominal cavity or nasal cavity, long in drug effect acting time in the body, excellent in pain alleviating effect, small in peptide side effect and suitable for the large-scale clinical application. The polypeptide provided by the invention is simple in preparation, controllable in quality in the preparation technology and preparation process, and suitable for industrialized mass production.
Owner:SHENZHEN RUIJIAN BIOSCI TECH LTD

Improved ziconotide

The invention relates to improved ziconotide. A C end of ziconotide is linked with an N end of cytomembrane penetrating peptide through two glycines so as to form fused peptide, so that the deficiencies that ziconotide cannot penetrate through a blood brain barrier, an intramuscular injection manner cannot be realized, the surgical operation risk is high, the infection risk is high, and the like are overcome. The improved ziconotide is suitable for an intravenous, abdominal or nasal delivery manner, convenient to operate and low in clinic risk; by utilizing the intravenous, abdominal or nasaldelivery manner, the pharmacodynamic time of the improved ziconotide in a human body is long, the analgesic effect is excellent, the side effect is small, and the improved ziconotide is suitable for large-scale clinic application. The improved ziconotide is easy to prepare, and the quality can be controlled in the preparation process and the preparation course, so that the improved ziconotide is suitable for large-scale industrial production.
Owner:SHENZHEN RUIJIAN BIOSCI TECH LTD

CH2 structure domain mutant of human IgG antibody Fc segment as well as preparation method and application thereof

The invention discloses a CH2 structure domain mutant of a human IgG antibody Fc segment as well as a preparation method and application thereof. A CH2 segment of an IgG antibody is taken as an object, the carboxyl-terminal amino acid of the CH2 segment is modified to obtain a new CH2 framework. The CH2 structure domain mutant has the advantages that the CH2 framework has higher stability than that of wild type CH2, so that more stable C-type single-domain antibodies are developed, and production, purification and storage costs of monoclonal antibodies or Fc fusion protein can be reduced; theanti-aggregating capability is high, and the clinical application risk caused by protein aggregation can be reduced.
Owner:武汉班科生物技术有限公司

Medical multifunctional operating bit

The invention provides a medical multifunctional operating bit. A bit is arranged at the front end of a rod-shaped body, and the rear end of the rod-shaped body is provided with a connecting handle; a cone frustum is arranged in the front part of the spindle shaped bit, and a first blade area is arranged on the surface of the cone frustum and accounts for one seventh of the spindle shaped bit; a cylinder is arranged on the rear part of the spindle shaped bit, and a second blade area is arranged on the surface of the cylinder and accounts for six sevenths of the spindle shaped bit; and a plurality of triangular cut blades or corundum are arranged on the first blade area, and a plurality of arc cut blades or corundum are arranged on the second blade area. The medical multifunctional operating bit can be used for perforating bone tissues in an operation, or cutting and polishing the bone tissues in the operation, so that the problem of repeatedly changing single-function operating bits in the operation can be solved, massive time for changing bits can be saved, adjacent critical nerves and blood vessels are protected, and clinical risks are effectively reduced.
Owner:THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA

Polypeptide capable of passing through hemato encephalic barrier

The invention relates to a polypeptide capable of passing through hemato encephalic barrier. According to the invention, the polypeptide capable of passing through hemato encephalic barrier is acquired by connecting C end of ziconotide with N end of cell penetrating peptide through a glycine. The polypeptide provided by the invention is suitable for vein, enterocoelia or nasal delivery, is convenient for operation and has small clinic risks. Through vein, enterocoelia or nasal delivery, the polypeptide has the characteristics of long acting time in human body, excellent analgesic effect, smallside effect of peptide and suitability for large-scale clinical application. The polypeptide provided by the invention is simply prepared, the preparation technology and the quality during the preparation process are controllable and the polypeptide is suitable for large-scale industrialized production.
Owner:SHENZHEN RUIJIAN BIOSCI TECH LTD

Multifunctional treatment catheter

ActiveCN112057133AImprove opening ratePrevent escapeSurgeryTriple lumen catheterThrombus
The invention relates to the field of medical instruments, in particular to a multifunctional treatment catheter. The multifunctional treatment catheter comprises a catheter body and a balloon wrapping the outer wall of the catheter body, wherein a micro-catheter is arranged in the catheter body, the inner part of the micro-catheter is hollow to form a micro-catheter inner cavity channel, a suction inlet is formed in the near end of the catheter body, and a pressurizing inlet is further formed in one side of the near end of the catheter body; the catheter body is a three-cavity catheter whichis not in communication with the catheter body, the three-cavity catheter comprises a suction cavity channel, a pressurizing cavity channel and a micro-catheter inner cavity channel, the suction cavity channel communicates with the suction inlet, the pressurizing cavity channel communicates with the pressurizing inlet, and the catheter not only can block blood flow, but also has a thrombus suctionfunction. The micro-catheter is arranged in the multifunctional treatment catheter, and a thrombectomy stent can be conveyed for mechanical thrombectomy. When catheter thrombus suction is performed,stent thrombus taking can be performed at the same time, so that the operation time is shortened, and expenses borne by a patient and medical insurance expenses are reduced.
Owner:玮铭医疗器械(上海)有限公司

Fused polypeptide of ziconotide and TAT peptide

The invention provides a fused polypeptide of ziconotide and TAT peptide. According to the invention, the fused polypeptide is acquired by connecting C end of ziconotide with N end of cell penetratingpeptide. The fused polypeptide can overcome the defects, such as, unsuitability for intramuscular injection. The fused polypeptide is capable of passing by blood brain barrier, is suitable for vein,enterocoelia or nasal delivery, is convenient for operation and has small clinic risks; through vein, enterocoelia or nasal delivery, the fused polypeptide has the characteristics of long acting timein human body, excellent analgesic effect, small side effect of peptide and suitability for large-scale clinical application; the fused polypeptide provided by the invention is simply prepared; the preparation technology and the quality during the preparation process are controllable; the fused polypeptide is suitable for large-scale industrialized production.
Owner:SHENZHEN RUIJIAN BIOSCI TECH LTD

Optimized Fc fragment and optimizing method and application thereof

InactiveCN105037538AImprove stabilityEnhanced anti-aggregationImmunoglobulinsFermentationHalf-lifeWild type
The invention provides an optimized Fc fragment and an optimizing method and application thereof. The optimized Fc fragment is obtained by removing seven irregular curved amino acids at N ends of an Fc fragment. The optimizing method comprises the amplifying steps that RT-PCR is utilized for amplifying wild type Fc out of a blood sample, a primer is designed to cut off the seven amino acids at the N ends of the wild type Fc, and the optimized Fc fragment is amplified out, and further comprises expressing and purifying steps. The optimized Fc fragment and the optimizing method and application thereof are used for applying improvement with the Fc fragment. A provided Fcs framework is better in stability, and the producing, purifying and storing cost of a monoclonal antibody or Fc fusion protein can be lowered. The gathering resisting capacity is better, and clinical use risks caused by protein gathering can be lowered. The optimized Fc fragment framework can be applied to complete IgG or relevant Fc fusion protein and used for further studying the influence on the plasma half-life of relevant biological agents.
Owner:WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI

Culture solution for inducing mesenchymal stem cells to differentiate into islet-like cells, and inducing method and application of culture solution

The invention discloses a culture solution for inducing mesenchymal stem cells to differentiate into islet-like cells, and an inducing method and application of the culture solution. The culture solution comprises the following materials: niacinamide, Conophylline, cell growth factor, betacellulin and a base medium. The base medium contains 97% of high glucose DMEM (Dulbecco Modified Eagle Medium), 2% of B-27 and 1% of N-2. The inducing method comprises the following steps of: preparing an inducing culture solution; preparing the human mesenchymal stem cells; taking the human mesenchymal stem cells, inoculating the human mesenchymal stem cells into a six-hole ultralow absorption culture plate by 1.5-2*105cells / hole, adding 3ml inducing culture medium into each hole and carrying out suspended induction; and changing liquid at every 3 days, collecting cell supernatant at the ninth day, and storing the cell supernatant at the temperature of -20 DEG C. The culture solution disclosed by the invention has the advantages that the human mesenchymal stem cells are induced to differentiate into the islet-like cells by utilizing the combination of the niacinamide and the Conophylline, so that the inducing cycle is shortened, the suspension cells are beneficial to being clustered to form cell clusters similar to natural islets, further the induced differentiation efficiency is obviously increased and the clinical application risk is reduced; and the function of inducing the secretion of the cell insulin is obviously improved.
Owner:UNION STEMCELL & GENE ENG

Device and method for anesthesia machine for automatically identifying patient information

The invention discloses a device and a method for an anesthesia machine for automatically identifying patient information. The device comprises an identification card, a transmission module and an identification module, wherein the identification card is used for storing information of a patient and configuring the information to be associated with the patient; the transmission module is used for transmitting the information of the patient to the identification card, and the identification module is in communication connection with an anesthesia machine control unit for identifying the identification card and guiding the information stored by the identification card into the anesthesia machine. According to the device and method for the anesthesia machine for automatically identifying patient information disclosed by the embodiment of the invention and the anesthesia machine comprising the device, the problems that a doctor needs to manually input control parameters of the anesthesia machine and the patient is likely to be hurt because the physiological property of the target patient is unknown under a computer-control mode are avoided, thereby improving the control precision of the product and reducing the clinical risk.
Owner:GE MEDICAL SYST GLOBAL TECH CO LLC

Extraction method of salvia extract and safflower extract and preparation method of salvia-safflower oral preparation

An extraction method of a salvia extract and a safflower extract and a preparation method of a salvia-safflower oral preparation relate to an extraction method of salvia and safflower, and a preparation method of a salvia-safflower preparation. The extraction of the salvia extract comprises the following steps: first, refluxing; second, acidification; third, adsorption. The extraction of the safflower extract comprises the following steps: first, decoction; second, acidification; third, adsorption. The preparation of the salvia-safflower oral preparation comprises the following steps: mixing the salvia extract and the safflower extract, adding auxiliary materials to prepare an oral dosage form. According to the invention, the salvia and the safflower are extracted separately; the effective components are extracted fully and completely, which effectively improves the inherent quality of the product, improves and guarantees the controllability of intermediates and the finished product; the control indexes of effective components in the salvia-safflower oral preparation of the invention are very scientific and reasonable; the invention increases the purity of effective components, reduces impurities, reduces risks for clinical application of injections; the preparation process of the invention has simple operations, high efficiency, low cost, and is applicable to industrial production.
Owner:哈药集团中药二厂

Endoscopic Stapler with Cannula Unlock

The invention discloses an endoscope anastomat unlocked by a cannula. The endoscope anastomat includes a nail box and a cutting knife; the nail box is composed of a nail box inner core and a nail boxcasing pipe, wherein the nail box inner core includes a nail box base and a nail box upper cover, the cutting knife is placed in the nail box inner core, the tail portion of the cutting knife is provided with a groove, and the nail box upper cover corresponding to the groove is provided with a through hole; the endoscope anastomat unlocked by the cannula further includes a steering lock, and the head of the steering lock is clamped in the groove by means of the through hole to fix the nutting knife; the steering lock is sleeved with the steering lock cannula. According to the endoscope anastomat unlocked by the cannula, an original protective jacket similar to a packing material is removed, and therefore the cost is saved; during use, the operation is more simplified, and the operation difficulty for operators is reduced; the situation that assemblies are unrecoverable because of operation mistakes can be avoided, and the potential clinical risks are reduced.
Owner:无锡贝恩外科器械有限公司

Medical combined operation drill bit

InactiveCN102871701BShorten the timeSolve the problem of repeated replacementSurgeryThree vesselsSpherical form
The invention relates to a medical combined operation drill bit; the operation drill bit is a rod-shaped body, wherein a spherical drill bit is arranged at one end of the rod-shaped body, and a connection handle is arranged at the other end of the rod-shaped body; two different types of cutting edges are arranged on the spherical drill bit and are positioned in different areas of the spherical drill bit and along the axial direction of the rod-shaped body; a first edge area is arranged at the front part of the spherical drill bit and occupies 1 / 5 to 4 / 5 of the spherical drill bit; a second edge area is arranged at the rear part of the spherical drill bit and occupies 2 / 3 to 4 / 5 of the spherical drill bit; a grinding edge or a cutting edge is arranged on the first edge area; and a cutting edge or a grinding edge is arranged on the second edge area. The medical combined operation drill bit can be used not only for punching osseous tissues in operations but also for cutting and polishing osseous tissues in operations, solves the problem that operation drill bits with simplex functions are replaced repeatedly during operations, saves a great amount of time wasted for replacement of drill bits, protects adjacent important nerves and blood vessels and effectively reduces clinical risks.
Owner:THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA

Method for producing plasmin through microbial fermentation

The invention relates to a method for producing plasmin through microbial fermentation. According to the method, microbes for generating plasmin are activated for 6 to 10 times and are subjected to product directional domestication for 4 to 6 times so that the microbes well grow under the environment condition being 24 to 30 DEG C; plasmin producing bacteria subjected to product directional domestication by a conventional method are subjected to step-by-step enlargement culture at 24 to 30 DEG C and are inoculated into a fermentation culture medium at the inoculation quantity being 3 to 9 percent of the fermentation liquid volume, the culture is carried out for 60 to 114 hours at 24 to 30 DEG C, and the plasmin production through microbial fermentation is completed; the fermentation liquid is centrifuged at 4000 to 8000 rpm, liquid is collected, and the collected liquid is crude enzyme liquid; and according to different requirements and use objects, the crude enzyme liquid can be further concentrated, separated and purified, and enzyme preparations with different activities, purities and preparation forms are prepared.
Owner:DALIAN UNIVERSITY

Polypeptide applicable to administration through vein, abdominal cavity or nasal cavity

The invention discloses polypeptide applicable to administration through vein, abdominal cavity or nasal cavity. According to the polypeptide disclosed by the invention, the terminal C of ziconotide is connected with the terminal N of cell penetrating peptide through 3 glycines to obtain polypeptide capable of passing through the blood brain barrier. The polypeptide disclosed by the invention is suitable for the administration through vein, abdominal cavity or nasal cavity while the operation is convenient and the clinical risk is low; when being applied through the vein, abdominal cavity or nasal cavity, the polypeptide has the advantages of long acting time in vivo, good analgesic effect and few peptide side effects and thus is suitable for large-scale clinical application. The polypeptide provided by the invention is easy to prepare, the preparation technology and the preparation process are controllable in quality, and the polypeptide is suitable for large-scale industrial production.
Owner:SHENZHEN RUIJIAN BIOSCI TECH LTD

A polypeptide bionano surface for serum-free cell culture and its preparation method

The invention discloses a polypeptide biological nano surface for serum-free cell culture and a preparation method thereof. The polypeptide biological nano surface is prepared from the following steps of: pre-treating cell culture surface by plasma, then exposing the cell culture surface in air or oxygen, then spreading a polypeptide solution on the cell culture surface, and irradiating under ultraviolet light to obtain the polypeptide biological nano surface for serum-free cell culture. The obtained polypeptide biological nano surface is stable, can be stored for a long time at normal temperature, is definite in grafting ingredients on the grafted surface, and can substitute for routine various protein-coated surfaces in the market, so that cells realize excellent wall adhesion and proliferation under the serum-free condition; and as compared with various animal-derived protein-coated surface, short peptide has the characteristics of no heterology or weak heterology, therefore, the chemically synthesized polypeptide grafted surface greatly reduces clinical application risk, thereby laying a solid foundation for subsequent clinical application.
Owner:BEAVERNANO TECH

Sample transmission detection method

The invention provides a sample transmission detection method, which is applied to a sample analysis system, the sample analysis system comprises a transverse transportation assembly, a processor anda controller, the sample analysis system also comprises a code reader, the sample analysis system has a scanning position, each sample container has an identification member, the transverse transportation assembly drives the sample container to move to a scanning position, and the code reader scans the identification member at the scanning position; the sample transmission detection method comprises the following steps: a controller controls a code reader to read the identification member corresponding to the sample container Xn in a current scanning position, and transmits the identificationmember to the processor; and the processor compares the identification member corresponding to the sample container Xn with the identification member corresponding to the previous sample container Xn-1. Whether clamping stagnation occurs in the sample frame conveying process or not is recognized by detecting and comparing whether the identification members of the adjacent sample containers are thesame or not, and the problem that at present, specimen results and labels are wrongly matched due to clamping stagnation of sample frames is effectively solved.
Owner:SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD

Avatrombopag maleate preparation composition as well as tablet or capsule prepared from composition and preparation method

The invention discloses an avatrombopag maleate preparation composition. The composition comprises an active component avatrombopag maleate and a filler, the filler comprises lactose and microcrystalline cellulose, the mass ratio of the active component to the filler is 1:1 to 1:5, and the active component and the filler are co-ground to obtain the preparation composition. The composition prepared by the invention can be used for preparing the avatrombopag maleate tablets or capsules, the dissolution rate in a preparation batch is uniform, the shelf life and the dissolution rate are stable, and an effective and feasible production process can be provided for domestic popularization of the avatrombopag maleate preparation. The invention also discloses a tablet or a capsule prepared from the preparation composition. The invention also discloses a preparation method of a tablet or a capsule prepared from the avatrombopag maleate preparation composition.
Owner:南京唯创远医药科技有限公司

Temperature testing device of thermal pad type therapeutic instrument

The invention discloses a temperature testing device for a thermal pad type therapeutic instrument, whichbelongs to the technical field of detection, and comprises a constant-temperature box and aconstant-temperature water tank. Three temperature sensors, a copper pipe and a fan are arranged in the constant-temperature box; a heater, a compressor, a stirrer, a temperature controller and a magnetic water pump which are connected through a wired circuit are arranged in the constant-temperature water tank, and the magnetic water pump is connected with the copper pipe in the constant-temperature box through a wired circuit. By measuring and researching the illuminance uniformity and the luminous flux of the medical cold light source, the developed detection device has a positive effect on implementation and promotion of related standard specifications, is very important for daily detection and maintenance of main quality parameters of the medical cold light source and understanding of the performance state of the medical cold light source, and medical accidents caused by cold light source quality can be effectively avoided, and clinical use risks are reduced.
Owner:NANJING COLLEGE OF INFORMATION TECH

Mesenchymal stem cell subculture method

The invention discloses a mesenchymal stem cell subculture method. The method is characterized by comprising the following steps of 1) preparing a serum-free subculture medium which comprises the following components of an alpha-MEM medium, a platelet-derived factor, a fibroblast growth factor and ascorbic acid, wherein the concentration of the platelet-derived factor is 10-15 ng / mL, and the concentration of the fibroblast growth factor is 10-15 ng / mL; and 2) adding primary mesenchymal stem cells into a T-75 porous culture bottle, adding the serum-free subculture medium, performing culture in a 5% CO2 incubator at 37 DEG C, performing digesting by using a trypsin-EDTA solution when the cell fusion degree reaches 80%-90%, and carrying out subculture according to a ratio of 1:(4-5) after the digestion is finished. According to the culture method, the human umbilical cord mesenchymal stem cells with high purity, strong differentiation capacity, stable stemness and strong multiplication capacity can be obtained in a short time.
Owner:广东佰鸿干细胞再生医学有限公司
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