72results about How to "Reduce clinical risk" patented technology

Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.

The invention discloses an in-vitro intervention embolism therapy simulation system which comprises a micro-vessel simulation area, a blood flow simulation area and a pressure monitoring area. The micro-vessel simulation area is placed in a constant temperature device and communicated with the blood flow simulation area through a pipeline, the pressure monitoring area is used for monitoring a pressure value in the pipeline, and the micro-vessel simulation area comprises a micro-fluidic chip. According to the in-vitro intervention embolism therapy simulation system, the difference of terminal embolism performances is quantified by observing pipeline classification in the chip plugged by different embolism agents, so that the terminal embolism performances of the different embolism agents can be more visually evaluated, and a simpler and more convenient data accumulation program is provided for research and development persons. Besides, the performances of the embolism agents are more effectively understood, clinical risk is reduced, blood flow washing resistance effects of the different embolism agents can be accurately analyzed in the pressure monitoring area under different conditions, so that embolism strength is evaluated in vitro, and blood vessel recanalization time can be monitored.

A Chinese medicine in the form of injection, freeze-dried powder injection, or perfusion is prepared from ginseng and prepared aconite root. It can decrease the toxin of aconite root.

The invention discloses an indigo carmine colorant as well as a preparation method and applications thereof. A mixed solution of indigo carmine and antioxidants contains 0.1%-1%(weight/volume percent concentration, g/100ml) of indigo carmine, the antioxidants are selected from one or combinations of ascorbic acid, tea polyphenols and phytic acid, and the amount of addition is 0.05%-0.5%(weight/volume percent concentration, g/100ml). The indigo carmine colorant has advantages as follows: a product is greatly improved in stability, is easy to use and store, and has a good clinical effect; the safety performance is high, and the clinical risk is low; the operation is simple. A prepared indigo carmine solution can be directly used in clinical treatment, dilution and other additional operations are not required, a clinical operation process is greatly simplified, and defects of a colorant obtained with an immediate preparation and use method in the prior art are solved.

The invention relates to an apnea awakening device, which comprises a setting terminal, a respiration sensor, a flow rate control device, a pressure generator, a pressure sensor, a microcontroller and a nose pipe, wherein the setting terminal is used for setting the apnea time threshold value and the wakening pressure threshold value, the respiration sensor is attached onto the body of a patient, and is used for detecting whether the patient has the breathe or not in the apnea time, the flow rate control device is used for outputting gas with the preset oxygen concentration, the pressure generator is used for generating the corresponding awakening pressure according to the flow rate of the gas output by the flow rate control device, the pressure sensor is used for collecting the awakening pressure generated by the pressure sensor in real time, the microcontroller is used for controlling the flow rate of the gas output by the flow rate control device according to the detection result of the respiration sensor and the awakening pressure threshold value, and the noise pipe is connected to the naris part of the patient and is used for conveying the wakening pressure generated by the pressure generator into the respiratory tract of the patient. The invention also provides an apnea awakening method. The device and the method have the advantage that the clinic risk and the cost can be simultaneously reduced.

The invention relates to improved ziconotide. A C end of ziconotide is linked with an N end of cytomembrane penetrating peptide through two glycines so as to form fused peptide, so that the deficiencies that ziconotide cannot penetrate through a blood brain barrier, an intramuscular injection manner cannot be realized, the surgical operation risk is high, the infection risk is high, and the like are overcome. The improved ziconotide is suitable for an intravenous, abdominal or nasal delivery manner, convenient to operate and low in clinic risk; by utilizing the intravenous, abdominal or nasaldelivery manner, the pharmacodynamic time of the improved ziconotide in a human body is long, the analgesic effect is excellent, the side effect is small, and the improved ziconotide is suitable for large-scale clinic application. The improved ziconotide is easy to prepare, and the quality can be controlled in the preparation process and the preparation course, so that the improved ziconotide is suitable for large-scale industrial production.

The invention discloses a CH2 structure domain mutant of a human IgG antibody Fc segment as well as a preparation method and application thereof. A CH2 segment of an IgG antibody is taken as an object, the carboxyl-terminal amino acid of the CH2 segment is modified to obtain a new CH2 framework. The CH2 structure domain mutant has the advantages that the CH2 framework has higher stability than that of wild type CH2, so that more stable C-type single-domain antibodies are developed, and production, purification and storage costs of monoclonal antibodies or Fc fusion protein can be reduced; theanti-aggregating capability is high, and the clinical application risk caused by protein aggregation can be reduced.

The invention relates to the field of medical instruments, in particular to a multifunctional treatment catheter. The multifunctional treatment catheter comprises a catheter body and a balloon wrapping the outer wall of the catheter body, wherein a micro-catheter is arranged in the catheter body, the inner part of the micro-catheter is hollow to form a micro-catheter inner cavity channel, a suction inlet is formed in the near end of the catheter body, and a pressurizing inlet is further formed in one side of the near end of the catheter body; the catheter body is a three-cavity catheter whichis not in communication with the catheter body, the three-cavity catheter comprises a suction cavity channel, a pressurizing cavity channel and a micro-catheter inner cavity channel, the suction cavity channel communicates with the suction inlet, the pressurizing cavity channel communicates with the pressurizing inlet, and the catheter not only can block blood flow, but also has a thrombus suctionfunction. The micro-catheter is arranged in the multifunctional treatment catheter, and a thrombectomy stent can be conveyed for mechanical thrombectomy. When catheter thrombus suction is performed,stent thrombus taking can be performed at the same time, so that the operation time is shortened, and expenses borne by a patient and medical insurance expenses are reduced.

The invention provides an optimized Fc fragment and an optimizing method and application thereof. The optimized Fc fragment is obtained by removing seven irregular curved amino acids at N ends of an Fc fragment. The optimizing method comprises the amplifying steps that RT-PCR is utilized for amplifying wild type Fc out of a blood sample, a primer is designed to cut off the seven amino acids at the N ends of the wild type Fc, and the optimized Fc fragment is amplified out, and further comprises expressing and purifying steps. The optimized Fc fragment and the optimizing method and application thereof are used for applying improvement with the Fc fragment. A provided Fcs framework is better in stability, and the producing, purifying and storing cost of a monoclonal antibody or Fc fusion protein can be lowered. The gathering resisting capacity is better, and clinical use risks caused by protein gathering can be lowered. The optimized Fc fragment framework can be applied to complete IgG or relevant Fc fusion protein and used for further studying the influence on the plasma half-life of relevant biological agents.

An extraction method of a salvia extract and a safflower extract and a preparation method of a salvia-safflower oral preparation relate to an extraction method of salvia and safflower, and a preparation method of a salvia-safflower preparation. The extraction of the salvia extract comprises the following steps: first, refluxing; second, acidification; third, adsorption. The extraction of the safflower extract comprises the following steps: first, decoction; second, acidification; third, adsorption. The preparation of the salvia-safflower oral preparation comprises the following steps: mixing the salvia extract and the safflower extract, adding auxiliary materials to prepare an oral dosage form. According to the invention, the salvia and the safflower are extracted separately; the effective components are extracted fully and completely, which effectively improves the inherent quality of the product, improves and guarantees the controllability of intermediates and the finished product; the control indexes of effective components in the salvia-safflower oral preparation of the invention are very scientific and reasonable; the invention increases the purity of effective components, reduces impurities, reduces risks for clinical application of injections; the preparation process of the invention has simple operations, high efficiency, low cost, and is applicable to industrial production.

The invention relates to a method for producing plasmin through microbial fermentation. According to the method, microbes for generating plasmin are activated for 6 to 10 times and are subjected to product directional domestication for 4 to 6 times so that the microbes well grow under the environment condition being 24 to 30 DEG C; plasmin producing bacteria subjected to product directional domestication by a conventional method are subjected to step-by-step enlargement culture at 24 to 30 DEG C and are inoculated into a fermentation culture medium at the inoculation quantity being 3 to 9 percent of the fermentation liquid volume, the culture is carried out for 60 to 114 hours at 24 to 30 DEG C, and the plasmin production through microbial fermentation is completed; the fermentation liquid is centrifuged at 4000 to 8000 rpm, liquid is collected, and the collected liquid is crude enzyme liquid; and according to different requirements and use objects, the crude enzyme liquid can be further concentrated, separated and purified, and enzyme preparations with different activities, purities and preparation forms are prepared.

The invention discloses polypeptide applicable to administration through vein, abdominal cavity or nasal cavity. According to the polypeptide disclosed by the invention, the terminal C of ziconotide is connected with the terminal N of cell penetrating peptide through 3 glycines to obtain polypeptide capable of passing through the blood brain barrier. The polypeptide disclosed by the invention is suitable for the administration through vein, abdominal cavity or nasal cavity while the operation is convenient and the clinical risk is low; when being applied through the vein, abdominal cavity or nasal cavity, the polypeptide has the advantages of long acting time in vivo, good analgesic effect and few peptide side effects and thus is suitable for large-scale clinical application. The polypeptide provided by the invention is easy to prepare, the preparation technology and the preparation process are controllable in quality, and the polypeptide is suitable for large-scale industrial production.

The invention discloses an avatrombopag maleate preparation composition. The composition comprises an active component avatrombopag maleate and a filler, the filler comprises lactose and microcrystalline cellulose, the mass ratio of the active component to the filler is 1:1 to 1:5, and the active component and the filler are co-ground to obtain the preparation composition. The composition prepared by the invention can be used for preparing the avatrombopag maleate tablets or capsules, the dissolution rate in a preparation batch is uniform, the shelf life and the dissolution rate are stable, and an effective and feasible production process can be provided for domestic popularization of the avatrombopag maleate preparation. The invention also discloses a tablet or a capsule prepared from the preparation composition. The invention also discloses a preparation method of a tablet or a capsule prepared from the avatrombopag maleate preparation composition.

The invention discloses a temperature testing device for a thermal pad type therapeutic instrument, whichbelongs to the technical field of detection, and comprises a constant-temperature box and aconstant-temperature water tank. Three temperature sensors, a copper pipe and a fan are arranged in the constant-temperature box; a heater, a compressor, a stirrer, a temperature controller and a magnetic water pump which are connected through a wired circuit are arranged in the constant-temperature water tank, and the magnetic water pump is connected with the copper pipe in the constant-temperature box through a wired circuit. By measuring and researching the illuminance uniformity and the luminous flux of the medical cold light source, the developed detection device has a positive effect on implementation and promotion of related standard specifications, is very important for daily detection and maintenance of main quality parameters of the medical cold light source and understanding of the performance state of the medical cold light source, and medical accidents caused by cold light source quality can be effectively avoided, and clinical use risks are reduced.