71 results about "Cell electrophysiology" patented technology

Provided herein are biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided including electronic devices useful for establishing in situ conformal contact with a tissue in a biological environment. The invention includes implantable electronic devices and devices administered to the surfaces(s) of a target tissue, for example, for obtaining electrophysiology data from a tissue such as cardiac, brain tissue or skin.

Apparatus and methods are provided for ablating body tissue using radio frequency (RF) energy. A catheter having a lumen for delivering fluid can be inserted into a patient's body. A porous member, which may be expandable, is attached to the distal portion of the catheter. The porous member defines an interior region in communication with the lumen, such that the interior region is capable of receiving electrolyte fluid delivered from the proximal portion of the catheter. An RF electrode is disposed in the interior region and is configured for coupling to a source of RF energy, whereby RF energy may be transferred from the electrode to selected tissue areas in a patient's body via electrolyte fluid delivered through the lumen and into the interior region of the porous member.

Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic device. The apparatus provided includes a microfluidic device coupled to a multi-well structure and an interface for controlling the flow of media within the microchannel device.

Described herein are devices and methods for treating tissue, comprising a catheter with a plurality of access sites and a plurality of sensors associated with the access sites. The catheter may be positioned along a tissue surface and the sensors may be used to identify a target site along the tissue surface using the plurality of sensors. Analysis of the tissue surface by the sensors is performed without requiring repositioning of the catheter. In some examples, the access sites of the catheter are side openings along a length of the catheter and the plurality of sensors are electrodes configured to measure electrophysiology parameters. In these examples, the catheter may comprise an internal lumen which permits a treatment device, such as an ablation catheter, to be slidably positioned at the desired target site without requiring displacement of the catheter. In other examples, the catheter may comprise a plurality of fixed ablation elements associated with the plurality of access sites.

A system for determining electrophysiological data comprising an electronic control unit configured to acquire electrophysiology signals from a plurality of electrodes (130) of one or more catheters, select at least one clique of electrodes from the plurality of electrodes (136) to determine a plurality of local E field data points, determine the location and orientation of the plurality of electrodes, process the electrophysiology signals from the at least one clique from a full set of bipole subcliques to derive the local E field data points associated with the at least one clique of electrodes, derive at least one orientation independent signal from the at least one clique of electrodes (138) from the information content corresponding to weighted parts of electrogram signals, and display or output catheter orientation independent electrophysiologic information to a user or process.

Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.

A method for the in vivo re-calibration of a force sensing probe such as an electrophysiology catheter provides for the generation of an auto zero zone. The distal tip of the catheter or other probe is placed in a body cavity within the patient. Verification that there is no tissue contact is made using electrocardiogram (ECG) or impedance data, fluoroscopy or other real-time imaging data and/or an electro-anatomical mapping system. Once verification that there is no tissue contact is made, the system recalibrates the signal emanating from the force sensor setting it to correspond to a force reading of zero grams and this recalibrated baseline reading is used to generate and display force readings based on force sensor data.

The inventive apparatus may be slid onto a guiding catheter or other thru-lumen catheters, solid catheters, such as Electrophysiology catheters and multi-lumen tubing and advanced to the distal end of the guiding catheter or other thru-lumen catheters, solid catheters, such as Electrophysiology catheters and multi-lumen tubing to assist in holding the distal end of the guiding catheter or other thru-lumen catheters, solid catheters, such as Electrophysiology catheters and multi-lumen tubing at a target location within a patient, by utilizing an externally applied magnetic field to hold a plurality of magnetic elements on the apparatus in alignment with the target location. A medical device may then be advanced through the guiding catheter, for example, to the target location in the patient, without the guiding catheter backing out. The apparatus in combination with magnetic navigation thus provides support to hold the guiding catheter or other thru-lumen catheters, solid catheters, such as Electrophysiology catheters and multi-lumen tubing in place to prevent back out of the catheter.

A method for mapping a body organ, including receiving a three-dimensional (3D) map of the body organ together with items of auxiliary information having respective location coordinates in a frame of reference of the 3D map and apportioning the items into a plurality of sub-groups. The method further includes assigning to a selected sub-group a visibility parameter indicative of a relative visibility of the selected sub-group in relation to the map and to other sub-groups. The method also includes displaying the 3D map of the body organ in a selected orientation while selectively superimposing on the 3D map one or more of the items in the selected sub-group responsively to the orientation, the respective location coordinates of the items, and the assigned visibility parameter.

A power supply and control apparatus operable in a bipolar mode, a unipolar mode, and a combined bipolar/unipolar mode.

An electrophysiology/ablation catheter assembly includes an elongated flexible casing that received a first catheter deflection assembly. Electrical leads are connected to each electrode on a distal portion of the catheter assembly and extend through the casing for external connection at a proximal end of the catheter assembly. A first actuator is operatively connected to the first catheter deflection assembly and operable upon movement to selectively effect displacement of the distal end. A second catheter deflection assembly is also disposed in the casing. A second actuator is connected adjacent the proximal end of the catheter deflection assembly and operable upon movement to selectively effect lateral displacement of the catheter at a location spaced from the first curved configuration of the distal end.

In one embodiment, a shaft-mounted electrode for ablating tissue comprises an end portion and a middle portion. The end portion is configured differently than the middle portion such that, when the electrode is energized, the ratio of a first density of ablation energy that is emitted in a vicinity of the end portion to a second density of ablation energy that is emitted in a vicinity of the middle portion is lower than the ratio would be if the end portion were configured the same as the middle portion. In another embodiment, a shaft-mounted electrode for ablating tissue comprises at least two separate coiled conductors having interleaved spirals.

Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be included with the access needle to provide image data and/or cardiac waveform information of the subject.

A method of generating a diagnosis map of at least a portion of the heart includes inserting an electrode within the portion of a heart, robotically moving the electrode therein, measuring electrophysiology information at a point on the surface of the heart, associating the measured electrophysiology information with position information for the point on the surface of the heart, repeating the measuring and associating steps for a plurality of points on the surface of the heart, thereby generating a plurality of surface diagnostic data points, and generating the diagnosis map therefrom. The electrode may be moved within the heart randomly, pseudo-randomly, or according to one or more predetermined patterns. A three-dimensional model of the portion of the heart may be provided and presented as a graphical representation, either with or without information indicative of the measured electrophysiology information superimposed thereon.

A system and method for treatment of tissue is provided. An electronic control unit is configured to generate displays signals used to create a graphical user interface. The display signals are generated in response to a first set of position signals indicative of the position of an electrophysiology mapping electrode relative to the tissue and a second set of position signals indicative of the position of a treatment device, such as a high intensity focused ultrasound transducer, that is configured to generate a beam of energy towards a selected region in the tissue. The graphical user interface displays an electrophysiology map of the tissue and an image of at least one of the treatment device and the beam of energy which may be superimposed on the electrophysiology map.

The invention is an electrophysiology lead body comprising two or more longitudinal elements, each having an outer surface, the longitudinal elements comprising electrical insulation material, the electrical insulation material consisting essentially of fluoropolymer; at least one conductor disposed within at least one of the longitudinal elements; and a cover consisting essentially of fluoropolymer, wherein the cover surrounds the longitudinal elements.