610 results about "Brains tissue" patented technology

Provided herein are biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and / or stretchable biomedical devices are provided including electronic devices useful for establishing in situ conformal contact with a tissue in a biological environment. The invention includes implantable electronic devices and devices administered to the surfaces(s) of a target tissue, for example, for obtaining electrophysiology data from a tissue such as cardiac, brain tissue or skin.

A method for delivering ultrasound energy to a patient's intracranial space includes forming at least one aperture in the patient's skull, introducing at least one acoustically conductive medium into the intracranial space to contact brain tissue of the patient, advancing an ultrasound device at least partially through the aperture in the skull, and transmitting ultrasound energy to the intracranial space, using the ultrasound device. In some embodiments, the acoustically conductive medium may be cooled to help regulate the temperature of the patient's brain tissue.

The invention discloses an ultrasound deep brain stimulation method and system. The ultrasound deep brain stimulation method comprises steps as follows: medical imaging is performed on the head of an animal or a human being, and image data are generated; a head three-dimensional digital model is established according to the image data; a three-dimensional digital model of an ultrasound transducer array is established according to structure, density and acoustic parameter information of the ultrasound transducer array; a first ultrasound emission sequence is generated according to the head three-dimensional digital model, the three-dimensional digital model of the ultrasound transducer array, structure, density and acoustic parameters of skull and brain tissue and the structure, density and acoustic parameter information of the ultrasound transducer array; the ultrasound transducer array is controlled to emit ultrasound waves according to the first ultrasound emission sequence, and ultrasound deep brain stimulation is implemented on to-be-stimulated brain nerve nuclei. With adoption of the method and the system, ultrasound can noninvasively penetrate through a skull and is concentrated in a deep brain area; by means of different ultrasound emission sequences, ultrasound nerve regulation can be realized, and an action mechanism can be researched.

The invention relates to a processing system of a CT image, which comprises a CT image acquiring module, an interesting region estimating module, a characteristic extracting module, an abnormal signal identifying module and a displaying module. The CT image acquiring module is used for acquiring a head CT image subjected to brain tissue segmentation; the interesting region estimating module is used for estimating an interesting region of subarachnoid space to the head CT image; the characteristic extracting module is used for extracting the characteristic to the head CT image subjected to the estimation of the interesting region to acquire a characteristic value; the abnormal signal identifying module is used for identifying whether an abnormal signal is included in the interesting region according to the characteristic value by using a method of mode identification; and the displaying module is used for displaying the identified result and the interesting region in which the abnormal signal exists. The invention also relates to a processing method of the CT image. The invention can display a position in which the abnormal signal exists, which is referred by medical staffs, so as to reduce misdiagnosis / missed diagnosis rate of the subarachnoid space hemorrhage.

Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

The present invention relates to dosage forms of a combination of carbidopa and levodopa comprising both immediate release and controlled release components for the treatment of ailments associated with depleted amounts of dopamine in a patient's brain tissue.

The invention discloses a treating method of CT cerebral hemorrhage image, comprising: automatically selecting gray level image, binary image of brain tissue or binary image of head of raw data based on nonsingular number and winkling the brain median sagittal plane based on singular number; robustly depicting the asymmetry of instant cerebral hemorrhage to the median sagittal plane based on general asymmetry of dotted pairs area; adaptively figuring out gray threshold of instant cerebral hemorrhage, threshold of general asymmetry, local contrast threshold and partial bulk effect threshold; determining threshold of instant cerebral hemorrhage near the fourth ventricle by searching the axial slice below the pertrous bone; obtaining instant cerebral hemorrhage symmetrical to the median sagittal plane from the obtained unsymmetric hemorrhage; determining darker instant cerebral hemorrhage from determined lighter (higher gray scale) instant cerebral hemorrhage; removing high signal of not instant cerebral hemorrhage; determining instant cerebral hemorrhage pixel due to partial bulk effect, therefore the final instant cerebral hemorrhage image is obtained.

The invention relates to a magnetic resonance diffusion tensor imaging fiber bundle tracking device. The process is respectively completed by each component through the following steps of (1) collecting magnetic resonance diffusion tensor images; (2) carrying out brain issue dividing on a sequence without a diffusion gradient magnetic field and any sequence with the diffusion gradient magnetic field, and using the sequence without the diffusion gradient magnetic field as an image reference template of the brain tissues; (3) carrying out three-dimensional affine conversion on the two image sequences of the brain tissues after being extracted, to obtain a space conversion relationship; (4) carrying out space conversion on the remained diffusion tensor images by an optimum conversion relationship; (5) calculating tensor fields and feature vectors; (6) setting the interested areas and tracking conditions; and (7) carrying out the bidirectional tracking and displaying based on a fiber bundle with variable step size, so as to quickly and effectively carry out fiber bundle tracking and displaying on the white matters of human brain. In the diffusion tensor imaging process, the image deviation caused by space positions can be corrected, and the elastic step size is adopted in the tracking process, so as to ensure the reliable fiber bundle tracking.

A transgenic animal, preferably a mouse, that expresses human antichymotrypsin (ACT) in brain tissues is provided, together with animal tissue-derived cell lines and progeny animals of said transgenic animal. Progeny are obtained by mating the transgenic animal with select animal strains used as models of Alzheimer's disease, related neurological disorders, or amyloidogenic diseases. Methods utilizing the parent and progeny animals and cells derived therefrom are disclosed for testing compounds for use as anti-inflammatory drugs, inhibitors of amyloidogenesis, and / or inhibitors of tau protein pathology associated with Alzheimer's disease, in the treatment of a variety of neurological diseases.

The present invention uses vertical-cavity surface-emitting lasers (VCSELs) as illumination source for simultaneous imaging of blood flow and tissue oxygenation dynamics in vivo, or a means to monitor neural activity in brain slices ex vivo. The speckle pattern on the brain tissue due to a VCSEL's coherence properties is the main challenge to producing low-noise high-brightness illumination, required for evaluating tissue oxygenation. Moreover, using oxide-confined VCSELs we show a fast switching from a single-mode operation scheme to a special multi-modal, multi-wavelength rapid sweep scheme. The multi-modal, multi-wavelength rapid sweep scheme reduces noise values to within a factor of 40% compared to non-coherent LED illumination, enabling high-brightness VCSELs to act as efficient miniature light sources for various brain imaging modalities and other imaging applications. These VCSELs are promising for long-term portable continuous monitoring of brain dynamics in freely moving animals.

The invention provides a neural stem cell (NSC) strain. The NSC strain can be isolated from animal brain tissues from different species. Embryonic stem cells (ES), induced pluripotent stem cells and other stem cells can be differentiated into the NSC. The NSC strain is characterized by quick proliferating and stable passaging; prolonged expressing biomarker proteins of Oct4 and Sox1; high efficient being differentiated into a plurality of neurons and glial cells. The invention further provides an establishing method and an application for the NSC.

Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and / or simulate a sensory-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and / or simulate “sensory” signals in nerves and / or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and / or to stimulate (i.e., trigger) and / or simulate a motor-nerve signal in nerve and / or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.

The invention provides a diffusion tensor imaging white matter fiber clustering method. The method includes the steps of pre-processing original rsf magnetic resonance imaging (MRI) data and the original diffusion tensor imaging (DTI) data, registering the pre-processed rsf MRI data into a DTI space, respectively conducting fiber tracking and brain tissue segmentation on the pre-processed DTI data, conducting fiber projection on white matter fiber which can not reach grey matter or exceed a grey matter surface in a white matter fiber obtained by DTI, then calculating functional similarities among the white matter fiber, obtaining a matrix of the similarities and clustering by adopting an affine spread clustering algorithm. Fiber bundle has functional independence, accuracy without need to relay on of a genetic linkage map and require complicated registration.

A neural stem cell preparation for treating human myelopathy, especially the motor neuron diseases, is prepared through digesting the brain tissue of human embryo, adding to culture medium, centrifugal processing, mechanical beating to obtain cell suspension, culturing in culture medium in CO2 atmosphere, screening neural stem cell balls, and passage by 3-6 generations.

A method for preparing the Monosialotetrahexosylganglioside with high purity is provided, which comprises the following process steps: (1) the fresh brain tissue of the licestock is used to prepare the acetone powder; (2) the acetone powder prepared in the step (1) is dissolved by the extracting solution and stirred for 4h to 5h, and is separated centrifugally and collects the supernatant, the supernatant is purified by LV chromatographic column to gain the total ganglioside; (3) the total ganglioside prepared in the step (2) is separated by MonoQ column chromatography to gain the ganglioside GM1 with purity of 90 per cent to 95 per cent; (4) the GM1 prepared in the step (3) is separated by the hydrophobic chromatography to gain the ganglioside GM1 with purity more than 98 per cent; (5) the GM1 aqueous solution prepared in the step (4) is hyperfiltrated by the hyperfiltration membrane with 50,000 to 100,000 MWCO, and the gained filter liquor produces the GM1 dry powder through freezing and drying. The method not only has simple process flow and safe operation, but also can improve the yield of the GM1 and avoid the pollution of other phospholipids.

Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease

An apparatus and method for detecting radiation damage in an area of brain tissues, where the area of brain tissues has at least a first region containing brain tissues damaged from radiation exposure and a second region containing no brain tissues damaged from radiation exposure. In one embodiment, the method includes the steps of illuminating in vivo the area of brain tissues with a coherent light at an incident wavelength, lambda0, between 330 nm and 360 nm, collecting electromagnetic emission returned from the illuminated brain tissues, and identifying a first peak of intensity of the collected electromagnetic emission at a first wavelength, lambda1, and a second peak of intensity of the collected electromagnetic emission at a second wavelength, lambda2, wherein lambda0, lambda1, and lambda2 satisfy the following relationship of lambda1>lambda2>lambda0. The method further includes the step of locating the first region containing brain tissues damaged from radiation exposure as the region of brain tissues where the first peak of intensity of the collected electromagnetic emission is corresponding to.

The invention discloses a preparation method of a brain tissue rapid freezing section. According to the method, acetone is used as a freezing embedding medium and a liquid nitrogen intermediate medium, so that brain tissue can be rapidly frozen , and formation of ice crystals on the brain tissue can be effectively reduced; besides, factors affecting manufacturing quality, such as temperatures during material drawing and sectioning, fixing and soring conditions after sectioning and the like, of the freezing section are optimized, and the quality of the finally prepared section is further guaranteed. According to the brain tissue rapid freezing section obtained with the method, the freezing section which has stability and can well protect antigens and the enzyme activity is provided for further immunofluorescence, immunohistochemistry and in situ hybridization tests on the brain tissue, and a pathological section meeting requirements is provided for future clinical diagnosis related to nervous system diseases and scientific researches. Particularly, molecular and biochemical index detection can be further performed on other tissue of a mouse which is not subjected to perfusion treatment in the scientific research.

The invention discloses a synchronous analysis method for trace nicotine in blood-brain samples of an animal and main metabolites thereof. The synchronous analysis method is characterized by comprising the following steps of: utilizing a microdialysis system to synchronously collect blood dialysate and brain tissue dialysate samples of an animal in lined pipes of different chromatographic sampling bottles, respectively adding NIC-d3 and COT-d3 to be mixed with internal labeled solution, and after mixing uniformly, directly analyzing and detecting the content of the nicotine and cotinine in a microdialysis sample by using UPLC-MS / MS. The synchronous analysis method disclosed by the invention has the advantages that the pretreatment steps of protein precipitation and purification for the samples are not needed, the synchronous and accurate analysis of nicotine and metabolites in an animal body is realized; and compared with the prior art, the synchronous analysis method has the characteristics of simple operation, high sensitivity and reliable result and the like, and a new method for researching the metabolism of the nicotine in the animal body is provided.

The invention discloses an implanted type flexible sensor based on an organic transistor. The implanted type flexible sensor comprises a substrate support layer, a left metal source electrode, a right metal leakage electrode, an insulating layer, an organic conductive polymer active layer, and a sheath structure, wherein the left metal source electrode is manufactured on one side in the middle of the surface of the substrate support layer; the right metal leakage electrode is manufactured on the other side of the middle of the surface of the substrate support layer and is spaced for a certain distance from the metal source electrode; the insulating layer is manufactured above the substrate support layer and above the left metal source electrode and the right metal leakage electrode; a disconnection window is formed in the middle of the insulating layer; the organic conductive polymer active layer is manufactured inside the opened window of the insulating layer and covers the left metal source electrode and the right metal leakage electrode; the conductive polymer active layer is sensitive to ion concentration caused by electric physiological activity; the sheath structure is used for promoting implanting the sensor into target tissue; and the sheath structure is manufactured above the opened side of the insulating layer. As the sheath structure is used for promoting implanting the whole flexible sensor into a deep part of brain tissue, single nerve cell signals can be conveniently recorded.

Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.

The invention provides a multimodal nuclear magnetic resonance image segmentation method for glioblastoma. The segmentation strategy combining the random forest method and the regional growth method is employed, the result of regional growth segmentation of a glioma multimodal magnetic resonance image is replaced with the corresponding random forest segmentation result with low confidence, retraining data is generated to re-train a random forest model, fine segmentation of the glioma multimodal magnetic resonance image is carried out, and a brain MRI image is segmented into a normal brain tissue area, a necrotic area, an active tumor area, a T1 abnormal area and a FLAIR abnormal area. The method is advantaged in that through fine segmentation and positioning of the glioblastoma, doctors are assisted in diagnosis and other treatment tasks, accurate positioning of the glioblastoma and more accurate fine segmentation of different tumor sub areas are carried out, the doctors are facilitated to diagnose the glioblastoma more quickly and accurately, and an accurate treatment scheme is made.

The invention discloses an application of the LRRC4 gene promoter methylation detection to the glioma diagnosis and a detecting system thereof. The brain tissue specificity expressive gene LRRC4 is the glioma specificity methylate alienation gene, thereby indicating that the LRRC4 gene promoter methylation detection can be applied to the early period diagnosis of the glioma and the LRRC4 gene promoter methylation detecting system can be prepared by comprising a DNA bisulfite modification kit and an LRRC4 promoter methylation specificity PCR augmentation kit. The detecting system detects the specificity of the plasma LRRC4 promoter methylation state up to 92 percent, has high sensitivity, and can detect the plasma LRRC4 promoter methylation state of people quantificationally, thereby diagnosing the glioma of the patient rapidly without wound in the early time.

The invention relates to a ginkgo biloba extract and fish oil soft capsule. Memory deterioration is one of body function debilitating symptoms of elders, the memory deterioration commonly occurs in youngsters and adults with the increasingly fierce social competition, and chemotherapy has a by-effect. The ginkgo biloba extract and fish oil soft capsule content is prepared by tuna oil, ginkgo biloba extract, natural vitamin E, beewax and soybean oil according to a proportion of parts by weight of (432-528):(135-165):(0.63-0.77):(40.95-50.05):(21.42-26.18). The invention further relates to a preparation of ginkgo biloba extract and fish oil soft capsule. The ginkgo biloba extract and fish oil soft capsule provided by the invention can be used for effectively improving the intracerebral DHA content, optimizing the brain tissue ingredients, improving the brain blood oxygen content and perfecting the memory, thereby being suitable for people of all agents and particularly suitable for elders with memory deterioration and brain function decline.

The invention discloses lactobacillus plantarum DP189 and application thereof, and relates to the field of functional food microorganisms. The strain is preserved in China Center for Type Culture Collection on March 25 , 2019 with the preservation number of CCTCC NO:M2019199. By means of the strain, the learning and memory capability of a depressed rat can be improved; the level of brain-derived neurotrophic factors of the depressed rat can be improved; the injury to hippocampal neurons and apoptosis of neuron cells of the depressed rat are reduced; the content of apoptosis proteins JUK2 and Bcl-2 of brain tissue of the depressed rat is lowered; the abundance of verrucomicrobiaceae of the intestinal tract is lowered; the abundance of bacterium lacticum of the intestinal tract is improved, the alpha-diversity of the intestinal floras is improved, and the intestinal flora disturbance of the depressed rat is alleviated. In this way, the lactobacillus plantarum DP189 has good effects of preventing and treating depression / anxiety, infantile autism and inflammatory enteritis. The strain has the anti-depression function, and can serve as a functional probiotic bacterium for preventingand treating the depression, infantile autism and inflammatory enteritis, and a new idea is provided for clinical intervention with and control over depression and other relevant mental diseases.

The invention discloses an extraction method of monosialotetrahexosylganglioside. The extraction method mainly comprises the following steps: separating G1S in the total extract of a brain tissue total extract by adopting a macroporous resin for separating a hydrophilic and lipophilic natural product through an adsorptive process, wherein the hydrophilic and lipophilic natural product is sugar and the like; and separating out high-quality monosialotetrahexosylganglioside (GM1) dry power by common silicagel column chromatography. As different metal ionic impurities still exist in the product subject to the silicagel column chromatography, a cation exchange column is used for further ionic exchange. After improving the traditional method, a large amount of solvent and time are saved, the yield is improved, and the cost is lowered to a great extent.

The invention discloses a white matter hyperintensitiesl automatic segmentation system and method based on a Unet model, and the system comprises an MRI image preprocessing module which is used for carrying out the normalization of inputted MRI image data, and removing the noise interference; a skull removing module which is used for removing the skull in the image by utilizing a skull removing algorithm so as to remove a non-brain tissue part and further remove noise interference; and a WMH segmentation module which is used for reading the MRI image data processed by the skull removal module,converting the MRI image data into image information data, transmitting the image information data to the neural network model for segmentation result prediction, and outputting an accurate segmentation result. By adopting the method, the WMH region can be automatically segmented by applying a deep learning algorithm in the process of automatically processing the image, so that the white matter hyperintensities focus of magnetic resonance imaging can be quantitatively and efficiently distinguished, and the aims of reducing the workload of doctors and facilitating subsequent diagnosis and research are fulfilled.