99 results about "Brain tissue injury" patented technology

The skull patch making process includes the following steps: computerized tomographic imaging to acquire the information of the skull defect part of the patient and the peripheral soft tissue, image designing to reconstruct the 3D head prototype of the patient, designing the dummy for the defect part, leading the designed dummy camber into fast laser forming machine for making patch mold, and final jointing, comparing and cutting titanium web plate to form the ultimate skull patch. The present invention has high precision, low cost, short making period and excellent post-operational restoring.

The invention relates to a double-layer titanium mesh for cranioplasty, which is characterized by comprising an inner-layer titanium mesh and an outer-layer titanium mesh, wherein the outer-layer titanium mesh coincides with the defective edge on the outer surface of the cranial bone; the curvature of the outer-layer titanium mesh conforms to the appearance of the head; the gap between the inner-layer titanium mesh and the outer-layer titanium mesh is filled with autologous bone granules or artificial bone granules; the outer-layer titanium mesh comprises a scalp contact surface and fixed-end grooves; the curvature of the outer-layer titanium mesh conforms to the outer surface of the skull; the edge of the outer-layer titanium mesh coincides with the defective edge on the outer surface of the cranial bone; the outer-layer titanium mesh is fixed on the defective position on the outer surface by screws, so that the outer surface of the cranial bone can be closed; and the outer-layer titanium mesh is provided with holes. The titanium mesh can simultaneously repair the inner surface and the outer surface of the cranial bone, thereby realizing full anatomical and functional recovery and avoiding the brain tissue damage caused by inner surface defects.

A method and apparatus for mitigating health risk from cell phone usage wherein a cell phone having a source of radiation generating excitatory radiation toward brain tissue and an earphone electrically connected to the cell phone via a cord of sufficient length to permit the cell phone to be located more than ten inches from brain tissue during operation of the cell phone. An automatic shutoff mechanism preventing operation of the cell phone unless the cord is extended at least ten inches whereby the excitatory radiation is at a sufficient distance from the brain tissue to prevent brain tissue damage from the excitatory radiation.

The invention discloses an image processing device of visual cortex prosthesis. The image processing device comprises a left miniature camera, a right miniature camera, an image preprocessor and an image coder, wherein the left and right miniature cameras output respectively and synchronously collected video information in real time to the image preprocessor; the image preprocessor splices and merges two paths of received video information into one full-view image, and further completes the preprocessing operation such as image filtering, enhancing and pixel reduction, and outputs the image to the image coder; the image coder performs further processing and coding on the preprocessed full-view image and converts the image into an electric signal capable of being received by the human body visual cortex. The image processing device provided by the invention realizes the goal of converting the image information collected by double cameras into a current signal used for irritating the visual cortex; on the premise of ensuring the nerve cells to issue the equivalent action potential, the intensity of the incitation current can be effectively reduced, so that the goal of effectively reducing the brain tissue injury can be achieved.

The invention discloses application of curcumin to preparation of drugs for treating cerebral ischemia / reperfusion injuries, belonging to the technical field of drug preparation. A cerebral ischemia / reperfusion injury model is prepared and curcumin-PVP (polyvinylpyrrolidone) solid dispersions are used for treating the disease model after being dissolved with the saline for injection. Results show that curcumin can obviously improve the injuries of vital organs such as distant livers and kidneys caused by cerebral tissue injuries and cerebral ischemia / reperfusion injuries and can control the expression levels of several factors related to apoptosis, inflammations and oxidation, control further aggravation of the injuries and protect the vital organs such as cerebral tissues and livers and kidneys.

An application of the brasileiin in preparing the medicines for treating the cerebral ischemia, encephalorrhagia and the cerebral disfunction caused by excessive peroxide in cerebral tissue is disclosed.

The invention relates to the technical field of NMN preparation and discloses a preparation process of high-purity NMN based on an enzymatic method. The preparation process comprises the following steps: (1) raw material pretreatment: performing microfiltration and nanofiltration on nicotinamide ribose at first, and collecting concentrated crude product solution; (2) a production process: enablingthe crude product solution to react under the catalysis of nicotinamide ribokinase or recombinant cells containing the nicotinamide ribokinase to generate beta-nicotinamide mononucleotide; and (3) apurification process: adjusting the pH value of the produced beta-nicotinamide mononucleotide solution to 3-7, sampling the beta-nicotinamide mononucleotide solution on a reversed-phase high-performance liquid chromatography preparation column, and carrying out gradient elution and purification to obtain the purified beta-nicotinamide mononucleotide solution. The preparation process of the high-purity NMN based on the enzyme method ensures the productivity of the nicotinamide mononucleotide, improves the purity of the product, and can make the nicotinamide mononucleotide more obvious in the effect of relieving and improving the injury of ischemic heart and brain tissues. The nicotinamide mononucleotide can better improve oxidation-related degenerative diseases and body dysfunction.

A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of substances selected from blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3, Spirulina, AFA or effective combinations and derivatives of these. For example, a supplement comprising wild blueberry, green tea extract, carnosine, vitamin D3, and a Spirulina and / or an AFA-Omega (EtOH) exhibited a synergistic and unexpected association with substantially increased proliferation of bone marrow stem cells and CD34+. A therapeutic amount of a substance that is associated with a substantial increase in stem cells may be used to prevent and repair damages tissues of the brain, due to stroke, the heart, due to coronary artery disease or a heart attack.

The invention relates to a preparation method of 24(R)-ocotillol DQ and pharmacal application thereof, belonging to the field of medicines. The preparation method comprises the following steps of: taking 1.0kg of ginsenoside, and adding water for dissolving; adding the dissolved ginsenoside onto a processed macroporous adsorption resin column; eluting with 35-55 percent alcohol until no saponin reacts, and then eluting with 60-90 percent alcohol; after the eluent is evaporated to dryness, adding sodium hydroxide for hydrolyzing, and regulating the pH of a hydrolysate to neutrality; adding the hydrolysate onto a macroporous adsorption resin column AB-8, desalting, and then eluting with 60-90 percent alcohol; and after the eluent is evaporated to dryness, oxidizing and recrystallizing to obtain a product. The invention can be applied to preparing medicaments for preventing and treating brain tissue damages caused by local and global brain ischemia, treating transient ischemic attacks, cerebral thrombosis and cerebral infarctions.

The invention discloses a visible cerebral ventricle and subdural external drainage system. The visible cerebral ventricle and subdural external drainage system comprises a visible cerebral ventricle puncture system and a drainage system. The visible cerebral ventricle puncture system comprises a visible puncture guiding core, and LED light sources and a miniature camera are coaxially arranged at the intracranial end of the visible puncture guiding core. The wall of a puncture sheath is see-through, and millimeter scales are arranged on the outer wall of the puncture sheath. The visible cerebral ventricle and subdural external drainage system has the remarkable advantages that as the miniature camera can be connected to one end of the visible puncture guiding core, and a monitor is connected to the other end of the visible puncture guiding core, cerebral puncture is completely performed in a direct-viewing mode, precision is improved, and it is avoided that due to operation based on a rule of thumb, the cerebral tissue is damaged, or cerebral hemorrhage occurs. As miniature vanes (fixing clamps) are arranged at the position distant from the cerebral ventricle by 10 cm-15 cm and used for fixing a drainage tube at the incised skin, the defect that a drainage tube used for the current clinic is simply bound and fixed through threads is overcome.

The invention discloses application of salvianolic acid C in preparing ischemic stroke resistant drug and / or healthcare products. The invention finds that the salvianolic acid C can remarkably improveneurobehavioral defect symptoms of cerebral ischemia-reperfusion rats, lower cerebral infarction volume and cerebral edema of the cerebral ischemia-reperfusion rats and reduce opening degree and permeability of rat blood brain barrier. The salvianolic acid C can be used for preparing the drug and / or the healthcare products for treating ischemic stroke, brain tissue nerve cell apoptosis can be reduced, survival rate of nerve cells can be increased, brain tissue injury degree can be lowered, and an effective solution is provided for disease prevention and treatment.

The invention relates to application of a salvianolic acid A composition in preparing medicines for protecting ischemic brain tissue damage. The composition is prepared from the following components in percentage by weight: 90-99% of salvianolic acid A, 0.1-3% of alkannic acid, 0.1-3% of rosmarinic acid, 0.1-3% of salvianolic acid B and 0.1-5% of salvianolic acid C.

An application of the sapan wood extract (brasileiin, C16H12O5) in preparing medicine for treating cerebral ischemia and cerebral function ariation caused by excessing peroxide in brain tissue is disclosed.

The invention relates to application of a salvianolic acid A composition in preparing medicines for protecting ischemic brain tissue damage. The composition is prepared from 94-97% of salvianolic acid A, 0.1-1.5% of alkannic acid, 0.1-1.5% of rosmarinic acid, 0.1-1.5% of salvianolic acid B and 0.1-2.0% of salvianolic acid C.

The invention comprises ultrasonic transducer, low-frequency power source, and the control circuit described above is connected ultrasonic transducer, the described ultrasonic transducer includes a sound head, which was set side of a focusing concave mirror. Through the focusing concave mirror, the low-frequency ultrasonic generated by ultrasonic transducer focuses and biological effects generated in focal area was restricted to certain position, not only focus the ultrasonic beam (targeted), reduce the required energy by two energy level change of one factor and the use of combinative micro vesicle, thus reduce injury risk of brain tissue, but also provides us a non-invasive, targeted thrombolytic, blood-brain barrier (BBB) opening and gene transfection of nerve cells therapy device, especially as a barrier to the blood-brain transmission of drugs and macromolecular in the central nervous system, and an important mean to enter the brain tissue.

The invention provides a cerebrospinal fluid drainage apparatus, which comprises a drainage tube, a liquid storage bottle and an air pump, wherein the near end of the drainage tube, the liquid storage bottle and an air inlet of the air pump are sequentially connected by virtue of pipes; the liquid storage bottle can be used for accommodating liquid; and the liquid, at least before the liquid storage bottle is full of the liquid, is prevented from flowing into the air inlet of the air pump. According to the cerebrospinal fluid drainage apparatus provided by the invention, a cerebrospinal fluid drainage rate can be controlled in an entire operation, so that brain tissue injury caused by too quick decompression of cerebral ventricle is prevented.

The invention discloses an inflatable brain retractor. The inflatable brain retractor comprises a retractor body, a puncture guide needle and a guide needle core, wherein flexible soft materials are adopted for the retractor body to form a hollow structure formed by combining an outer layer membrane and an inner layer membrane, an inflating valve is arranged on the retractor body, the puncture guide needle is a hollow round tube, a wire groove is formed in the circumferential tube wall of the puncture guide needle, the guide needle core is inserted from the middle of the retractor body, and the guide needle core and the retractor body are together guided into the hollow position of the puncture guide needle. Besides, the invention discloses a using method of the inflatable brain retractor. According to the inflatable brain retractor and the using method of the inflatable brain retractor, the inflatable brain retractor can reach the hematoma portion and other operational sites through a puncture operation with smallest injury to the brain tissue, and the operation procedure can be directly observed after the brain tissue is fully expanded by the retractor.

The invention provides new application of danshinolic acid C, and particularly, the danshinolic acid C can be used for preparing a drug for protecting the ischemic brain tissue damage. The danshinolicacid C has a good effect of resisting the ischemic brain tissue damage, the effect is obvious, and the danshinolic acid C has development and utilization values.

A method and apparatus for mitigating health risk from wireless communication device (WCD) usage wherein a WCD having a source of radiation generating excitatory radiation toward brain tissue and an earphone electrically connected to the WCD via a transceiver and a cord of sufficient length to permit the WCD to be located more than ten inches from brain tissue during operation of the WCD. An automatic shutoff mechanism preventing operation of the WCD unless the cord is extended at least ten inches whereby the excitatory radiation is at a sufficient distance from the brain tissue to prevent brain tissue damage from the excitatory radiation.

The invention belongs to the field of medicine preparation, and particularly relates to application of Adjudin in preparing medicine for inhibiting glial scar formation. The glial scar is formed by activation and proliferation of astrocyte after central lesion. The medicine is at least in a form of tablets, capsules, granules, dripping pills, suspensions, syrup, enteric-coated preparation, emulsion suspension and injections. Experiments show that Adjudin can effectively reduce size of the glial scar of mice after brain tissue injury; in an in-vitro primary cell scratch model, Adjudin remarkably inhibits proliferation and migration of astrocyte cells, improves ethology of the mice after brain injury and promotes recovery, so that Adjudin has important application value in preparing the medicine for inhibiting glial scar formation.

The invention discloses functional mandulapalka milk rich in crocin and iridoid glycoside and a preparing method thereof. The functional mandulapalka milk is composed of, by weight, 1-10 parts of gardenia milk pulp, 1-9 parts of mandulapalka milk pulp and 1-3 parts of tea pulp. The gardenia milk pulp is composed of, by weight, 10-20 parts of gardenia powder and 80-90 parts of water. The gardenia powder is prepared by at least one of gardenia whole fruits, gardenia florida and skim gardenia meal. The mandulapalka milk pulp is composed of, by weight, 10-20 parts of mandulapalka powder and 80-90 parts of water. The mandulapalka powder is prepared by mandulapalka and / or skim mandulapalka meal. The tea pulp is composed of, by weight, 1-5 parts of tea and 95-99 parts of water. The functional mandulapalka milk contains protein, unsaturated fat and other nutritious substance, the health care functions of the crocin and iridoid glycoside in gardenia can be fully utilized, and the functions of being resisting to depression, preventing nerve cell and brain tissue damage and improving the heart and cerebral vessel functions and cognitive ability of middle-aged and aged people are achieved.

The invention discloses novel use for brasilein, which relates to the novel use of the brasilein with brazilwood as raw material in the medical aspect, in particular to an application of the brasilein in the preparation of medicines used to treat cerebral ischemia or cerebral hemorrhage, brain tissue peroxide increase and brain function damage diseases caused by the brain tissue peroxide increase. As shown in experimental research, the brasilein has the effects on resisting oxidation, protecting brain neurons, enhancing cerebral blood flow, and suppressing the activity of erythrocyte membrane Na-K-ATP enzyme. The brasilein has an apparent effect on brain issue damage caused by cerebral ischemia reperfusion. When the diseases are treated, the brasilein, taken as an active ingredient, is independently used or matched with other medicines to prepare various medicines with different preparation formulations, and the medicines can be clinically used.

The invention belongs to the pharmaceutical technical field, and discloses an ischemic cerebrovascular disease treatment composition, a medicament, a preparation method and application, the ischemic cerebrovascular disease treatment composition comprises ginsenoside Rg1 and astragaloside, and the weight ratio of ginsenoside Rg1 to astragaloside is 5:4. The animal pharmacodynamics experiments prove that the ischemic cerebrovascular disease treatment composition can inhibit the cerebral ischemia reperfusion injury of brain tissue, has the anti-cerebral ischemia-reperfusion injury enhancement effect by the astragaloside and ginsenoside Rg1 compatibility, also can improve energy metabolism disorders of the cerebral ischemia reperfusion injured brain tissue, anti-oxidative stress damage functions and the like, and ultimately achieves the purposes of enhancing the efficacy and reducing the toxic and side effects.

The invention discloses a brain taking device for simulating the surgical injury. The brain taking device comprises a long handle, wherein the lower end of the long handle is connected with a spoon-shaped container, the edge of the spoon-shaped container is provided with a cutter point, a rough groove is distributed at the inner surface of the spoon-shaped container, and three to five point-shaped bulges are attached at the outer side. The spoon-shaped container can dig a certain number of brain tissues, the brain tissue injury can be caused, the cutter point of the edge simulates the cutter cutting injury, and the point-shaped bulges can cause heat burning burn and the like. Various kinds of injury caused by the injury surgery of the central nervous system of the human body are simulated, in addition, the operation is simple, convenient and feasible, the effect is indeed, the cost performance is high, the workload of scientific research personnel and medical care personnel is lightened, in addition, the standardization and the quantification can be realized, and the brain taking device is particularly suitable for standard research and scientific data collection and statistics. Through information retrievals applied by applicants, a similar device in the same kind is also not found.

The invention relates to the field of medicine, in particular to application of salvianolic acid A and derivatives to prevention and / or treatment of high-altitude sickness. The application of the salvianolic acid A involves protection of cardiovascular diseases, cerebrovascular endothelial cells and ischemic brain tissues, prevention and / or treatment of cerebral thrombosis, improvement on neurological function symptoms after cerebral ischemia, prevention and / or treatment of diabetes mellitus and complications, inhibition of brain tissue neuron damage or death, prevention and / or treatment of cerebral thrombosis, drugs for treating ischemic penumbra and multi-drug resistance of tumors, prevention and treatment of HIV encephalopathy and the like. Application of the salvianolic acid A and the derivatives thereof to prevention and / or treatment to the high-altitude sickness has not been reported.

The invention relates to a pharmaceutical composition. The pharmaceutical composition is prepared from phellodendrine, paeoniflorin and optional EGCG (epigallocatechin gallate). The pharmaceutical composition can prevent or treat brain tissue damage caused by local and whole cerebral ischemia, can specifically prevent or treat cerebral hemorrhage, cerebral infarction, cerebral thrombosis and otherdiseases, especially has a very good treatment effect on cerebral infarction, and is high in safety and free from side effect.

The invention provides calcium silicate nano hollow microsphere modified thermosensitive hydrogel and a preparation method and application thereof. The preparation method includes: preparing calcium silicate nano hollow microspheres, dispersing the microspheres in the complex solution of carboxymethyl chitosan and beta-sodium glycerophosphate, and processing at 30-70 DEG C. The preparation methodhas the advantages that the method is simple and low in cost, the reaction conditions of the method can be achieved easily, and the raw materials used by the method are cheap and easy to obtain; the prepared thermosensitive hydrogel is safe, low in cytotoxicity, good in biocompatibility and good in low-temperature flowability, the hydrogel can fast turn into gel at 37 DEG C, the surface of the gelis loose and porous, and the gel is large in specific surface and capable of benefiting neural stem cell adsorption; the calcium silicate nano hollow microspheres are evenly dispersed in the thermosensitive hydrogel, and the thermosensitive hydrogel can promote neural stem cell differentiation; when the thermosensitive hydrogel is applied to brain tissue damage repairing, neural stem cell adsorption can be promoted effectively, the neural stem cells can be effectively promoted to differentiate into neurons and neuroglia, and the thermosensitive hydrogel is promising in clinical application prospect.

The invention provides an application of isoliquiritigenin to medicines for treatment of lung and liver damage diseases caused by septicopyemia, and an application of the isoliquiritigenin to medicines for treatment of brain tissue injury diseases caused by wounds. The medicines are favorable for delaying of progress deterioration of state of an illness, the case-fatality rate and the illness anddisability rate are notably reduced, and the quality of life is improved. The medicines are high in treatment maneuverability and low in cost, and the diagnosis and treatment cost for patients and medical institutions can be notably reduced.