43 results about "Brain tissue injury" patented technology

The invention relates to a brain-computer interface system and a brain-computer interface device.The brain-computer interface system comprises an implant host and a probe connected to the implant host, the probe is used for being implanted into the intracranial position of the human body to obtain electroencephalogram signals, and the implant host is used for being implanted into the non-intracranial position of the human body and processing the electroencephalogram signals; the implant host comprises a wireless charging module and a wireless communication module, the wireless charging module is used for wirelessly charging the implant host, and the wireless communication module is used for wirelessly transmitting the electroencephalogram signals processed by the implant host. According to the brain-computer interface system, the brain-computer interface system is designed into a split type, the probe used for acquiring the electroencephalogram signals is implanted into the brain of the human body, the implant host used for processing the electroencephalogram signals is implanted into the non-brain of the human body, the implant body with the power supply part can be far away from the brain, and brain tissue damage caused by fever is avoided.

The embodiment of the invention discloses a brain operation path determination method and device, equipment, a medium and a medical system. The brain operation path determination method comprises the steps that a brain structure model and at least one target spot of a target user are obtained; based on the brain structure model, determining an information transfer relationship between each nuclear group sub-model and each nerve fiber sub-model; determining a plurality of candidate operation schemes based on the plurality of preset path starting points, the target group sub-model to which the at least one target point belongs and the information transfer relationship; for each candidate operation plan, performing quality evaluation on the candidate operation plan based on a quantitative evaluation model under at least one evaluation dimension, and determining a path quality attribute corresponding to each candidate operation plan; according to the method, at least one target recommended operation scheme is determined based on each path quality attribute, a plurality of candidate paths conforming to nerve conduction characteristics are automatically generated, and an optimal scheme is screened through a quantitative evaluation model, so that the brain tissue injury risk and the operation complexity are effectively reduced while the operation precision is improved.

The invention provides a rigidity-flexibility variable multifunctional optical genetic implantable probe and a preparation method thereof. The probe comprises a thin film electrode layer and a rigidity-flexibility variable shape memory layer arranged at the bottom of the thin film electrode layer. The micro LED is integrated in the flexible nerve probe through contact type laser transfer printing to serve as a light stimulation light source, the preparation success rate is remarkably increased, heat radiated outwards during light stimulation is reduced, and damage to brain tissue of the brain caused by high-Young-modulus optical fibers is avoided; meanwhile, a rigid-flexible variable shape memory layer is also integrated, so that the Young modulus of the probe is high when the in-vitro temperature is relatively low, fixed-point implantation can be directly carried out without an auxiliary tool, the Young modulus of the probe is reduced along with the rise of the body temperature after the probe is implanted into the body, and the probe finally adapts to the mechanical tissue strength of the brain; therefore, the implantation efficiency and the mechanical adaptability of the probe to brain tissues are improved, and micron-scale accurate implantation of the probe, neuron-scale positioning of electrical stimulation and light stimulation points and long-term stable recording of electrophysiological signals are realized.

The invention belongs to the technical field of nutritional compositions, and particularly relates to a composition, a preparation method thereof and application of the composition in protecting brain health. The composition provided by the invention is prepared from docosahexaenoic acid, 3-sialic acid lactose and phosphatidylserine. The composition is clear in sleep improvement effect, can effectively solve the problem of sleep maintenance caused by sleep deprivation, has the effects of protecting neural functions, improving memory and relieving anxiety from multiple dimensions, and can repair brain tissue damage and protect brain health. Based on the composition, products for assisting in improving memory, preventing and treating insomnia and anxiety, regulating neurodevelopmental disorders, protecting brain health and improving concentration can be developed, the health requirements of different people are comprehensively met, and the application value is high.

The scheme provides a kind of engineered exosome double drug delivery system loaded with ergosterol and its preparation method and application, belongs to the field of nanomaterials and nanobiomedicine, based on the innovative ROS-responsive nanomaterial CHPG design, load the active ingredient ergosterol to play the role of treatment and repair, which realizes the blood-brain barrier penetration and precise drug release in lesion area through targeted functional modification;It is wrapped in the nasal mucosa-derived stem cell exosome to form a drug delivery system Exo@Erg-CHPG-M, which combines the natural biological characteristics of exosome and the precise targeting advantage of nanomicelle, significantly improves the drug delivery efficiency, in vitro and animal model verification show that, the system can improve the neurological impairment and brain tissue injury after ischemic stroke by synergistically regulating inflammation and neural repair pathways, the scheme provides a new technical scheme for the precise treatment of central nervous system diseases such as cerebral stroke.

The invention provides an ergosterol-loaded engineered exosome double-drug-loading system as well as a preparation method and application thereof, belongs to the field of nano materials and nano biological medicines, and is based on innovative ROS response type nano material CHPG design, a therapeutic active component ergosterol is loaded to play a role in treatment and repair, and the curative effect of the ergosterol is improved. Blood-brain barrier penetration and accurate drug release in a focus area are realized through targeted function modification; the Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG-M / Erg-CHPG- the nerve function defect and brain tissue damage after ischemic stroke are improved, and a new technical scheme is provided for precise treatment of central nervous system diseases such as cerebral stroke.

The invention relates to the technical field of medicines, in particular to application of DP-b99 and a derivative thereof in preparation of a medicine for treating cerebral ischemia mechanical thrombus extraction reperfusion injury. On the basis of mechanical thrombus extraction and reperfusion of cerebral ischemia, DP-b99 is combined to reduce mechanical thrombus extraction and reperfusion injury of cerebral arterial thrombosis, so that the inflammation level of brain tissues can be reduced, the volume of cerebral infarction can be reduced, the injury of the brain tissues can be effectively reduced, and the treatment effect is remarkable.

The present invention discloses the application of a Chinese medicinal material Dendrobium officinale flower extract in the preparation of a drug or health product for preventing cerebral ischemia. The present invention finds that the Dendrobium officinale flower extract can significantly improve the neurobehavioral deficit symptoms of rats with cerebral ischemia-reperfusion, and significantly reduce the cerebral infarction volume of rats with cerebral ischemia-reperfusion. The Dendrobium officinale flower extract is prepared by extracting the flowers of the Chinese medicinal material Dendrobium officinale with alcohol and water, and the yield is 13.71-18.39%. The Dendrobium officinale flower extract can be used to prepare a drug or health product for preventing ischemic stroke, reduce the degree of brain tissue damage, and provide an effective solution for the prevention of the disease.

The invention provides a compound composition for treating cerebral hemorrhage, a preparation method, application and a medicine, and relates to the technical field of traditional Chinese medicines. The compound composition is prepared from the following raw materials in parts by weight: 10 to 30 parts of cortex moutan, 2 to 10 parts of radix et rhizoma rhei, 5 to 15 parts of herba lycopi, 10 to 21 parts of radix puerariae and 5 to 15 parts of loofah sponge. Mixing the moutan bark, the rheum officinale, the herba lycopi, the radix puerariae and the loofah sponge, and adding water for soaking; decocting twice, and combining filtrates to obtain the compound composition. The five medicines of moutan bark, rheum officinale, herba lycopi, radix puerariae and loofah sponge are adopted and are scientifically matched, so that the effects of remarkably improving brain microcirculation and promoting hematoma absorption are achieved; the hematoma volume can be obviously reduced, the inflammatory response is relieved, the brain tissue damage is relieved, and the treatment effective rate of cerebral hemorrhage is improved.

This invention discloses a method, apparatus, device, medium, and medical system for determining brain surgical pathways. The method involves acquiring a brain structure model of a target user and at least one target point; determining the information transmission relationship between each nucleus sub-model and each neural fiber sub-model based on the brain structure model; determining multiple candidate surgical plans based on multiple preset path starting points, the target nucleus sub-model to which at least one target point belongs, and the information transmission relationship; evaluating the quality of each candidate surgical plan using a quantitative evaluation model based on at least one evaluation dimension, and determining the path quality attributes corresponding to each candidate surgical plan; determining at least one recommended surgical plan based on each path quality attribute; automatically generating multiple candidate paths that conform to neural conduction characteristics; and selecting the optimal plan through a quantitative evaluation model. This approach improves surgical accuracy while effectively reducing the risk of brain tissue damage and the complexity of surgical procedures.

The present invention belongs to the technical field of magnetic resonance imaging, and specifically discloses a magnetically compatible rodent brain injection device and method, which includes a fixed base, an injection catheter system, and a drug delivery system. The bottom surface of the fixed base is fixedly connected to the surface of the skull through an adhesive. A stereotactic fine-tuning system is provided on the top surface of the fixed base. The stereotactic fine-tuning system is fixedly connected to the outer ring of the injection catheter system. One end of the injection catheter system sequentially passes through the stereotactic fine-tuning system and the fixed base and is connected to the interior of the skull. The other end of the injection catheter system is connected to the drug delivery system. By adopting the above-mentioned magnetically compatible rodent brain injection device and method, the present invention avoids signal artifacts or interference, has both imaging compatibility and operation convenience, realizes high-precision, good repeatability, and small damage to brain tissue for intracerebral drug injection, and provides a reliable technical means for brain research.

The invention relates to the technical field of medical devices, in particular to a medical device special for long-term drug delivery of skull marrow and a use method. According to the technical scheme, the skull drilling device comprises a drill rod for drilling a hole in a skull, the outer ring of the drill rod is sleeved with a first positioning sleeve, and the first positioning sleeve is used for limiting the drilling depth and preventing the skull from being drilled through to cause brain tissue damage; the dosing tube is used for dosing into the drill hole, one end of the dosing tube is fixed in the drill hole, a second positioning sleeve is arranged on the outer ring of the dosing tube in a sleeving manner, and the second positioning sleeve is used for limiting the depth of the dosing tube entering the drill hole. The skull bone marrow long-term stable drug delivery can be achieved, the limitation of the blood brain barrier on drug delivery is broken through, clinical transformation of an efficient drug delivery pathway is promoted, and the treatment effect of central nervous system diseases is improved.

This application belongs to the field of traditional Chinese medicine technology and relates to a traditional Chinese medicine composition for treating cerebral infarction. The traditional Chinese medicine composition of this application comprises the following raw materials in parts by weight: Ligusticum chuanxiong, Astragalus membranaceus, Pueraria lobata, Uncaria rhynchophylla, and a compound fungus; the traditional Chinese medicine composition is prepared by the following method: S1, Ligusticum chuanxiong, Astragalus membranaceus, Pueraria lobata, and Uncaria rhynchophylla are pulverized and the active ingredients are extracted by water extraction and alcohol precipitation to obtain an extract; S2, the compound fungus is pulverized, extracted by boiling with deionized water at normal pressure, and then fermented with fermenting bacteria in a sealed container to obtain a fermentation liquid; S3, the extract and fermentation liquid are combined, concentrated under reduced pressure, and spray-dried to obtain the traditional Chinese medicine composition. This application has a simple formula and safe ingredients. Through multiple effects such as promoting blood circulation and removing blood stasis, tonifying qi and strengthening the exterior, clearing heat and detoxifying, dilating blood vessels, and calming the liver and extinguishing wind, it jointly promotes cerebral blood circulation, reduces brain tissue damage, and promotes nerve cell repair and regeneration, showing broad clinical application prospects.

The invention discloses a brain spatula for neurosurgery, and belongs to the technical field of neurosurgery medical instruments, the brain spatula comprises a fixing plate and two brain spatula bodies, the surface of the end of the fixing plate is provided with an action mechanism and a shell, and the action mechanism comprises a lifting plate, an opening and closing assembly and a telescopic assembly. The distance between the two brain spatula bodies can be controlled by arranging the opening and closing assembly and pushing the sliding block to be in linkage with the opening and closing connecting rod, a surgery operation channel is formed, through cooperative use of the lifting plate and the telescopic assembly, vertical descending and retracting of the brain spatula bodies are achieved, gradual weak traction on brain tissue is completed, sudden pressing caused by the lever effect is avoided, and the brain spatula body is prevented from being damaged. Brain tissue damage caused by continuous single-point pressing can be prevented, the warning assembly and the small pressure sensor are arranged to monitor the pressure of the brain spatula on the tissue in real time in the operation, and when the pressure exceeds the limit, the control chip triggers an optical fiber to warn and remind a doctor to adjust operation, and tissue damage is avoided.

The invention discloses application of CKB K11 lactic acid modification as a cerebral apoplexy I / R injury diagnosis or neuroprotection drug target, and belongs to the technical field of biological medicine. The CKB K11 lactic acid modification provided by the invention can obviously improve the cerebral apoplexy ischemia reperfusion injury and motor function, and the CKB K11 lactic acid modification is closely related to the cerebral apoplexy ischemia reperfusion injury and can be used as a specific diagnosis index of the cerebral apoplexy ischemia reperfusion injury. By detecting the CKB K11 lactic acid modification level in a biological sample, the brain tissue damage degree and the postoperative recovery condition of a detected object can be rapidly and accurately evaluated, and a new effective means is provided for clinical diagnosis.

The invention provides a free activity state brain imaging system and method based on a multimode optical fiber, and belongs to the field of optical fiber brain imaging, the free activity state brain imaging system comprises a light source module, a modulation module, a multimode optical fiber probe, a correction module and a detection module; a multimode optical fiber is introduced to perform brain detection, a laser light source is modulated, a transmission focus point is generated at a transmission end of a multimode optical fiber probe, a reflection focus point is generated at a correction module, the bending state of the optical fiber probe is monitored in real time according to the intensity of the reflection focus point, and a currently used transmission matrix is adjusted in real time. And in combination with a fluorescence signal collected by the detection module, real-time brain imaging in a free activity state is realized. According to the invention, the introduced multimode optical fiber is small in diameter, high in resolution and small in damage to brain tissues, and more accurate, comprehensive and lossless research on the brain in a free activity state can be realized through real-time adjustment of an optical fiber transmission matrix.

The invention provides wine gastrodia elata derived extracellular vesicles and application thereof in cerebral ischemia reperfusion injury, relates to the technical field of biological medicines, and provides application of the wine gastrodia elata derived extracellular vesicles in preparation of medicines for preventing and / or treating cerebral ischemia reperfusion injury. The traditional Chinese medicine composition can improve injury of nerve cells caused by oxygen deficit, inhibit phenotypic polarization of microglial cells to M1, promote phenotypic polarization of microglial cells to M2, reduce the area of cerebral infarction and improve neurological impairment after cerebral ischemia reperfusion. The invention reveals and verifies that the wine gastrodia elata-derived extracellular vesicle has an excellent nerve protection effect for the first time, and the vesicle can obviously relieve the injury of an anoxic environment to nerve cells, effectively maintain the cell activity and improve the survival ability of the cells in a stress state, so that the protection on brain tissue injury is realized from the cellular level.

The application provides application of IL-17A as a target point in preparation of a drug for screening treatment or prevention of cardiac arrest. The application also provides application of IL-17A as a target point in preparation of a monoclonal antibody drug for screening treatment or prevention of cardiac arrest. The application also provides application of an anti-IL-17A monoclonal antibody in preparation of a drug for improving post-cardiac arrest syndrome. The application provides application of an anti-IL-17A monoclonal antibody in preparation of a drug for early intervention of cardiac arrest. The application also provides application of an anti-IL-17A monoclonal antibody in preparation of a drug for improving myocardial injury, cardiac dysfunction, brain injury or neurological dysfunction caused by cardiac arrest. The application also provides application of a reagent for detecting IL-17A level in serum in preparation of a kit for detecting a myocardial infarction combined with cardiac arrest patient. The application proves by experiments that IL-17 related pathways in heart and brain tissues are significantly activated after cardiac arrest, and IL-17A in serum is significantly increased, and early antagonism of IL-17A by using an IL-17A monoclonal antibody after resuscitation can improve myocardial injury, cardiac dysfunction (systolic and diastolic dysfunction), brain tissue injury or neurological dysfunction after cardiac arrest, and improve survival rate after cardiac arrest.

The application provides a nerve regulation device based on photoelectric effect, comprising a transparent embedding plate, a photoelectric conversion material layer arranged on the inner surface of the transparent embedding plate, and a focused laser system, the transparent embedding plate adopts a profiled structure of at least a part of a skull, the focused laser system provides a regulation light signal to the transparent embedding plate, and the photoelectric conversion material layer is used for converting the regulation light signal into an electric signal. The nerve regulation device of the application generates a photoelectric current after absorbing laser by the photoelectric conversion material, and the photoelectric conversion material layer only contacts the surface of the cerebral cortex, without being implanted into the brain, thereby combining the advantages of electric stimulation and light regulation, and through semi-invasive light-to-electricity stimulation, the range of nerve regulation is significantly improved by improving the signal penetration depth, and the problem of significant brain tissue damage caused by the traditional method is reduced.

The invention discloses a quantification method and device for brain tissue damage degrees under different strain rates and a medium. The quantification method comprises the steps that a constitutive model is constructed; fitting a brain tissue loading and unloading curve under different strain rate conditions based on the constitutive model to obtain a super-elastic-viscoelastic parameter, a Mullins effect parameter and a residual deformation parameter of the brain tissue, so as to evaluate the damage state of the brain tissue; the area defined by the brain tissue loading curve and the brain tissue unloading curve serves as total dissipated energy, the area defined by the unloading curve only considering viscoelasticity and the brain tissue unloading curve serves as damage dissipated energy, the ratio of the damage dissipated energy to the total dissipated energy is calculated, and therefore the damage degree of the brain tissue is evaluated; and fitting the ratio of the damage dissipated energy to the total dissipated energy and the maximum engineering strain so as to analyze the change relation of the brain tissue tensile damage degree along with the strain.

The present invention provides a compound composition for treating cerebral hemorrhage and a preparation method, application and medicine, relating to the field of traditional Chinese medicine technology. The raw materials of the compound composition according to weight parts are: 10-30 parts of moutan bark, 2-10 parts of rhubarb, 5-15 parts of zedoaria root, 10-21 parts of kudzu root and 5-15 parts of luffa sponge;moutan bark, rhubarb, zedoaria root, kudzu root and luffa sponge are mixed and soaked in water;decoction is carried out twice, and the filtrate is combined to obtain a compound composition. The present invention adopts moutan bark, rhubarb, zedoaria root, kudzu root, luffa sponge five flavors, scientific compatibility, brings about the effect of significantly improving brain microcirculation, promoting hematoma absorption;It is also possible to significantly reduce hematoma volume, reduce inflammatory reaction, reduce brain tissue damage, and improve the treatment efficiency of cerebral hemorrhage.

The invention relates to the technical field of biology, in particular to a medicine and application thereof. The drug is an exosome (DPSCs-Exos) derived from dental pulp stem cells (DPSCs-Exos). The DPSCs-Exos is given after acute cerebral apoplexy, so that sensory movement and cognitive function recovery after cerebral ischemia can be promoted. The DPSCs-Exos can improve ischemia for 45 minutes, and brain tissue injury and neurological function injury of animals after reperfusion for 28 days. The DPSCs-Exos promotes the expression increase of protein arginine methyltransferase (PRMT5) in oligodendroglia precursor cells (OPC), inhibits the expression of a differentiation inhibition factor 2 (ID2) through nucleation, promotes the OPCs to proliferate and differentiate into oligodendroglia cells (OL), and promotes the integrity repair of white matter. In addition, DPSCs-Exos can promote proliferation and migration of vascular endothelial cells and promote blood brain barrier repair.

The invention discloses a pharmaceutical composition of artesunate and Xingnaojing and application of the pharmaceutical composition, and relates to the technical field of pharmacy, the active ingredients of the pharmaceutical composition comprise artesunate and Xingnaojing injection, and the application of artesunate and Xingnaojing injection in preparation of drugs for treating cerebral malaria. According to the application disclosed by the invention, the artesunate and Xingnaojing have a remarkable treatment effect on experimental cerebral malaria mice, and a GPR68 / cAMP / EPAC1 signal channel is activated, so that a blood brain barrier is protected, and brain tissue damage is relieved. The research provides a new drug combination strategy for clinical treatment of cerebral malaria, and lays a theoretical foundation for deep understanding of the action mechanism of cerebral malaria.

The utility model discloses a deep brain long needle electrode, which comprises a needle body, at least one connecting part and a contact assembly, the connecting part is detachably connected with the needle body, the contact assembly comprises a flexible part and a plurality of electric contacts, the flexible part is connected with the at least one connecting part and can wrap or fall off the outer surface of the needle body, and the electric contacts are electrically connected with the flexible part. The plurality of electric contacts are distributed at intervals along the surface of the flexible part and are connected to the flexible part. The utility model can effectively solve the problems that the diameter of the whole probe is increased due to the fact that a large number of conductive wires are needed for increasing the number of channels, and brain tissues are damaged due to the increased diameter of the probe.

The utility model belongs to the technical field of medical instruments, and provides a controllable nasal cavity cooling brain protection device, which comprises a cooling mechanism, a nasal cavity cooling mechanism and a nasal cavity cooling mechanism, and the nasal cavity cooling mechanism comprises a pressurizing cooling tank and an intubation tube assembly which is provided with at least one hose capable of being inserted into the nasal cavity and a flow regulating valve; the temperature measuring mechanism is provided with at least one temperature measuring probe capable of extending into the auditory meatus tympanic chamber; and the control mechanism is used for adjusting the conveying flow of the cooling spray through the flow adjusting valve according to the tympanic membrane temperature data detected by the temperature measuring probe. The controllable cooling brain protection device in the nasal cavity is convenient to carry, can be used for carrying out brain hypothermia treatment protection on site or in the transportation process, shortens the intervention opportunity of hypothermia treatment on a patient, reduces brain tissue damage caused by brain temperature rise, improves the neurological function prognosis condition of the patient, and meanwhile, can be used for protecting the patient. The brain temperature change is monitored in real time through the temperature measuring mechanism, and the conveying amount of the cooling spray is adjusted according to feedback, so that the brain temperature is maintained at a constant level.

The present invention relates to a compound of formula (I) or a tautomer, stereoisomer, hydrate, solvate, polymorph, prodrug, isotope or co-crystal thereof, or a pharmaceutically acceptable salt thereof: [Formula 1] JPEG2025539466000191.jpg30165 where A, R 1 and R 2 is as defined in the specification and claims. The present invention also relates to a pharmaceutical composition comprising a compound according to the present invention and a pharmaceutically acceptable carrier.The present invention also relates to the compound for use as a pharmaceutical and / or diagnostic agent.The present invention also relates to the compound for use in the prevention and / or treatment of a GPR17-mediated disorder, such as a disorder or syndrome selected from disorders or syndromes associated with myelination disorders and brain tissue damage.

The invention relates to a proton radiation brain injury tissue marker and application thereof, radiation brain injury differential metabolite markers comprise prostaglandin F2alpha, fructose-1, 6-diphosphate, dihydroxyacetone phosphate and inosine, and differential protein markers comprise fibroblast growth factor receptor 2 and calcium / calmodulin dependent protein kinase II. Differential metabolites and differential proteins are used as proton radiation brain damage biomarkers. According to the invention, the differential marker is used as a potential biomarker of radiation brain tissue injury, and demonstrative research is provided for multi-omics analysis of radiation brain injury and explanation of an action mechanism of radiation brain injury.

The invention provides an automatic accurate control system for a small animal intracranial implantation operation, and particularly relates to the technical field of experimental equipment, the automatic accurate control system for the small animal intracranial implantation operation comprises a speed controller, a time controller and a stepping motor controller, wherein the stepping motor controller is electrically connected with the speed controller and the time controller respectively, the stepping motor controller is connected with the stepping motor, and the output end of the stepping motor is connected with the implanting device; the screw rod is connected with the output end of the stepping motor, the fixing support is connected with the stepping motor, the sliding rail is connected with one side of the fixing support, the sliding block is arranged on the sliding rail and the screw rod, a clamping arm is arranged on the sliding block, and the motor drives the screw rod to rotate and enables the sliding block to drive the clamping arm to clamp an implant to move. The clamping arms are controlled through the speed controller and the time controller, so that the accuracy and controllability of the implanting speed and depth of the implant can be ensured, micron-level precision movement is realized, and the risk of brain tissue injury is effectively reduced.

The application provides a Pediococcus pentosaceus strain NCU16V with thrombus prevention and cerebral ischemic injury prevention, a microbial inoculum containing the same and application, and relates to the technical field of microorganisms.The preservation number of the Pediococcus pentosaceus strain NCU16V is CGMCC No.35427.The Pediococcus pentosaceus strain NCU16V has good gastrointestinal digestion tolerance, and has a high survival rate after being digested in simulated artificial gastric juice and intestinal juice for 3 hours, as verified by the research of the application.Meanwhile, it is verified that the Pediococcus pentosaceus strain NCU16V and the microbial inoculum containing the same can be widely applied in drugs for preventing thrombosis, drugs for relieving brain tissue injury after cerebral ischemia and preparation of ginkgo fermented products with thrombosis prevention.

The invention discloses application of a composition containing sulodexide and ceftriaxone in preparation of a medicine for treating bacterial meningitis, and belongs to the technical field of biological medicines. According to the invention, it is found for the first time that sulodexide and ceftriaxone are combined to have the effect of preventing and / or treating bacterial meningitis; animal experiments prove that the composition containing sulodexide and ceftriaxone improves cognitive impairment of a patient with bacterial meningitis by improving encephaledema of the patient with bacterial meningitis, reduces brain tissue damage of the patient with bacterial meningitis, inhibits brain neuroinflammation of the patient with bacterial meningitis, improves cognitive impairment of the patient with bacterial meningitis, and has a remarkable curative effect. Therefore, bacterial meningitis is prevented and / or treated, a new thought is provided for preparing bacterial meningitis products, and the application prospect is wide.