55 results about "Unsaturated fat" patented technology

The invention discloses an artemisinin derivative nano assembly with anti-tumor activity and a preparation method and application thereof. The nano assembly is formed by self-assembling artemisinin derivatives through intermolecular force and modifying the artemisinin derivatives with a PEG modifier; the artemisinin derivative is artesunate or dihydroartemisinin of which the side chain is binary acid or saturated fatty alcohol or unsaturated fatty alcohol; the mass ratio of the artemisinin derivative to the PEG modifier is (10: 90)-(90: 10), so that the technical effects of high drug loading capacity, good stability, low toxic and side effects and the like are realized, the urgent demand on high-efficiency and low-toxicity preparations in clinic is met, a new strategy is provided for the assembly of homotype synergistic drug nanoparticles, and the application prospect is broad. An effective nano platform is provided for developing a carrier-free nano assembly and a high-efficiency and low-toxicity nano preparation.

The invention discloses a cationic lipid capable of being ionized and application of the cationic lipid. According to the ionizable cationic grease, adsorption is formed by the structural design of the head and biological drugs such as nucleic acid, and the encapsulation efficiency is improved; the tail part adopts a saturated or unsaturated aliphatic chain to form a branch structure, and the head part and the tail part are connected by an ester bond, so that in-vivo degradation is facilitated to reduce toxicity; due to the design of the unsaturated aliphatic chain, the membrane flowability during release of the endosome is improved, and the release efficiency of the biological medicine is effectively improved; moreover, the ionizable cationic grease provided by the invention has good temperature stability, not only can the product quality be improved, but also the accessibility of the product is expanded. In a word, the ionizable cationic lipid disclosed by the invention has the advantages of high encapsulation efficiency, low toxicity, high endosome release efficiency, good temperature stability and the like, the quality and the treatment effect of lipid nanoparticle drugs can be improved, and a new scheme and a new choice are provided for biological drug delivery.

The invention relates to a petrochemical technology, in particular to a modified nano calcium carbonate material, a preparation method and application thereof and fracturing fluid. The molecular aggregate fluid dynamic diameter D10 of the modified nano calcium carbonate material in water is 2-10 [mu] m, the molecular aggregate fluid dynamic diameter D50 is 8-31 [mu] m, and the molecular aggregate fluid dynamic diameter D90 is 20-90 [mu] m. The preparation method of the modified nano calcium carbonate material comprises the following steps: carrying out hydroxylation treatment on unsaturated fat monobasic acid, and carrying out contact reaction on the hydroxylated unsaturated fat monobasic acid and a nano calcium carbonate raw material; and carrying out amination treatment on the product of the contact reaction. The modified nano calcium carbonate material not only has degradation performance meeting fracturing construction requirements, but also can realize multi-size plugging in tight reservoirs and improve the plugging rate of pore throats, and can enter the pore throats to adsorb and occupy space so as to reduce retention volume of fracturing fluid and reduce damage to the reservoirs.

This DNA methylation promoter contains a compound represented by formula (I), a racemate thereof, or a salt thereof. [In formula (I), X represents a carbon atom or an oxygen atom, R1 represents a saturated aliphatic hydrocarbon group optionally including a ring structure, R2 represents a saturated or unsaturated aliphatic hydrocarbon group that has 10-30 carbon atoms and that optionally has a substituent group which is an alkyl group having 1-4 carbon atoms or an alkoxy group having 1-4 carbon atoms, a carbon atom of a glycerol skeleton optionally has a substituent group, * represents an oxygen atom bound to R3, and R3 represents an AA optionally having a substituent group.]

The invention discloses application of natural unsaturated fatty aldehyde in prevention and control of storage pests. The natural unsaturated fatty aldehyde is trans-2, 4-heptadienal and trans-2-heptenal, and the natural unsaturated fatty aldehyde is trans-2, 4-heptadienal and trans-2-heptenal. The storage pests comprise coleoptera storage pests such as rice weevil, corn weevil, callosobruchus chinensis, coffee weevil, salopterus sajori, tribolium cavaleriei, delavay beetle, barbeque beetle, lasioderma serricorne, round bark beetle, black bark beetle and melanogaster, and lepidoptera storage pests such as corcyra cephalonica, wheat moth, Indian rice moth, diplodia rubella and mediterranean sea moth. The invention discloses that trans-2, 4-heptadienal and trans-2-heptenal can show excellent stored insect killing activity in a fumigation manner for the first time, provides a basis for developing green and environment-friendly insecticides, and has a good application prospect of replacing traditional chemical insecticides.

The present application relates to the technical field of 5G high-frequency copper-clad plate, and particularly relates to polyimide, a preparation method thereof, a composition and a polyimide film. The polyimide is shown as formula 1, wherein n is an integer of 10-100; A is selected from one or more of substituted or unsubstituted aromatic hydrocarbon groups, saturated or unsaturated aliphatic groups; R1 is selected from substituted or unsubstituted saturated aliphatic hydrocarbon groups; and R is selected from one or more of substituted or unsubstituted aromatic hydrocarbon groups, saturated or unsaturated aliphatic groups. The present application adopts an anhydride containing a terminal carboxyl structure, seals the polyimide to form an oligomer prepolymer containing a carboxyl group, and then introduces a fatty alcohol containing a terminal hydroxyl group to form an ester group structure, so as to obtain a polyester polyimide. The material has a lower dielectric constant and higher adhesion. The polyimide is applied to thermoplastic polyimide (TPI), and the pressure bonding temperature is lower.

The roller end sealing device comprises a rubber fixing part, a sealing lip part and a framework part located between the rubber fixing part and the sealing lip part, and the inner end face of the sealing lip part is provided with a first sealing lip located on the medium side, a second sealing lip located on the air side and a third sealing lip located on the air side. Wherein the first sealing lip makes contact with the surface of the shaft body, non-contact gaps are formed between the second sealing lip and the shaft body and between the third sealing lip and the shaft body, and oleamide materials are doped in the first sealing lip and used for forming a lubricating grease film on the surface of a lip opening of the first sealing lip. According to the design scheme, the multiple sets of lip bodies making contact with or not making contact with the shaft body are integrated on the sealing lip part, oleamide is doped in the lip bodies making contact with the shaft body, an ultra-thin lubricating oil film can be formed in the using process, and the requirement for high-speed and grease lubrication can be met under the working conditions of high speed and grease lubrication; and meanwhile, the problems of lubrication, cooling, pollution prevention and leakage prevention of the sealing lip are solved.

The application provides a preparation method of a corrosion-resistant nanometer wave-absorbing agent, paint and application, and the preparation method comprises the following steps: S1, mixing polyunsaturated fatty acid, polyunsaturated fatty amine and trivalent iron raw materials in a stirrer until the mixture is uniform, heating at 100-150 DEG C for 20-60 min to remove moisture; S2, preheating the reaction system at 200-250 DEG C for 20-60 min, heating to 270-300 DEG C for 20-60 min, and naturally cooling to room temperature; S3, discarding the solution after heating reaction, then adding an organic solvent, mechanically stirring for 20-50 min, and then performing solid-liquid separation, and drying to obtain the product. According to the control of the addition proportion of the reaction raw materials, the particle size, micro-morphology and electromagnetic absorption performance of the final wave-absorbing agent can be changed, and the optimization and improvement of the electromagnetic wave absorption capacity can be realized; the ester organic matter wrapped outside in the reaction process can form a capsule protection layer outside the nanoparticles, isolate external corrosion elements, and itself does not have dielectric characteristics, and has good hydrophobicity, so that the corrosion resistance of the magnetic electromagnetic absorbing agent can be effectively improved.

Corrosion protection agents, in particular for cavity preservation, containing: - at least one corrosion protection additive selected from alkali and alkaline earth sulfonates, salicylates, wool grease and combinations thereof, - at least one unsaturated compound (1) selected from unsaturated oils, unsaturated fats and / or unsaturated fatty acids, wherein a proportion of the unsaturated compound (1) is 1.5 to 2.1% by mass, based on the total weight of the corrosion inhibitor, and - urea (8) and / or at least one urea derivative, wherein a proportion of the urea (8) and / or the at least one urea derivative is less than 5% by mass, based on the total weight of unsaturated compound (1).

An aqueous cosmetic composition for keratin fibers comprising: a) at least one acetylated or non-acetylated glucomannan polymer, b) at least one linear or branched, saturated or unsaturated C12-C22 fatty alcohol, c) at least one conditioning agent.

A long-chain composition has at least one long-chain alkane selected from the group consisting of C9-18 linear or branched alkanes and at least one long-chain carboxylic acid selected from the group consisting of C9-18 linear or branched, saturated or unsaturated aliphatic monocarboxylic acids. The mass ratio of the long-chain alkane to the long-chain carboxylic acid ranges from 1:1 to 40:1. The long-chain composition has a higher fermentation degree or higher substrate utilization rate and the like, when used as a starting material in the production of long-chain dibasic acids via fermentation.

The present invention discloses an amphiphilic molecule, a micelle, and a preparation method and application thereof. The amphiphilic molecule of the present invention is composed of structural units of mannose, polytyrosine, and fatty amine connected together; wherein, the polytyrosine is selected from a peptide chain polymerized by 2 to 8 tyrosine molecules; the fatty amine is selected from C 16 or C 18 saturated or unsaturated fatty amines. The micelle prepared from the above amphiphilic molecule can be used to prepare a drug for treating melanoma, can be used to inhibit the growth and metastasis of malignant melanoma, but has very high biosafety for normal cells. The melanin endogenously produced in melanoma induced by it can be used for subsequent efficient photothermal therapy, providing a safe and reliable technical means for melanoma treatment and having good clinical application prospects.

The invention relates to the technical field of nutritional agents, and particularly discloses an enteral nutritional agent. The enteral nutritional agent comprises protein, saturated fat, unsaturated fat, carbohydrate, maltodextrin, corn starch, oligosaccharide, vitamin A, vitamin C, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, nicotinic acid, folic acid, calcium, phosphorus, potassium, zinc, magnesium, iron, copper, manganese, selenium, glutamine, dietary fiber nucleotide, choline and the like. According to the invention, whey protein, casein and other high-quality proteins are used as main components, are rich in essential amino acids for human bodies, are high in bioavailability, can fully meet the requirement of mass loss of proteins caused by skin barrier damage of burn patients, and provide a key material basis for wound healing and body repair. Meanwhile, sufficient energy is provided for patients, and the risk of cardiovascular diseases is reduced. And various vitamins and minerals can promote epithelial tissue repair, resist oxidation and enhance immunity.

The present invention relates to a method for biosynthesizing unsaturated C-terminal polyols which can be used as insect pheromones, spices, flavoring agents and polymer intermediates. 6 ‑C 24 The recombinant microorganism can express the recombinant microorganism for producing unsaturated C 6 ‑C 24 The enzymes or enzyme variants that produce fatty alcohols, fatty aldehydes, and fatty acetates and / or can be modified to down-regulate the pathway to divert production toward unsaturated C 6 ‑C 24 Fatty alcohols, fatty aldehydes and fatty acetates. 6 ‑C 24 Fatty alcohols, fatty aldehydes and fatty acetates can be used as substrates for metathesis reactions to expand the library of target compounds and pheromones. Also provided is a method for producing unsaturated C 6 ‑C 24 Methods for producing fatty alcohols, fatty aldehydes and fatty acetates, and compositions comprising the recombinant microorganisms and / or optionally one or more of the product alcohols, aldehydes or acetates.

The present application relates to the technical field of organic synthesis, and particularly provides a polyimide and a preparation method and a composition thereof.The polyimide of the present application is shown as formula 1, wherein n is an integer of 10-100; A is selected from one or more of substituted or unsubstituted aromatic hydrocarbon groups, saturated or unsaturated aliphatic groups; R1 is selected from one or more of hydrogen, alkyl, cycloalkyl, aryl; and R is selected from one or more of substituted or unsubstituted aromatic hydrocarbon groups, saturated or unsaturated aliphatic groups.The present application adopts an anhydride containing a terminal carboxyl structure, and terminates the polyimide to form an oligomer prepolymer containing a carboxyl group, and then introduces a polyphenyl ether containing a terminal hydroxyl group to form an ester group structure, so as to obtain a polyester imide.The material has a lower dielectric constant and higher adhesion, and the polyimide is applied to a thermoplastic polyimide (TPI), so that the pressure bonding temperature is lower.

The present application relates to a kind of fatty acid continuous separation system, utilize the different separation adsorption material to different saturation fatty acid adsorption ability different characteristics, realize the continuous separation of fatty acid on separation device, reach the accurate separation of different carbon chain length C12-C24 fatty acid, different double bond number fatty acid.The system can separate saturated fatty acid, unsaturated fatty acid and monounsaturated fatty acid, polyunsaturated fatty acid in fatty acid gradually, continuously;And saturated fatty acid separation rate is as high as 85% or more, unsaturated fatty acid separation rate is as high as 90% or more, wherein monounsaturated fatty acid separation rate is as high as 85% or more, polyunsaturated fatty acid separation rate is as high as 85% or more, with excellent market application prospect.

The application discloses an environment-friendly waterproof carton and a preparation method thereof, and relates to the technical field of waterproof cartons. The environment-friendly waterproof carton is prepared by coating a waterproof coating emulsion on the surface of a paperboard, solidifying, and folding; the waterproof coating emulsion comprises the following raw material components in a weight ratio: 30-40 parts of modified polyvinyl alcohol, 15-20 parts of modified starch, 6-10 parts of epoxy soybean oil, 0.2-0.4 parts of alkyl polyglycoside, and 40-50 parts of deionized water; wherein the modified polyvinyl alcohol is prepared by esterification modification grafting of polyvinyl alcohol with unsaturated fatty acyl chloride and saturated fatty acyl chloride, and then grafting with polycaprolactone-sulfhydryl through a sulfhydryl-alkene click reaction; and the modified starch is prepared by esterification modification grafting of starch with saturated fatty acyl chloride, and then carboxymethylation treatment.

The invention discloses a preparation method and a separation and purification method of all-cis and / or all-trans long-chain monounsaturated fatty acid and / or long-chain monounsaturated fatty alcohol. The structure of the all-cis and / or all-trans long-chain monounsaturated fatty acid and / or long-chain monounsaturated fatty alcohol is as shown in the following formula I. The invention further discloses a preparation method and a separation and purification method of the all-cis and / or all-trans long-chain monounsaturated fatty acid and / or long-chain monounsaturated fatty alcohol. The compound can be applied to preparation of lipid materials and ionizable lipid materials and further construction of drugs and gene delivery carriers.

A topical cyclooxygenase (COX) inhibitor formulation comprising an inhibitor of COX-1 and / or COX-2, one or more long chain monounsaturated fatty acids, long chain monounsaturated fatty alcohols, terpenes, or combinations thereof; and a solvent mixture comprising ethanol, propylene glycol, 2-(2-Ethoxyethoxy)ethanol, and optionally dimethylsulfoxide.

Provided herein are polyesters that comprise (i) monomer units derived from sugar-based bicyclic diol; (ii) monomer units derived from an unsaturated aliphatic diacid; and (iii) monomer units derived from a saturated aliphatic diacid. The monomer units derived from the ethylenically unsaturated aliphatic diacid can be present in an amount of from greater than 0 mole % to 40 mole % of the polyester. These polyesters can be formed into articles using additive manufacturing methods. The resulting articles can be biocompatible, resorbable over a span of from 3 months to 12 months following implantation in the human body, and can exhibit desirable mechanical properties for applications, including porosity and elasticity.

The application discloses ionizable cationic lipids and application thereof. The ionizable cationic lipids of the application can form adsorption with biological drugs such as nucleic acids through structural design of a head part, so as to improve encapsulation efficiency; a saturated or unsaturated fatty chain is used to form a branched structure in a tail part, and an ester bond is used to connect the head part and the tail part, so as to facilitate in-vivo degradation and reduce toxicity; the design of the unsaturated fatty chain increases membrane fluidity during endosome release, so as to effectively improve the release efficiency of biological drugs; and the ionizable cationic lipids of the application have good temperature stability, which can not only improve product quality, but also expand product accessibility. In a word, the ionizable cationic lipids of the application have the advantages of high encapsulation efficiency, low toxicity, high endosome release efficiency and good temperature stability, can improve the quality and treatment effect of lipid nanoparticle drugs, and provide a new scheme and selection for biological drug delivery.

The invention discloses a preparation method of stable Pickering emulsion based on thirteen-spice powder, and relates to the technical field of emulsion stabilization, and the preparation method comprises the following steps: sieving thirteen-spice powder through a sieve of two hundred meshes, dispersing different amounts of thirteen-spice powder in distilled water to form mixed liquid by taking distilled water as a water phase, adding oil phases with different volume fractions into the mixed liquid, and uniformly mixing to obtain the stable Pickering emulsion based on thirteen-spice powder. After mixing, shearing by using a high-speed shearing machine, transferring the obtained mixture into a flat-bottomed glass bottle, and storing at low temperature for subsequent experiments; food-borne solid particle thirteen-spices are adopted as a stabilizer, rich dietary fibers, low cholesterol and high raw material safety are contained, corn oil and distilled water are selected as solutions, and the corn oil is rich in nutrition and high in unsaturated fat content, can be used as a fat substitute, has antioxidant activity and antibacterial performance, can be used as an antibacterial emulsion, and can be used as an anti-aging agent. And the texture and taste of food can be improved.

The invention provides a central nervous system delivery structure as well as a conjugate, a preparation method and application thereof. The delivery structure is represented by L-R, where L is a lipophilic group and R is a group comprising a structure for covalent attachment to a nucleic acid molecule; the lipophilic group is selected from a saturated or unsaturated hydrocarbyl group, a saturated or unsaturated fatty acid, and a saturated or unsaturated fatty alcohol; the structure covalently linked with the nucleic acid molecule comprises an-O-group in a hydroxyl group, and is covalently linked with a phosphorothioate group or a phosphate group of the nucleic acid molecule through the-O-group; r at least comprises an optionally substituted cycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted heteroaryl group or an optionally substituted aryl group. The delivery structure is high in delivery efficiency, low in toxicity and simple in preparation method.

A dissolvable solid article, comprising: water soluble polymer; a surfactant; at least one selected from diaminocarboxylic acid chelants and salts thereof; at least one selected from aromatic carboxylic acids and salts thereof; a phenolic derivative; at least one selected from α, β-unsaturated Aliphatic Carboxylic Acids, salts, and derivatives thereof; at least one selected from non-aromatic organic alpha hydroxy acids and salts thereof; wherein the dissolvable solid article has a pH of from about 3 to about 5.5 when dissolved with 20 parts water to 1 part of the dissolvable solid article. The present invention provides dissolvable solid articles which provide preservative efficacy even after dissolution of the articles, while controlling the concentrations of preservative ingredients in the solid articles.

An acid-soluble nano material and a preparation method therefor and a use thereof, and a fracturing fluid, relating to petrochemical technology. The hydrodynamic particle size D10 of molecular aggregates of the acid-soluble nano material in water is 2-10 μm, D50 is 8-31 μm, and D90 is 20-90 μm. The preparation method for the acid-soluble nano material comprises: carrying out hydroxylation treatment on an unsaturated fatty monoacid, and carrying out a contact reaction between the hydroxylated unsaturated fatty monoacid and a nano carbonate raw material; and carrying out amination treatment on a product of the contact reaction, wherein the nano carbonate raw material contains a nano calcium carbonate raw material and / or a nano magnesium carbonate raw material. The acid-soluble nano material has the dissolution performance meeting fracturing construction requirements, can realize multi-size plugging in a compact reservoir and improve the plugging rate of a pore throat, and can enter the pore throat for adsorption and space occupation to reduce the retention amount of the fracturing fluid, thereby reducing damage to the reservoir.

An acid-soluble nano material and a preparation method therefor and a use thereof, and a fracturing fluid, relating to petrochemical technology. The hydrodynamic particle size D10 of molecular aggregates of the acid-soluble nano material in water is 2-10 µm, D50 is 8-31µm, and D90 is 20-90µm. The preparation method for the acid-soluble nano material comprises: carrying out hydroxylation treatment on an unsaturated fatty monoacid, and carrying out a contact reaction between the hydroxylated unsaturated fatty monoacid and a nano carbonate raw material; and carrying out amination treatment on a product of the contact reaction, wherein the nano carbonate raw material contains a nano calcium carbonate raw material and / or a nano magnesium carbonate raw material. The acid-soluble nano material has the dissolution performance meeting fracturing construction requirements, can realize multi-size plugging in a compact reservoir and improve the plugging rate of a pore throat, and can enter the pore throat for adsorption and space occupation to reduce the retention amount of the fracturing fluid, thereby reducing damage to the reservoir.

The application discloses a low-temperature self-healing full-biological-based elastomer and belongs to the technical field of materials. The full-biological-based elastomer is synthesized by using a carboxyl-terminated low-molecular-weight biological-based unsaturated aliphatic prepolymer which is synthesized by polycondensation of nontoxic and renewable biological resources dihydric alcohol and diacid and then is crosslinked by an epoxy structure. The elastomer prepared by the application contains a physical crosslinking double dynamic network formed by beta hydroxy ester groups dynamic covalence and H bonds, which endows the full-biological-based elastomer with the functions of self-healing at low temperature and reprocessing of the material. The full-biological-based elastomer is prepared by using full-biological-based monomers, does not depend on fossil resources, and has simple preparation process, and can be used in multiple fields such as flexible wearable sensors and organic solar power generation.

The application discloses a kind of self-assembled nano-preparations based on hyaluronic acid-fatty acid coupling prodrug, the self-assembled nano-preparations use hyaluronic acid-fatty acid coupling prodrug as active ingredient, the hyaluronic acid-fatty acid coupling prodrug has structure shown in formula I, wherein, R is saturated or unsaturated fatty acyl;N=1~900, m=0~899.The application also discloses the preparation method of the above-mentioned self-assembled nano-preparations, and the application of the above-mentioned self-assembled nano-preparations in preparing anti-colitis drugs.The application avoids using pharmaceutical adjuvant, can avoid the allergic reaction and toxicity caused by adjuvant, has good biocompatibility and can be biodegraded, has good clinical conversion prospect.And it can realize intestinal inflammatory site and M1 macrophage target enrichment, eliminate excess ROS while inhibiting inflammatory response, has better anti-intestinal inflammation efficacy compared with clinical 5-amino salicylic acid, dexamethasone.

The invention discloses application of natural unsaturated fatty aldehyde to prevention and control of plant parasitic nematodes. The natural unsaturated fatty aldehydes are trans-2, 4-heptadienal and trans-2-heptenal, and the natural unsaturated fatty aldehydes are trans-2, 4-heptadienal and trans-2-heptenal. The plant parasitic nematodes are root-knot nematodes, cyst nematodes and pine wood nematodes. The trans-2, 4-heptadienal and the trans-2-heptenal can show excellent nematicidal activity in a contact killing and fumigation mode, a basis is provided for developing a green and environment-friendly nematicide, and the compound has a good application prospect of replacing a traditional chemical nematicide.