277 results about "Vitamin b" patented technology

The invention provides a composition beneficial to improvement of brain cognition, memory and sleep and prevention and improvement of Alzheimer's disease, and belongs to the technical field of health food. The composition comprises L-alpha-glycerophosphorylcholine (GPC), phosphatidylserine (PS), docosahexaenoic acid (DHA), tea leaf theanine (L-theanine), vitamin B groups, vitamin D3 and the like, and is prepared into a health care product, a dietary supplement, a functional food, a medical food or a nutritional supplement by adopting the existing technology. The traditional Chinese medicine composition has the effects of effectively nourishing nerve cells, improving the brain sensitivity and improving the cognitive function. The composition is particularly directed at age-related cognitive decline and neurodegenerative diseases. Repair and regeneration of nerve cells can be promoted, the transmission efficiency of neural signals is enhanced, and the overall working efficiency of the brain is improved. Daily life challenges caused by cognitive decline can be relieved, and individual life quality can be improved.

The invention relates to an oral mucosa repairing medicine and a preparation method thereof, and belongs to the technical field of medicines, the medicine comprises barnacle peptide, salivary lactobacillus, resveratrol, a biphasic adhesion matrix, hydroxyapatite, vitamin B family and other components. The preparation method comprises the following steps: sequentially carrying out enzymolysis on barnacle gooseneck by pepsin and lumbrukinase to obtain barnacle peptide. The double-phase adhesion matrix comprises a water-phase matrix, an oil-phase matrix and lecithin; the water-phase matrix contains a chondroitin sulfate-chitosan quaternary ammonium salt compound, sodium alginate and other components; the oil-phase matrix comprises sesame oil, beeswax, a polylactic acid-glycolic acid copolymer and the like. According to the invention, barnacle peptide and salivary lactobacillus are prepared by adopting a special method and are matched with resveratrol for use, so that multi-target and multi-path promotion of oral mucosa repair can be realized; the chondroitin sulfate-chitosan quaternary ammonium salt compound is prepared through electrostatic and physical embedding, the chondroitin sulfate-chitosan quaternary ammonium salt compound is matched with other components to prepare the biphasic adhesion matrix, the biocompatibility is good, the adhesion is high, and the action time of a sustained-release drug is well prolonged.

The invention discloses a preparation method of visible-light-cured fibroin / sericin protein hydrogel, silk fibers containing different amounts of sericin are obtained by adjusting the concentration of a degumming reagent and the degumming time, the silk fibers are directly dissolved to prepare a fibroin / sericin protein composite aqueous solution by a one-step method, extra extraction of sericin or addition of sericin protein powder is not needed, and the preparation method is simple and convenient. The cost is reduced while the preparation process is greatly shortened; environment-friendly and nontoxic riboflavin (vitamin B2) is used as a photoinitiator, and crosslinking can be initiated under visible light without using ultraviolet light; the visible light curing fibroin / sericin hydrogel makes full use of respective performance advantages of silk fibroin and sericin in silk fibers, is safe in components, free of additional chemical cross-linking agents, good in light transmission, good in biocompatibility, high in elasticity, especially suitable for the field of biomedical materials, short in preparation process, short in time consumption and high in efficiency.

The invention discloses a cultivation material for increasing the content of B vitamins of straw mushrooms and application of the cultivation material in straw mushroom cultivation. The cultivation material is formed by mixing and fermenting the following components in percentage by weight: 52-72% of pilose antler mushroom dregs, 10-20% of rice straws, 15-25% of waste cotton and 3% of lime. The contents of vitamin B3, vitamin B5, vitamin B6 and vitamin B12 in the volvariella volvacea sporocarp cultivated by adopting the cultivation material disclosed by the invention are obviously increased, the nutritional value of the volvariella volvacea is increased, and the market competitiveness and economic benefits of products are greatly enhanced. The pilose antler mushroom residues are used for replacing part of waste cotton raw materials, the production cost is reduced, meanwhile, efficient recycling of agricultural waste is achieved, and the method is suitable for large-scale industrial production.

The invention relates to the technical field of pet feed additives, and discloses a feed additive capable of relieving animal hair falling and a preparation method of the feed additive capable of relieving animal hair falling. Comprising the following substances: 5 parts of an angelica sinensis extract, 10 parts of a cacumen biotae extract, 1.51 parts of vitamin B family, 0.1 part of vitamin H, 1 part of zinc, 0.1 part of selenium, 5 parts of methionine and 5 parts of cysteine. According to the feed additive capable of relieving animal hair falling, the hair quality can be improved, and hair falling can be reduced; the strength and the elasticity of hair are improved; healthy hair growth is promoted; the composition has the advantages that the health of the skin and hair follicles is enhanced, a better growth environment is provided for the hair, the healthy hair state of animals can be maintained, and the hair loss phenomenon caused by nutrition deficiency or environmental problems is reduced.

The invention relates to the technical field of daily chemicals, in particular to an anti-hair-loss composition and shampoo. The composition comprises a soapberry fruit extract, a cacumen biotae extract, a ginseng root extract and a peptide compound. By removing dirt, grease and dead skin cells on the scalp, the anti-hair loss shampoo is beneficial to keeping the scalp clean and preventing hair follicle blockage, so that the hair growth environment is improved. The hair conditioner contains components (such as ginseng and cacumen biotae) capable of promoting blood circulation, and provides more nutrition for hair follicles and promotes hair growth by stimulating blood flow of the hair follicles. The hair conditioner contains plant extract, vitamin B group, amino acid and other components, and can nourish hair follicles, strengthen hair roots and reduce hair loss.

The invention discloses a method for preparing a liquid fertilizer from vitamin B12 waste liquid, and relates to the field of liquid fertilizers. When the liquid fertilizer is prepared, the vitamin B12 waste liquid is filtered and then subjected to alkaline pretreatment, and solid protein and filtrate are obtained through separation; acidifying the filtrate with sulfuric acid, adding potassium hydroxide, and concentrating under reduced pressure to obtain regenerated mixed salt; carrying out flash explosion treatment on the solid protein, and carrying out enzymolysis by using trypsin and subtilisin to obtain a proteolysis solution; urea, formaldehyde and dimethyl hydrogen phosphate are mixed to prepare slow-release phosphorus-nitrogen macromolecules; and uniformly mixing the protein enzymatic hydrolysate, the regenerated mixed salt, fulvic acid, slow-release phosphorus-nitrogen macromolecules and deionized water to obtain the liquid fertilizer. The prepared liquid fertilizer has the advantages of excellent long-term effect, easy absorption and waste liquid utilization rate.

The invention discloses an application of a dendrobium extract in preparation of a medicine for treating type 2 diabetes, and mainly relates to the technical field of dendrobium. Particularly, the invention provides the dendrobium extract-containing medicine for treating the type 2 diabetes, so that the stability of components applied to the medicine for treating the type 2 diabetes in acidic, neutral and alkaline environments is improved, and the blood sugar rising amplitude is slowed down. Compared with the prior art, the medicine for treating type 2 diabetes mellitus prepared by the invention takes the dendrobium extract as a core and is matched with the synergistic emulsion, the rhizoma polygonati extract, the dogwood extract, the radix salviae miltiorrhizae extract, the bitter gourd extract, the vitamin B and the trace element chromium element; the traditional Chinese medicine composition disclosed by the invention can be used for synergistically regulating blood sugar metabolism, enhancing insulin sensitivity, improving microcirculation, stabilizing blood sugar, improving insulin resistance and lipid metabolism and enhancing immunity and cardiovascular functions, and a safe and effective medicine is provided for preventing and treating type II diabetes.

The invention belongs to the technical field of medicines and health-care products, and discloses an earthworm protein peptide polypeptide tablet with functions of dissolving thrombus and protecting blood vessels. Comprising the following components in parts by mass: 20 to 50 parts of earthworm protein peptide, 30 to 40 parts of sorbitol, 2 to 5 parts of lactose, 2 to 10 parts of freeze-dried natto powder, 2 to 10 parts of rice bran fatty alkanol, 1 to 5 parts of dunaliella salina powder, 1 to 5 parts of bovine myocardial peptide powder, 0.01 to 0.05 part of collagen peptide, 0.01 to 0.05 part of soybean peptide powder, 0.01 to 0.05 part of vitamin B6, 0.04 to 0.12 part of a compound nutrition enhancer, 1 to 5 parts of fructo-oligosaccharide, 0.01 to 0.05 part of magnesium stearate and 0.04 to 0.012 part of a compound coating agent. The earthworm protein peptide polypeptide tablet has the effects of thrombolysis and blood fat reduction, can assist in preventing thrombosis, regulating blood fat metabolism and assisting in reducing cholesterol, and has an antioxidant function.

A microbial composite reagent, a preparation method thereof, and a method for removing perfluorooctanoic acid are disclosed. The preparation method of the microbial composite reagent includes steps of: preparing a glucose-based carbonaceous material by pyrolyzing glucose at 400° C. to 1000° C. for at least 0.5 hours under a protective atmosphere; mixing perfluorooctanoic acid-contaminated soil with a basal medium, molasses, a vitamin B, and water, and subjecting the mixture to microbial acclimation under an anaerobic condition to obtain an acclimated microorganism solution; subjecting the glucose-based carbonaceous material to microbial loading by anaerobically mixing the glucose-based carbonaceous material with the acclimated microorganism solution, thereby obtaining the microbial composite reagent.

A lamb stomach extract Vitamin B12 preparation composition composed of lamb stomach extract and Vitamin B12 is provided. The lamb stomach extract has a chymosin activity of >40 U / g and a pepsin activity of >15 U / g, and the weight ratio of the lamb stomach extract and Vitamin B12 is 100000:0.5-5, which is useful in the treatment of moderate-to-severe chronic atrophic gastritis, intestinal metaplasia reversal, and gastric cancer prevention. Lamb stomach extract and Vitamin B12 produced synergistic or synergistic effects in specific ratios.

The invention provides a method for preparing a protease beverage by fermenting cyperus esculentus powder and a product thereof. Comprising the steps of directional pretreatment, fermentation medium preparation, segmented fermentation and optional blending, specifically, directional pretreatment adopts low-temperature extrusion at the temperature of 60-70 DEG C and ultrasonic treatment at the power of 200-300 W for cooperative treatment, and the fiber structure and antinutritional factors of soybean meal are effectively broken; in the fermentation stage, lactobacillus plantarum, saccharomyces cerevisiae and bacillus coagulans composite flora are inoculated, anaerobic fermentation is performed at the temperature of 35-37 DEG C, the pH value of the system is reduced to 4.0-4.5, and then L-cysteine hydrochloride-vitamin B synergist is added for secondary fermentation in a micro-aerobic environment at the temperature of 38-40 DEG C. The fermentation process provided by the invention is simple, the treatment is convenient, the used equipment is conventional equipment in the food industry, and the method is suitable for large-scale industrial production. Meanwhile, in the prepared fermentation liquor, the protease activity is larger than or equal to 320 U / mL, the total number of viable bacteria is larger than or equal to 1.2 * 10 CFU / mL, the optimum pH of the protease is 3.8-4.8, the optimum temperature is 37-39 DEG C, the protease is highly matched with the human gastrointestinal tract environment, and the method has wide industrialization prospects.

The invention discloses low-alcohol rose and litchi monascus rice wine and a making method thereof, and belongs to the technical field of food and beverage fermentation engineering. The rose and the litchi are organically combined with the monascus rice wine, the composite flavor of the rose and the litchi is given to the monascus rice wine, the defect that a traditional monascus rice wine body is prominent in sourness is overcome, and meanwhile the mood after drinking of the monascus rice wine can be relieved through the sedative effect of the rose and vitamin B in the litchi; in addition, polyphenol compounds, flavonoid compounds and vitamin C are introduced into the wine body, the polyphenol compounds in the roses and vitamin C antioxidant components in the litchis cooperate with each other, the antioxidant effect of the monascus rice wine is enhanced, damage caused by oxidative stress is reduced, and the health-care effect of the monascus rice wine is improved. The litchi is rich in vitamin C, so that the absorption of non-heme iron in the roses is effectively improved, the absorption rate of the iron element is improved, and the monascus rice wine also has an excellent anti-oxidation effect and an effect of promoting the absorption of the iron element.

The invention discloses a garden branch decomposition inoculant and a preparation method thereof, and relates to the technical field of garden waste treatment.The garden branch decomposition inoculant is composed of microbial strains, organic matter, inorganic nutrients and adjuvants.The garden branch decomposition inoculant shows excellent performance advantages through unique component combination, and the preparation method is simple. A plurality of microbial strains have a synergistic effect, the bacillus subtilis firstly decomposes protein and starch, the bacillus licheniformis inhibits harmful microorganisms and assists cellulose decomposition, and the sporotrichum thermophilus focuses on overcoming cellulose and lignin, so that the decomposition rate of the branches is greatly increased, and the decomposition rate of the branches is increased. Organic substances and inorganic nutrients provide sufficient and balanced nutrient sources for microorganisms and promote vigorous growth and reproduction of the microorganisms, enzyme and vitamin B are added to further enhance the activity of the microorganisms and accelerate the decomposition process, and after the decomposition agent is applied to soil, the soil structure can be remarkably improved, the soil porosity can be increased, and the soil quality can be improved. The air permeability of the soil is better.

The invention belongs to the technical field of biological medicines, and particularly relates to a nutritional composition as well as a preparation method, application and a product thereof. The nutritional composition provided by the invention consists of nicotinamide, B vitamins and a fungal polysaccharide compound, the vitamin B consists of vitamin B1, vitamin B2, vitamin B6, vitamin B12 and folic acid; the fungal polysaccharide compound is composed of a lucid ganoderma extract, a mushroom extract, an agaricus blazei murill extract, a hericium erinaceus extract, a coprinus comatus extract, a grifola frondosa extract and a cordyceps militaris extract. Western medicine source substances (nicotinamide and B vitamins) and traditional Chinese medicine source substances (fungal polysaccharide compounds) are combined, and the nutrition composition is prepared through combination of the Chinese medicine and the western medicine. The nutritional composition has remarkable effects of enhancing immunity, delaying senescence, resisting fatigue and resisting oxidation, and shows extremely wide application prospects in the field of preparation of health-care products, medicines and cosmetics.

The invention provides a collagen-containing composition which comprises the following components in parts by weight: 15-30 parts of a collagen mixture, 10-20 parts of a plant extract, 2-4 parts of a vitamin mixture, 1-3 parts of D ribose and 3-7 parts of glucosamine, the collagen mixture is fish scale collagen, deer collagen and bovine bone collagen; the plant extract is an ethanol extract obtained by mixing rhizoma phragmitis, cherries, grapes, liriodendron tulipifera, blueberries, caulis sinomenii and sagittaria sagittifolia; the vitamin mixture is a mixture of vitamin B, vitamin C and vitamin E; when the composition is applied to food, the effects of obviously improving skin and resisting aging can be achieved.

The invention discloses an infinitesimal bio-enzyme fertilizer capable of degrading pesticide residues of crops as well as a preparation method and application of the infinitesimal bio-enzyme fertilizer, and belongs to the technical field of bio-fertilizers. The infinitesimal biological enzyme fertilizer is prepared from the following components in parts by weight: 600 to 700 parts of water, 100 to 150 parts of immobilized beneficial microorganism bacterial material, 80 to 120 parts of activated carbon, 31 to 62 parts of amino acid material, 55 to 65 parts of organic material, 35 to 50 parts of mineral material, 32 to 64 parts of enzyme-containing base material, 1 to 5 parts of vitamin B material, 1 to 2 parts of vitamin C, 5 to 10 parts of acid-base balancing agent, 1 to 2 parts of plant growth regulator and 0.1 to 0.5 part of modified nano-selenium, the modified nano-selenium is prepared from zinc selenite, potassium selenite, sodium selenite and calcium selenite through reduction modification; the immobilized beneficial microbial material is prepared by beneficial microbial fermentation, immobilization and reinforcement. The infinitesimal biological enzyme fertilizer provided by the invention can improve the pesticide degradation rate.

The invention discloses a composition and a preparation method of a single-dose vitamin B12 eye drop without a bacteriostatic agent, and the single-dose vitamin B12 eye drop without the bacteriostatic agent is prepared from vitamin B12, a buffering agent, sodium hyaluronate, edetate disodium and water for injection. According to the vitamin B12 eye drops and the preparation method thereof disclosed by the invention, the vitamin B12 eye drops are produced by adopting a totally-closed sterile filling process, and a disposable single-dose packaging container is arranged, so that the sterility of medicines is ensured, and meanwhile, the use safety, the operation convenience index and the safety performance are improved.

The present invention relates to a composition in the form of a water-in-oil emulsion, comprising: a) at least one oily continuous phase comprising at least one volatile oil chosen from volatile hydrocarbon oils, volatile silicone oils and their mixtures, and b) at least one aqueous phase dispersed in said oily phase, the amount of water being greater than or equal to 20% by weight, with respect to the total weight of the composition, and c) at least one hydrophobic film-forming polymer, and d) at least one emulsifying surfactant chosen from polyoxyalkylenated linear polydimethylmethylsiloxanes with an HLB ≤ 8.0, and e) at least 3.0% by weight of a vitamin B3 and / or one of its derivatives, with respect to the total weight of the composition, said composition not containing a water-soluble organic UV screening agent comprising at least one benzylidenecamphorsulfonic acid group nor a water-soluble organic UV screening agent comprising at least one benzoxazolesulfonic acid group.

Disclosed are compositions, devices, and methods to prevent and recover from detrimental effects of alcohol consumption, including significant undesirable symptoms of a hangover consciously felt by the alcohol consumer, as well as those that may not be consciously experienced. The present technology comprehensively targets multiple negative effects of hangovers. In one aspect, a composition includes dihydromyricetin (DHM); and N-acetyl cysteine (NAC). The composition may further include Prickly Pear Extract, Milk Thistle, Ginger Root, Vitamins B, C, and E, electrolytes, and / or sugars.

To provide a pharmaceutical composition for treating hypercortisolism in a subject of Cushing's syndrome.SOLUTION: A pharmaceutical composition contains levoketoconazole or a pharmaceutically acceptable salt thereof, and is administered to a subject in need thereof in a therapeutically effective amount. The pharmaceutical composition is administered with a therapeutically effective amount of metformin or a pharmaceutically acceptable salt thereof. The subject also has type 2 diabetes and has had previous surgery or radiation to treat Cushing's syndrome. The therapeutically effective amount of the pharmaceutical composition is determined via a titration scheme including dose escalation of the pharmaceutical composition. When the subject experiences a dose limitation event, metformin or a pharmaceutically acceptable salt thereof is administered at a dose that is less than the therapeutically effective amount. The dose limitation event is reduction of a fasting blood glucose level, an abnormal renal function, a low vitamin B-12 level or any combination thereof.SELECTED DRAWING: None

The invention relates to the technical field of beverage processing, in particular to a corn juice compound beverage and a preparation method thereof. The feed comprises the following raw materials: corn, black rice, oat, carrots, corncob powder, orange peel, compound enzyme, beta-cyclodextrin, Arabic gum, inulin, a yeast extract, monopotassium phosphate, vitamin B and compound strains. The compound enzyme seed is prepared from the following components: alpha-amylase, pullulanase, tannase and neutral protease; the composite strain is prepared from the following components: saccharomycetes, lactobacillus plantarum and monascus purpureus. According to the corn juice composite beverage and the preparation method thereof, through multi-dimensional synergistic interaction, the beverage realizes a layering flavor with both freshness, fruity flavor and cereal sweetness and fragrance, an anti-oxidation network constructed by polyphenol, carotenoid and ferulic acid and an intestinal tract nursing effect brought by complementation of soluble-insoluble fibers form the corn juice composite beverage with functional value and sensory experience.

The invention discloses a beverage with a body warming effect and a preparation method of the beverage. The beverage is prepared from the following raw material components: ginger, organic lemon fermentation liquor, a grape seed extract, a lycium ruthenicum extract, aronia melanocarpa, rhizoma polygonati, astragalus membranaceus, red dates, vitamin B family, citric acid and water. The preparation method comprises the following steps: washing the ginger, the aronia melanocarpa, the astragalus membranaceus and the red dates with clear water, mixing, crushing and pulping to obtain a mixed liquid, and refrigerating at 4 DEG C for 30 minutes for later use; the preparation method comprises the following steps: weighing the grape seed extract, the lycium ruthenicum extract, the vitamin B group, the citric acid and the trace elements according to a ratio, uniformly mixing, then adding water at 50-70 DEG C, dissolving, and stirring for 10-20 minutes to obtain a mixed solution I; mixing the organic lemon fermentation liquor, the mixed slurry and the mixed solution I, stirring for 10-20 minutes, and cooling to 20 DEG C or below to obtain a mixed solution II; and sterilizing the mixed solution II at high temperature, filling a packaging bottle with the sterilized mixed solution II, and then filling the packaging bottle with a packaging box for packaging.

The present invention discloses an agricultural composition containing lecithin. Its active ingredients include component A and component B, wherein component A is lecithin and component B is a combination of one or both of vitamin B and vitamin E. Furthermore, the agricultural composition is used in combination with an additive package, wherein the active ingredients of the additive package are a combination of chitosan oligosaccharide and gamma-aminobutyric acid. Within a certain ratio range, the agricultural composition can enhance the stress resistance of crops, eliminate pesticide damage to crops, and promote crop growth.

The application belongs to the technical field of health products, and provides a growth-promoting amino butyric acid tablet and a preparation method thereof. 12 The preparation method of the amino butyric acid tablet is as follows: first, vitamin B1, vitamin B2, vitamin B6, vitamin B , vitamin D, folic acid and a first part of fillers are fully mixed and dried to obtain premix I; then, amino acids (gamma-amino butyric acid and L-lysine), the first part of premix I and a first part of binders are uniformly mixed; then, the remaining premix I is added and uniformly mixed to obtain premix II; then, calcium citrate, magnesium oxide, ferrous fumarate and sodium selenite are fully mixed, the remaining binders are dissolved in water and sprayed, wet granulation is carried out, and the granules are dried; finally, total mixing is carried out, and the tablet is pressed to be prepared. Through the improvement of the preparation process, the stability and content uniformity of B vitamins are improved, and the growth-promoting effect is improved.

The invention relates to the technical field of biology, and particularly discloses a special diet nutrient solution for promoting growth and development and a preparation method thereof. The invention discloses a special diet nutrient solution for promoting growth and development. Comprising the following raw materials in parts by weight: animal-derived collagen peptide, milk-derived peptide, isomaltooligosaccharide powder, plant-derived bioactive peptide, yeast extract, salmon nasal cartilage composite powder, cereal oligopeptide, N-acetylneuraminic acid, BioPerine black pepper extract, L-calcium lactate, zinc gluconate, magnesium gluconate, vitamin B group composition, beta-carotene powder and acerola cherry fruit powder. The sour cherry concentrated powder, the roxburgh rose powder, the seasoning components and the balance of purified water are added. The product disclosed by the invention has the advantages of being high in nutrient content, good in absorptivity and capable of promoting growth and development.

The present invention relates to a method for the treatment of keratin fibres comprising the application, to the fibres, of a composition comprising at least one chemical oxidizing agent, at least one (bi)carbonate and at least one silicate, this application being preceded and / or followed by the application, to the keratin fibres, of a composition comprising one or more compounds chosen from organic acids, amino acids, chitosans, vitamins B, vitamin C, vanillin, their salts, their solvates and their mixtures.

The invention relates to the technical field of foliar fertilizers, in particular to a foliar fertilizer for prolonging the leaf color viewing period of a color-leafed plant. The foliar fertilizer is prepared from the following components in 100 parts by weight: 0.5 to 1.5 parts by weight of vitamin B compounds, 0.01 to 0.05 part by weight of benzylaminopurine compounds, 0.02 to 0.05 part by weight of ethylenediamine tetraacetic acid chelated titanium, 0.3 to 0.5 part by weight of rhamnolipid, 0.4 to 0.8 part by weight of malic acid, 0.5 to 1.5 parts by weight of modified polyethylene glycol and 0.5 to 1.5 parts by weight of modified cellulose nanocrystals.

The invention discloses a solid beer-flavor effervescent tablet and a preparation method thereof. The solid beer-flavor effervescent tablet comprises an acid source, an alkali source, a beer-flavor matrix, a sweetening agent, a filling agent, a nutrition enhancer and a processing aid, wherein the acid source comprises anhydrous citric acid, and the alkali source comprises sodium bicarbonate; the beer flavor matrix comprises malt flour, a humulus lupulus extract and a flavor enhancer, and the flavor enhancer comprises flavor essence and concentrated guava juice; the nutrition enhancer comprises vitamin B, mineral salt and an amino acid composition. According to the invention, rich and pure beer flavor and rich, fine and lasting foam can be generated after the beer is disintegrated in water, and the beer has good portability and long shelf life, and has a nutrition supplementing function.

The present application provides a kind of complex probiotic paste, which combines Enterococcus faecalis, Saccharomyces cerevisiae and vitamin B 12 Producing lactic acid bacteria of canine source, adds prebiotics, flavoring substances and auxiliary substances such as paste matrix preparation.In the paste, the viable count of Enterococcus faecalis, Saccharomyces cerevisiae and lactic acid bacteria is 1-2:1-2:1-8;Paste matrix includes fructooligosaccharide 0.5-3%, psyllium husk powder 0.1-2%, goat milk powder 2-8%, chicken liver powder 1-5%, potassium sorbate 0.5-2%, xanthan gum 1-4%, and the balance is water.The above-mentioned complex probiotic paste can be stably stored for 56 days at 4 DEG C and normal temperature dry place, has good storage stability, good safety, and can adjust intestinal flora and increase the content of intestinal lactic acid bacteria.The above-mentioned complex probiotic paste has good palatability and oral tolerance for pets such as dogs and cats, and has good therapeutic effect on DSS-induced chronic enteritis diarrhea and vitamin B 12 Deficiency.