The invention discloses a degradable organic
silicon nanocapsule
drug carrier as well as a preparation method and application thereof. The carrier has a core-shell structure, wherein the core is a nano particle
drug; the shell is a degradable organic
silicon nanocapsule layer containing a large amount of disulfide bonds; the degradable organic
silicon nanocapsule layer wraps
small molecule drugs; the shell contains disulfide bonds, disulfide bonds can be in oxidation-reduction reaction with
glutathione that excessively expresses in
cancer cells, therefore the shells of capsules are disintegrated, drugs wrapped in the shells can be slowly released, while disulfide bonds cannot be disintegrated due to the fact that the content of
glutathione outside cells is inadequate, the internal drugs can be prevented from being influenced by the external environment, the
in vivo circulation time can be prolonged, and the purpose of releasing drugs in the
tumor cells can be achieved. According to the degradable organic silicon nanocapsule
drug carrier as well as the preparation method and application thereof, provided by the invention, the disadvantages that the conventional
silicone drug carrier cannot be degraded and has difficulty in
metabolism in biological bodies are overcome, an excellent dual drug carrying and tumor specificity transferring ability and a good
biocompatibility are achieved, and a broad application prospect in the field of
cancer treatment is further achieved.