The invention provides modified hydroxypropyl
methyl cellulose for a
capsule shell
wall material and a preparation method of the modified hydroxypropyl
methyl cellulose, and belongs to the technical field of pharmaceutic adjuvants. The preparation method comprises the following steps: modifying hydroxypropyl
methyl cellulose prepared from straws through KH560 to prepare
silane modified hydroxypropyl methyl
cellulose, mixing the
silane modified hydroxypropyl methyl
cellulose with modified enzymolysis
starch prepared through enzymolysis and
silane coupling agent modification, adding the mixture into water, adding
gelatin, stirring and mixing uniformly to form a glue solution, adding EDC, and stirring and reacting to prepare the modified hydroxypropyl methyl
cellulose for the
capsule shell
wall material. The prepared modified hydroxypropyl methyl cellulose for the
capsule shell
wall material has better stability, film-forming property, water and
oxygen resistance and
mechanical strength, is green and non-toxic, is low in cost, also has low
allergy and
chemical stability, has proper
drug dissolution rate and
bioavailability, has biodegradability and good
biocompatibility, and can be used for preparing the capsule for treating the
hyperplasia and
hyperplasia of the
hyperplasia and hyperplasia of the hyperplasia and hyperplasia of the hyperplasia and hyperplasia of the hyperplasia and hyperplasia. The capsule shell material is a good capsule shell material and has a wide application prospect.