22results about How to "Reduced bioavailability" patented technology

The invention discloses a method for degrading dioxin in fly ash and stabilizing heavy metals, which comprises the following steps: carrying out water washing treatment on the fly ash, and carrying out solid-liquid separation to obtain water washing slag; mixing the washed slag with water, adding zero-valent iron and sulfite, carrying out hydrothermal treatment, and carrying out solid-liquid separation to obtain hydrothermal slag and hydrothermal liquid; according to the method for degradation of dioxin in fly ash and stabilization of heavy metal in cooperation with degradation of dioxin in fly ash, under the combined action of zero-valent iron, chlorite and a hydrothermal environment, efficient degradation of dioxin in fly ash can be rapidly achieved under the lower reaction condition, stabilization of heavy metal in fly ash can be synchronously achieved, and the method is suitable for industrial production. The method has the advantages of being low in cost, mild in reaction condition, high in treatment efficiency, good in treatment effect, environmentally friendly and the like, can effectively solve the problems existing in the prior art, provides powerful support for harmless treatment and resource utilization of the waste incineration fly ash, and has wide engineering application prospects.

The invention relates to the technical field of soil improvement and ecological restoration, and discloses a liquorice planting method based on synergistic utilization of coal-based solid waste and desertified land, which comprises the following steps: crushing alkaline coal-based solid waste and acidic coal-based solid waste, mixing according to a mass ratio of 2: 8-4: 6, adding a modified humic acid-based heavy metal passivator and water, and uniformly mixing to obtain a mixture; uniformly mixing and aging to obtain a coal-based solid waste mixture; spreading the mixture on the surface layer of the desertification land, performing rotary tillage and deep tillage to mix the mixture with the sandy soil, and adjusting the pH value to be stable at 7.5-8.5; the treated liquorice seeds are sown, main roots are harvested in autumn of the third year, deep root systems and lateral root bud points are reserved, and overground straw is smashed and returned to the field; soil nutrition indexes are monitored regularly, other commercial crops are planted when the soil nutrition indexes reach a set threshold value, and if not, regeneration planting of the liquorice is maintained. Through synergistic compounding of acid-base solid waste and chelating of the passivating agent, substrate pH self-regulation and heavy metal resistance control are achieved, and the physicochemical property of sandy soil is improved.

The present application relates to the technical field of soil remediation, and discloses a composite microbial inoculum for activating reverse conversion of oxidized iron in dry land soil and application thereof.The composite microbial inoculum comprises aerobic iron-reducing bacteria and phenazine electron shuttles.The present application mediates the aerobic iron-reducing process of the aerobic iron-reducing bacteria strain through the phenazine electron shuttles, significantly improves the electron transfer efficiency, enhances the iron-reducing capacity, and can efficiently generate high-activity weak-crystalline iron oxide under aerobic conditions, thereby breaking through the limitation of traditional iron reduction relying on anaerobic environment;by promoting the reverse conversion of high-crystalline oxidized iron to weak-crystalline oxidized iron, the mineral interface activity is improved, the fixation capacity for Cd, Pb, As and other multi-metals in dry land soil is significantly enhanced, the biological availability thereof is reduced, the biological toxicity and migration risk thereof are greatly weakened, the remediation process is stable, the risk of secondary pollution is low, and the present application has good application prospect and popularization value in the field of heavy metal contaminated soil remediation.

The invention belongs to the technical field of heavy metal pollution treatment, and discloses a method for reducing soil cadmium activity and wheat grain cadmium content. According to the method, the low-cadmium-accumulation wheat variety is selected, the composite conditioner is applied, the low-cadmium-accumulation wheat variety is Jimai 22, and the composite conditioner is composed of mineral source potassium fulvate and zinc fertilizer. The complex passivation effect of humic acid components in mineral source potassium fulvate on soil heavy metal is utilized, the ion antagonism effect of zinc and cadmium and the low cadmium accumulation characteristic of Jimai 22 are combined, the cadmium content of wheat grains is synergistically reduced to 0.1 mg / kg or below, meanwhile, the cadmium content of the soil can be remarkably reduced, and the soil with cadmium exceeding the standard can be repaired. The treatment method provided by the invention has the advantages of simple operation, easily available raw materials, low cost, stable synergistic cadmium reduction effect and the like.

The present invention discloses a method for repairing soil contaminated by electrolytic manganese slag by inoculating white rot fungi, comprising the following steps: mixing biomass and soil contaminated by electrolytic manganese slag to obtain compost raw materials; inoculating white rot fungi in the compost raw materials to obtain a pile; composting and fermenting the pile to obtain compost mature material, thereby completing the repair of soil contaminated by electrolytic manganese slag. The present invention effectively reduces the leaching amount of heavy metal manganese by inoculating white rot fungi, effectively reduces the mobility and bioavailability of heavy metal manganese, effectively changes the structure of microbial communities, increases the number and diversity of microorganisms, improves the seed germination index, and realizes the repair of soil in contaminated sites. It has the advantages of quickly starting composting repair, effectively reducing the leaching amount of heavy metal manganese, reducing the mobility and bioavailability of heavy metal manganese, increasing microbial diversity and community abundance, and improving the seed germination index.

The application provides a kind of eye drop composition and its preparation method and application, belong to ophthalmic preparation technical field.The eye drop composition used in the application includes the following components: brimonidine tartrate, hyaluronic acid, collagen, trehalose, injection water;By compounding each component, a kind of eye drop capable of realizing brimonidine tartrate sustained release, prolonging the time of antihypertensive effect, and having the characteristics of reducing blinking discomfort, long-acting moisturizing, anti-inflammatory soothing, mild antiseptic, etc. is prepared;The eye drop of the application is helpful to glaucoma, high eye pressure, dry eye, postoperative inflammation or allergy, preservative-sensitive or preservative-allergic population, improves the quality of life, relieves the disease.

The present invention provides a JAK inhibitor having high oral bioavailability, characterized in that the JAK inhibitor comprises: a Formula I compound, or a stereoisomer, geometric isomer, tautomer, hydrate, solvate, or pharmaceutically acceptable salt thereof as an active ingredient. The JAK inhibitor with high oral bioavailability provided by the present invention can overcome the problem that existing JAK inhibitors have low oral bioavailability, and involves further modifying a chemical compound so as to change the physicochemical characteristics of one or several small molecule compounds, thus increasing the in-vivo cell absorption performance of said compound(s), greatly improving the bioavailability of the medication and providing new possibilities for drug delivery and utilization for said compound medication.

The invention belongs to the technical field of soil heavy metal remediation, and relates to an adsorbent for soil heavy metal remediation and a preparation method and application thereof. The invention provides a preparation method of an adsorbent for soil heavy metal remediation. The preparation method comprises the following steps: grinding nostoc sphaeroids kutz through liquid nitrogen, and extracting with an organic solution to obtain a nostoc sphaeroids kutz extract; dispersing the nostoc sphaeroids kutz extract, charcoal and sodium alginate in a polyethyleneimine solution to prepare a core material; and dropwise adding the core material into a calcium chloride solution to prepare the adsorbent. The adsorbent provided by the invention can realize soil heavy metal remediation, is beneficial to improvement of AMF activity and mycelial growth, improves the infection rate of AMF to rice, and reduces the content of heavy metals in rice grains. The invention aims to solve the technical problem that application of biochar to soil heavy metal remediation and agricultural safety production cannot be considered at the same time.

The present application belongs to the field of soil remediation, and particularly relates to a method for remediation of cadmium contaminated soil. The specific technical scheme is as follows: a soil remediation method comprises the following steps: before planting economic crops, applying sulfate-reducing bacteria to the soil to be remediated; after harvesting the economic crops, planting cadmium extraction crops in the soil to be remediated. The present application provides a water-flood rotation soil remediation method which can produce while remediation. On the one hand, the biological passivation can reduce the biological availability of cadmium in the soil, thereby reducing the stress of cadmium on plants and the absorption and accumulation of cadmium by plants; on the other hand, the biological technology can strengthen the ability of nightshade to extract cadmium, thereby extracting cadmium in farmland soil.

The invention discloses application of baicalin in relieving copper toxicity of duckweed, and belongs to the technical field of plant adversity physiology and heavy metal pollution remediation. Systematic research on the physiological regulation mechanism of baicalin on duckweed under copper stress innovatively discovers that the relative growth rate of duckweed can be remarkably increased through treatment of baicalin; according to the application, the chlorophyll synthesis level is effectively recovered, the photosynthesis inhibition effect caused by copper toxicity is fundamentally improved, it is proved that the threshold concentration for effectively relieving the copper toxicity is 400 [mu] M, the optimal action concentration window is 200-800 [mu] M, and the concentration interval can achieve synergistic antagonism on the toxicity of copper ions by adjusting the antioxidant metabolic pathway of duckweed. And a green and efficient new strategy is provided for heavy metal polluted water body remediation. The method is not only suitable for ecological restoration engineering of copper-polluted water areas, but also can be expanded and applied to cultivation of stress-resistant varieties of aquatic economic plants, and has important theoretical value and practical application prospect in improvement of heavy metal tolerance of stressed plants.

The invention relates to the technical field of urban residual sludge treatment, and particularly discloses a sludge aerobic composting method based on a carbon-loaded functional fungicide, which comprises the following steps: A1, mixing sludge powder and straw powder, fully soaking the mixture with a pore-forming agent solution, drying, and heating and calcining at high temperature to obtain biomass charcoal; a2, livestock manure, biomass charcoal and straw powder are mixed, aspergillus niger liquid is added into the mixture for fermentation, then compound bacteria liquid is added, fermentation continues, after fermentation is finished, strain protection liquid is added, drying is conducted, and a charcoal-loaded functional bacterial agent is obtained; and A3, uniformly mixing the sludge, the straw powder and the carbon-loaded functional fungicide, and carrying out aerobic composting on the sludge. According to the method, the aerobic composting temperature of the sludge can be increased, the composting time can be shortened, the form of heavy metals in the compost can be changed, the bioavailability of the heavy metals can be reduced, and harmless, reduction and resource utilization of the residual sludge can be realized.

The invention discloses a method for repairing low-permeability fluorine-polluted bottom mud, which comprises the following steps: S1, mixing three solutions of citric acid, diethylenetriamine pentaacetic acid and cocamidopropyl betaine in proportion to obtain an eluting agent; s2, repairing the fluorine-polluted bottom mud: adding the eluting agent obtained in S1 into the fluorine-polluted bottom mud, and continuously stirring for 1-2 hours in an eluting and stirring box; in the leaching process, a pressurizing air pump is used for pumping air from the lower portion of a porous disc at the bottom of a leaching stirring box, and formed microbubbles are used for conducting microbubble-leaching combined enhanced remediation on the fluorine pollution bottom mud saturated through leaching; and S3, performing mud-water separation on the bottom mud repaired in the step S2 to complete leaching. The method is simple in process, convenient to operate, high in reaction speed and good in leaching effect, the leaching agent and the microbubble device are easy to obtain, and the method has a combined enhancement effect on fluorine-polluted bottom mud remediation and is suitable for fluorine-polluted remediation of low-permeability bottom mud such as clay, silty clay and floury soil.

The utility model relates to the technical field of solid waste recycling and sewage treatment, in particular to a soil remediation bionic plant body. The bionic plant body for soil remediation comprises a water collecting part, the water collecting part is in a funnel shape, a liquid outlet pipe is arranged below the water collecting part, a cover body is arranged at an opening in the upper portion of the funnel part, and water seepage holes are formed in the cover body; the liquid outlet pipe is sleeved in from an upper opening of the sleeve cup part, a plurality of through holes are formed in the sleeve cup part, bionic root hairs penetrate through the through holes, the through holes are sealed by the bionic root hairs, liquid can enter the water collecting part through the water seepage holes, and the liquid enters the sleeve cup part through the liquid outlet pipe. And then water and nutrients are provided for the soil through the bionic root hair. Pollutants in soil can be adsorbed and enriched on the bionic root system, and bionic mycorrhiza are formed after soil microorganisms are colonized, so that organic pollutants in the soil can be degraded or heavy metals can be fixed, and the bioavailability of the heavy metals is reduced.

The invention provides a chromium-polluted brick red soil repairing agent and a repairing method thereof.The method comprises the steps of soil pretreatment, application of a repairing agent I and application of an electric field, addition of a repairing agent II for maintenance, final inoculation of biological strains and the like, and effective repairing of brick red soil is achieved. The method comprises the following steps: removing impurities, ploughing soil, applying a repairing agent I containing a reducing agent, citric acid and other components, and treating under a specific electric field condition. Then, organic fertilizer, iron oxide, nano zeolite, chitosan derivatives and other repairing agents II are added; and finally, inoculating aspergillus, citrobacter freundii and ice-living bacteria in a specific proportion to carry out bioremediation. According to the method, physical, chemical and biological remediation means are comprehensively considered, chromium pollution in the soil is efficiently removed, the content of organic carbon in the brick red soil is increased, and the ecological function of the soil is restored.

The current invention affords new formulations which deliver reversible and irreversible covalent kinase inhibitors, in particular BTK inhibitors, into the small intestine and specifically into the ileum and jejunum of the small intestine.

The invention discloses a method for preparing a functional biological flora in a targeted biological bacterium and host original flora coupling mode and application of the functional biological flora in ginseng, and relates to the field of agricultural microbial technology and traditional Chinese medicinal material cultivation, and the method comprises the following steps: a, constructing a targeted biological strain resource library, and screening a functional single strain; b, purifying and compounding the single strain to form a compound flora; the core of the method is in vitro pre-coupling, exogenous targeting bacteria and host original flora are subjected to symbiotic adaptation in advance in a controlled environment to form a stable micro-ecological complex, the micro-ecological complex can be rapidly colonized and establish advantages after being applied to soil, the industrial pain point that a traditional microbial agent is living but not long and long but not effective is solved, and the selected strains are scientific in combination and easy to control. The bacillus subtilis and the brevibacillus laterosporus are used for resisting diseases and promoting growth, the bacillus mucilaginosus and the pseudomonas fluorescens are used for activating nutrients and removing heavy metal toxicity, and the arbuscular mycorrhizal fungi are used for expanding the root system absorption area.

This invention provides a method and application for preparing bio-organic fertilizer through synergistic composting of biochar-containing biogas residue, belonging to the field of organic fertilizer preparation technology. The method includes: preparing biogas residue through anaerobic fermentation of livestock and poultry manure and crop straw; adding biochar and a compound microbial agent; conducting high-temperature aerobic composting; and obtaining bio-organic fertilizer through maturation and aging. The amount of biochar added is 5%-10% of the dry basis weight of the composting raw materials; the aerobic composting time is 35-45 days; and the high-temperature composting temperature is 55-65℃. The compound microbial agent includes *Bacillus steatophilus*, *Bacillus amyloliquefaciens*, and *Bacillus mucilaginosus*. The bio-organic fertilizer obtained by this invention can be used for crop soil improvement. This invention, through the synergistic effect of biogas residue, biochar, and compound microbial agent, effectively shortens the composting cycle, improves compost maturity, reduces nitrogen loss, passivates heavy metals, and significantly improves the quality of organic fertilizer.

This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a TNF inhibitor.

The invention provides a soil cation heavy metal repairing agent and a preparation method thereof. The soil cation heavy metal repairing agent is prepared from the following raw materials in parts by mass: 30 to 40 parts of inorganic fertilizer B, 40 to 60 parts of organic fertilizer C and 10 to 20 parts of starch glue, wherein the inorganic fertilizer B is prepared from the following raw materials in parts by mass: 40-60 parts of a carrier A, 24-36 parts of monoammonium phosphate and 16-24 parts of potassium sulfate; the carrier A is prepared by mixing pyrolytic charcoal, attapulgite and kaolin; the organic fertilizer C is prepared by mixing dry cow dung, potassium hydroxide and K2SO3; the starch glue is prepared by mixing corn starch, CaO2 and deionized water. According to the soil cation heavy metal repairing agent and the preparation method thereof, cation heavy metal can be converted from an effective state to a low-activity state by adding the soil repairing agent, so that the mobility and bioavailability of the cation heavy metal in soil are reduced, and the soil cation heavy metal repairing agent is low in cost and easy to popularize and apply on a large scale.

The application discloses a kind of low permeability fluorine pollution sediment repair methods, comprising: S1, citric acid, diethylene triamine pentaacetic acid and coconut amide propyl betaine three solutions are mixed in proportion, to obtain leaching agent;S2, fluorine pollution sediment is repaired: to fluorine pollution sediment, leaching agent obtained in S1 is added, continuously stirring 1~2h in leaching stirring tank;In the process of leaching, gas is pumped from the porous disc at the bottom of leaching stirring tank using pressurized air pump, and the fluorine pollution sediment saturated with leaching is repaired using micro-bubble-leaching combined enhancement repair formed by micro-bubble;S3, the sediment after S2 repair is separated, and the leaching is completed.The application has the advantages of simple process, convenient operation, fast reaction speed, good leaching effect, easy to obtain leaching agent and micro-bubble device, and has combined enhancement effect on fluorine pollution sediment repair, and is suitable for fluorine pollution repair of low permeability sediment such as clay, silty clay and silt.

This invention discloses the application and method of green manure return to the field in the remediation of cadmium pollution in red soil, belonging to the field of agricultural heavy metal pollution remediation technology. This method addresses the problems of high cost, potential secondary pollution, and difficulty in coordinating with agricultural production associated with chemical passivating agents in the remediation of cadmium-contaminated farmland in red soil. It utilizes a crop rotation system combining continuous planting and incorporation of milkvetch with rice planting and fertilization to simultaneously regulate and significantly increase soil microbial biomass carbon and amorphous iron oxide content, synergistically driving the transformation of soil cadmium from a highly active, weakly acidic extractable state to a more stable iron-manganese oxide-bound and organically bound state. This method achieves long-term, stable reduction of soil cadmium bioavailability without the need for additional chemical passivating agents, realizing a green, low-cost, and in-situ synergistic approach to cadmium pollution remediation and agricultural production, and has significant application value.

The present invention relates to the field of health care products, and in particular to a sophora japonica and cistanche composition for improving bone and joint health, and a preparation method and application thereof. The composition is composed of the following components in parts by weight: 3 to 6 parts of sophora japonica extract, 3 to 6 parts of cistanche extract, 1 to 5 parts of fungus powder, 1 to 3 parts of dried shrimp powder, 1 to 3 parts of dried plum powder, 1 to 3 parts of spinach powder, 1 to 3 parts of amaranth powder and 0.01 to 0.1 parts of vitamin D. Most of the components of the composition are medicinal and edible and daily dietary foods, which are easy to obtain, green and safe, and the combination of the specially treated components has the effect of synergistically inhibiting bone loss, increasing bone density and improving osteoblast activity, and improving bone and joint health.