134results about How to "Maximize the effect of treatment" patented technology

A method of treating regurgitation of a mitral valve in a patient's heart. The method includes the steps of: delivering a tissue shaping device to the coronary sinus; and deploying the tissue shaping device to reduce mitral valve regurgitation, the deploying step comprising applying a force through the coronary sinus wall toward the mitral valve solely proximal to a crossover point where a coronary artery passes between a coronary sinus and the mitral valve. The invention is also a set of devices for use in treating mitral valve regurgitation. The set includes a plurality of tissue shaping devices having different lengths, each of the tissue shaping devices being configured to be deliverable to a coronary sinus of a patient within a catheter having an outer diameter no greater than ten french.

An electric stimulator for alpha-wave derivation is characterized in that frequency selected from a range of 1 Hz to 50 Hz, preferably, 7 Hz to 14 Hz, and an output voltage are applied to auricle of a patient's ears to derive alpha-waves, and that cycle and intensity of stimulation are varied depending upon body temperature and blood sugar. Prompt reaction may be obtained by directly applying the voltage to the ears, and the reaction may continue when stimulation is extended. In addition, it is suitable to treat various diseases having common cause due to stress or arousal reaction in the human body.

One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.

New pharmaceutical compositions in unit dosage form are disclosed for both intraoral and oral administration to a patient, said unit dosage form configured to be placed intraorally of said patient, which comprises:(a) as a first portion, at least one discrete molded triturate tablet comprising a therapeutically effective amount of at least one pharmaceutically active ingredient capable of intraoral administration; and(b) as a second portion located around the said first portion, a therapeutically effective amount of at least one pharmaceutically active ingredient capable of oral administration and which is releasable and orally ingestible by the patient after the molded triturate tablet has disintegrated or has dissolved intraorally.

Percutaneous transmyocardial revascularizaton systems are disclosed for creating thin, linear incisions through the endocardium and partially into the myocardium. The systems mitigate the deficiencies of current approaches that position a distal tip channeling mechanism against the endocardial surface. The systems position a catheter body lengthwise along the endocardial surface and incorporate a cutting mechanism movable radially relative to the catheter body to create one or more elongate thin, linear incisions along one or more windows through the catheter body. Flexible support strands are used to urge each window into intimate contact with the endocardial surface. Each cutting element is adapted to protrude radially outward from the catheter body to contact tissue adjacent each window. The cutting mechanism incorporates a mechanical cutting element or an electrode designed to transmit direct current or radiofrequency energy into tissue to simultaneously cut and coagulate tissue. The catheter also can infuse a therapeutic agent directly into the incisions to encourage angiogenesis. The catheter also cuts thin, linear incisions capable of ablating arrhythmia substrates by disrupting electrical propagation through the affected myocardium.

The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.

An implantable, time-released substance delivery device includes a casing having an exterior surface, and a number of pores disposed on the exterior surface of the casing. The time-released substance delivery device further has an interior chamber disposed within the casing, and a number of excretion tubes disposed within the casing. Each of the excretion tubes fluidly connects the interior chamber to one of the pores.

An apparatus and method for providing treatment feedback relating to a patient undergoing therapeutic treatment of tissue during dynamic motion therapy are provided. The apparatus includes a platform configured to support a body of the patient; an oscillator connected to the platform and configured to impart an oscillating force at a predetermined frequency on the platform for transmitting mechanical vibration energy through the patient's body; and a processing device in operable communication with the platform for processing data related to the therapeutic treatment and for determining the amount of mechanical vibration energy transmitting through the patient's body. The apparatus further includes a treatment feedback indicator for indicating (e.g., displaying) the amount of mechanical vibration energy transmitting through the patient's body.

An isolated fusion protein is provided which is a conjugate of a therapeutic polypeptide and an albumin fragment, such as a fragment including an individual domain or subdomain of albumin, or a polymer of albumin (e.g., dimers, trimers, etc.) and which is used to optimize the half-life of that therapeutic agent in the bloodstream in a tunable fashion based on the molecular weight of the fragment or polymer. Albumin fragments useful in the invention include fragments containing any of the individual domains and subdomains of human serum albumin, as well as fragments including specific combinations of binding regions or subdomains. The present invention thus provides fragments or polymers which will allow for optimizing half-lives of therapeutic polypeptides depending on their molecular weight, and this will optimizes protein and vaccine therapeutics to have desired half lives for their greatest effectiveness.

The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.

A system and apparatus for remote monitoring of data related to therapeutic treatment of tissue are provided. The system and apparatus includes a platform configured to support a body of the patient; an oscillator connected to the platform and configured to impart an oscillating force at a predetermined frequency on the platform for transmitting mechanical vibration energy through the patient's body; and a processing device in operable communication with the platform for processing data related to the therapeutic treatment. The apparatus further includes a communication device in operative communication with the processing device.

Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide having a biological function in vitro or in vivo, and preferably, having a therapeutic activity when administered to a human. By fusing the bioactive molecule to HSA, stability of the bioactive molecule in vivo can be improved and the therapeutic index increased due to reduced toxicity and longer-lasting therapeutic effects in vivo. In addition, manufacturing processes are provided for efficient, cost-effective production of these recombinant proteins in yeast.

A method of manufacturing a stent includes forming a first cylindrical mesh structure by bending a first member in a zigzag-shape having peaks and valleys and a plurality of turns wound around an outer circumference of a manufacturing frame and forming a second cylindrical mesh structure by bending a second member in a zigzag-shape having peaks and valleys and a plurality of turns wound around an outer circumference of a manufacturing frame, wherein a bending track the second member crosses a bending track of the first member.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

New pharmaceutical compositions in unit dosage form are disclosed for both intraoral and oral administration to a patient, said unit dosage form configured to be placed intraorally of said patient, which comprises: (a) as a first portion, at least one discrete molded triturate tablet comprising a therapeutically effective amount of at least one pharmaceutically active ingredient capable of intraoral administration; and (b) as a second portion located around the said first portion, a therapeutically effective amount of at least one pharmaceutically active ingredient capable of oral administration and which is releasable and orally ingestible by the patient after the molded triturate tablet has disintegrated or has dissolved intraorally.

The invention relates to a combination therapy for the treatment of tumors and tumor metastases, preferably breast and prostate tumors, comprising administration of anti-EGFR (Her1) antibodies and anti-hormonal agents, optionally together with cytotoxic / chemotherapeutic agent. The method and the pharmaceutical compositions comprising said agents can result in a synergistic potentiation of the tumor cell proliferation inhibition effect of each individual therapeutic agent, yielding more effective treatment than found by administering an individual component alone.

The invention comprises a treatment probe and method delivering radiofrequency stimulation for controlled heating of tissue within the vagina to treat vaginal laxity. The treatment probe includes a rounded disposable treatment tip to accommodate the anatomy of the vagina which is coupled with an electrode assembly, both of which are assembled to transfer radiofrequency energy to vaginal surface and subsurface. The treatment tip includes a skin temperature sensor that monitors skin temperature to maintain a pre-set treatment temperature; the entire assembly is connected to a reusable treatment probe handle and radiofrequency generator.

A method of manufacturing a stent includes forming a first cylindrical mesh structure by bending a first member in a zigzag-shape having peaks and valleys and a plurality of turns wound around an outer circumference of a manufacturing frame and forming a second cylindrical mesh structure by bending a second member in a zigzag-shape having peaks and valleys and a plurality of turns wound around an outer circumference of a manufacturing frame, wherein a bending track the second member crosses a bending track of the first member.

A lie-down massager comprises a frame having an elongated top panel with an elongated opening, a rider below the top panel, a guide member movably engaged between the frame and the rider to enable the rider to make a horizontal reciprocation relative to the frame, a lifter moving vertically relative to the rider, and a roller gear engaged to the rider. The roller gear is engaged to a vertical rack gear in an opening of an engagement body extending from the lifter so the roller gear rotation enables the lifter to make a vertical reciprocation. Massage bumps attached to the top portion of the lifter move vertically and / or horizontally along the elongated top opening of the elongated top panel of the frame by the lifter and the rider.

Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide having a biological function in vitro or in vivo, and preferably, having a therapeutic activity when administered to a human. By fusing the bioactive molecule to HSA, stability of the bioactive molecule in vivo can be improved and the therapeutic index increased due to reduced toxicity and longer-lasting therapeutic effects in vivo. In addition, manufacturing processes are provided for efficient, cost-effective production of these recombinant proteins in yeast.

The present invention relates to an ozone treatment apparatus using ozone gas, in which the ozone gas is directly injected to a lesion of the human body by utilizing the sterilizing power caused by oxidation of ozone gas, so that the lesion can be sterilized and stanched to relieve the pain in the lesion, thereby maximizing therapeutic effect by the ozone irrespective of the shape of bodily regions having the lesion and the kind of lesion, and so that the treatment using ozone gas can be readily conducted, thereby improving convenience in use as well as significantly reducing the cost and time spent for the treatment.

Disclosed herein are a pure silver device and a method for diagnosing and treating pain on human body. The pure silver device comprises an elongated handle, a head having both a hammer head and a comb opposed to each other, a panel, and an outwardly extending protrusion on the bottom end of the handle. The pure silver device is used to diagnose and treat pain by finding out pressure pain points on both abdominal area, at which root of pain is located, and a symptomatic area of the human body and then by releasing the pressure pain points by tapping, pressing, rubbing, combing or combining the foregoing. Owing to the highest thermal and electrical conductivity of silver, the pure silver device produces amazingly better stimulation of the pressure pain points. Therefore, the pure silver device is more effectively used for diagnosing and treating pain than other devices made out of any other material, even sterling silver and magnetic material. In addition, the pure silver device is portable and useful in that anyone can diagnose and treat himself or herself anytime and anyplace. The pure silver device and the method are simple, easy, safe without any side effects and medical risks, and economical.