The application belongs to the field of
drug research and development, and particularly relates to application of an acid
glycoprotein ORM in preparation of a
drug for treating
muscle reduction, and the application uses ORM1 knockout mice to evaluate the role of ORM in
muscle reduction, and results show that
glucocorticoid (
dexamethasone) can induce
muscle reduction, which is manifested in that the
body weight of mice is reduced, the
grip strength is reduced, and the
skeletal muscle mass is reduced, and these indexes are more seriously reduced after ORM is knocked out, and exogenous ORM can significantly improve the
cell muscle reduction model induced by
dexamethasone, thereby providing a new idea for treatment of muscle reduction.