14 results about "Brown adipose tissue" patented technology

Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose tissue which has extensive communication with other organs, particularly with the brain through the sympathetic nervous system (SNS). Our study reveals a new light-triggered crosstalk between adipose tissue and the hypothalamus. Direct blue-light exposure to subcutaneous white fat improves high-fat diet-induced metabolic abnormalities in an Opsin3-dependent manner. Metabolomic analysis shows that blue light increases circulating levels of histidine, which activates histaminergic neurons in the hypothalamus and stimulates brown adipose tissue (BAT) via SNS. Blocking central actions of histidine and denervating peripheral BAT blunts the effects of blue light. Human white adipocytes respond to direct blue light stimulation in a cell-autonomous manner, highlighting the translational relevance of this pathway. Together, these data demonstrate a light-responsive metabolic circuit involving adipose-hypothalamus communication, offering a potential strategy to alleviate obesity-induced metabolic abnormalities.

The invention discloses an application of Pantoea ananatis, and relates to the technical field of microorganisms. Aiming at the defects of the existing obesity intervention means, the invention provides a brand-new solution: Pantoea anatitis adapted to a high-altitude environment is used as a core functional strain, through an intestinal flora driving mechanism, the expression of UCP1 protein in brown adipose tissue (BAT) is activated, the heat production function of the BAT is enhanced, and meanwhile, the storage of white adipose tissue (WAT) and the level of liver triglyceride (TG) are reduced; the weight-losing effect is realized. The strain can play a role through an'intestinal flora-BAT 'axis without cold exposure, has no obvious influence on liver functions, and is excellent in safety. The invention discloses a flora-mediated non-cold-dependent BAT activation way for the first time, can be used for preparing products such as weight-reducing medicines and health-care foods, has the advantages of mechanism innovation, exact effect and wide application, and provides a new technical choice for obesity intervention.

This invention discloses an emergency product and method for hypothermia protection in low-temperature environments, belonging to the field of hypothermia protection and emergency care. This invention is the first to apply triiodothyronine (T3) to the preparation of an emergency product for hypothermia protection in low-temperature environments, fully utilizing T3's ability to rapidly increase heat production in tissues such as brown adipose tissue, thereby enhancing the body's active heat production capacity. Combining the physiological metabolic characteristics of the human body with the pharmacological properties of T3, this invention has achieved excellent results in animal experiments. On the one hand, T3 can maintain the core body temperature of hypothermic experimental animals at a higher level for a longer period, resulting in increased swimming time and extending the golden time for rescue. On the other hand, it can effectively improve the recovery of body temperature after rescue, significantly increasing the success rate of treatment. However, when using T4, which is considered more effective in conventional clinical settings, no significant improvement in these two aspects was observed, fully demonstrating the specificity and superiority of T3.

The invention relates to the technical field of health-care functional food, in particular to novel application of a composition. The composition provided by the invention is prepared from the following raw materials in parts by weight: 120 parts of lotus leaves, 30 parts of haws and 80 parts of mulberry leaves. The raw materials are mainly selected from medicinal and edible food materials and part of common nutritional food materials which are all natural plant raw materials. The applicant deeply studies the characteristics of the raw materials, carries out comprehensive and systematic in-vivo and in-vitro experimental verification respectively by screening and blending various food raw materials according to the two characteristics of preventing and reducing obesity of the product, and finally determines the composition of the optimized variety of the raw materials. The invention also relates to an application of the functional health-care food for preventing and reducing obesity and synchronously protecting intestinal barriers and liver tissues, and the functional health-care food is used for preventing and reducing obesity by inhibiting the whitening of brown fat, promoting the browning of white fat and enhancing the heat energy conversion of body lipid after being taken.

The application provides a brown fat recognition method and recognition device based on plain CT images, and solves the technical problem that the recognition cost and recognition accuracy of the existing brown fat recognition cannot be matched. The method comprises the following steps: establishing a tissue feature recognition model of brown fat by using the image features of the brown fat in the plain CT image resources; identifying the brown fat in the to-be-detected plain CT image according to the tissue feature recognition model, and quantifying the physical properties of the brown fat. The tissue feature recognition model is mainly trained or optimized by using low-cost plain CT image data, so that the brown fat and white fat can be effectively distinguished. The application provides a basic tool for target point recognition and tissue quantification, so as to explore how to activate the brown fat tissue in the human body through drugs, nutrition and other means, and to expect to find new strategies for treating obesity and diabetes.

To provide a novel method for obtaining brown adipose tissue by differentiating stem cells. [Solution] A method for producing brown adipose tissue, comprising a culture step of culturing a hydrogel containing stem cells and a cationic polymer in a medium containing 3,3',5-triiodo-L-thyronine and insulin, thereby inducing differentiation of the stem cells into brown adipose tissue.

The application discloses a kind of adipose tissue-derived mitochondrial-derived vesicles and its preparation method and application, belong to the field of biological medicine.The preparation method includes obtaining mouse adipose tissue, including at least one of interscapular brown adipose tissue, epididymal white adipose tissue, beige adipose tissue, in vitro cultured adipocyte;Mouse adipose tissue homogenate is removed by differential centrifugation Unbroken cell, nucleus, mitochondrial and organelle precipitate, the supernatant obtained is treated by trypsin and then ultracentrifuged, the precipitate is collected, washed, to obtain mitochondrial-derived vesicles, which are membrane-coated vesicles, with a particle size of 100-200 nm, enriched in mitochondrial membrane proteins and oxidative phosphorylation-related proteins, and proved by ischemic heart disease model that it can improve heart function, reduce the degree of ventricular remodeling in mice with ischemic heart disease and reduce the fibrosis area, for the preparation of drugs for preventing or treating ischemic heart disease, and has important clinical application value.

The invention discloses application of nolinoleic acid in preparation of a medicine for treating obesity, and belongs to the technical field of biological medicine. The molecular formula of the nolinoleic acid disclosed by the invention is C17H28O2. The nolinoleic acid plays a positive role in enhancing brown fat heat production and treating obesity, and animal model experiment verification shows that intervention of the nolinoleic acid reduces the weight of obese mice induced by high fat diet, improves the weight of brown fat tissues, improves sugar tolerance and insulin sensitivity, and can be used for treating obesity. And the brown fat heat production function phenotype and the overall metabolism level of mice are increased, which indicates that the nolinoleic acid has an enhancement effect on brown fat heat production and has a certain improvement effect on obesity. The research result of the invention provides a new treatment approach for obesity treatment.

The invention discloses a polypeptide and application thereof, and relates to the technical field of biology. The amino acid sequence of the polypeptide is shown as SEQ ID NO: 1. The polypeptide designed based on the precise binding site of the Gabp alpha and the Ppargamma comprises an aa164-189 amino acid sequence fragment of the Ppargamma, ARG168 and LYS184 sites can be specifically bound with ASP332 and GLN324 sites of the Gabp alpha respectively, a natural binding interface of the Gabp alpha and the Ppargamma can be competitively occupied, specific blocking of the interaction of the Gabp alpha and the Ppargamma is achieved, and the effect of inhibiting the Gabp alpha and the Ppargamma is achieved. Non-specific interference caused by interaction of other proteins is avoided, and a high-specificity tool is provided for targeted regulation of a brown adipose tissue related metabolic process.

The utility model relates to the technical field of phototherapy, in particular to a light-operated blood glucose eyeshade device and a light-operated blood glucose eyeshade system. The light-operated blood glucose eyeshade device comprises a middle shell, an LED lamp panel and a rear shell. The middle shell and the rear shell are arranged on the two sides of the LED lamp panel. A plurality of LED lamp beads are arranged on the side, close to the rear shell, of the LED lamp panel. And the LED lamp panel is connected with the rear shell. And the middle shell is connected with the rear shell and covers the LED lamp panel. After a user correctly wears the eyeshade, red light emitted by the eyeshade can irradiate human eyes; red light enters from a visual window, signals can be directly transmitted by activating photosensitive retinal ganglion cells (ipRGCs) (special photoreceptor cells) through optic nerves to a series of nerve nuclei of hypothalamus and medulla oblongata, finally, the red light acts on peripheral brown adipose tissue BAT through sympathetic nerves, the metabolic capacity of blood sugar can be affected, and therefore the sugar control effect is achieved. And when the embodiment is used for reducing blood sugar, the user only needs to wear the equipment, so that the method is easy to implement.

According to the human body brown adipose tissue characterization method and device and the metabolic function evaluation system, automatic processing and visual comparison of multi-wavelength opto-acoustic / ultrasonic images before and after activation of the brown adipose tissue are achieved, and the clinical practicability and the image processing efficiency are improved. The method comprises the following steps: (1) acquiring a multi-wavelength photoacoustic image and an ultrasonic image of a region of interest of a target subject before and after cold stimulation; (2) performing luminous flux correction on the multi-wavelength photoacoustic image; segmenting different organizational structures in the region of interest by using the ultrasonic image, and performing luminous flux compensation on the photoacoustic image; (3) performing spectral unmixing processing on the multi-wavelength photoacoustic image after luminous flux compensation to obtain distribution images of different tissue components; the different tissue components at least comprise brown fat; and (4) based on the distribution image, calculating photoacoustic signal characteristic parameters of brown fat under different wavelengths before and after cold stimulation, and / or concentration change information of other tissue components except the brown fat, and generating a characterization evaluation result.

A method for directing a change in cell state of white adipose tissue (WAT) which involve treating WAT cells with mRNA encapsulated inside lipid nanoparticles (LNPs). The mRNA encodes UCP1 or other proteins that may transition WAT to brown adipose tissue (BAT). The LNP may contain (C14-4:NCL:Cholesterol:PEG / Lipid Conjugate) at the molar ratio of (35:16:46.5:2.5), (50:10:38.5:1.5) or (56.5:10:31.8:1.7).

Provided are an application of a GluN3B inhibitor in the preparation of a drug for preventing or treating obesity and related metabolic syndrome, and an application of the GluN3B inhibitor in the prevention and treatment of obesity. By means of using a high-fat diet (45% fat)-induced obesity model as a research subject, it has found that GluN3B gene knockout or knockdown can effectively inhibit the weight gain of mice. In vivo animal experiments show that the GluN3B gene knockout or knockdown can activate brown adipose tissue to significantly promote the energy consumption of mice, which is an important reason for the slowed weight gain of mice.

This invention provides the application of fuscin acid in the preparation of weight loss, lipid reduction, and metabolism improvement products, offering a new use for fuscin acid. It can effectively reduce subcutaneous fat weight, decrease the whitening degree of brown adipose tissue, reduce the size of adipocytes in visceral adipose tissue, improve the fatty liver phenotype, improve glucose tolerance, and reduce serum TG and TC levels, without affecting the weight of brown adipose tissue and muscle tissue, providing an effective solution for safe and effective weight loss using traditional Chinese medicine extracts.