6 results about "Brown adipose tissue" patented technology

This invention discloses an emergency product and method for hypothermia protection in low-temperature environments, belonging to the field of hypothermia protection and emergency care. This invention is the first to apply triiodothyronine (T3) to the preparation of an emergency product for hypothermia protection in low-temperature environments, fully utilizing T3's ability to rapidly increase heat production in tissues such as brown adipose tissue, thereby enhancing the body's active heat production capacity. Combining the physiological metabolic characteristics of the human body with the pharmacological properties of T3, this invention has achieved excellent results in animal experiments. On the one hand, T3 can maintain the core body temperature of hypothermic experimental animals at a higher level for a longer period, resulting in increased swimming time and extending the golden time for rescue. On the other hand, it can effectively improve the recovery of body temperature after rescue, significantly increasing the success rate of treatment. However, when using T4, which is considered more effective in conventional clinical settings, no significant improvement in these two aspects was observed, fully demonstrating the specificity and superiority of T3.

The application provides a brown fat recognition method and recognition device based on plain CT images, and solves the technical problem that the recognition cost and recognition accuracy of the existing brown fat recognition cannot be matched. The method comprises the following steps: establishing a tissue feature recognition model of brown fat by using the image features of the brown fat in the plain CT image resources; identifying the brown fat in the to-be-detected plain CT image according to the tissue feature recognition model, and quantifying the physical properties of the brown fat. The tissue feature recognition model is mainly trained or optimized by using low-cost plain CT image data, so that the brown fat and white fat can be effectively distinguished. The application provides a basic tool for target point recognition and tissue quantification, so as to explore how to activate the brown fat tissue in the human body through drugs, nutrition and other means, and to expect to find new strategies for treating obesity and diabetes.

To provide a novel method for obtaining brown adipose tissue by differentiating stem cells. [Solution] A method for producing brown adipose tissue, comprising a culture step of culturing a hydrogel containing stem cells and a cationic polymer in a medium containing 3,3',5-triiodo-L-thyronine and insulin, thereby inducing differentiation of the stem cells into brown adipose tissue.

The application discloses a kind of adipose tissue-derived mitochondrial-derived vesicles and its preparation method and application, belong to the field of biological medicine.The preparation method includes obtaining mouse adipose tissue, including at least one of interscapular brown adipose tissue, epididymal white adipose tissue, beige adipose tissue, in vitro cultured adipocyte;Mouse adipose tissue homogenate is removed by differential centrifugation Unbroken cell, nucleus, mitochondrial and organelle precipitate, the supernatant obtained is treated by trypsin and then ultracentrifuged, the precipitate is collected, washed, to obtain mitochondrial-derived vesicles, which are membrane-coated vesicles, with a particle size of 100-200 nm, enriched in mitochondrial membrane proteins and oxidative phosphorylation-related proteins, and proved by ischemic heart disease model that it can improve heart function, reduce the degree of ventricular remodeling in mice with ischemic heart disease and reduce the fibrosis area, for the preparation of drugs for preventing or treating ischemic heart disease, and has important clinical application value.

This invention provides the application of fuscin acid in the preparation of weight loss, lipid reduction, and metabolism improvement products, offering a new use for fuscin acid. It can effectively reduce subcutaneous fat weight, decrease the whitening degree of brown adipose tissue, reduce the size of adipocytes in visceral adipose tissue, improve the fatty liver phenotype, improve glucose tolerance, and reduce serum TG and TC levels, without affecting the weight of brown adipose tissue and muscle tissue, providing an effective solution for safe and effective weight loss using traditional Chinese medicine extracts.