The invention provides a method and device for evaluating the coma degree. The method comprises: electroencephalogram data of a patient is acquired; the electroencephalogram data is pretreated, and purified electroencephalogram signals are obtained; according to the purified electroencephalogram signals, the coma degree of the patient is evaluated. According to the method, the coma degree of the patient is automatically evaluated according to the purified electroencephalogram signals of the coma patient, manual intervention in the evaluating process of the coma degree is lowered, the influence of subjective factors of medical personnel on the evaluating process is avoided, man-made erroneous judgment is avoided, the evaluating error is reduced, and the evaluating accuracy is improved. Sample entropy is applied to evaluation of the coma degree, the sample entropy corresponding to the purified electroencephalogram signals is calculated, according to a threshold value range of the sample entropy, the coma degree is evaluated, quantification evaluation of the coma degree is achieved, and the evaluation efficiency is greatly improved. Meanwhile, according to the purified electroencephalogram signals, prognosis judgment is automatically conducted, the sample entropy is applied to the prognosis judgment of the coma patient, and the efficiency and accuracy of the prognosis judgment are improved.