The invention provides a rapid generation method of a five-axis NC tool path of scattered point cloud data. The method is characterized in that a spatial clustered index structure of the scattered point cloud is established firstly, then a data point set of a section of the tool path is rapidly obtained based on the structure, and a normal vector of the data points of the section is determined according to the local differential geometrical properties of, the data points of the section, and tool position points corresponding to the data points of the section are calculated by the space projection method, the tool position point set is sorted by the minimal spanning tree algorithm to generate the tool path, the generated tool path is cut and modeled based on a triangular mesh surface model, the generation precision of the tool path is detected, and the tool path generation parameters are corrected based on the detection result, and finally the five-axis NC tool path meeting the precision requirements is obtained. Examples prove that the method can quickly and efficiently obtain the five-axis NC tool path of the scattered point cloud data, accurately detect the precision of the obtained tool path, and realize rapid profiling manufacture of complex curved surface products.