The invention discloses a numerical simulation method suitable for the influence of pile shoe plugging on an adjacent pile foundation, and the method comprises the following steps: S1, building a numerical calculation analysis model which comprises a soil body model, a pile shoe foundation model and a pile foundation model according to an actual working condition, and the soil body model comprising an Euler region and a Lagrange region; S2, endowing the established model with material attributes; S3, assembling the established model; S4, establishing a corresponding analysis step; S5, establishing interaction among the pile shoe foundation model, the pile foundation model and the soil body model; S6, establishing a reasonable boundary condition; S7, performing material attribute assignmenton the soil body in the Euler area and applying a ground stress field to the soil body; and S8, meshing the established numerical calculation analysis model, and submitting calculation to obtain results of displacement and bending moment of the pile foundation model. The method conforms to engineering practice. The method is simple, clear and easy to calculate, and related parameters are easy todetermine and reliable.