209 results about "Multivariate statistical" patented technology

Fluorescence spectral data acquired from tissues in vivo or in vitro is processed in accordance with a multivariate statistical method to achieve the ability to probabilistically classify tissue in a diagnostically useful manner, such as by histopathological classification. The apparatus includes a controllable illumination device for emitting electromagnetic radiation selected to cause tissue to produce a fluorescence intensity spectrum. Also included are an optical system for applying the plurality of radiation wavelengths to a tissue sample, and a fluorescence intensity spectrum detecting device for detecting an intensity of fluorescence spectra emitted by the sample as a result of illumination by the controllable illumination device. The system also include a data processor, connected to the detecting device, for analyzing detected fluorescence spectra to calculate a probability that the sample belongs in a particular classification. The data processor analyzes the detected fluorescence spectra using a multivariate statistical method. The five primary steps involved in the multivariate statistical method are (i) preprocessing of spectral data from each patient to account for inter-patient variation, (ii) partitioning of the preprocessed spectral data from all patients into calibration and prediction sets, (iii) dimension reduction of the preprocessed spectra in the calibration set using principal component analysis, (iv) selection of the diagnostically most useful principal components using a two-sided unpaired student's t-test and (v) development of an optimal classification scheme based on logistic discrimination using the diagnostically useful principal component scores of the calibration set as inputs.

A near real-time system and method for continuous online monitoring of a plurality of operations in a continuous chemical process facility is described. The method of monitoring the operations is based on a multivariate statistical model developed using off-line, selected process-specific historical process data. Such a model is used by an online monitoring system to monitor the continual operation of a chemical manufacturing facility or refinery in real-time from a remote location. Such real-time monitoring allows for determination of whether one or more of the plurality of operations are operating within their normal operational parameters. This real-time, continuous monitoring system can further be used to predict impending failures or trouble-spots within the continuous production process, or to minimize catastrophic process failures which may occur in a continuous chemical manufacturing process. Process variables, or ''tags'', that are most likely related to predicted process failures can be identified by the model system, such that appropriate control actions can be taken to prevent an actual process failure occurrence, which can lead to costly production down times.

Machine condition monitoring on a system utilizes a wireless sensor network to gather data from a large number of sensors. The data is processed using a multivariate statistical model to determine whether the system has deviated from a normal condition. The wireless sensor network permits the acquisition of a large number of distributed data points from plural system modalities, which, in turn, yields enhanced prediction accuracy and a reduction in false alarms.

An apparatus, system, method, and computer readable medium containing computer-executable code for implementing image analysis uses multivariate statistical analysis of sample images, and allows segmentation of the image into different groups or classes, depending on a correlation to one or more sample textures, or sample surface features. In one embodiment, the invention performs multivariate statistical analysis of ultrasound images, wherein a tumor may be characterized by segmenting viable tissue from necrotic tissue, allowing for more detailed in vivo analysis of tumor growth beyond simple dimensional measurements or univariate statistical analysis. Application of the apparatus and method may also be used for characterizing other types of samples having textured features including, for example, tumor angiogenesis biomarkers from Power Doppler.

A system and method for monitoring a process in a process plant and detecting an abnormal condition includes collecting data representative of the operation of the process, performing a multivariate statistical analysis to represent the operation of the process in a known state based on a set of collected reference data, where the reference data includes a statistical measure of the operation of the process in the known state. The system and method may further include representing the operation of the process in an unknown state based on a set of monitored data, where the monitored data includes a statistical measure of the operation of the process in an unknown state, and using the output of the multivariate statistical analysis as an input, and comparing the process in the unknown state to the multivariate statistical representation of the operation of the process in the known state to determine the operational state of the process.

Methods and systems to detect steady-state operations in a process of a process plant include collecting process data. The collected process data is generated from a plurality of process variables of the process. A multivariate statistical model of the operation of the process is generated using the process data. The multivariate statistical model may be generated from a principal component analysis. The model is executed to generate outputs corresponding to the most significant variations in the process. Statistical measures of the outputs are generated and used to determine whether a steady-state or unsteady-state is related to the process.