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839 results about "Predictive value" patented technology

Predictive value. P value Decision-making A value that predicts the likelihood that a result from a test reflects the presence or absence of a disease. Cf ROC curve. pre·dic·tive va·lue. An expression of the likelihood that a given test result will correlate with the presence or absence of disease.

Binary prediction tree modeling with many predictors and its uses in clinical and genomic applications

The statistical analysis described and claimed is a predictive statistical tree model that overcomes several problems observed in prior statistical models and regression analyses, while ensuring greater accuracy and predictive capabilities. Although the claimed use of the predictive statistical tree model described herein is directed to the prediction of a disease in individuals, the claimed model can be used for a variety of applications including the prediction of disease states, susceptibility of disease states or any other biological state of interest, as well as other applicable non-biological states of interest. This model first screens genes to reduce noise, applies k-means correlation-based clustering targeting a large number of clusters, and then uses singular value decompositions (SVD) to extract the single dominant factor (principal component) from each cluster. This generates a statistically significant number of cluster-derived singular factors, that we refer to as metagenes, that characterize multiple patterns of expression of the genes across samples. The strategy aims to extract multiple such patterns while reducing dimension and smoothing out gene-specific noise through the aggregation within clusters. Formal predictive analysis then uses these metagenes in a Bayesian classification tree analysis. This generates multiple recursive partitions of the sample into subgroups (the “leaves” of the classification tree), and associates Bayesian predictive probabilities of outcomes with each subgroup. Overall predictions for an individual sample are then generated by averaging predictions, with appropriate weights, across many such tree models. The model includes the use of iterative out-of-sample, cross-validation predictions leaving each sample out of the data set one at a time, refitting the model from the remaining samples and using it to predict the hold-out case. This rigorously tests the predictive value of a model and mirrors the real-world prognostic context where prediction of new cases as they arise is the major goal.
Owner:DUKE UNIV

Methods and systems for preemptive and predictive page caching for improved site navigation

A method for a first computer to request documents from a second computer includes steps of sending a first request for a first document to the second computer responsive to a first user action, receiving the first document sent by the second computer responsive to the first request; identifying all references to second documents in the received first document; independently of any user action, automatically sending a second request for at least one of the second documents referred to by the identified references; receiving the second document(s) requested by the second request and storing the received second document(s) in a storage that is local to the first computer, and responsive to a user request for one or more of the second documents, attempting first to service the user request from the local storage and sending a third request to the second computer for second document(s) only when the second document(s) is not stored in the local storage. A method of servicing a request for access to a Web site by a remote computer may include a receiving step to receive the request for access to the Web site; a first sending step to send a first page of the accessed Web site to the remote computer responsive to the request, and independently of any subsequent request for a second page of the Web site originating from the remote computer, preemptively carrying out a second sending step to send the remote computer at least one selected second page based upon a prediction of a subsequent request by the remote computer and/or a history of second pages previously accessed by the remote computer.
Owner:ORACLE INT CORP

Determination of treatment results prior to treatment or after few treatment events

InactiveUS20080167571A1Predict and evaluate long lasting change in overall neurocognitive functionIncrease doseElectroencephalographyElectrotherapyTreatment resultsNeurocognitive Dysfunction
Disclosed are methods and data on determining response to a drug or other therapy prior to administration by obtaining a direct neurocognitive brain function measurement; obtaining an indirect neurocognitive brain function measurement; and, assessing the direct neurocognitive brain function measurement and the indirect neurocognitive brain function measurement collectively to obtain a response determination preferably the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements. Also disclosed are methods of determining dosage of a drug comprising administering a drug; comprising obtaining a direct neurocognitive brain function measurement; obtaining an indirect neurocognitive brain function measurement; and, assessing the direct neurocognitive brain function measurement and the indirect neurocognitive brain function measurement collectively to obtain a dosage, preferably the predictive value of the collective assessment is greater than a predictive value obtained from the separate predictive values for the direct and indirect measurements; optionally, additional cycles of obtaining and assessing indirect and direct measurements are performed.
Owner:GEVINS ALAN

Self-adaptation three-dimensional attitude positioning method based on microinertia and geomagnetic technology

The invention discloses a self-adaptation three-dimensional attitude positioning method based on microinertia and a geomagnetic technology, comprising the following steps of: (1) inducing a motion attitude of a carrier by utilizing a sensor of a microinertia measuring device; (2) setting an initial attitude of the microinertia measuring device and accelerated speed and geomagnetic field information under a global coordinate system; (3) solving the attitude value of the microinertia measuring device; (4) predicting the attitude value of the microinertia measuring device by utilizing triaxial micro-gyroscope sensor data; (5) carrying out confidence judgment on the triaxial micro-acceleration sensor data and triaxial magnetic field sensor data, detecting the interference of a surrounding environment, and setting self-adaptation parameters; (6) obtaining the attitude error value of the microinertia measuring device by utilizing the triaxial micro-acceleration sensor data and the triaxial magnetic field sensor data which are processed in the step (5); (7) fusing the attitude predictive value obtained from the step (4), corrected information obtained from the step (6) and the self-adaptation parameters obtained from the step (5) to obtain the attitude value of the microinertia measuring device; and (8) outputting attitude information.
Owner:INST OF AUTOMATION CHINESE ACAD OF SCI

State monitoring and failure diagnosis method for wind generating set variable pitch system

The invention discloses a state monitoring and failure diagnosis method for a wind generating set variable pitch system. The method includes the steps that 1, in data collection, operation parameters related with the operation state of the variable pitch system are extracted from a wind generating set SCADA system; 2, according to feature parameter extraction, a Relief algorithm is utilized for extracting effective feature parameters of the variable pitch system; 3, in data analysis and prediction, historical data during normal operation of the variable pitch system are screened out to establish a health model of a fan and calculate the prediction value of a real-time signal and the difference between an actual output value and the prediction value; 4, according to a diagnosis algorithm, the operation state of the fan is judged according to residual error information transmitted by the step 3, and the main failure reason of the variable pitch system is found according to a corresponding diagnosis rule and the contribution rate of residue errors; 5, according to data storage, real-time data, prediction data and the diagnosis result are stored to facilitate failure analysis at the later period and provided as reference data for modifying the failure diagnosis rule.
Owner:北京中恒博瑞数字电力科技有限公司

Diagnostic and predictive system and methodology using multiple parameter electrocardiography superscores

A plurality of ECG Superscore formulae, created from multiple parameter ECG measurements including those from advanced ECG techniques, can be optimized using additive multivariate statistical models or pattern recognition procedures, with the results compared against a large database of ECG measurements from individuals with known cardiac conditions and/or previous cardiac events. Superscore formulae utilize multiple ECG parameters and accompanying weighting coefficients and allow data obtained from any given patient to be used in calculating that patient's ECG Superscore results. ECG Superscores have retrospectively optimized accuracy for identifying and screening individuals for underlying heart disease and/or for determining the risk of future cardiac events. They thus have greater predictive value than that of any conventional or advanced ECG measurement alone or of any non-optimized combinations of conventional or advanced ECG measurements that have been used in the past. Ongoing optimization of ECG Superscore diagnostic and predictive accuracy may be realized through the iterative adjustment of Superscore formulae based on the incorporation of data from new patients into the database and/or from longitudinal follow-up of the disease and cardiac event status of existing patients.
Owner:BRIAN ARENARE

Short-term wind power prediction method based on integrated empirical mode decomposition and deep belief network

The invention discloses a short-term wind power prediction method based on integrated empirical mode decomposition and a deep belief network. The short-term wind power prediction method comprises the steps of: decomposing an original wind power sequence into a series of intrinsic mode functions with different features by adopting integrated empirical mode decomposition, calculating sample entropy of the original wind power sequence and the intrinsic mode functions, combining the intrinsic mode functions with similar sample entropy values into a new sequence, and forming a random component, a detail component and a trend component; selecting an input variable set by adopting a partial autocorrelation function; constructing a training sample set according to the input variable set of each component; and establishing a deep belief network short-term wind power prediction model for each component, and superposing prediction results of the components, so as to obtain a final short-term wind power predicted value. The short-term wind power prediction method provided by the invention effectively improves the short-term wind power prediction precision, and can effectively solve the wind power prediction problem of the electric power system, so as to provide more reliable guarantee for large-scale wind power integration.
Owner:STATE GRID JIANGSU ELECTRIC POWER CO ELECTRIC POWER RES INST +3

Methods of determining acute myeloid leukemia response to treatment with farnesyltransferase

We analyzed bone marrow from 67 patients from a phase 2 study of farnesyltransferase inhibition with tipifarnib (R115777, ZARNESTRA®), in older adults with previously untreated, poor-risk acute myeloid leukemia (AML) for N-Ras mutations, global gene expression, and/or quantitative PCR (qPCR) of specific genes. Microarray profiling identified a two-gene expression ratio (RASGRP1:APTX) which provided the greatest accuracy for predicting response to tipifarnib. We demonstrated that this classifier could predict response to tipifarnib in an independent set of 54 samples from relapsed or refractory AML, with a NPV and PPV of 92% and 28%, respectively (odds ratio of 4.4). Therefore, in both newly diagnosed and relapsed or refractory AML, this classifier improves the overall response rate by approximately 50% while maintaining a high NPV, and significantly improves patient overall survival. The two-gene classifier was also validated by qPCR in thirty AML samples from the same clinical study demonstrating a negative predictive value (NPV) and positive predictive value (PPV) of 81% and 50%, respectively (odds ratio of 4.3). These data indicate that a simple two-gene expression assay may have utility in diagnosing a population of AML patients who are more likely to respond to tipifarnib.
Owner:JANSSEN DIAGNOSTICS LLC
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