942 results about "Necrotic tissue" patented technology

Device and methods for the treatment of wounds using ultrasound energy are disclosed. The portable wound treatment device may deliver ultrasound energy to a wound through direct contact with the ultrasound tip and / or through a liquid coupling medium. Several ultrasound tips specially designed to concentrate and focus ultrasound energy onto a wound are also disclosed. The ultrasound tip may also possess an abrasive peripheral boundary to aid in debriding the wound and / or removing necrotic tissue. The disclosed invention may have multiple beneficial effects in treating a wound such as sterilizing a wound, reducing external bleeding, and / or providing pain relief.

A device for excluding the left atrial appendage (LAA) includes first and second members, each with first and second ends. The second ends are connected by a hinge. The first ends interlock to close the device about the LAA. The members are shaped such that they can exclude the LAA without causing the development of necrotic tissue. If desired, a flexible cover can be provided and the first and second members can be disposed within the cover. If such a cover is used, it will contact the LAA in order to cushion the contact between the members and the LAA and minimize the tendency of the LAA to bleed. The invention also includes methods for using the device to exclude the LAA.

An ablation catheter system for capturing and removing necrotic tissue and thrombi generated during an ablative procedure is disclosed. The catheter typically includes an elongate member, a filtration assembly disposed within the distal region, and an ablation instrument at the distal end. Alternatively, the ablation instrument is carried on the distal end of an ablation catheter, which is disposed within a lumen of the catheter system. The catheter may further include an aspiration port and lumen. Methods of using the devices in preventing distal embolization during ablative procedures are disclosed.

A device for occluding a conduit includes first and second members, each with first and second ends. The second ends are connected by a hinge. The first ends interlock to close the device about the conduit. The members are shaped such that they can occlude the conduit without causing the development of damaged or necrotic tissue. If desired, a flexible cover can be provided and the first and second members can be disposed within the cover. If such a cover is used, it will contact the conduit in order to cushion the contact between the members and the conduit, minimize the tendency of the conduit to bleed, and increase traction relative to the conduit. The invention also includes methods for using the device to occlude a conduit.

An apparatus, system, method, and computer readable medium containing computer-executable code for implementing image analysis uses multivariate statistical analysis of sample images, and allows segmentation of the image into different groups or classes, depending on a correlation to one or more sample textures, or sample surface features. In one embodiment, the invention performs multivariate statistical analysis of ultrasound images, wherein a tumor may be characterized by segmenting viable tissue from necrotic tissue, allowing for more detailed in vivo analysis of tumor growth beyond simple dimensional measurements or univariate statistical analysis. Application of the apparatus and method may also be used for characterizing other types of samples having textured features including, for example, tumor angiogenesis biomarkers from Power Doppler.

A method and apparatus for treating in situ biologic tissue include identifying a patient with a condition susceptible to treatment by forming a lesion in the tissue and accessing a surface of the tissue. A lesion formation tool is positioned against the accessed surface. The tool includes an optical fiber for guiding a coherent waveform of a selected wavelength to a fiber tip for discharge of light energy from the fiber tip. The wavelength is selected for the light energy to penetrate a full thickness of the tissue to form a volume of necrosed tissue through the thickness of the tissue. The tool further includes a guide tip coupled to the fiber tip. The guide tip is adapted to have a discharge bore aligned with the fiber tip to define an unobstructed light pathway from the fiber tip to the tissue surface. The guide tip is further adapted to be placed against the tissue surface with the guide tip slidable along the tissue surface in atraumatic sliding engagement with the discharge bore opposing the tissue surface. The lesion formation tool is manipulated to draw the guide tip over the tissue surface in a pathway while maintaining the discharge bore opposing the tissue surface to form a transmural lesion in the tissue extending a length of the pathway.

Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing and preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used to reduce the microbial infection, manage exudates secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from 160–400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation, and increases collagenase expression to debride necrotic tissue at the wound site. After a first treatment period, a second treatment period at a lower concentration of nitric oxide, preferably ranging from 5–20 ppm may be used to restore the balance of nitric oxide and induce collagen expression aiding in the wound closure.

Device and methods for the treatment of wounds using ultrasound energy are disclosed. The portable wound treatment device may deliver ultrasound energy to a wound through direct contact with the ultrasound tip and / or through a liquid coupling medium. Several ultrasound tips specially designed to concentrate and focus ultrasound energy onto a wound are also disclosed. The ultrasound tip may also possess an abrasive peripheral boundary to aid in debriding the wound and / or removing necrotic tissue. The disclosed invention may have multiple beneficial effects in treating a wound such as sterilizing a wound, reducing external bleeding, and / or providing pain relief.

A device for excluding the left atrial appendage (LAA) includes first and second members, each with first and second ends. The second ends are connected by a hinge. The first ends interlock to close the device about the LAA. The members are shaped such that they can exclude the LAA without causing the development of necrotic tissue. If desired, a flexible cover can be provided and the first and second members can be disposed within the cover. If such a cover is used, it will contact the LAA in order to cushion the contact between the members and the LAA and minimize the tendency of the LAA to bleed. The invention also includes methods for using the device to exclude the LAA.

The invention provides a near-infrared spectrum imaging system for diagnosis of depth and area of burn skin necrosis. The near-infrared spectrum imaging system comprises a spectrum imager and a computer-control system. The spectrum imager acquires 1100-2500nm waveband spectral signals of burn skin necrosis tissue of a target area, the spectral signals are subjected to image analyzing and processing through the computer-control system, the depth and area of burn of the target area can be acquired through spectral matching recognition upon a spectral reflectance curve corresponding to each image element in spectral images and a standard spectral reflectance curve in a burn skin necrosis spectral database in a data module and are synthesized into three-dimensional image display of the target area. By the near-infrared spectrum imaging system, the spatial structure of skin changed due to tissue protein denaturation before and after the skin burn can be specified, so that micron-level information about boundaries of normal skin tissue and necrotic tissue and the depth of burn skin necrosis can be provided visually, and clinical diagnosis, treatment and prognosis judgment can be supportively facilitated.

Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.

A method that includes the following effects: the ability to expand, porositize, clean, decontaminate, debride, break-down and / or destroys, or aids and accentuates the dissolution or extraction of biological structures, nerves and tissues. The methodology uses nano-technology and / or other chemistries may or may not be excited by energy sources to expand and porositize the tissue, which enhances the penetration and effectiveness and acceleration of subsequent chemical, mechanical, and / or procedural steps in the protocol or process. Furthermore, the method includes the ability to associate with and / or initiate in the reconstructive growth and healing process associated with healthy tissue after surgery and / or the ability to destroy diseased or necrotic tissues or cells. The method also includes the ability to begin, construct or stage the activation of cells and / or tissues, including the area of transplantation and use in stem or primordial cell accentuation, their attachment and / or stimulation for growth and differentiation.

The disclosed embodiments include tools for aiding a user in debriding necrotic tissue. For example, in one embodiment, a debridement tool is disclosed that includes a housing having an interior space. A motor and a power source are disposed within the interior space of the housing. The power source is operable to provide power to the motor. A blade is coupled to a first end of the housing. The blade is operable to vibrate when the motor is powered. The debridement tool further includes a lighting element disposed within the housing and beneath a cutting edge of the blade. The lighting element is operable to illuminate the tissue site. In some embodiments, the lighting element operates at a particular wavelength that assists in distinguishing between necrotic tissue and healthy tissue.

The invention discloses an image segmentation method based on feature pyramid fusion, which is used for analyzing a magnetic resonance image and segmenting edema and necrosis tissues and normal tissues. A method for remove edema without inclusion by preprocessing that data, Magnetic resonance imaging of necrotic tissue information, data enhancement is then performed to prevent over-fitting, and then the data is put into the depth learning model with characteristic pyramid fusion, Firstly, the feature of the data is extracted by the downsampling process, and then the resolution of the input data is recovered gradually in the upsampling process. Finally, the segmentation results are obtained by the pyramid fusion of the information extracted from the upsampling process at various scales. Experiments are performed using BraTS 2015 and BraTS 2017 datasets, and five cross validations are performed. Compared with the depth learning model without pyramid fusion, the segmentation accuracy of the method proposed by the invention is obviously improved, which indicates that the method proposed by the invention is effective.

The invention provides an external traditional Chinese medicine preparation for treating chronic wounds, which is prepared from the following raw medicines in parts by weight: 10-20 parts of draconis sanguis, 10-20 parts of chuanxiong rhizome, 10-20 parts of notoginseng, 10-20 parts of fried sanguisorba, 10-20 parts of safflower, 10-20 parts of spatholobus stem, 10-20 parts of giant knotweed, 10-20 parts of oldenlandia, 10-20 parts of red sage root, 10-20 parts of herba patriniae, 10-20 parts of moutan bark, 10-20 parts of myrrh, 10-20 parts of mastic, 10-20 parts of rhubarb, 10-20 parts of natural indigo, 10-20 parts of gromwell, 10-20 parts of catechu, 10-20 parts of borneol, 10-20 parts of phellodendron bark and 10-20 parts of boneset. The external traditional Chinese medicine preparation provided by the invention can promote healing of infectious wounds, increase pus, enhance qualitative viscosity and regenerate granulation to enable the wounds to quickly heal, has an obvious effect on treating wound infection, and can be used for treating partial ulcer, removing necrotic tissue and promoting granulation, accelerating the degeneration process of the necrotic tissue, promoting dilation of capillary vessels, accelerating microcirculation of the capillary vessels and filling the wounds.

Methods of regulating angiogenesis, ischemic injury and / or wound healing by modulating the activity of leptin, particularly as mediated by the leptin receptor, and / or the interaction between leptin and the leptin receptor. Correspondingly, these methods can also be used to treat diseases mediated by angiogenesis, including wound healing, tumors and tumor metastasis, diabetic microangiopathy, retinal neovascularization, neovascularization of adipose tissue and fat metabolism, revascularization of necrotic tissue, enhancement or vascularization in microvascular transplants, and ovarian follicle maturation. Assays for identifying agents that modulate leptin and / or leptin receptor-mediated angiogenesis and / or wound healing and their use in treating angiogenesis-mediated diseases or conditions involving wound healing are also disclosed.

An apparatus, system, method, and computer readable medium containing computer-executable code for implementing image analysis uses multivariate statistical analysis of sample images, and allows segmentation of the image into different groups or classes, depending on a correlation to one or more sample textures, or sample surface features. In one embodiment, the invention performs multivariate statistical analysis of ultrasound images, wherein a tumor may be characterized by segmenting viable tissue from necrotic tissue, allowing for more detailed in vivo analysis of tumor growth beyond simple dimensional measurements or univariate statistical analysis. Application of the apparatus and method may also be used for characterizing other types of samples having textured features including, for example, tumor angiogenesis biomarkers from Power Doppler.

The present inventors revealed for the first time in the world that 1) a large amount of bone marrow-derived cells are mobilized in transplanted skin; 2) the mobilized bone marrow-derived cells are differentiated into any of dermal fibroblasts, adipocytes, muscle cells, vascular endothelial cells and epidermal keratinocytes in a transplanted skin graft, and in the mobilized bone marrow-derived cells, bone marrow-derived mesenchymal stem cells are contained; 3) what mobilize the bone marrow-derived mesenchymal stem cells to the graft from the peripheral blood are HMGB1, HMGB2 and HMGB3 released from necrotic tissue of the transplanted skin; 4) purified HMGB1, HMGB2 and HMGB3 promote migration of mesenchymal stem cells isolated from the bone marrow and cultured; 5) active substances including HMGB1 that allow bone marrow mesenchymal stem cells to migrate can be simply purified from an extract of a large number of organs including skin, brain and heart; 6) active substances that allow bone marrow mesenchymal stem cells to migrate can be simply extracted from cultured cells; and 7) a heparin column-purified fraction of skin extract mobilizes a large amount of bone marrow-derived cells during brain damage.

The present inventors revealed the following for the first time in the world:1) a large amount of bone marrow-derived cells are mobilized to grafted skin;2) the mobilized bone marrow-derived cells are differentiated into any of dermal fibroblasts, adipocytes, muscle cells, vascular endothelial cells, and epidermal keratinocytes in the grafted skin, and the mobilized bone marrow derived cells include bone marrow-derived mesenchymal stem cells;3) the factors which mobilize bone marrow-derived mesenchymal stem cells from peripheral blood to the grafted skin are HMGB1, HMGB2, and HMGB3 released from the necrosed tissue of recipient skin;4) purified HMGB1, HMGB2, and HMGB3 promote the migration of mesenchymal stem cells isolated and cultured from bone marrow;5) activators containing HMGB1 which allows the migration of bone marrow mesenchymal stem cells can be conveniently purified from several organ extracts including skin, brain, and heart;6) activators which allow the migration of bone marrow mesenchymal stem cells can be conveniently extracted from cultured cells; and7) a heparin-column purified fraction of skin extract mobilizes a large amount of bone marrow-derived cells in case of brain injury.

It is described a composition comprising an effective amount of the HMGBl protein or functional parts thereof, of HMGBl expressing vectors, for the treatment of tissue damage and / or to promote tissue repair and regeneration. It is further described a composition comprising an effective amount of an antagonist of the HMGBl protein for the treatment of adverse effects induced by necrotic tissue, such as recruitment and activation of mveloid cells, loss of the barrier function of endothelia, edema.

This invention relates to biology, veterinary and medicine, and more particularly to methods and devices for physiotherapy with the use of electromagnetic radiation in the ultra-high frequency band. The method consists in that patients are irradiated with electromagnetic microwave field at, at least, one frequency belonging to, at least, one of the 18 frequency ranges. The intensity of radiation at the place of location of the patient does not exceed 3.6 μW / cm2. The device for carrying out the method comprises, at least, one oscillator ensuring the production of electromagnetic radiation in the 18 frequency ranges, both at the main frequencies and at multiple ones. In the result the effect of pain relief is achieved, inflammatory processes are lessened, processes of regeneration of damaged tissues are stimulated, an affected immune status is corrected, the processes of cell proliferation in neoplasms are stabilized, the lysis of necrotic tissue cells occurs.

The invention discloses a hydrogel skin wound dressing capable of resisting bacteria and promoting healing and a preparation method of the hydrogel skin wound dressing. The dressing comprises the following components: 10-15% of water-soluble macromolecular compounds, 0.1-5% of Chinese herbal medicine extracts, 0.1-1% of natural moisturizing and healing promoting materials, and the balance of water, wherein the natural moisturizing and healing promoting materials are selected from at least one kind of micromolecule collagen peptides, low-molecular weight hyaluronic acid and micromolecule natural silk peptides. According to the hydrogel skin wound dressing disclosed by the invention, Chinese herbal medicines which have the functions of resisting bacteria, diminishing inflammation, promotingtissue regeneration and removing necrotic tissues and the natural moisturizing and healing promoting materials are compounded and are in combined use to have a synergistic effect, so that the compatibility of the Chinese herbal medicines and the natural moisturizing and healing promoting materials with a hydrogel basal body is improved; the hydrogel skin wound dressing is slowly released and deeply infiltrates into skin, so that absorption of medicines and nutrient contents is promoted, and the healing of wounds is accelerated; besides, the hydrogel dressing disclosed by the invention has favorable bacterium resistance, high water absorption, favorable transparency and favorable healing promoting effects; the product is pure, and the technology is simple and convenient; the hydrogel skin wound dressing is especially suitable for wound healing of the skin, and can effectively promote healing of a II degree burn wound.

Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data. In either case, the members of the dataset pair are combined (110, 122) by subtraction or division to effect the piece-wise cancellation / enhancement for display (218) of the resulting signal in real time.

The present invention relates to the use of plasminogen and plasmin as agents for enhancing healing of tympanic membrane perforations or other wounds, and for reducing scars or necrotic tissue forming during wound healing. The invention also relates to a method for screening of compounds which enhance wound healing by evaluating the healing of tympanic membrane perforations in an animal model.

The invention discloses a traditional Chinese medicine composition for treating oral ulcer. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients: gypsum, calamine, natural indigo, borneol, dried alum, dark plum fruit, mint, oyster, pearl, calculus bovis, radix scutellariae, coptisine hydrochloride, coix seed, amur corktree bark, radix sophorae flavescentis, licorice roots northwest origin, Chinese gentian root, Chinese gall, dandelions, sediment of human urine, realgar, carbonized spider, ivory chips, abroma angusta, wusuli dragonflyorchis rhizome, anhydrous sodium sulphate and alumen. The composition has the functions of clearing away heat and toxic materials, relieving swelling and pain, removing necrotic tissue and promoting granulation and astringing to stop bleeding, is mainly used for treating oral ulcer caused by endogenous pathogenic heat, has simple preparation processes and small toxic and side effects, is convenient to administrate, is easy to prepare, is low in cost, can directly treat focuses, ensures short cure time and avoids relapse after cure.