The invention discloses a hydrogel skin wound dressing capable of resisting bacteria and promoting healing and a preparation method of the hydrogel skin wound dressing. The dressing comprises the following components: 10-15% of water-soluble macromolecular compounds, 0.1-5% of Chinese herbal medicine extracts, 0.1-1% of natural moisturizing and healing promoting materials, and the balance of water, wherein the natural moisturizing and healing promoting materials are selected from at least one kind of micromolecule collagen peptides, low-molecular weight hyaluronic acid and micromolecule natural silk peptides. According to the hydrogel skin wound dressing disclosed by the invention, Chinese herbal medicines which have the functions of resisting bacteria, diminishing inflammation, promotingtissue regeneration and removing necrotic tissues and the natural moisturizing and healing promoting materials are compounded and are in combined use to have a synergistic effect, so that the compatibility of the Chinese herbal medicines and the natural moisturizing and healing promoting materials with a hydrogel basal body is improved; the hydrogel skin wound dressing is slowly released and deeply infiltrates into skin, so that absorption of medicines and nutrient contents is promoted, and the healing of wounds is accelerated; besides, the hydrogel dressing disclosed by the invention has favorable bacterium resistance, high water absorption, favorable transparency and favorable healing promoting effects; the product is pure, and the technology is simple and convenient; the hydrogel skin wound dressing is especially suitable for wound healing of the skin, and can effectively promote healing of a II degree burn wound.