The application discloses a kind of
sodium hyaluronate-
polyurethane composite hemostatic anti-adhesion sponges for
uterine cavity and its preparation method and application, it is related to medical biological
composite material technical field;The composite hemostatic anti-adhesion
sponge includes
sodium hyaluronate crosslinking gel and
polyurethane and its
porosity is 70%~95%, water absorption is 8~20 times of its own
mass, tensile strength is 0.4~1.2MPa,
in vitro degradation period is 20~45 days, crosslinking agent residual amount is less than 0.1ug / g,
cytotoxicity is less than or equal to 1 level;
Sodium hyaluronate crosslinking gel will form soft and lubricious
physical barrier after water absorption and expansion, effectively isolate uterine anterior and
posterior wall wound, prevent adhesion, provide environment for
wound healing;
Polyurethane sponge can quickly reach relatively balanced water absorption, help to quickly absorb
uterine cavity exudate, keep wound clean, also can provide mechanical support, prevent
uterine cavity contracture deformation;
Polyurethane is matched with uterine cavity clinical healing period, and degradation product has no
toxicity residue.