High-moisture-permeability hydrogel nursing patch and preparation method thereof

Abstract

The invention discloses a high-moisture-permeability hydrogel nursing patch and a preparation method thereof, and belongs to the technical field of medical supplies. Sodium alginate and gelatin are scientifically compounded to serve as a gel skeleton, functional components such as the aloe extract, the humectant and the penetration enhancer are supplemented, a stable three-dimensional network structure is constructed, the synergistic effect of multiple effects of moisturizing, resisting bacteria, promoting absorption of active ingredients and the like is achieved, and the synergistic improvement of high moisture permeability, antibacterial property and mechanical property of the product is achieved; the prepared nursing patch can quickly and largely absorb exudate at a wound, keep the wound clean and dry, reduce the risk of wound infection by absorbing the exudate, promote wound healing, effectively relieve skin surface wounds and scratches, and avoid skin infection and ulceration caused by the wounds.

Description

Technical Field

[0001] This invention relates to the field of medical supplies technology, specifically to a highly permeable hydrogel nursing patch and its preparation method. Background Technology

[0002] Skin is a vital organ covering the human body and in direct contact with the external environment. It functions to sense external stimuli and regulate body temperature, protecting the body from harm caused by external stimuli. However, due to various internal and external factors, we inevitably get injured, forming acute or chronic wounds of varying sizes and depths. In such cases, ideal wound dressings are urgently needed. Wound dressings cover the wound surface, providing a temporary barrier to prevent exogenous infection, and can also induce skin cell remodeling and tissue integration, significantly impacting the promotion of normal wound healing.

[0003] Currently used dressings are categorized by form into fibers, films, sponges, hydrogels, hydrocolloids, and medical adhesives. Among these, hydrogels, due to their high water content, can provide a good moist environment for wounds, improve the removal rate of necrotic tissue, and accelerate wound healing. In addition, they also have an easily controllable surface structure. Hydrogels can absorb wound exudate and promote wound hydration, thus promoting wound healing and reducing patient discomfort and potential infection. Hydrogel dressings are also commonly used for pressure sores, local lesions of skin tissue, and wounds with tissue devitalization, and are very effective for superficial wounds.

[0004] Chinese patent document CN118512642A discloses a hydrogel dressing, its preparation method, and its application. The hydrogel dressing comprises the following components by weight percentage: 1%–5% quaternized carboxymethyl chitosan, 1%–5% aldehyde-modified sodium alginate, 0.01%–0.2% chelating agent, 0.5%–1.5% exosome-calcium alginate microspheres, and 0.001%–0.01% inorganic antibacterial agent. This hydrogel dressing provides a protective barrier for the wound site, while also preventing or treating wound infection, reducing wound inflammation, promoting wound angiogenesis, and inhibiting scar formation. However, the dense covalent cross-linked network formed by the aldehyde-amino reaction severely hinders the effective transport of water vapor, easily initiating or aggravating infection. Furthermore, water vapor impregnation and infection can also hinder normal cell proliferation and migration, significantly slowing down or even interrupting the wound healing process. Summary of the Invention

[0005] The main objective of this invention is to provide a highly permeable hydrogel nursing patch and its preparation method, wherein the nursing patch has good antibacterial and permeable properties.

[0006] To achieve the above objectives, the present invention proposes a highly permeable hydrogel nursing patch, comprising a hydrogel layer and an anti-adhesive layer covering the hydrogel layer; the hydrogel layer comprises the following components by weight: 2-3 parts sodium alginate, 1-4 parts gelatin, 0.5-1 part crosslinking agent, 3-5 parts aloe vera extract, 0.5-1 part preservative, 1-1.5 parts penetration enhancer, 2-3 parts modified mesoporous silica, 1-3 parts anhydrous ethanol, 0.1-0.5 parts sodium hydroxide, and 80-100 parts deionized water.

[0007] Preferably, the anti-adhesive layer is one of polypropylene film, release paper, and polyethylene film.

[0008] Preferably, the crosslinking agent is at least one selected from alumina, alum, calcium chloride, and calcium sulfate.

[0009] Preferably, the preservative is potassium sorbate and / or sodium benzoate.

[0010] Preferably, the penetration enhancer is menthol and / or eucalyptus oil.

[0011] Preferably, the method for preparing the modified mesoporous silica includes the following steps: (1) Immerse mesoporous silica in dilute sulfuric acid solution, filter, collect solids and wash until the filtrate is neutral to obtain pretreated mesoporous silica; (2) Disperse the pretreated mesoporous silica in water, add polyethyleneimine and epichlorohydrin, adjust the pH to 8-9, stir the reaction, filter, collect the solid, wash and dry to obtain aminated mesoporous silica. (3) Dissolve baicalin and rhein in anhydrous ethanol, add aminated mesoporous silica and disperse by ultrasonication, adjust pH to 4-6, heat to react, cool, filter, wash and dry after reaction to obtain antibacterial mesoporous silica. (4) Dissolve collagen in acetic acid, add antibacterial mesoporous silica and p-toluenesulfonic acid, heat the reaction, cool and filter after the reaction is complete, wash and dry to obtain modified mesoporous silica.

[0012] Preferably, the immersion temperature in step (1) is 30-50℃ and the immersion time is 2-4h.

[0013] Mesoporous silica has a regular pore structure and a high specific surface area, which can serve as a water vapor transport channel and improve the moisture permeability of the hydrogel layer. In this step, acid treatment can effectively remove impurities remaining in the pores, making the pores more open and activating the hydroxyl groups on the surface.

[0014] Preferably, in step (2), the mass ratio of mesoporous silica, polyethyleneimine and epichlorohydrin is 10:4-6:1-3; the stirring reaction temperature is 40-60℃ and the reaction time is 3-5h.

[0015] In this step, polyethyleneimine is introduced onto the surface of mesoporous silica through the cross-linking effect of epichlorohydrin. Polyethyleneimine molecules themselves have good hydrophilicity and a large number of amine groups, which can effectively adsorb and bind water molecules, thereby improving the adsorption of water vapor molecules by mesoporous silica and thus improving the moisture permeability of the hydrogel.

[0016] Preferably, in step (3), the mass ratio of baicalin, rhein, and aminated mesoporous silica is 1-3:1-3:5-8; the heating reaction temperature is 50-70℃, and the reaction time is 6-8h.

[0017] In this step, the antibacterial components baicalin and rhein are grafted onto the mesoporous silica by reacting with aminated mesoporous silica, which is beneficial to improving the antibacterial properties of the hydrogel layer and also introduces more phenolic hydroxyl groups.

[0018] Preferably, in step (4), the mass ratio of collagen, antibacterial mesoporous silica and p-toluenesulfonic acid is 1.2-1.5:1.2-1.5:0.1-0.3; the heating reaction temperature is 70-80℃ and the reaction time is 20-24h.

[0019] Collagen is the main protein in animal connective tissue and a core component of the extracellular matrix. In this step, a large number of amino and carboxyl groups can be introduced onto mesoporous silica by reacting the phenolic hydroxyl groups on baicalin and rhein with some of the carboxyl groups in collagen.

[0020] This invention also discloses a method for preparing a highly permeable hydrogel nursing patch, comprising the following steps: Weigh each component according to the formula, mix sodium alginate, gelatin, crosslinking agent, aloe vera extract, preservative, penetration enhancer, modified mesoporous silica, anhydrous ethanol, sodium hydroxide, and deionized water evenly, then degas under vacuum, coat it onto non-woven fabric, cover it with an anti-adhesive layer, and cut it after curing to obtain a highly breathable hydrogel care patch.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: 1) This invention provides a highly permeable hydrogel nursing patch and its preparation method. By scientifically compounding sodium alginate and gelatin as the gel framework, and supplementing with functional components such as aloe vera extract, moisturizers, and penetration enhancers, a stable three-dimensional network structure is constructed. This achieves a synergistic effect of multiple functions, including moisturizing, antibacterial properties, and promoting the absorption of active ingredients. It also achieves a synergistic improvement in the product's high permeability, antibacterial properties, and mechanical properties. The nursing patch prepared by this invention can rapidly and extensively absorb exudate from wounds, keeping them clean and dry. By absorbing exudate, it can reduce the risk of wound infection and promote wound healing. It can effectively relieve skin surface trauma and abrasions, and prevent skin infection and ulceration caused by injury; 2) This invention, by adding modified mesoporous silica to the hydrogel formulation, can simultaneously and effectively improve the mechanical properties, antibacterial properties, and moisture permeability of the hydrogel. The preparation process first involves removing surface impurities through acid treatment, then introducing the hydrophilic compound polyethyleneimine onto the surface to enhance the hydrogel's adsorption of water vapor molecules, which is beneficial for synergistically improving the hydrogel's moisture permeability with mesoporous silica. Furthermore, the antibacterial active ingredients baicalin and rhein are fixed onto the surface, solving the problem of easy loss of antibacterial active ingredients with wound exudate in traditional physical addition methods. Baicalin's excellent anti-inflammatory and antioxidant capabilities can neutralize wound exudate. The oxidative stress and inflammatory response are reduced; while rhein can promote cell proliferation. The two work together to provide a long-lasting, stable and safe broad-spectrum antibacterial environment for the hydrogel nursing patch, effectively preventing wound infection. Finally, collagen is introduced into the mesoporous silica. Its abundant amino and carboxyl groups form a large number of hydrogen bonds and ionic bonds with sodium alginate and gelatin network to form a three-dimensional network structure with good flexibility and high structural stability. This increases the overall density of the gel, makes the polymer entanglement more compact, improves the compressive strength, and also improves the tensile strength and elongation at break, resulting in excellent mechanical properties and giving the hydrogel excellent comprehensive performance. Detailed Implementation

[0022] To avoid unnecessary details, unless otherwise specified, all items used in the following examples are commercially available products, and all methods used are conventional methods unless otherwise specified.

[0023] The sources of some of the raw materials used in this invention are as follows: Mesoporous silica, with a pore size of 5-20nm, model SS-S05J, was purchased from Hangzhou Jikang New Materials Co., Ltd.

[0024] Aloe vera extract, water extract, 80-100 mesh, purchased from Shanyang Lianfeng Biotechnology Co., Ltd.

[0025] Example 1

[0026] A method for preparing a highly moisture-permeable hydrogel nursing patch includes the following steps: 5g sodium alginate, 5.6g gelatin, 1.7g calcium chloride, 8g aloe vera extract, 1.6g potassium sorbate, 5.4g menthol, 5.5g modified mesoporous silica, 4g anhydrous ethanol, 0.6g sodium hydroxide, and 180g deionized water were mixed evenly and then degassed under vacuum. The mixture was then coated onto a non-woven fabric, covered with release paper, cured, and cut to obtain a highly permeable hydrogel care patch.

[0027] The method for preparing the modified mesoporous silica includes the following steps: (1) Place 50g of mesoporous silica in a 20wt% dilute sulfuric acid solution and immerse it at 40℃ for 3h. Filter, collect the solid, wash until the filtrate is neutral, and then dry to obtain pretreated mesoporous silica. (2) Disperse 40g of pretreated mesoporous silica in 200mL of water, add 20g of polyethyleneimine and 8g of epichlorohydrin, adjust the pH to 8, stir and react at 50℃ for 4h, filter, collect the solid, wash and dry to obtain aminated mesoporous silica. (3) Dissolve 10g of baicalin and 10g of rhein in 200mL of anhydrous ethanol, add 30g of aminated mesoporous silica, disperse by ultrasonication, adjust pH to 5, heat at 50℃ for 7h, cool, filter, wash and dry to obtain antibacterial mesoporous silica. (4) Dissolve 13g of collagen in 200mL of 10wt% acetic acid, add 14g of antibacterial mesoporous silica and 2g of p-toluenesulfonic acid, heat to 70℃ and react for 20h. After the reaction is completed, cool, filter, wash and dry to obtain modified mesoporous silica.

[0028] Example 2

[0029] A method for preparing a highly moisture-permeable hydrogel nursing patch includes the following steps: 4g sodium alginate, 2g gelatin, 1g calcium chloride, 6g aloe vera extract, 1g potassium sorbate, 2g eucalyptus oil, 4g modified mesoporous silica, 2g anhydrous ethanol, 0.2g sodium hydroxide, and 160g deionized water were mixed evenly and then degassed under vacuum. The mixture was then coated onto a non-woven fabric, covered with release paper, cured, and cut to obtain a highly permeable hydrogel care patch.

[0030] The method for preparing the modified mesoporous silica includes the following steps: (1) Place 50g of mesoporous silica in a 20wt% dilute sulfuric acid solution and immerse it at 30℃ for 4h. Filter, collect the solid, wash until the filtrate is neutral, and then dry to obtain pretreated mesoporous silica. (2) Disperse 40g of pretreated mesoporous silica in 200mL of water, add 16g of polyethyleneimine and 4g of epichlorohydrin, adjust the pH to 9, stir and react at 40℃ for 5h, filter, collect the solid, wash and dry to obtain aminated mesoporous silica. (3) Dissolve 6g of baicalin and 6g of rhein in 200mL of anhydrous ethanol, add 30g of aminated mesoporous silica, disperse by ultrasonication, adjust pH to 4, heat at 60℃ for 8h, cool, filter, wash and dry to obtain antibacterial mesoporous silica. (4) Dissolve 12g of collagen in 200mL of 10wt% acetic acid, add 12g of antibacterial mesoporous silica and 1g of p-toluenesulfonic acid, heat to 80℃ and react for 24h. After the reaction is completed, cool, filter, wash and dry to obtain modified mesoporous silica.

[0031] Example 3

[0032] A method for preparing a highly moisture-permeable hydrogel nursing patch includes the following steps: 6g sodium alginate, 8g gelatin, 2g calcium chloride, 10g aloe vera extract, 2g potassium sorbate, 3g eucalyptus oil, 6g modified mesoporous silica, 6g anhydrous ethanol, 1g sodium hydroxide, and 280g deionized water were mixed evenly and then degassed under vacuum. The mixture was then coated onto a non-woven fabric, covered with release paper, cured, and cut to obtain a highly permeable hydrogel care patch.

[0033] The method for preparing the modified mesoporous silica includes the following steps: (1) Place 50g of mesoporous silica in a 20wt% dilute sulfuric acid solution and immerse it at 50℃ for 2h. Filter, collect the solid, wash until the filtrate is neutral, and then dry to obtain pretreated mesoporous silica. (2) Disperse 40g of pretreated mesoporous silica in 200mL of water, add 24g of polyethyleneimine and 12g of epichlorohydrin, adjust the pH to 9, stir the reaction at 60℃ for 3h, filter, collect the solid, wash and dry to obtain aminated mesoporous silica. (3) Dissolve 12g of baicalin and 12g of rhein in 200mL of anhydrous ethanol, add 32g of aminated mesoporous silica, disperse by ultrasonication, adjust pH to 6, heat at 70℃ for 6h, cool, filter, wash and dry to obtain antibacterial mesoporous silica. (4) Dissolve 15g of collagen in 250mL of 10wt% acetic acid, add 15g of antibacterial mesoporous silica and 3g of p-toluenesulfonic acid, heat to 80℃ and react for 24h. After the reaction is completed, cool, filter, wash and dry to obtain modified mesoporous silica.

[0034] Comparative Example 1 A method for preparing a highly moisture-permeable hydrogel nursing patch includes the following steps: 5g sodium alginate, 5.6g gelatin, 1.7g calcium chloride, 8g aloe vera extract, 1.6g potassium sorbate, 5.4g menthol, 5.5g modified mesoporous silica, 4g anhydrous ethanol, 0.6g sodium hydroxide, and 180g deionized water were mixed evenly and then degassed under vacuum. The mixture was then coated onto a non-woven fabric, covered with release paper, cured, and cut to obtain a highly permeable hydrogel care patch.

[0035] The preparation method of the modified mesoporous silica is similar to that of Example 1, except that collagen is not added, and specifically includes the following steps: (1) Place 50g of mesoporous silica in a 20wt% dilute sulfuric acid solution and immerse it at 40℃ for 3h. Filter, collect the solid, wash until the filtrate is neutral, and then dry to obtain pretreated mesoporous silica. (2) Disperse 40g of pretreated mesoporous silica in 200mL of water, add 20g of polyethyleneimine and 8g of epichlorohydrin, adjust the pH to 8, stir and react at 50℃ for 4h, filter, collect the solid, wash and dry to obtain aminated mesoporous silica. (3) Dissolve 10g of baicalin and 10g of rhein in 200mL of anhydrous ethanol, add 30g of aminated mesoporous silica, disperse by ultrasonication, adjust the pH to 5, heat at 50℃ for 7h, cool, filter, wash and dry to obtain modified mesoporous silica.

[0036] Comparative Example 2 A method for preparing a highly moisture-permeable hydrogel nursing patch includes the following steps: 5g sodium alginate, 5.6g gelatin, 1.7g calcium chloride, 8g aloe vera extract, 1.6g potassium sorbate, 5.4g menthol, 5.5g modified mesoporous silica, 4g anhydrous ethanol, 0.6g sodium hydroxide, and 180g deionized water were mixed evenly and then degassed under vacuum. The mixture was then coated onto a non-woven fabric, covered with release paper, cured, and cut to obtain a highly permeable hydrogel care patch.

[0037] The preparation method of the modified mesoporous silica is similar to that in Example 1, except that baicalin, rhein, and collagen are not added. Specifically, it includes the following steps: (1) Place 50g of mesoporous silica in a 20wt% dilute sulfuric acid solution and immerse it at 40℃ for 3h. Filter, collect the solid, wash until the filtrate is neutral, and then dry to obtain pretreated mesoporous silica. (2) Disperse 40g of pretreated mesoporous silica in 200mL of water, add 20g of polyethyleneimine and 8g of epichlorohydrin, adjust the pH to 8, stir and react at 50℃ for 4h, filter, collect the solid, wash and dry to obtain modified mesoporous silica.

[0038] Comparative Example 3 A method for preparing a highly moisture-permeable hydrogel nursing patch includes the following steps: 5g sodium alginate, 5.6g gelatin, 1.7g calcium chloride, 8g aloe vera extract, 1.6g potassium sorbate, 5.4g menthol, 5.5g modified mesoporous silica, 4g anhydrous ethanol, 0.6g sodium hydroxide, and 180g deionized water were mixed evenly and then degassed under vacuum. The mixture was then coated onto a non-woven fabric, covered with release paper, cured, and cut to obtain a highly permeable hydrogel care patch.

[0039] The modified mesoporous silica is pretreated mesoporous silica, and its preparation method includes the following steps: 50g of mesoporous silica was immersed in a 20wt% dilute sulfuric acid solution at 40℃ for 3 hours, filtered, and the solid was collected, washed until the filtrate was neutral, and then dried to obtain pretreated mesoporous silica.

[0040] Comparative Example 4 A method for preparing a highly moisture-permeable hydrogel nursing patch includes the following steps: 5g sodium alginate, 5.6g gelatin, 1.7g calcium chloride, 8g aloe vera extract, 1.6g potassium sorbate, 5.4g menthol, 5.5g mesoporous silica, 4g anhydrous ethanol, 0.6g sodium hydroxide, and 180g deionized water were mixed evenly and then degassed under vacuum. The mixture was then coated onto a non-woven fabric, covered with release paper, cured, and cut to obtain a highly permeable hydrogel care patch.

[0041] Performance testing The high moisture-permeable hydrogel layers obtained in Examples 1-3 and Comparative Examples 1-4 were tested for compressive strength, tensile strength, elongation at break, antibacterial properties, and moisture permeability. Compression strength: Under room temperature conditions, cylindrical gels with a diameter of 20 mm and a height of 5 mm were prepared using a 12-well plate. The samples were subjected to compression tests using a physical property analyzer until they burst. The compression rate was set to 0.5 mm / s. Each group of samples was subjected to five compression tests, and the average value of the test results was taken. Tensile strength and elongation at break test: Cut the sample into dumbbell shape with a cutter. The total length of the sample is 75cm, the test part is 40mm long and 4mm wide. Clamp the upper and lower ends of the sample onto the tensile testing machine and stretch it at a tensile speed of 100mm / min. Measure the tensile strength and elongation at break. Test each sample three times and take the average value. Antibacterial activity: Take 0.1g of the sample and 10mL of 1×10 7 A CFU / mL Escherichia coli culture was mixed in a test tube (E. coli preservation number ATCC 8099) and incubated on a constant temperature shaker at 37℃ and 120 rpm for 4 h. Then it was incubated in a shaking incubator under natural light for 24 h. The inhibition rate was calculated by plate count method, where the inhibition rate is calculated as follows: Inhibition rate = (M1-M2) / M1×100%, where M1 and M2 are the initial colony count and the colony count after incubation, respectively. Moisture permeability: Refer to section 3.2 of YY / T0471.2-2004 "Test Methods for Contact Wound Dressings Part 2: Water Vapor Transmission Rate of Breathable Membrane Dressings" to test the moisture permeability of the hydrogel layer. The specific test method is as follows: Cut the sample into a circle the size of the moisture permeability cup diameter (inner diameter 35.7 mm), attach it to a black support frame, add purified water to the bottom of the moisture permeability cup to make the air gap between the liquid surface and the placed sample (5±1 mm), place a black sealing ring, place the sample along with the black support frame on the black sealing ring, then place another black sealing ring to seal the sample, and finally place a white sealing ring and tighten the cap. Weigh the assembled moisture permeability cup as a whole and record the mass as W1. Then place it in a forced-air drying oven with the sample facing upwards, maintain the temperature at (37±1℃), and after 24 hours, remove it from the drying oven and record the test time T. Immediately weigh it again and record the mass W2. The formula for calculating water vapor transmission rate (MVTR) is as follows: Water vapor transmission rate (g / m 2 / day)=(W1-W2)×1000×24 / T; Each sample was tested in parallel 3 times, and the average value of the test results was taken. The test results are shown in Table 1: Table 1 Performance test results of highly moisture-permeable hydrogels

[0042] As can be seen from the experimental results in Table 1, the high-permeability hydrogel nursing patch obtained by the present invention has good mechanical, antibacterial and moisture-permeable properties.

[0043] The above are merely preferred embodiments of the present invention and do not limit the patent scope of the present invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the patent protection scope of the present invention.

Claims

1. A highly breathable hydrogel nursing patch, characterized in that, It includes a hydrogel layer and an anti-adhesive layer covering the hydrogel layer; the hydrogel layer comprises the following components in parts by weight: 2-3 parts sodium alginate, 1-4 parts gelatin, 0.5-1 part crosslinking agent, 3-5 parts aloe vera extract, 0.5-1 part preservative, 1-1.5 parts penetration enhancer, 2-3 parts modified mesoporous silica, 1-3 parts anhydrous ethanol, 0.1-0.5 parts sodium hydroxide, and 80-100 parts deionized water.

2. The nursing patch according to claim 1, characterized in that: The anti-stick layer is one of polypropylene film, release paper, or polyethylene film.

3. The nursing patch according to claim 1, characterized in that: The crosslinking agent is at least one of alumina, alum, calcium chloride, and calcium sulfate.

4. The nursing patch according to claim 1, characterized in that: The preservative is potassium sorbate and / or sodium benzoate.

5. The nursing patch according to claim 1, characterized in that, The method for preparing the modified mesoporous silica includes the following steps: (1) Immerse mesoporous silica in dilute sulfuric acid solution, filter, collect solids and wash until the filtrate is neutral to obtain pretreated mesoporous silica; (2) Disperse the pretreated mesoporous silica in water, add polyethyleneimine and epichlorohydrin, adjust the pH to 8-9, stir the reaction, filter, collect the solid, wash and dry to obtain aminated mesoporous silica. (3) Dissolve baicalin and rhein in anhydrous ethanol, add aminated mesoporous silica and disperse by ultrasonication, adjust pH to 4-6, heat to react, cool, filter, wash and dry after reaction to obtain antibacterial mesoporous silica. (4) Dissolve collagen in acetic acid, add antibacterial mesoporous silica and p-toluenesulfonic acid, heat the reaction, cool and filter after the reaction is complete, wash and dry to obtain modified mesoporous silica.

6. The nursing patch according to claim 5, characterized in that: The immersion temperature in step (1) is 30-50℃ and the immersion time is 2-4h.

7. The nursing patch according to claim 5, characterized in that: In step (2), the mass ratio of mesoporous silica, polyethyleneimine and epichlorohydrin is 10:4-6:1-3.

8. The nursing patch according to claim 5, characterized in that: In step (3), the mass ratio of baicalin, rhein, and aminated mesoporous silica is 1-3:1-3:5-8.

9. The nursing patch according to claim 5, characterized in that: In step (4), the mass ratio of collagen, antibacterial mesoporous silica and p-toluenesulfonic acid is 1.2-1.5:1.2-1.5:0.1-0.

3.

10. A method for preparing the nursing patch according to any one of claims 1-9, characterized in that, The process includes the following steps: Weigh each component according to the formula, mix sodium alginate, gelatin, crosslinking agent, aloe vera extract, preservative, penetration enhancer, modified mesoporous silica, anhydrous ethanol, sodium hydroxide, and deionized water evenly, then degas under vacuum, coat it onto non-woven fabric, cover it with an anti-adhesive layer, and cut it after curing to obtain a highly breathable hydrogel care patch.

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