Intelligent adhesive bandage and preparation method thereof, textile and wearable device

Abstract

The invention discloses an intelligent adhesive bandage and a preparation method thereof, a textile and a wearable device. The intelligent adhesive bandage comprises a super-hydrophilic thin film, an electrochemical sensor and a hydrophobic thin film, the electrochemical sensor is connected to the super-hydrophilic thin film, and the hydrophobic thin film and the super-hydrophilic thin film are connected in a stacked mode to achieve packaging of the electrochemical sensor. By constructing the super-hydrophilic thin film and the hydrophobic thin film and integrating the electrochemical sensor between the two layers of thin films, the prepared intelligent adhesive bandage has wound exudate one-way conduction and dynamic detection capabilities, and a low-cost, rapid and convenient intelligent adhesive bandage processing scheme is realized; the method is expected to assist in wound cleaning and drying, wound environment dynamic monitoring and wound infection condition prompting.

Description

Technical Field

[0001] The present application relates to the fields of biomedicine and medical device technology, and in particular to a smart band-aid and a preparation method thereof, textiles and wearable devices. Background Art

[0002] Impaired healing of chronic wounds not only affects the quality of life of patients, but also incurs high treatment costs. According to the latest data from the World Health Organization, more than 40 million people suffer from chronic wounds worldwide, which cause long-term physical and mental pain to patients and lead to a rapidly increasing global economic burden. In recent years, research on wound dressings has developed rapidly, providing new solutions for advanced wound care. For example, traditional gauze dressings have been developed into hydrogel dressings with controlled drug release functions, which can effectively deliver drugs while reducing the need for frequent replacement. In addition, wearable wound dressings can provide electrical stimulation to chronic wounds, providing a new strategy to accelerate wound healing. A variety of methods using antibiotic drugs, near-infrared photothermal therapy, temperature-activated motor synergy therapy and other technologies have emerged to prevent wound infection and promote wound healing, and have great potential in assisting the treatment of chronic wounds. However, none of these wound dressings with drug release or stimulation therapy functions can clean and remove wound exudate, resulting in the accumulation of wound exudate on the wound surface for a long time, hindering the wound healing process.

[0003] Based on this, a band-aid that can automatically drain liquid has been developed. The band-aid can be used to remove excess exudate around the wound, promote wound cleaning and drying, and accelerate the wound healing process. For example, by electrospinning a hydrophobic nanofiber array onto a hydrophilic microfiber network, excess biological fluids can be unidirectionally moved away from the wound; and a single-layer Janus membrane was prepared on a copper mesh by ammonia-alkali etching, superhydrophobic modification, and single-sided hydrophilic treatment. The membrane enhances the air permeability of the dressing and significantly reduces the critical breakthrough pressure of unidirectional water delivery. However, these automatic drainage band-aids make it difficult to assess the wound healing status, which hinders timely wound management and timely dressing changes. In addition, the prior art also provides a multifunctional Janus membrane that integrates phenol red nanoparticles and can unidirectionally remove wound exudate while sensing the pH level of the wound; and a pH-responsive cellulose-based Janus nonwoven dressing that has unidirectional liquid drainage capabilities and is used for chronic wound management. Although both the Janus membrane and the Janus nonwoven dressing can estimate the wound microenvironment by on-site colorimetry, they are basically designed for single use and lack the ability to dynamically sense the microenvironment around the wound, making it difficult to dynamically reflect the state of the wound. Summary of the invention

[0004] Based on this, it is necessary to provide a smart wound patch. The smart wound patch of the present invention can dynamically reflect the state of the wound and continuously remove excessive wound exudate to promote advanced wound management.

[0005] An embodiment of the present application provides a smart bandage.

[0006] A smart wound patch comprises a super-hydrophilic film, an electrochemical sensor and a hydrophobic film, wherein the electrochemical sensor is connected to the super-hydrophilic film, and the hydrophobic film and the super-hydrophilic film are laminated and connected to realize the encapsulation of the electrochemical sensor.

[0007] In some of the embodiments, the thickness of the super hydrophilic film is 20 μm to 500 μm.

[0008] In some embodiments, the electrochemical sensor includes a sensor substrate and an electrode interface for specifically identifying and capturing the biological molecules to be tested in the sample to be tested, the sensor substrate fixes a customized electrochemical sensing pattern on the surface of the super hydrophilic film by one or more methods including screen printing, sputtering, transfer, and physical deposition through a conductive paste, and the electrode interface is connected to the sensor substrate.

[0009] In some of the embodiments, the customized electrochemical sensing pattern is a three-electrode sensing system pattern that shares a reference electrode and a counter electrode, and the number of the electrochemical sensors is 1 to 10.

[0010] In some embodiments, the electrode interface is a three-dimensional conductive structure, and the three-dimensional conductive structure includes one or more of a three-dimensional porous structure, a planar mesh structure, and a three-dimensional skeleton structure.

[0011] In some embodiments, the smart wound dressing satisfies one or more of the following conditions:

[0012] (1) The three-dimensional porous structure includes one or more of foamed carbon, foamed gold, foamed nickel and foamed nickel;

[0013] (2) The planar mesh structure comprises one or more of carbon fiber cloth, carbon fiber paper and carbon fiber yarn;

[0014] (3) The three-dimensional skeleton structure includes one or more of a non-conductive protein skeleton, a polymer skeleton and a porous ceramic modified by a two-dimensional conductive nanomaterial.

[0015] In some of the embodiments, the thickness of the hydrophobic film is 1 nm to 200 nm.

[0016] An embodiment of the present application provides a method for preparing a smart wound dressing.

[0017] A method for preparing a smart wound dressing comprises the following steps:

[0018] Preparation of super hydrophilic films;

[0019] preparing an electrochemical sensor on the super hydrophilic film; and

[0020] A hydrophobic film is prepared on the super-hydrophilic film to encapsulate the electrochemical sensor.

[0021] In some of the embodiments, when preparing a super hydrophilic film, the super hydrophilic film is prepared by using a first film solution containing a hydrophilic material through one or more of spin coating evaporation, electrospinning, hot pressing stretching, and weaving processes, or is prepared by surface modification of a hydrophobic material; wherein the hydrophilic material includes one or more of a water-soluble polymer, a cellulose material, and a hydrogel material, and the hydrophobic material includes a polymer material.

[0022] In some embodiments, the preparation method satisfies one or more of the following conditions:

[0023] (1) The water-soluble polymer includes one or more of polyvinyl alcohol (PVA), polyacrylic acid (PAA) and polyvinyl pyrrolidone (PVP);

[0024] (2) The cellulose material includes one or more of cotton, flax and straw paper;

[0025] (3) The hydrogel material includes one or more of hyaluronic acid (HA), gelatin, chitosan and polyacrylamide (PAM);

[0026] (4) The polymer material includes one or more of polytetrafluoroethylene (PTFE), polyethersulfone (PES), polycaprolactone (PCL) and polyurethane (TPU);

[0027] (5) The hydrophobic material is subjected to surface modification methods including one or more of surface modifier coating, plasma treatment, ultraviolet light grafting treatment and block polymer modification;

[0028] (6) The concentration of the hydrophilic material in the first film solution is 10% to 20%;

[0029] (7) The solvent of the first thin film solution is one or more of dimethyl sulfoxide (DMSO), aromatic amines and N,N-dimethylacetamide (DMAC);

[0030] (8) The first film solution further includes a porogen, and the porogen includes one or more of polyethylene glycol, hydroxypropyl cellulose, polyurethane, sodium chloride and polyvinyl pyrrolidone.

[0031] In some embodiments, when preparing an electrochemical sensor on the super-hydrophilic film, the following steps are included:

[0032] preparing a sensor substrate on the super hydrophilic film; and

[0033] An electrode interface for specifically identifying and capturing the biomolecules to be detected in the sample to be detected is prepared on the sensor substrate.

[0034] In some embodiments, the preparation of the sensor substrate on the super-hydrophilic film includes the following steps:

[0035] The sensor substrate fixes the customized electrochemical sensing pattern on the surface of the super-hydrophilic film through conductive paste by one or more methods including screen printing, sputtering, transfer printing and physical precipitation.

[0036] In some embodiments, the preparation method satisfies one or more of the following conditions:

[0037] (1) The conductive paste includes one or more of metal paste, conductive non-metal paste and two-dimensional conductive nano paste; wherein the metal paste includes one or more of gold, silver, platinum, nickel and titanium; the conductive non-metal paste includes one or more of carbon paste, carbon fiber and polyethylene dioxythiophene; the two-dimensional conductive nano paste includes one or more of graphene, carbon nanotubes and metal nanoparticles;

[0038] (2) The customized electrochemical sensing pattern is a three-electrode sensing system pattern that shares a reference electrode and a counter electrode;

[0039] (3) The number of the electrochemical sensors is 1 to 10.

[0040] In some of the embodiments, the electrochemical detection method used by the electrochemical sensor to collect electron transfer signals during the redox process of biomolecules includes one or more of steady-state current method (IT), differential pulse voltammetry (DPV), square wave voltammetry (SWV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), linear sweep voltammetry (LSV), alternating current voltammetry (ACV) and anodic stripping voltammetry (ASV).

[0041] In some embodiments, the preparation method satisfies one or more of the following conditions:

[0042] (1) The electrode interface can fix biological enzymes and their cross-linked products to dynamically monitor the metabolites of the sample to be tested, and the metabolites include glucose, uric acid, lactic acid, etc.;

[0043] (2) The electrode interface can modify cyanocobalamin to dynamically monitor nitrite in the sample to be tested;

[0044] (3) The electrode interface is capable of electrodepositing polyaniline to dynamically detect the pH value of the sample to be tested;

[0045] (4) The electrode interface is modified with two-dimensional nanomaterials, wherein the two-dimensional nanomaterials include one or more of graphene, carbon nanotubes and MXene.

[0046] In some embodiments, the preparation material for preparing the hydrophobic film on the super-hydrophilic film includes a second film solution containing a biocompatible hydrophobic polymer material.

[0047] In some embodiments, when preparing a hydrophobic film on the super-hydrophilic film, one or more of the following conditions are met:

[0048] (1) The biocompatible hydrophobic polymer material includes one or more of polydimethylsiloxane (PDMS), polyethylene terephthalate (PET), polyamide (PI), polyurethane (TPU), and polycaprolactone (PCL);

[0049] (2) The solvent of the second thin film solution is one or more of acetone, dimethyl sulfoxide (DMSO) and anhydrous ethanol;

[0050] (3) The preparation process of the hydrophobic film includes one or more of spin coating evaporation, electrospinning and air drying curing.

[0051] An embodiment of the present application provides a textile.

[0052] A textile, on which the above-mentioned smart bandage is arranged, or the smart bandage prepared by the above-mentioned preparation method is arranged.

[0053] An embodiment of the present application provides a wearable device.

[0054] A wearable device comprises the above-mentioned smart bandage, or a smart bandage prepared by the above-mentioned preparation method.

[0055] The smart bandage of the present application integrates a super-hydrophilic film, an electrochemical sensor and a hydrophobic film to obtain a smart bandage, wherein the super-hydrophilic film and the hydrophobic film together constitute a Janus film, and the smart bandage can promote the rapid cleaning of wound exudate, dynamic detection of wound microenvironment and wound infection prompt, so as to be used for advanced care of chronic wounds. The smart bandage of the application has lower processing cost, better sensing performance and wider application range, and meets the requirements of mass production. BRIEF DESCRIPTION OF THE DRAWINGS

[0056] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application, and those skilled in the art can obtain other drawings based on these drawings without creative work.

[0057] In order to more completely understand the present application and its beneficial effects, the following description will be given in conjunction with the accompanying drawings. In the following description, the same reference numerals represent the same parts.

[0058] FIG1 is a schematic diagram of the use of a smart bandage according to an embodiment of the present invention;

[0059] Figure 2 A schematic diagram of an electrochemical sensor of a smart wound dressing according to an embodiment of the present invention;

[0060] FIG3 is a schematic diagram of a preparation process of a smart wound dressing according to an embodiment of the present invention;

[0061] FIG4 is a physical diagram of a smart bandage according to an embodiment of the present invention;

[0062] FIG5 is a cross-sectional microscopic topological structure diagram of a smart wound dressing according to an embodiment of the present invention;

[0063] FIG6 is a contact angle test result of the forward fluid conduction of the smart wound patch according to an embodiment of the present invention;

[0064] FIG. 7 is a test result of the electrochemical performance of the smart bandage according to an embodiment of the present invention; in FIG. 7 , the abscissa is the potential (V), and the ordinate is the current (μA);

[0065] FIG8 is a dynamic detection result of pH of the smart bandage according to an embodiment of the present invention; in FIG8 , the abscissa is time (s), and the ordinate is potential (V);

[0066] FIG. 9 is a linear fitting curve of pH detection of the smart wound dressing according to an embodiment of the present invention; in FIG. 9 , the abscissa is the pH value, and the ordinate is the electric potential (V).

[0067] Description of Reference Numerals

[0068] 1. Super hydrophilic film; 2. Electrochemical sensor; 21. Counter electrode; 22. Working electrode; 23. Reference electrode; 24. Electrode lead; 3. Hydrophobic film; 4. Miniaturized electrochemical workstation; 5. User-side slave computer. DETAILED DESCRIPTION

[0069] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.

[0070] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0071] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0072] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0073] In the description of the present invention, "several" means more than one, "many" means more than two, "greater than", "less than", "exceed", etc. are understood to exclude the number itself, and "above", "below", "within", etc. are understood to include the number itself. If there is a description of "first" or "second", it is only used for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0074] In the present application, when it comes to a numerical interval (i.e., a numerical range), unless otherwise specified, the distribution of the optional numerical values ​​in the numerical interval is considered to be continuous, and includes the two numerical endpoints (i.e., the minimum and maximum values) of the numerical interval, and each numerical value between the two numerical endpoints. Unless otherwise specified, when the numerical interval only refers to an integer in the numerical interval, it includes the two endpoint integers of the numerical range, and each integer between the two endpoints, which is equivalent to directly listing each integer. When multiple numerical ranges are provided to describe features or characteristics, these numerical ranges can be combined. In other words, unless otherwise specified, the numerical range disclosed in the present application should be understood to include any and all sub-ranges included therein. The "numerical value" in the numerical interval can be any quantitative value, such as a number, a percentage, a ratio, etc. "Numerical interval" allows for a broad range of quantitative intervals such as percentage intervals, ratio intervals, and ratio intervals.

[0075] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which the present invention belongs. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0076] The present application provides a smart bandage to solve the problems of frequent bandage replacement, long prognosis time, and difficulty in wound status assessment during wound care in the prior art, as well as the problems of low exudate removal efficiency, single biochemical detection index, and high cost of existing wound dressings. The smart bandage will be described below with reference to the accompanying drawings.

[0077] The smart band-aid provided in the embodiment of the present application is exemplified in FIG1 , which is a schematic diagram of the use of the smart band-aid provided in the embodiment of the present application. The smart band-aid of the present application can be used for wound treatment.

[0078] In order to more clearly illustrate the structure of the smart band-aid, the smart band-aid will be introduced below with reference to the accompanying drawings.

[0079] Exemplarily, a smart wound-adhesive comprises a super-hydrophilic film 1, an electrochemical sensor 2 and a hydrophobic film 3. The electrochemical sensor 2 is connected to the super-hydrophilic film 1. The hydrophobic film 3 is stacked and connected with the super-hydrophilic film 1 to realize the encapsulation of the electrochemical sensor 2.

[0080] The present application constructs a super-hydrophilic film 1 and a hydrophobic film 3 and integrates an electrochemical sensor 2 between the two films. The prepared smart band-aid has the ability of unidirectional conduction and dynamic detection of wound exudate, realizes a low-cost, fast and convenient smart band-aid processing solution, and is expected to assist in wound cleaning and drying, dynamic monitoring of wound environment, and indication of wound infection.

[0081] As shown in FIG1 , the smart band-aid of the present application can be matched with a miniaturized electrochemical workstation 4 and a user-side lower computer 5 through an electrode lead 24 for use. The user-side lower computer 5 can be a mobile phone, a computer, a tablet computer, a phone watch and other devices. Specifically, the smart band-aid of the present application integrates a super-hydrophilic film 1, an electrochemical sensor 2 and a hydrophobic film 3 to obtain a smart band-aid. The super-hydrophilic film 1 and the hydrophobic film together constitute a Janus film. The smart band-aid can promote the rapid cleaning of wound exudate, dynamic detection of the wound microenvironment and wound infection prompts, so as to be used for advanced care of chronic wounds. The smart band-aid of the application has lower processing cost, better sensing performance and wider application range, which meets the requirements of mass production.

[0082] In some embodiments, the thickness of the super-hydrophilic film 1 is 20 μm to 500 μm. The thickness of the super-hydrophilic film 1 includes 20 μm, 30 μm, 40 μm, 50 μm, 100 μm, 200 μm, 300 μm, 400 μm, 500 μm or a range between any two of the above values.

[0083] In some embodiments, the electrochemical sensor 2 includes a sensor substrate and an electrode interface for specifically identifying and capturing the biomolecules to be tested in the sample to be tested. The sensor substrate fixes the customized electrochemical sensing pattern on the surface of the super-hydrophilic film 1 by one or more methods of screen printing, sputtering, transfer, and physical precipitation through a conductive paste. The electrode interface is connected to the sensor substrate.

[0084] Among them, the electrode interface is prepared by modifying the surface of the working electrode 22 of the sensor substrate using different interface materials. The electrode interface is used to specifically identify and capture the biological molecules to be tested in the sample to be tested. The biological molecules to be tested include but are not limited to metabolites such as glucose, lactic acid, uric acid, etc., ions such as sodium ions, potassium ions, and hydrogen ions, or infection-related biomarkers such as C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT). The electrode interface can modify biological enzyme molecules including glucose oxidase, lactate oxidase, uricase, etc., including inorganic biomimetic enzyme materials such as metal organic framework materials (MOF), boric acid, and cyanocobalamin, and various ion-selective films, including protein-specific recognition molecules such as nucleic acid aptamers and antibodies.

[0085] In some of these examples, see Figure 2 As shown, the customized electrochemical sensing pattern is a three-electrode sensing system pattern that shares a reference electrode 23 and a counter electrode 21 .

[0086] In some embodiments, the number of the electrochemical sensors 2 is 1 to 10. The number of the electrochemical sensors 2 includes 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

[0087] It should be noted that the working electrode 22 of the electrochemical sensor 2 can be designed as an N-channel according to actual use requirements. For example, using a single-channel electrochemical workstation as an example, the single-channel electrochemical sensor 2 is printed on the super-hydrophilic film 1 and the hydrophobic film 3 is used as an insulating package.

[0088] In some embodiments, the electrode interface is a three-dimensional conductive structure, which includes one or more of a three-dimensional porous structure, a planar mesh structure, and a three-dimensional skeleton structure.

[0089] In some embodiments, the three-dimensional porous structure includes one or more of foamed carbon, foamed gold, foamed nickel, and foamed nickel.

[0090] In some embodiments, the planar mesh structure includes one or more of carbon fiber cloth, carbon fiber paper and carbon fiber yarn.

[0091] In some of the embodiments, the three-dimensional framework structure includes one or more of a non-conductive protein framework, a polymer framework and a porous ceramic modified by a two-dimensional conductive nanomaterial.

[0092] In some embodiments, the thickness of the hydrophobic film 3 is 1 nm to 200 nm. The thickness of the hydrophobic film 3 may be 1 nm, 10 nm, 30 nm, 50 nm, 100 nm, 150 nm, 200 nm, or a range between any two of the above values.

[0093] An embodiment of the present application provides a method for preparing a smart wound dressing.

[0094] It should be noted that, in this article, unless otherwise specified, each reaction step can be carried out in the order described herein, or can be carried out in a non-sequential manner. For example, other steps may be included between each reaction step, and the order of the reaction steps may also be appropriately swapped. This can be determined by the technician based on conventional knowledge and experience. Preferably, the reaction method herein is carried out sequentially.

[0095] A method for preparing a smart wound dressing comprises the following steps:

[0096] S1. Prepare a super hydrophilic film 1.

[0097] S2. preparing an electrochemical sensor 2 on the super hydrophilic film 1.

[0098] S3 . Prepare a hydrophobic film 3 on the super hydrophilic film 1 to encapsulate the electrochemical sensor 2 .

[0099] The intelligent wound patch of the present invention has a simple processing method, low production cost, simple operation and strong versatility. The method is based on the principle of one-way conduction of fluid caused by asymmetric wettability, and constructs a super-hydrophilic film 1 that can quickly guide out wound exudate. The super-hydrophilic film 1 can assist in cleaning and drying the wound surface and accelerate wound healing; the electrochemical sensor 2 integrated on the super-hydrophilic film 1 can dynamically monitor the wound microenvironment and biochemical markers, prompt the healing and infection of the wound, assist in timely wound management and intervention, and is of great significance for the long-term care of chronic wounds.

[0100] In some of the embodiments, in step S1, when preparing the super hydrophilic film 1, the super hydrophilic film 1 is prepared by using a first film solution containing a hydrophilic material through one or more of spin coating evaporation, electrospinning, hot pressing stretching, and weaving processes, or is prepared by surface modification of a hydrophobic material; wherein the hydrophilic material includes one or more of a water-soluble polymer, a cellulose material, and a hydrogel material, and the hydrophobic material includes a polymer material.

[0101] In some embodiments, the water-soluble polymer includes one or more of polyvinyl alcohol (PVA), polyacrylic acid (PAA) and polyvinyl pyrrolidone (PVP).

[0102] In some embodiments, the cellulosic material includes one or more of cotton, flax, and straw paper.

[0103] In some embodiments, the hydrogel material includes one or more of hyaluronic acid (HA), gelatin, chitosan and polyacrylamide (PAM).

[0104] In some embodiments, the polymer material includes one or more of polytetrafluoroethylene (PTFE), polyethersulfone (PES), polycaprolactone (PCL) and polyurethane (TPU).

[0105] In some embodiments, the solvent in the first thin film solution includes one or more organic solvents such as dimethyl sulfoxide (DMSO), aromatic amines, and N,N-dimethylacetamide (DMAC).

[0106] In some embodiments, the concentration of the hydrophilic material in the first film solution is controlled to be 10%-20%. For example, the concentration of the hydrophilic material in the first film solution is 10%, 12%, 15%, 18%, 20%, or a range between any two of the above values.

[0107] In some embodiments, the first thin film solution further includes a porogen.

[0108] In some embodiments, the porogen includes one or more of polyethylene glycol, hydroxypropyl cellulose, polyurethane, sodium chloride and polyvinyl pyrrolidone.

[0109] In some of the embodiments, during hot pressing and stretching, the first film solution is cast into a mold and then placed in a vacuum drying oven for drying. The drying time is 20 min to 90 min, and the temperature setting range is 20° C. to 180° C.

[0110] In some of the embodiments, the surface modification method of the hydrophobic material includes one or more of surface modifier coating, plasma treatment, ultraviolet light grafting treatment and block polymer modification.

[0111] In some embodiments, the electrochemical sensor 2 is prepared on the super-hydrophilic film 1, comprising the following steps:

[0112] S21, preparing a sensor substrate on the super hydrophilic film 1.

[0113] S22. Prepare an electrode interface on the sensor substrate for specifically identifying and capturing the biological molecules to be tested in the sample to be tested.

[0114] In some embodiments, the step S21 of preparing the sensor substrate on the super hydrophilic film 1 includes the following steps:

[0115] The sensor substrate fixes the customized electrochemical sensing pattern on the surface of the super-hydrophilic film 1 through conductive paste by one or more methods including screen printing, sputtering, transfer printing, and physical deposition.

[0116] In some of the embodiments, the conductive paste includes one or more of metal paste, conductive non-metal paste and two-dimensional conductive nano paste; wherein the metal paste includes one or more of gold, silver, platinum, nickel and titanium, the conductive non-metal paste includes one or more of carbon paste, carbon fiber and polyethylene dioxythiophene, and the two-dimensional conductive nano paste includes one or more of graphene, carbon nanotubes and metal nanoparticles.

[0117] In some embodiments, the customized electrochemical sensing pattern is a three-electrode sensing system pattern that shares a reference electrode 23 and a counter electrode 21 .

[0118] In some of the embodiments, the electrode interface can fix biological enzymes and their cross-linked products to perform dynamic monitoring of metabolites of the sample to be tested, and the metabolites include glucose, uric acid, lactic acid, etc.

[0119] In some embodiments, the electrode interface can be modified with cyanocobalamin for dynamic monitoring of nitrite.

[0120] In some of the embodiments, the electrode interface is capable of electrodepositing polyaniline for dynamic detection of pH, etc.

[0121] For example, the number of electrochemical sensors 2 is 3. The three electrochemical sensors 2 can be used to detect the pH value, nitrite content and glucose content of the sample to be tested, respectively. Among them, the electrode interfaces of the working electrodes 22 on the three electrochemical sensors 2 are modified as follows: the working electrode 22 of one of the electrochemical sensors 2 is used to detect the pH value of the sample and is modified by a polyaniline ion selective membrane for specifically selecting hydrogen ions; the working electrode 22 of one of the electrochemical sensors 2 is used to detect the nitrite content of the sample and is modified by a cyanocobalamin ion selective membrane for specifically selecting and oxidizing nitrite ions; the working electrode 22 of one of the electrochemical sensors 2 is used to detect the glucose content of the sample and is modified by glucose oxidase and its cross-linked product glutaraldehyde for selectively oxidizing glucose.

[0122] In some of the embodiments, the electrode interface is modified with two-dimensional nanomaterials to promote electron transfer in electrochemical reactions. The two-dimensional nanomaterials include one or more of graphene, carbon nanotubes and MXene.

[0123] In some of the embodiments, the electrochemical detection method used by the electrochemical sensor 2 to collect electron transfer signals during the redox process of biomolecules includes one or more of steady-state current method (IT), differential pulse voltammetry (DPV), square wave voltammetry (SWV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), linear sweep voltammetry (LSV), alternating current voltammetry (ACV) and anodic stripping voltammetry (ASV).

[0124] In some of the embodiments, in some of the embodiments, the preparation material for preparing the hydrophobic film 3 on the super-hydrophilic film 1 includes a second film solution containing a biocompatible hydrophobic polymer material.

[0125] In some of the embodiments, the biocompatible hydrophobic polymer material includes one or more of polydimethylsiloxane (PDMS), polyethylene terephthalate (PET), polyamide (PI), polyurethane (TPU), and polycaprolactone (PCL).

[0126] In some embodiments, the concentration of the biocompatible hydrophobic polymer material in the second film solution is 10%-20%.

[0127] In some embodiments, the solvent of the second thin film solution is one or more of acetone, dimethyl sulfoxide (DMSO) and anhydrous ethanol.

[0128] In some of the embodiments, the preparation process of the hydrophobic film 3 includes one or more of spin coating evaporation, electrostatic spinning and air drying curing.

[0129] In some of the embodiments, the voltage of electrospinning is controlled at 5 kV to 25 kV, and the electrospinning rate is 1 h to 2.5 h.

[0130] An embodiment of the present application provides a textile.

[0131] A textile is provided with the above-mentioned smart wound patch, or the smart wound patch prepared by the above-mentioned preparation method.

[0132] In some of these embodiments, the textile may be sportswear containing a smart band-aid that can be used for sweat detection.

[0133] In some of these embodiments, textiles also include but are not limited to clothing, dressings, shoes, socks, scarves, masks, face towels, gloves, hats, etc.

[0134] The smart band-aid of the present application can also be combined with textile technology to prepare sports textiles for dynamic monitoring of perspiration and sweat metabolites, providing new possibilities for users such as athlete status detection, home monitoring and management of metabolite levels, and early diagnosis of chronic diseases, and has good versatility.

[0135] An embodiment of the present application provides a wearable device.

[0136] A wearable device comprises the above-mentioned smart bandage, or a smart bandage prepared by the above-mentioned preparation method.

[0137] Example 1

[0138] This embodiment provides a smart wound dressing.

[0139] The smart wound dressing of this embodiment is prepared by the following method, as shown in FIG3 :

[0140] S1. Select polyethersulfone (PES), use N,N-dimethylacetamide (DMAC) to dissolve polyethersulfone (PES), and prepare a 14% PES film solution.

[0141] Sodium chloride was added to the PES film solution and stirred to make the sodium chloride evenly distributed in the PES film solution. The PES film solution was used to prepare a polyethersulfone film through a hot pressing and stretching process, and the film was placed in a vacuum drying oven and dried at 60° C. for 45 min to prepare a polyethersulfone film.

[0142] Subsequently, ultraviolet light grafting surface treatment is performed to increase hydroxyl groups and improve the hydrophilicity of the polyethersulfone film, thereby improving the hydrophilicity of the polyethersulfone film and preparing a super hydrophilic film 1. The thickness of the super hydrophilic film 1 is 80 μm.

[0143] S21, fix the customized electrochemical sensing pattern on the surface of the super-hydrophilic film 1 by screen printing using conductive carbon paste and conductive silver paste to form a sensor substrate. The customized electrochemical sensing pattern is a three-electrode sensing system pattern, please refer to Figure 2 As shown, the three-electrode sensing system includes a reference electrode 23, a counter electrode 21 and a working electrode 22. The reference electrode 23 and the counter electrode 21 are shared, wherein the counter electrode 21 and the working electrode 22 are transferred using carbon paste, the reference electrode 23 is transferred using silver chloride paste, and the electrode wires are connected using silver paste.

[0144] S22, using the electrodeposition method to modify the polyaniline network on the surface of the working electrode 22 to form an electrode interface for dynamic monitoring of the pH value of the sample to be tested. Graphene is used to modify the interface of the electrode 21 to promote electron transfer in the electrochemical reaction.

[0145] S3. Dissolve the polyurethane TPU polymer material with acetone to obtain a second film solution, wherein the TPU concentration in the second film solution is 12.5%.

[0146] A single-layer hydrophobic film 3 was obtained by electrospinning the second film solution for 1 min. The electrospinning voltage was 15 kV, the rate was 1.5 mL / h, and the thickness of the hydrophobic film 3 was 100 nm. The hydrophobic film 3 was prepared on the super hydrophilic film 1 to encapsulate the electrochemical sensor 2.

[0147] Referring to FIG. 4 , FIG. 4 is a structure of the smart band-aid prepared in this embodiment, including a super-hydrophilic film 1, an electrochemical sensor 2, and a hydrophobic film 3. The electrochemical sensor 2 is connected to the super-hydrophilic film 1. The hydrophobic film 3 is stacked and connected with the super-hydrophilic film 1 to realize the encapsulation of the electrochemical sensor 2. Referring to FIG. 5 , FIG. 5 is a cross-sectional microscopic topological structure diagram of the smart band-aid of this embodiment. FIG. 4 and FIG. 5 are respectively the physical image and microscopic topological structure diagram of the smart band-aid of this embodiment. It can be seen from FIG. 4 and FIG. 5 that the processed smart band-aid has good flexibility, can be bent freely under the premise of ensuring the integrity of the electrode structure, and has the potential to be worn; in addition, the thickness of the smart band-aid is about 100 μm, which is mainly composed of a porous super-hydrophilic film 1 and a single-layer hydrophobic film 3 formed by electrospinning, and has good air permeability, which is conducive to the air permeability and healing of the wound after bandaging.

[0148] Phosphate buffer was used to simulate wound exudate. By dropping 1 μL of phosphate buffer onto the surface of the hydrophobic film 3 of the smart band-aid, the process of the smart band-aid quickly draining out wound exudate was simulated. As shown in Figure 6, the droplet dripped on the front of the smart band-aid first showed a contact angle greater than 90°, proving the hydrophobicity of the hydrophobic film 3. Then, the droplet gradually entered the underlying superhydrophilic film 1 under the action of the asymmetric wettability of the smart band-aid, and was finally completely drained out at 4 s without remaining on the surface of the hydrophobic film 3 of the smart band-aid, verifying that the smart band-aid has the ability to quickly drain wound exudate from the wound surface to the outside of the band-aid.

[0149] 1 μL of 10 mM potassium ferrocyanide solution was dripped onto the surface of the hydrophobic film 3 of the smart bandage, and the cyclic voltammetry curve of the electrochemical sensor 2 was collected during the process of the potassium ferrocyanide solution being led from the hydrophobic film 3 of the smart bandage to the superhydrophilic film 1. As shown in FIG7 , the cyclic voltammetry curve has symmetrical redox peaks, proving that the integrated electrochemical sensor 2 has excellent sensing capability and can complete the analysis and detection of the sample to be tested during the dynamic process of fluid lead-out.

[0150] 1 μL of phosphate buffer with different pH values ​​was continuously added to the surface of the hydrophobic film 3 of the smart bandage to simulate wound exudate under different wound conditions, and the open circuit voltage-time curve (OCPT) of the electrochemical sensor 2 was continuously recorded, as shown in Figures 8 and 9. The detection range of the pH sensing module of the smart bandage is as wide as 4-10, covering the possible pH range of normal wounds and infected wound microenvironments, and the detection sensitivity and repeatability are high. It can continuously and dynamically perform pH detection of the sample to be tested, which can meet the needs of the smart bandage for long-term care of chronic wounds.

[0151] In summary, the smart bandage of the present application is based on the asymmetric wettability of the Janus film, and uses the capillary effect and osmotic pressure to drive the wound exudate to be directional from the hydrophilic surface to the hydrophobic surface, while avoiding the backflow of external fluid, forming a smart bandage that can quickly clean the wound exudate; the present application uses modular transfer technology to complete the preparation of electrochemical biosensors on the super-hydrophilic film 1, and realizes the synchronous dynamic monitoring of multiple targets of the wound microenvironment through the design and modification of different sensing units, thereby forming a smart bandage that can quickly clean wound exudate, dynamically monitor the wound microenvironment with multiple targets, and prompt wound infection in real time, assisting the long-term management of chronic wounds. By integrating it with textile technology, sports textiles for dynamic monitoring of perspiration and sweat metabolites can be prepared, or it can be prepared into wearable devices, which can provide new possibilities for athlete status detection, home monitoring and management of metabolite levels, and early diagnosis of chronic diseases.

[0152] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0153] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0154] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A smart bandage, characterized in that: The invention comprises a super-hydrophilic film, an electrochemical sensor and a hydrophobic film. The electrochemical sensor is connected to the super-hydrophilic film. The hydrophobic film and the super-hydrophilic film are stacked and connected to realize the packaging of the electrochemical sensor.

2. The smart bandage according to claim 1, characterized in that: The electrochemical sensor includes a sensor substrate and an electrode interface for specifically identifying and capturing the biomolecules to be tested in the sample to be tested. The sensor substrate fixes a customized electrochemical sensing pattern on the surface of the super-hydrophilic film by one or more methods including screen printing, sputtering, transfer, and physical precipitation through a conductive paste, and the electrode interface is connected to the sensor substrate.

3. The smart bandage according to claim 2, characterized in that: The customized electrochemical sensing pattern is a three-electrode sensing system pattern that shares a reference electrode and a counter electrode, and the number of the electrochemical sensors is 1 to 10.

4. A method for preparing a smart wound dressing, characterized in that: The steps include: Preparation of super hydrophilic films; preparing an electrochemical sensor on the super hydrophilic film; and A hydrophobic film is prepared on the super-hydrophilic film to encapsulate the electrochemical sensor.

5. The preparation method according to claim 4, characterized in that: When preparing a super-hydrophilic film, the super-hydrophilic film is prepared by using a first film solution containing a hydrophilic material through one or more of spin coating evaporation, electrospinning, hot pressing stretching, and weaving processes, or is prepared by surface modification of a hydrophobic material; wherein the hydrophilic material includes one or more of a water-soluble polymer, a cellulose material, and a hydrogel material, and the hydrophobic material includes a polymer material.

6. The preparation method according to claim 4, characterized in that: When preparing an electrochemical sensor on the super-hydrophilic film, the following steps are included: preparing a sensor substrate on the super hydrophilic film; and An electrode interface for specifically identifying and capturing the biomolecules to be detected in the sample to be detected is prepared on the sensor substrate.

7. The preparation method according to claim 6, characterized in that: The preparation of the sensor substrate on the super-hydrophilic film comprises the following steps: The sensor substrate fixes the customized electrochemical sensing pattern on the surface of the super-hydrophilic film through conductive paste by one or more methods including screen printing, sputtering, transfer printing and physical precipitation.

8. The preparation method according to any one of claims 4 to 7, characterized in that When preparing the hydrophobic film on the super-hydrophilic film, the preparation material includes a second film solution containing a biocompatible hydrophobic polymer material.

9. A textile, characterized in that: The textile is provided with the smart wound patch according to any one of claims 1 to 3, or the smart wound patch prepared by the preparation method according to any one of claims 4 to 8.

10. A wearable device, characterized in that: The invention relates to a smart wound patch according to any one of claims 1 to 3, or a smart wound patch prepared by the preparation method according to any one of claims 4 to 8.

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