28 results about "Rf ablation" patented technology

Various embodiments of the invention provide binding agents for glypican-3 (GPC3), including antibodies or antigen-binding fragments thereof that bind to GPC3 and antigen recognizing receptors (e.g., CARs) that target GPC3 including cells that express GPC3. Embodiments of the i n vention also provide cells comprising such binding agents such as CAR T-cells, therapeutic compositions comprising such cells and methods of using one or more of the binding agents, cells or therapeutic compositions for the treatment of diseases or disorders associated with GPC3 expression such as various neoplastic diseases or disorders (e.g., hepatocellular carcinoma). Various embodiments of the invention also provide methods and systems for treati ng hepatocellular carcinoma (HCC) utilizing a combi nation of radiofrequency (RF) ablation and GPC3-targeted cell therapy. In certain embodiments, immune modulators, such as checkpoint inhibitors, may be co-administered to potentiate immune responses. Additionally, compositions and kits comprising RF ablation devices and GPC3-targeted cell therapy formulations are provided.

A radiofrequency ablation catheter (100) and a radiofrequency ablation device. The radiofrequency ablation catheter (100) comprises a radially contractible and expandable electrode stent (20), a connecting tube (30), and a core wire (40). The proximal end of the connecting tube (30) is connected to the distal end of the electrode stent (20), and the connecting tube (30) has a first lumen (34) running through the proximal and distal ends thereof. The core wire (40) movably runs through the electrode stent (20) and the first lumen (34). The core wire (40) is provided with a first limiting portion (41), the first limiting portion (41) being located in the first lumen (34); and the inner wall of the first lumen (34) is correspondingly provided with a second limiting portion (35). When the first limiting portion (41) abuts against the second limiting portion (35) and the central wire (40) moves from the distal end to the proximal end, the electrode stent (20) is switched from a contracted state to an expanded state. The radiofrequency ablation catheter (100) can reduce the risk of vascular injury, improve the accuracy of the core wire (40) in accessing a target branch vessel, and thus improve the ablation efficiency of radiofrequency ablation.

This invention discloses a positionable bipolar radiofrequency ablation electrode, relating to the field of medical device technology. It includes a handheld end with an electrode needle at its bottom. A hollow screw is disposed within the inner cavity of the handheld end. A partition is rotatably connected to the surface of the hollow screw and fixedly connected to the inner wall of the handheld end. A threaded seat is threadedly connected to the bottom of the hollow screw. A hollow tube communicates with the bottom of the threaded seat and is fixedly connected to the electrode needle. A first driving component is disposed on one side of the threaded seat. A second driving component allows for flexible adjustment of the distance between the second electrode and the electrode needle, expanding the ablation range. The first driving component allows for flexible adjustment of the extension and retraction length of the electrode needle, adapting to lesions of different depths. Simultaneously, the adsorption component efficiently adsorbs accumulated fluid and gas generated during the ablation process, with the adsorption range expanding synchronously with the ablation range, ensuring that accumulated fluid and gas in different ablation areas are completely discharged, maintaining the stability of the local thermal field.

The application relates to a radiofrequency ablation system and a radiofrequency ablation clamp for renal sympathetic denervation, which comprises an upper jaw and a lower jaw that can be opened and closed relative to each other, the upper jaw is provided with upper jaw radiofrequency electrodes, the lower jaw is provided with lower jaw radiofrequency electrodes, the lower jaw comprises a lower jaw main body in an arc structure with an axis extending along a left-right direction, a lower electrode seat made of insulating material corresponding to each lower jaw radiofrequency electrode is movably arranged on the lower jaw main body in a circumferential direction, each lower jaw radiofrequency electrode is fixed on the corresponding lower electrode seat, the upper jaw radiofrequency electrodes are at least three, each upper jaw radiofrequency electrode is arranged in a left-right direction at intervals, the lower jaw radiofrequency electrodes are at least three, each lower jaw radiofrequency electrode is arranged in a left-right direction at intervals, and the radiofrequency ablation clamp further comprises an electrode seat driving mechanism for driving the circumferential movement of the corresponding upper electrode seat and lower electrode seat. The purpose of the application is to provide a radiofrequency ablation system capable of retaining part of parasympathetic nerves and a radiofrequency ablation clamp used in the radiofrequency ablation system.

This invention relates to the field of radiofrequency ablation power control and neurological safety monitoring technology, specifically a data processing system based on dynamic adjustment of radiofrequency plasma power. The system includes: a data acquisition module for real-time acquisition of multimodal input data streams, including instantaneous radiofrequency power, tissue impedance, local tissue surface temperature, and raw signal amplitudes from intraoperative neurophysiological monitoring; an interference identification module for determining interference identification markers; a thermal load estimation module for iteratively estimating the latent thermal load index; a safety verification module for calculating the neurological instability index; an optimal strategy generation module for calculating the optimal power strategy; a conflict detection module for determining model conflict markers; and a power adjustment module for determining the final power output. This invention prevents catastrophic surgical complications, ensures the integrity of biological nerves, and effectively avoids misjudgments caused by relying on only a single data source.

A radiofrequency ablation system will comprise a radiofrequency ablation catheter. The radiofrequency ablation catheter will comprise an expandable ballon, an inner tube with a multi-lumen structure, a guidewire tube, an outer sheath, and a radiofrequency electrode. The radiofrequency electrode will be flexible with a metal electrode layer, liner layer, flexible conductor layer, and substrate layer. The radiofrequency ablation catheter can be used to treat a subject's condition by ablating target tissue, such as Type II Diabetes Mellitus. Diabetes can be treated or alleviated due to a decrease in a subject's blood glucose and weight in response to the ablation of the target tissue.

The invention relates to the technical field of radio frequency ablation needle temperature control, and discloses an intelligent temperature control system and method for multiple radio frequency ablation needles, a working unit controls the ablation needles to carry out radio frequency ablation work, and an acquisition unit is used for acquiring temperature data and position data when the ablation needles work; the central unit calculates the temperature difference SW and sends a carbonization instruction and a heat sink instruction, the control unit controls the working power of the ablation needle, the model unit establishes a three-dimensional temperature field, the matching unit calculates the matching degree of the three-dimensional temperature field, the adjusting unit adjusts the working frequency of the ablation needle, and the control unit controls the working power of the ablation needle. The temperature sensors are arranged at the tip end and the needle body respectively, so that the temperature of the ablation needle can be accurately detected, when the temperature difference SW is smaller than a low-temperature threshold value DY, the tissue is possibly carbonized, and when the temperature difference SW is larger than a high-temperature threshold value GY, the heat sink phenomenon is possibly generated, and therefore accurate judgment is conducted.

1. Name of the product in this design: Cardiac Radiofrequency Ablation Device. 2. Purpose of this design: For use in medical devices, connected to an ablation needle, for radiofrequency ablation treatment of heart diseases. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This utility model provides a head fixation device for interventional surgery, relating to the field of medical device technology. It includes a head support base, a head support body, a head support fixation component, and a back pad. Both the head support fixation component and the head support body are mounted on the head support base. The head support fixation component is used to mount the head support base onto the operating table. The head support body has at least three sets of protrusions, which together form a head fixation area. This design effectively solves the problem of fixing and maintaining the patient's position during interventional radiofrequency ablation surgery for trigeminal neuralgia. The patient lies comfortably, maintaining a tilted-back posture during the procedure, ensuring the puncture angle remains unchanged, reducing the difficulty of the puncture surgery, shortening the operation time, significantly improving the success rate, significantly reducing surgical complications, and significantly improving the surgical outcome.

The present application relates to a kind of radio frequency ablation equipment, it includes electrode, balloon and delivery tube;The electrode is in net shape, with the contraction state of being shrunk together when being constrained, and the expansion state of being automatically expanded outward when losing constraint, which is connected with the external electrical connector by electrode lead;The balloon is located in the inside of the electrode, and pushes against the electrode when in the inflation state;The delivery tube includes outer tube and inner tube, and the electrode lead is located between the outer tube and inner tube, and the delivery tube further includes balloon catheter communicated with one end of the balloon, which is located in the inside of the inner tube and has gap between the inner tube.When electrode is delivered to target position, it can be automatically unfolded and form good abutment effect with the inner wall of bronchus by the support of balloon.

This invention discloses a temperature control method and system for water-cooled radiofrequency ablation, belonging to the field of temperature control technology. The method includes: determining a temperature control threshold range based on individual patient characteristics; real-time temperature sampling during ablation and comparison with a model; calculating the optimal radiofrequency power using a temperature prediction and control algorithm when the temperature deviates from the threshold; adjusting the electrode output power; and determining the temperature difference after a pre-hysteresis time, otherwise employing a self-learning correction algorithm. This invention constructs a temperature prediction and control algorithm based on the target ablation temperature, accurately calculating the optimal radiofrequency output power and adjusting the output power of the ablation electrodes in a timely manner. This effectively avoids the risk of tissue damage caused by excessively high or low temperatures in the ablation area, providing patients with a safer radiofrequency ablation treatment environment.

The application relates to a radio frequency ablation composite electrode needle and relates to the ablation technical field.The radio frequency ablation composite electrode needle comprises a main needle, a sub needle and a handle assembly, the main needle comprises a needle head and a needle rod assembly; the needle head comprises a needle handle, a puncture needle tip located at the far end of the needle handle and a needle head inner cavity arranged in the puncture needle tip and the inner side of the needle handle; the needle rod assembly comprises a needle rod, a second inner tube and a first inner tube arranged in sequence from outside to inside, the sub needle is arranged between the second inner tube and the needle rod, and the outer surface of the second inner tube and the inner surface of the needle rod define a sub needle outer cavity; the sub needle comprises a sub needle inner cavity; first, second and third liquid cavities are arranged in sequence in the handle assembly; wherein the first liquid cavity is in fluid communication with the sub needle outer cavity; the second liquid cavity is in fluid communication with the sub needle inner cavity; a liquid circulation channel is formed between the third liquid cavity, the first inner tube, the needle head inner cavity and the second inner tube.

Provided in the present disclosure are a radio frequency ablation catheter and a radio frequency ablation system. The radio frequency ablation catheter comprises: a balloon, an inner tube, a guide wire tube, an outer sleeve, and a radio frequency electrode. A proximal end of the balloon is provided with a proximal tube section extending along a longitudinal axis thereof. The inner tube is provided with an inflation cavity and a guide wire tube penetration cavity that are not in communication with each other. A distal end of the inner tube is inserted into the proximal tube section, and the inner tube is hermetically connected to the proximal tube section. A distal end of the inflation cavity is in communication with an inner cavity of the balloon. A distal section portion of the guide wire tube extends from a distal end of the guide wire tube penetration cavity and extends to the inner cavity of the balloon, and the guide wire tube is hermetically connected to the guide wire tube penetration cavity. The outer sleeve sleeves the inner tube. A distal end of the outer sleeve is connected to the proximal tube section, and a gap is formed at the joint. A threading cavity between the outer sleeve and the inner tube is used for accommodating a cable. The radio frequency electrode has a distal ablation region and a proximal wiring region connected to the cable. From the proximal wiring region to the distal ablation region, the radio frequency electrode extends along the threading cavity to the gap, passes through the gap, and then extends against a surface of the proximal tube section to an outer surface of the balloon.

The application discloses a lung nodule positioning and ablation integrated device and method, which comprises a positioning and ablation needle, the positioning and ablation needle comprises an outer needle tube one, which is hollow inside and coated with an insulating layer on the surface; a positioning member made of a material with electric conductivity is arranged inside the outer needle tube one and used for being stabbed into a lung nodule and simultaneously serving as a radio frequency ablation electrode; a positioning guide wire made of a material with electric conductivity is coated with an insulating layer on the surface, and a hydrophilic coating layer is coated on the insulating layer; one end of the positioning guide wire is connected with the positioning member, and the other end of the positioning guide wire is led out from the inside of the outer needle tube one and connected with a radio frequency ablation device; and a pushing mechanism is sleeved on the positioning guide wire and used for pushing the positioning guide wire and stabbing the positioning member into the lung nodule. The application can solve the problems that the existing lung nodule positioning and radio frequency ablation need to be carried out in steps, the positioning is inaccurate, the lung nodule is prone to displacement and bleeding in the multiple puncture processes.

This invention provides the application of TROP2-CAR-T cells in the preparation of drugs that enhance the efficacy of radiofrequency ablation for lung adenocarcinoma, specifically belonging to the field of antitumor drug technology. This invention utilizes TROP2-CAR-T cells as a therapeutic target for lung adenocarcinoma and combines it with radiofrequency ablation, which can enhance the efficacy of radiofrequency ablation for lung adenocarcinoma, significantly reduce residual tumor burden and delay tumor progression, exhibit good safety characteristics, improve overall efficacy, and enhance convertibility.

The application discloses a radio frequency ablation catheter and radio frequency ablation equipment, which is characterized in that a protection module is arranged between the catheter heating unit and the catheter body in the heating area. The protection module specifically comprises at least two parallel arranged conductive components which are separated by a temperature sensitive insulation layer. The physical state and / or chemical state of the temperature sensitive insulation layer can change when reaching or exceeding a preset temperature threshold, thereby destroying the electrical insulation state between the adjacent conductive components to form a detectable electrical state change. The control unit can execute the protection operation of reducing or cutting off the radio frequency energy output according to the electrical signal formed by the electrical state change. The protection module of the embodiment is equivalent to arranging countless potential overheating sensors in the whole heating area. No matter where the overheating occurs, it can be immediately sensed as long as the trigger temperature is reached. Moreover, the trigger of the protection mechanism is the direct result of the physical and / or chemical process, and the response speed is extremely fast.

1. Name of the product in this design: Animal radiofrequency ablation needle. 2. Purpose of this design: for radiofrequency ablation. 3. The key design feature of this product is its shape. 4. Images or photos that best illustrate the design key points: usage status reference diagrams. 5. Other situations requiring explanation: Component 1 is a sheath, and component 2 is an ablation needle. They can be used in sets, used individually, sold in sets, or sold individually.

1. Name of the product in this design: Radiofrequency ablation electrode. 2. Purpose of this design: For radiofrequency ablation treatment of human tissues or organs. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This utility model relates to the field of medical aesthetics technology, specifically disclosing an ion radiofrequency ablation device for removing eye bags. The device includes a mask with a first cavity and a second cavity inside. The first cavity is located above the second cavity, and a connecting pipe connects the first and second cavities. An ablation component is located at the rear end of the mask. The ablation component includes a slider movably connected inside the first cavity, a connecting rod fixedly connected to the rear end of the slider, and a circular frame fixedly connected to the rear end of the connecting rod. A sealing block is movably connected inside the second cavity, and an ablation module is fixedly connected to the rear end of the sealing block. When performing ablation for eye bag removal after wearing the mask, the device ensures that the probe remains in close contact with the skin surface, preventing the distance between the probe and the skin from affecting the ablation process and causing burns or scalds, thereby improving the efficiency of the eye bag removal procedure.

This utility model relates to the field of medical supplies technology and discloses a disposable sterile protective sleeve for the tail wire of a radiofrequency ablation electrode catheter. It includes a ring-shaped, stacked sterile protective film, with an annular fixing sleeve at one end and a handle at the other end. This utility model also discloses a connection structure for the disposable sterile protective sleeve for the tail wire of a radiofrequency ablation electrode catheter. This disposable sterile protective sleeve for the tail wire of a radiofrequency ablation electrode catheter and its connection structure can properly fix the sterile end, solving the problem of cumbersome and time-consuming connection of electrode catheter tail wires in cardiac electrophysiological diagnosis / ablation procedures, and reducing the risk of nosocomial infection.

The application discloses a multifunctional puncture positioning and fixing device for liver tissue radiofrequency ablation, and relates to the technical field of medical devices.The device comprises a belt, a positioning assembly for fixing effect, and a puncture assembly for puncture action.The two sides of the belt are provided with side belts, and the top end of the belt is provided with an abdominal belt.The two ends of the belt and the abdominal belt are both provided with elastic ropes, and the two elastic ropes are both provided with the side belts at corresponding positions.The surface of the abdominal belt is provided with a window.The application effectively reduces the respiratory displacement of liver tissue by setting a winding mechanism, supports independent and fine adjustment of the puncture point and the puncture angle by setting a distance adjusting mechanism, accurately controls the puncture depth of the needle tip by setting the puncture assembly, and realizes flexible mechanical interlocking between the needle body and the liver tissue after reaching the target position, further limits the respiratory displacement amplitude of the liver tissue, and thus guarantees the complete form of the ablation zone.

Wiring is disclosed herein that is configured to supply IRE ablation signals through a catheter body and is resistant against dielectric breakdown, arcing, and noise during ablation. The wiring includes a highly conductive core, a conductive cover surrounding the core that has lower electrical and / or thermal conductivity than the core, and an insulative jacket surrounding the conductive cover. A catheter including such wiring may be suitable for supplying electrical signals to tissue to perform IRE ablation. In some examples, such a catheter can also be suitable for reversible electroporation and / or RF ablation.

A tool arrangement for forming a tunnel in a vertebra to perform nerve ablation includes a tamp having a distal end portion that includes a tip for creating the tunnel in the vertebra and a curvable portion to direct the tip along a curved path within the vertebra; a first cannula including a cannula body that is straight along an entire length of the cannula body and configured to receive the curvable portion of the tamp and straighten the curvable portion; and a tool hub including a stationary cannula attachment coupled to the first cannula and a movable head coupled to the tamp and configured to move toward or away from the stationary cannula attachment to extend or retract, respectively, the curvable portion of the tamp from or into, respectively, the first cannula.

The application discloses a radio frequency ablation electrode real-time control device based on fusion of intracardiac ultrasound and magnetic navigation applied to the field of radio frequency ablation electrodes, and through the setting of the limiting clamping plate, the operator only needs to rotate the dial piece to drive the limiting clamping plate to slide in the clamping groove to the side close to the winding mechanism, so that the second wire groove and the first wire groove are close to each other, the traction line between the two is extruded, until the traction line is clamped and fixed, then the fixed bolt is screwed to complete the position locking of the limiting clamping plate, the winding and unwinding state of the traction line can be maintained, the form stability of the radio frequency ablation electrode ring can be maintained, the operator does not need to continuously maintain the tension control of the traction line, the operation burden in the operation is reduced; when the electrode ring form needs to be adjusted again, the fixed bolt is loosened, the limiting clamping plate is rotated to slide to the other side along the clamping groove, the clamping locking of the traction line is released, the winding and unwinding length of the traction line can be adjusted through the winding mechanism again, the fixed demand of any adjustment range can be adapted, and the use is more flexible.

The application provides a liver cancer incomplete radiofrequency ablation mouse model and a construction method and application thereof. The method comprises the following steps: S1. Injecting a liver cancer cell suspension into a mouse, so that the liver cancer cells form tumors in the mouse; and S2. Implementing local radiofrequency ablation on the mouse with tumors formed in vivo, to obtain a liver cancer incomplete radiofrequency ablation mouse model. The liver cancer incomplete radiofrequency ablation mouse model obtained by the method provided by the application can simulate the biological process after tumor thermal ablation, overcome the difficulty that the tumor microenvironment is difficult to completely simulate in vitro, and can be directly used for researching the adaptation of liver cancer and the influence on the liver cancer microenvironment, thereby providing an important scientific basis for the research on the progress after liver cancer ablation.

The present invention relates to a system and method for adaptive multivariate control for performing a radiofrequency (RF) ablation procedure with a power delivery device. The system includes a power source for supplying energy to a patient's body; one or more power delivery devices; two or more sensors for measuring at least two factors related to an ablation procedure, respectively; and at least one processor.The method includes the steps of: measuring at least two factors related to an ablation procedure; determining a first operating threshold based, at least in part, on a first factor; controlling a power delivery device based on the first operating threshold to create a lesion at the target site within the patient; determining a second operating threshold based, at least in part, on a second factor; switching control of the power delivery device from the first factor to the second factor; and controlling the power delivery device based on the second operating threshold to create a lesion at the target site within the patient. The present invention also relates to an RF probe configured for use with the adaptive multivariate control system and method for performing RF ablation procedures.

The application discloses a real-time positioning method for rotor sites of atrial fibrillation. The method performs three-dimensional modeling on an atrium in operation, derives bipolar endocardial electrical signals and electrode positions collected by a multi-pole mapping catheter PENTARAY electrode pair from a CARTO3 system, then calculates average fuzzy entropy of the bipolar endocardial electrical signals, selects electrodes according to the calculated average fuzzy entropy of each electrode, draws a vector through entropy difference between the selected electrode pairs, finds a direction where the rotor is located by using a vector method and an expression, and finally determines a specific position of the rotor through the expression and a relationship between distance and energy. The application adopts endocardial bipolar electrical signals, can well remove ventricular noise, better guides a doctor to find a rotor direction of the atrial fibrillation in operation, accurately positions a specific position of the rotor site, greatly reduces an ablation area, increases a success rate and a recurrence rate of radiofrequency ablation operation, and can have a lower sequelae after operation.

Provided are a flexible electrode (22) for a radio frequency ablation catheter (100), the radio frequency ablation catheter (100), and a radio frequency ablation system. The flexible electrode (22) comprises: a flexible metal electrode layer (223), a liner layer (224), a first flexible conductor layer (226), a substrate layer (227), and a second flexible conductor layer (229) that are sequentially stacked. The liner layer (224) and the substrate layer (227) are made of a flexible insulating material. A power connection region of the flexible metal electrode layer (223) is configured to be connected to the distal end of a radio frequency cable of the radio frequency ablation catheter (100), and a radio frequency conduction region at the distal end of the flexible metal electrode layer (223) is configured to conduct radio frequency energy to a target tissue. The distal end of the substrate layer (227) is provided with an electrical connection part (2271). The distal end of the second flexible conductor layer (229) is electrically connected to the distal end of the first flexible conductor layer (226) by means of the electrical connection part (2271). In addition, the orthographic projections of junctions between the distal ends of both the first flexible conductor layer (226) and the second flexible conductor layer (229) and the electrical connection part (2271) on a first surface fall within the radio frequency conduction region, and the proximal ends of both the second flexible conductor layer (229) and the first flexible conductor layer (226) are configured to be respectively connected to the distal ends of two wires (40a, 40b) of the radio frequency ablation catheter to form a thermocouple circuit.