264 results about "Rf ablation" patented technology

Aspects of the present disclosure relate to flexible catheters for electrophysiological mapping and ablation using high-density electrode arrays. These catheters can be used to detect the electrophysiological properties of tissue in contact with the electrodes and perform monopolar and bipolar ablation of the tissue.

The invention discloses a radiofrequency ablation navigation device based on multi-modal image fusion. The device comprises a respiration sensor, an image reconstruction server, an interaction terminal and a processor. The respiration sensor is worn on a target object and used for collecting respiration data of the target object. The image reconstruction server is used for receiving the multi-modal image of the target object and reconstructing the multi-modal image into a three-dimensional model; the three-dimensional model comprises an organ geometric model, nerve distribution and a blood vessel network. And the interaction terminal is connected with the image reconstruction server and is used for marking a starting point and an ending point for the three-dimensional model. The processor is connected with the respiration sensor, the image reconstruction server and the interaction terminal; and the processor generates a predicted path output according to the respiration data and the three-dimensional model marking the starting point and the ending point. The method has the advantages that respiratory movement errors are accurately compensated, the nerve mistaken injury risk is reduced, and the operation safety is improved.

Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) is provided by delivering specialized pulsed electric field energy to target tissue areas in a specific dose so as to obtain a superior outcome. The specialized PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. The specialized PEF energy provides superior outcomes to radiofrequency ablation and irreversible electroporation.

The utility model relates to a bipolar water-cooling radiofrequency ablation needle, and belongs to the technical field of medical instruments. The bipolar water-cooling radiofrequency ablation needle mainly comprises a needle head arranged at the farthest end of the ablation needle; the inner needle tube is a long and thin tube which is through front and back, and the needle head is connected with the inner needle tube; the outer needle tube is arranged outside the inner needle tube in a sleeving manner, and an insulating separator is arranged between the outer needle tube and the needle head; a middle insulating sleeve is also arranged between the outer needle tube and the inner needle tube; the water inlet pipe is arranged in the inner needle tube and divides an inner cavity of the inner needle tube into a water inlet channel and a water return channel. The cold cutting water cools the needle head, so that the temperature of the working end of the radiofrequency ablation needle can be effectively reduced, and tissue carbonization and adhesion are avoided.

The invention relates to a radiofrequency ablation combined electrode needle and an ablation system, and relates to the technical field of ablation. The radiofrequency ablation combined electrode needle comprises a main needle, a plurality of sub-needles and a handle assembly used for adjusting the main needle and the sub-needles, the main needle comprises a needle head assembly and a needle rod assembly, and the needle rod assembly comprises a first inner tube, a second inner tube and a needle rod which are sequentially and coaxially arranged from inside to outside; the far end of the second inner tube is fixedly connected with the near end of the needle head assembly, a guide groove is formed between the far end of the needle rod and the near end of the needle head assembly, and the needle rod can move relative to the needle head assembly to change the width of the guide groove.

The title of the invention is "using blood conductivity to control cardiac ablation". Methods and systems provide lesion size assessment for ablation in tissue, such as cardiac tissue. The lesion size assessment is based on parameters including blood conductivity, hot spot temperature, catheter tip temperature, and current data of radio frequency (RF) ablation energy used, such as power, duration, temperature, irrigation, and contact force.

An integrated cannula / RF electrode for an RF ablation system includes a cannula including a cannula hub and a shaft extending from the cannula hub, wherein the shaft includes a distal portion; an RF electrode including a distal portion, wherein at least a portion of the RF electrode is permanently disposed within the cannula; and a deployment mechanism coupled to the RF electrode and either coupled to the cannula hub or extending from the cannula hub, wherein the deployment mechanism includes an actuator coupled to the RF electrode and is configured to extend the distal portion of the RF electrode out of the distal portion of the shaft of the cannula by actuation of the actuator.

The invention provides a radiofrequency ablation system based on multi-source data, and relates to the technical field of medical instruments, and the system comprises an ablation area judgment device which is used for judging whether an operation target meets the ablation requirement or not according to a real-time ultrasonic image of the operation target; the data processing device is used for determining an ablation strategy of an ablation area of the operation target according to the real-time electrocardiogram data and the real-time vital sign data of the operation target in combination with a preset radiofrequency ablation working mode when the operation target meets the ablation requirement; the radio frequency energy generating device is used for generating corresponding radio frequency energy according to the ablation strategy; and the ablation device is used for performing ablation operation according to the radio frequency energy action. By integrating multi-source data such as real-time ultrasonic images, electrocardiogram monitoring and vital sign monitoring, accurate judgment of ablation requirements, dynamic adjustment of ablation strategies and accurate output of ablation energy are achieved, and the safety, accuracy and curative effect of cardiac radiofrequency ablation treatment are improved.

The invention relates to the technical field of medical image processing and three-dimensional reconstruction, and particularly discloses a reconstruction and analogue simulation method based on a cardiac image. The method comprises the following steps: firstly, preprocessing an input CT or MRI medical image, and automatically segmenting a heart multi-tissue structure by using an nnUNetv2 model, including a plurality of anatomical regions such as atrium, ventricle, myocardial tissue and blood pool; and then performing topology repair, smoothing processing and label resampling on the segmentation result to obtain a three-dimensional label body with a continuous structure and a complete boundary. And based on the optimized tag body, constructing a heart three-dimensional surface model by adopting a Marching Cubes algorithm, and generating a multi-material volume grid suitable for finite element analysis. According to an electrode position and a radio frequency parameter set by a user, a radio frequency ablation simulation model based on a Pennes biological heat conduction equation and an Arrhenius model is established, a temperature field and a tissue thermal damage range are calculated, and a simulation result is displayed in a three-dimensional mode in an overlapping mode. According to the method, the integrated process from medical image automatic segmentation to heart three-dimensional reconstruction and thermal simulation is realized, the segmentation precision, the modeling efficiency and the simulation reliability are improved, and the method can be applied to application scenes such as surgical planning, preoperative evaluation and medical teaching.

The invention discloses a bending-adjustable endoscope type liver cutting radiofrequency ablation electrode, and relates to the technical field of medical apparatuses and instruments. The device comprises a handle, the top of the handle is provided with a depth adjusting block, one side of the handle is provided with a trigger, the top of the trigger is provided with an extension rod, one side of the extension rod is fixedly connected with an adjustable bent pipe, and one side of the adjustable bent pipe is provided with a cutting electrode. Through the design of the adjustable bent pipe and the snake bone cutting structure, the front end of the instrument can realize multi-angle flexible bending, the surgical operation range is obviously expanded, the instrument is particularly suitable for areas such as the back of the liver which are difficult to directly touch, dependence on other auxiliary instruments is reduced, the flexibility and operability of the surgery are improved, and the surgical efficiency is improved. The depth limiting head is linked with the trigger, and the seven-gear design of the depth adjusting block is matched, so that the depth of the cutting electrode penetrating into the liver can be accurately controlled, excessive puncture or insufficient ablation is avoided, and the safety and effectiveness of an operation are improved.

A radiofrequency ablation electrode needle with multi-dimensional nerve monitoring, comprising a nerve monitoring flexible electrode, a radiofrequency thermocoagulation electrode, and three knob modules for adjusting the angle of the nerve monitoring flexible electrode. The X-axis rotation knob, Y-axis rotation knob, and Z-axis telescopic knob are respectively arranged on a triangular fixing seat. The X-axis rotation knob, Y-axis rotation knob, and Z-axis telescopic knob are respectively connected to the nerve monitoring flexible electrode through control cables. The front end of the triangular fixing seat is fixedly connected to the radiofrequency thermocoagulation electrode, and the rear end is docked with a cable. Compared with the prior art, the multi-dimensionally extendable electrode head of the present invention penetrates from the head end of the radiofrequency thermocoagulation electrode, and can achieve deflection in the front, back, left, and right directions in the X / Y directions and telescoping in the Z direction. The detection position of the flexible electrode head can be controlled by the X / Y / Z knobs. The monitoring electrode of the present invention can comprehensively monitor the ablated nerve lesion part, and to a certain extent, avoid the problems of incomplete nerve destruction or excessive nerve destruction.

The invention provides an ultrasonic imaging ablation system and device, and relates to the technical field of medical instruments, the ultrasonic imaging ablation system comprises a system interface module and an ultrasonic imaging radiofrequency ablation catheter; a sheathing canal component of the ultrasonic imaging radiofrequency ablation catheter comprises a main control chip, an ultrasonic transducer and an ablation device. The main control chip and the ablation device are connected to the host through the system interface module; the system interface module is used for responding to the control mode of the host to control the conduction state of the first communication interface and / or the second communication interface so as to carry out signal transmission on the ultrasonic transducer; and / or the operation state of the ablation device is controlled. The radiofrequency ablation function and 4D intracardiac ultrasound imaging are integrated on the same catheter, the advantages of the radiofrequency ablation function and the 4D intracardiac ultrasound imaging can be combined, and the clinical operation process is simplified. The ultrasonic transducer of the same catheter can provide accurate positioning for the radiofrequency ablation position, and can better control the operation process by combining real-time imaging and a feedback mechanism, so that only a predetermined target area is influenced, and the misoperation risk is reduced.

The invention provides a radiofrequency ablation instrument for treating heart diseases, and relates to the technical field of medical equipment. The radiofrequency ablatometer comprises a man-machine interaction device, a data processing device, a radiofrequency energy generating device, an ablation device, an ablation parameter acquisition device, a twelve-lead ECG signal acquisition device, an ultrasonic image acquisition device, a vital sign monitoring acquisition device and a circulating cooling device which are respectively connected with the radiofrequency energy generating device and the ablation device, the cooling device is used for supplying cooling liquid to the ablation device; the data processing device controls power output of the radio frequency energy generating device according to the twelve-lead ECG signals and ablation parameters, and the man-machine interaction device displays ultrasonic images, vital sign parameters and ECG data. According to the invention, concentrated display and linkage analysis of ultrasonic images, twelve-lead ECG signals and vital sign parameters are realized for the first time, and the device can be widely applied to percutaneous intracardiac radiofrequency ablation treatment of hypertrophic cardiomyopathy, cardiac tumor and other diseases, and has extremely high clinical application value.

The utility model discloses an ophthalmology radiofrequency ablation training model which is used for assisting an ophthalmology radiofrequency ablation electrode used in cooperation with an ophthalmology radiofrequency ablation instrument in simulated puncture training on eyeballs, and the ophthalmology radiofrequency ablation electrode is provided with an electrode needle and an impedance detection unit electrically connected with the electrode needle. The ophthalmology radiofrequency ablation training model comprises a base and an eyeball model, wherein the eyeball model comprises a simulated sclera structure, a simulated ciliary body structure and simulated aqueous humor; the simulated sclera structure and the simulated ciliary body structure are made of conductive materials, the simulated sclera structure has a first impedance range, the simulated ciliary body structure has a second impedance range, and the simulated aqueous humor has a third impedance range; when the needle point of the electrode needle pierces into the simulated sclera structure, the simulated ciliary body structure and the simulated aqueous humor, the impedance detection unit can feed back an impedance value, and an operator can judge whether the piercing position and the piercing depth meet requirements or not according to the impedance value.

Various embodiments of the invention provide binding agents for glypican-3 (GPC3), including antibodies or antigen-binding fragments thereof that bind to GPC3 and antigen recognizing receptors (e.g., CARs) that target GPC3 including cells that express GPC3. Embodiments of the i n vention also provide cells comprising such binding agents such as CAR T-cells, therapeutic compositions comprising such cells and methods of using one or more of the binding agents, cells or therapeutic compositions for the treatment of diseases or disorders associated with GPC3 expression such as various neoplastic diseases or disorders (e.g., hepatocellular carcinoma). Various embodiments of the invention also provide methods and systems for treati ng hepatocellular carcinoma (HCC) utilizing a combi nation of radiofrequency (RF) ablation and GPC3-targeted cell therapy. In certain embodiments, immune modulators, such as checkpoint inhibitors, may be co-administered to potentiate immune responses. Additionally, compositions and kits comprising RF ablation devices and GPC3-targeted cell therapy formulations are provided.

Radiofrequency ablation systems having a user interface. Pre-therapy planning and testing is performed and data gathered by the radiofrequency ablation system. A user interface for the radiofrequency ablation system displays anatomical mapping locations that have been tested, with indicia of testing outcomes including positive and negative outcome information and the type of testing performed.

This application relates to the field of medical devices and discloses a needle withdrawal system for radiofrequency ablation devices that avoids scarring. Based on a standard radiofrequency ablation device, the system integrates a needle position detection device (real-time monitoring of depth and speed) and a needle tip temperature sensor. During needle withdrawal, the radiofrequency power is dynamically adjusted according to the withdrawal speed (higher power for faster speed); when the needle tip depth is less than a predetermined threshold (close to the body surface), the radiofrequency output is automatically stopped and a prompt to wait for cooling occurs; once the temperature drops below a safe threshold, a prompt indicates that the needle can be completely withdrawn. Through this closed-loop control, the thermal coagulation and end-point cooling processes of the needle track are precisely managed, effectively preventing thermal damage to the skin and subcutaneous tissue and significantly reducing scar formation.

The utility model discloses a radiofrequency ablation electrode for infant laryngeal airway microsurgery, and belongs to the technical field of radiofrequency ablation electrodes, the radiofrequency ablation electrode for infant laryngeal airway microsurgery comprises a handle shell, a telescopic mechanism is arranged in the handle shell, the interior of the telescopic mechanism is fixedly connected with a sleeve, and the sleeve is fixedly connected with the handle shell. An electrode stem and a smoke tube are arranged in the sleeve, the other end of the smoke tube is connected with a hose, and the other end of the electrode stem is fixedly connected with an electrode needle. The telescopic mechanism is designed to control the electrode rod to stretch out and draw back, the electrode needle head is designed to be bent, a doctor can conveniently observe and position a target spot during an operation, the smoke tube is designed to solve the problem of mist generated during tissue electric resection during the operation, the mist generated during the operation is sucked away through the smoke tube by being connected with a negative pressure tube of a hospital, and the operation is convenient. The interference of smoke on the sight of a doctor is avoided, the use is very convenient, and medical personnel can be helped to perform an operation better.

A medical device includes an elongate member and one or more expandable elements positioned on the elongate member, the one or more expandable elements being configured to expand radially outward from the elongate member. The one or more expandable elements have inner surfaces facing the elongate member and outer surfaces opposite the inner surfaces. At least a portion of the one or more expandable elements provide a radiofrequency ablation electrode. A set of temperature sensors is attached to the inner surfaces of at least one of the one or more expandable elements, or on a flexible circuit surrounding at least a portion of the outer surfaces of the one or more expandable elements.

Radiofrequency ablation systems having a user interface. Pre-therapy planning and testing is performed and data gathered by the radiofrequency ablation system. A user interface for the radiofrequency ablation system displays anatomical mapping locations that have been tested, with indicia of testing outcomes including positive and negative outcome information and the type of testing performed.

A radiofrequency ablation catheter (100) and a radiofrequency ablation device. The radiofrequency ablation catheter (100) comprises a radially contractible and expandable electrode stent (20), a connecting tube (30), and a core wire (40). The proximal end of the connecting tube (30) is connected to the distal end of the electrode stent (20), and the connecting tube (30) has a first lumen (34) running through the proximal and distal ends thereof. The core wire (40) movably runs through the electrode stent (20) and the first lumen (34). The core wire (40) is provided with a first limiting portion (41), the first limiting portion (41) being located in the first lumen (34); and the inner wall of the first lumen (34) is correspondingly provided with a second limiting portion (35). When the first limiting portion (41) abuts against the second limiting portion (35) and the central wire (40) moves from the distal end to the proximal end, the electrode stent (20) is switched from a contracted state to an expanded state. The radiofrequency ablation catheter (100) can reduce the risk of vascular injury, improve the accuracy of the core wire (40) in accessing a target branch vessel, and thus improve the ablation efficiency of radiofrequency ablation.

The invention belongs to the technical field of biomedical information analysis, and particularly relates to duodenum mucosa surface replacement and electrotransfection integrated equipment and a parameter feedback-based operation method. The invention firstly provides a duodenum mucosa surface replacement and electrotransfection integrated device. The device comprises an endoscope guide module, a radio frequency ablation module, an electrotransfection module and an intelligent terminal control module. The invention further provides a method for operating the DMR-EP integrated equipment based on organization parameter feedback. According to the method, individualized strategy generation and data-driven treatment path selection in DMR postoperative local gene therapy are proposed for the first time, and the safety, effectiveness and indication range of treatment are remarkably improved.

The present invention discloses a spider vein medical device and medical equipment that integrates radiofrequency ablation and sclerotherapy. Radiofrequency ablation therapy is achieved by providing an RF energy input terminal within a gripping portion, securing the puncture needle body and electrically connecting it to the first electrical connection terminal of an electrode conduction assembly. Furthermore, the second electrical connection terminal of the electrode conduction assembly is electrically connected to the RF energy input terminal when the assembly is mounted on the gripping portion. Furthermore, a clearance space is provided on the electrode conduction assembly to avoid the liquid conduction section at the tail end of the puncture needle body, allowing an injection line to be connected to the liquid conduction section. The injection line can then be connected to an external liquid injection device to achieve sclerotherapy. This embodiment allows sclerotherapy and radiofrequency ablation to be performed separately within the same punctured blood vessel, or separately within different blood vessels in the same region, thereby achieving combined treatment of spider veins using different surgical procedures.

The present invention provides a data processing method, device, system, equipment and storage medium for radiofrequency ablation. The data processing method includes: obtaining a three-dimensional anatomical model corresponding to a target object; constructing a medium distribution model of the cooling medium in the three-dimensional anatomical model based on the three-dimensional anatomical model and the description information of the cooling medium; constructing a temperature change model corresponding to the target object based on the constructed medium distribution model and the radiofrequency energy released by the acquired radiofrequency ablation device at a second position point in the three-dimensional anatomical model; combining the simulated cooling position points, the position points to be ablated and the temperature change model preset in the three-dimensional anatomical model, predicting the temperature change of the tissue in the target object during the radiofrequency ablation process.

Systems and methods for cardiac radiofrequency ablation treatment planning are disclosed. In some examples, a computing device receives image volume and dose matrix data. The computing device generates a first mesh of an organ substructure for an organ based on a substructure contour of the organ. Further, the computing device generates a second mesh of an isodose volume based on the dose matrix data. The computing device displays the first mesh of the organ substructure and the second mesh of the isodose volume within the same scene. In some examples, the computing device samples a plurality of dose values, determines a representative dose value for each of a plurality of points along a surface of the dose matrix, and generates an image for display based on the representative dose value. In some examples, a segmentation model is generated for display based on the representative dose value.

A method for treatment of volume of interest (VOI), for example tumor, comprising a device for application of therapy in multi sites in a pre-defined volumetric array through a single needle insertion into the body. Therapies applied by this method include injection of therapeutic agents, including cytotoxic, immunologic and biologic drugs or drug combinations; radioactive substances; thermal ablation including radiofrequency ablation, microwave ablation, or cryoablation. The method addresses the problem of inadequate distribution of therapy throughout the VOI through a single needle insertion.

The application provides a multipurpose electrode for positioning, guiding and puncturing, comprising a mapping electrode head, a bending sheath, a magnetic positioning sensor, a mapping tube electrode, a mapping tube, a handle and a guide wire; wherein the mapping tube is a multi-cavity tube, comprising a signal line cavity, a magnetic sensor cable cavity and a bending sheath cavity for the bending sheath; the guide wire is arranged in the bending sheath, the mapping electrode head is arranged at one end of the mapping tube, the handle is connected to the other end of the mapping tube, two mapping tube electrodes are arranged on the mapping tube, and the magnetic positioning sensor is arranged between the two mapping tube electrodes; the application integrates many functions such as electromagnetic positioning, endocardial potential mapping, electrical excitation sequence mapping, excitation time slot mapping, accurate positioning of the catheter head end region, point radio frequency ablation and guide wire delivery. One catheter can be used in many different surgical procedures and scenes.

A power generator is disclosed for generating ablating energy deliverable to a catheter for treatment of heart rhythm disorders. The power generator includes a first output port configured to deliver ablation energy through a first conductive wire of a catheter and a second output port configured to receive a sensing signal from a thermocouple junction formed at a catheter electrode. The generator includes a first power driver for producing waveforms suitable for radiofrequency ablation (RFA) and a second power driver for generating pulsed waveforms suitable for pulsed field ablation (PFA). A switching circuit selectively couples one of the power drivers to the first output port based on a selected ablation modality. A control circuit receives an input indicating the selected modality and controls the switching circuit accordingly. The system enables dual-modality ablation using a shared catheter interface, facilitating seamless transition between RFA and PFA without requiring hardware reconfiguration.

A catheter is disclosed comprising a catheter shaft including a proximal end and a distal end. A flexible framework can be connected to the distal end of the catheter shaft, wherein the flexible framework includes a plurality of heating electrodes and a temperature sensor. The plurality of heating electrodes can be configured to be heated to a first temperature, the first temperature being lower than which radio frequency ablation is performed. The plurality of heating electrodes can be configured to be heated to a second temperature, the second temperature being a temperature at which radio frequency ablation is performed.

The utility model provides a radiofrequency ablation catheter and a radiofrequency ablation system. The radiofrequency ablation catheter comprises a balloon, an inner tube, a guide wire tube, an outer sleeve and a radiofrequency electrode, the near end of the balloon is provided with a near-side tube section extending along the longitudinal axis of the balloon; the inner tube is provided with an inflation cavity and a guide wire tube penetrating cavity which are not communicated with each other, the far end of the inner tube is inserted into the near-side tube section, the inner tube is in sealed connection with the near-side tube section, and the far end of the inflation cavity is communicated with an inner cavity of the balloon; the far section part of the guide wire tube extends out of the far end of the guide wire tube penetrating cavity and extends to an inner cavity of the balloon, and the guide wire tube is in sealed connection with the guide wire tube penetrating cavity; the outer sleeve is arranged outside the inner tube in a sleeving mode, the far end of the outer sleeve is connected with the near-side tube section, a gap is formed in the joint, and a threading cavity between the outer sleeve and the inner tube is used for containing a cable; the radio frequency electrode is provided with a far-side ablation area and a near-side wiring area connected with the cable, extends to the gap from the near-side wiring area to the far-side ablation area along the threading cavity, penetrates out of the gap and then is attached to the surface of the near-side pipe section to extend to the outer surface of the balloon.