496 results about "Interventional treatment" patented technology

A sheath attached to a guide wire, a tubular shaft member slidable on the guide wire and a filtering assembly constricted within the sheath are movable in a vessel to a position distal to a lesion in the direction of fluid flow. The filtering assembly may be formed from a plurality of angularly spaced splines and a mesh disposed on the splines having properties of passing fluid in the vessel while blocking the passage of emboli in the fluid. The splines may be provided with shape memory for expanding against the wall of the vessel when released from constriction by the sheath. The sheath may be moved relative to the filtering assembly and the support member to release the filter for expansion against the vessel wall. An interventional device can be used to treat the lesion. Any emboli released into the vessel as a result of the interventional treatment are blocked by the filter member while fluid is allowed to pass there through.

MRI compatible localization and / or guidance systems for facilitating placement of an interventional therapy and / or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

The present invention discloses a method for determining the position and / or orientation of a catheter or other interventional access device or surgical probe using phase patterns in a magnetic resonance (MR) signal. In the method of the invention, global two-dimensional correlations are used to identify the phase pattern and orientation of individual microcoils, which is unique for each microcoil's position and orientation. In a preferred embodiment of the invention, tracking of interventional devices is performed by one integrated phase image projected onto the axial plane and a second image in an oblique plane through the center of the coil and normal to the coil plane. In another preferred embodiment, the position and orientation of a catheter tip can be reliably tracked using low resolution MR scans clinically useful for real-time interventional MRI applications. In a further preferred embodiment, the invention provides real-time computer control to track the position of endovascular access devices and interventional treatment systems, including surgical tools and tissue manipulators, devices for in vivo delivery of drugs, angioplasty devices, biopsy and sampling devices, devices for delivery of RF, thermal, microwave or laser energy or ionizing radiation, and internal illumination and imaging devices, such as catheters, endoscopes, laparoscopes, and related instruments.

The vasoocclusive device for use in interventional therapy and vascular surgery adapted to be inserted into a portion of a vasculature, includes a vasoocclusive coil disposed about an inner reinforcement coil wherein said vasoocclusive coil is helically wound and the inner reinforcement coil forms a reverse helical winding opposite the vasoocclusive coil winding, thereby forming a biplex wound coil. The vasoocclusive device biplex winding provides improved mechanical properties to the device. An inner reinforcement stretch resistant member attached within the biplex windings limits coil stretchability.

A method for determining the position and / or orientation of a catheter or other interventional access device or surgical probe using phase patterns in a magnetic resonance (MR) signal. In the method of the invention, global two-dimensional correlations are used to identify the phase pattern around individual microcoils, which is unique for each microcoil's position and orientation. In one embodiment the position and orientation of a catheter tip can be reliably tracked using low resolution MR scans clinically useful for real-time interventional MRI applications. In a further embodiment, the invention provides real-time computer control to track the position of endovascular devices and interventional treatment systems, including surgical tools and tissue manipulators, devices for in vivo delivery of drugs, angioplasty devices, biopsy and sampling devices, devices for delivery of RF, thermal, microwave or laser energy or ionizing radiation, and internal illumination and imaging devices, such as catheters, endoscopes, laparoscopes, and related instruments.

MRI compatible localization and / or guidance systems for facilitating placement of an interventional therapy and / or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

A sheath attached to a guide wire, a tubular shaft member slidable on the guide wire and a filtering assembly constricted within the sheath are movable in a vessel to a position distal to a lesion in the direction of fluid flow. The filtering assembly may be formed from a plurality of angularly spaced splines and a mesh disposed on the splines having properties of passing fluid in the vessel while blocking the passage of emboli in the fluid. The splines may be provided with shape memory for expanding against the wall of the vessel when released from constriction by the sheath. The sheath may be moved relative to the filtering assembly and the support member to release the filter for expansion against the vessel wall. An interventional device can be used to treat the lesion. Any emboli released into the vessel as a result of the interventional treatment are blocked by the filter member while fluid is allowed to pass there through.

The invention relates to a realization method for an interactive coronary artery virtual angioscope, which pertains to the technical field of medical imaging and aims at solving the visible problem of making a diagnosis and giving treatment of coronary artery. The technical proposal is that the realization method obtains the three-dimensional model of blood vessels by means of combining three-dimensional geometrical feature information of lumen by a nearly orthorhombic X-ray visualization picture of coronary artery with the data of the section of lumen by lumen endobronchial ultrasonography, then adopts virtual reality modeling language to interactively describe the model of blood vessels and realizes the visualization of coronary artery in the endoscope roaming mode. The realization method realizes interactive visit and display of the three-dimensional model of blood vessels and provides an ideal platform for the research on the development of coronary atherosclerosis pathological changes, the visible diagnosis and treatment of coronary heart diseases, the involvement in the evaluation of curative effect, and the like, and the training of medical personnel.

Electrical activity can be chronically detected in first and second cardiac regions in the subject. Discordant alternans in at least one component of the detected electrical activity can by identified. Interventional therapy can be initiated in the subject responsive to the identification of discordant alternans.

A system for use in a vascular procedure includes a guidewire dimensioned to remotely access a neurovascular space, a microcatheter for positioning over the guidewire, an interventional treatment element for passage within the catheter member of the microcatheter, and an outer guide positionable over the catheter member of the microcatheter upon removal of the catheter hub. The microcatheter includes an elongated catheter member and a catheter hub. The catheter member defines a longitudinal axis and has a longitudinal length and with proximal and distal ends. The catheter hub is connected to the proximal end of the catheter member and is dimensioned and adapted to be selectively released from the catheter member. The outer guide is advanceable over the catheter member of the microcatheter after the catheter hub is released from the catheter member to a location proximate the lesion. The interventional treatment element is adapted to perform treatment on the lesion within the vasculature

The invention provides a visualization calculation method for a whole intracranial aneurysm interventional therapy stent implantation process, establishes a stent release expansion model, provides an effective numerical simulation method for the intracranial aneurysm interventional therapy stent implantation, and provides a visualization method used for detection, calculation and analysis of the surgical planning of intracranial aneurysm interventional therapy. The adopted technical scheme is as follows: firstly, a blood vessel centerline is utilized to implant a numerical simulation stent into the blood vessel, and an active contour model is utilized to perform stent expansion, then the distance of each two nodes of the stent is changeless through optimization, and finally hemodynamics calculation and analysis are performed, and optimal configuration for stent implantation is simulated and calculated. The image simulation method can be directly applied to three-dimensional vascular angiography tomographic images, enables the stent to keep own geometric morphological characters through optimization, and can utilize weight adjustment to enable the stent to be clung to the blood vessel wall as far as possible. The simulation process can control the stent implantation position conveniently, and better clinical application value is achieved in the surgical planning of interventional therapy.

The invention relates to a degradable drug loading stent and a preparation method of the degradable drug loading stent. The degradable drug loading stent is characterized by comprising a skeleton structure made of a medical degradable metal or an alloy of the metal, a degradable macromolecular transition layer adhered to the surface of the skeleton structure and a drug loading layer. The degradable metal / macromolecular / drug multilayer composite stent provided by the invention has excellent mechanical property, degradable property and biocompatibility, and such drugs as taxol, taxol derivative, actinomycin D, 5-fluorouracil and sirolimus are loaded to the stent to perform active directional treatment on the focus position, so the stent is a functional degradable stent. The degradable multifunctional drug loading stent provided by the invention is suitable for interventional therapy in the blood vessel field and non-blood vessel fields and is especially suitable for interventional therapy of stenosis, obstruction or tumor of such non-blood vessel cavities as esophagus, bile duct, ductus pancreaticus, intestinal tract, urethral canal, trachea and bronchus, etc.

The present invention, in an exemplary embodiment, provides a therapeutic medical appliance, delivery device and method of use. In particular, plug therapeutic medical appliances are provided that allow for the interventional treatment of pulmonary disorders such as defects characterized by pulmonary blebs and / or diffused destructive parenchymal disease. The plug therapeutic medical appliances themselves combine many of the excellent characteristics of both silicone and metal therapeutic medical appliances while eliminating the undesirable ones. In particular, these therapeutic medical appliances are preferably self-expanding in nature and allow the predetermined differential selection of relative hardness / softness of regions of the therapeutic medical appliance to provide additional patient comfort. An exemplary embodiment also provides a family of delivery devices that facilitate flexibility, durability and / or proper installation of one or more medical appliances in a single procedure. Moreover, the preferred embodiment of the delivery device provides for the reloading of the delivery device with additional medical appliances for additional inferventional procedures.

The invention belongs to the field of biological medicines, and particularly discloses a mesenchymal stem cell and cytokine preparation having treatment effects on premature ovarian failures and perimenopausal syndromes, and a preparing method for the preparation. The preparation is composed of umbilical cord or placenta mesenchymal stem cells and cytokines, as well as hyaluronate which is used for bearing the umbilical cord or placenta mesenchymal stem cells and cytokines and has the slow-release and anti-inflammatory effects; and the preparation is injected into a part of the endometrium and ovary in a targeted manner to be slowly released and absorbed. The curative effect of repairing the ovary and endometrium can be achieved, functional ovulation can be promoted, the premature ovarian failures can be treated, and the various perimenopausal syndromes can be remitted. Compared with an existing intravenous re-transfusion and intervention path, untoward effects of intravenous transfusion are avoided through the preparation and a using method of the preparation, abdomen and local wounds caused by interventional treatment are avoided, and side effects and hurts caused by treatment to a patient can be effectively prevented, so that the preparation is safer and more effective, is high in practicability and easy to popularize, and has the huge application value.

The invention relates to a functionalized modified polyvinyl alcohol embolic microsphere and a preparation method thereof, and belongs to the field of medical intervention treatment. The functionalized modified polyvinyl alcohol embolic microsphere is prepared by taking polyvinyl alcohol as a base material, taking amino / hydroxyl carboxylic acid derivatives / sulfonic acid derivatives capable of crosslinking after acylation as a modifying agent and performing modification. The modified microsphere prepared by the method has perfect sphere shape, uniform size, high suspending property and shape change elasticity of the polyvinyl alcohol microsphere before modification. Meanwhile, a polycarboxylic / mucopolysacchariden functional group with negative charges is introduced and can be combined with micromolecular anti-tumor medicines with positive charges, so that the microsphere has high medicine loading property. Compared with the polyvinyl chloride microsphere which is not functionalized and cannot carry medicines or the microsphere which only introduces single group with negative charges and has low medicine carrying quantity in the prior art, the microsphere increases the medicine carrying quantity and improves the controlled release capability greatly.

The invention discloses an involvement type prosthetic heart valve stent with barbs and a preparation method thereof, and belongs to the technical field of involvement type medical devices. The stent is an elastic stent which can stretch or retract in a radial direction, and comprises a tubular structural part and a skirt-shaped open structural part; the diameter of the skirt-shaped open structural part is greater than that of the tubular structural part; the tubular structural part and the skirt-shaped open structural part are coaxially and fixedly connected; barks are also arranged in the stent; the barbs extend from the tubular structural structure to the skirt-shaped open structural part and are tilted to the outer side of the stent. The stent can extend and retract in the radial direction so as to facilitate the mounting, the transporting and the releasing in involvement treatment; the stent structure is matched with the physiological structure of a natural valve, has a certain self-positioning function, and is convenient to position and release quickly and accurately; the barbs can penetrate into the tissues around the valve after the heart valve is planted into a specific position so as to achieve a positioning effect; displacement and perivalvular leakage are not easily caused after the valve is released.

The invention provides a balloon guide catheter, and in particular relates to the technical field of medical apparatus and instruments. The catheter is a composite pipe composed of an outer tube, an inner tube, and a suction tube positioned at the far end of the catheter which are coaxial, and a flexible balloon capable of realizing the full or contraction state is connected to the outer layer ofthe far end of the outer tube; an annular cavity between the inner tube and the outer tube forms a balloon filling cavity; the far end of the inner tube is welded to the near end of the suction tube;an inner cavity of the inner tube is connected with the inner cavity of the suction tube in series to form a guide cavity of the catheter, namely, a thrombus suction cavity; a main inner hole of a Y-shaped joint communicates with the inner cavity of the inner tube to form a wire guide cavity and the thrombus suction cavity; and the axis of side holes of the Y-shaped joint and the axis of the maininner hole of the Y-shaped joint have intersection at the near end direction of the catheter to form an acute angle, and the side holes of the Y-shaped joint and a gap between the outer wall of the inner tube and the inner wall of the outer tube communicate to form the balloon filling cavity. For the balloon guide catheter, during the interventional treatment process, blood flow can be blocked, sothat small broken thrombus is prevented from blocking the far end, and meanwhile, large thrombus blocks at the near end can be sucked, so that the surgery effect is greatly improved.

An apparatus for interventional treatment of atherosclerosis at a vascular bifurcation includes structure for receiving a first guidewire and a second guidewire. An exit for the second guidewire is located in a central section of the structure. A first balloon portion is secured to the structure so a proximal end is located adjacent the exit. A second balloon portion is secured to the structure so a distal end is located adjacent the exit. An annular gap is defined between the proximal end of the first balloon portion and the distal end of the second balloon portion. The annular gap, at a radial outermost location relative to the structure, has a width that is equal to or less than a width of the annular gap at a radially innermost location relative to the structure. The apparatus also comprises an expandable stent that is mountable about the first and second balloon portions.

A method for treatment of atrial fibrillation is disclosed. This method includes utilizing mathematical analysis, e.g., logistic regression, on a collection of variables selected from the group including effective refractory period, wavelength, tissue area, tissue weight, maximum tissue width, minimum tissue width, and average tissue width to design a set of lesions that would make an atria fibrillation-proof. Preferably the most preferred variables are tissue area, effective refractory period, and conduction velocity. This is preferably a electrophysiologically-customized procedure that is preferably minimally invasive, which could include transvenous or port access, either off or on bypass to create the set of lesions that render an atria fibrillation-proof based on the mathematical analysis of selected variables. Long linear lesions are created from a variety of energy sources as well as surgical techniques. Preferably, there are fixation and marking mechanisms utilized.

The invention discloses a cerebral aneurysm hemodynamic index evaluation method, system and device and a medium. The evaluation method comprises the following steps: acquiring human body cerebral artery image data; carrying out anatomical modeling on the human body cerebral artery medical image data to obtain a cerebral aneurysm anatomical model; fluid mechanics calculation processing is conductedon the cerebral aneurysm anatomical model, and outputting a calculation result; and adding the calculation result to a corresponding position of the cerebral aneurysm anatomical model, and carrying out visual display of hemodynamic indexes. According to the method, the system, the equipment and the medium, the hemodynamic indexes of the cerebral aneurysm can be obtained according to the medical image data of the human cerebral artery. Therefore, the relationship between the hemodynamic characteristics and the occurrence, development and rupture of the aneurysm can be analyzed based on the obtained hemodynamic indexes, and a theoretical basis is provided for risk factor assessment and interventional therapy of the cerebral aneurysm.

The invention discloses a shock wave generation system applied to angioplasty. The shock wave generation system applied to angioplasty is provided with an axially extending elongated member with an outer surface; a plurality of wired electrodes arranged in series; at least one non-conductive gap; and a non-conductive member arranged on the at least one non-conductive gap, wherein each of the wireelectrodes is connected to an output terminal of a high-voltage source by a wire extending from one terminal on an outer surface of the elongated member to the wire electrode; and each non-conductivemember has a shape, the configuration of which affects the direction and / or intensity of shock waves generated by arc discharge from the first electrode to the second electrode, or affects the direction and / or intensity of shock waves generated by arc discharge from the second electrode to the first electrode. Calcified plaques in arteries can be effectively crushed, vascular tissue is not damaged, further interventional treatment of the calcified arteries is facilitated, and occurrence of interlayers and restenosis can be reduced.

Described herein is a system and method for identifying elastic lamina during interventional procedures, such as atherectomy. Such identification can be used to avoid trauma to the external elastic lamina during the procedure.

The invention relates to a medical oncology medical interventional treatment device, and belongs to the technical field of a medical appliance. The medical oncology medical interventional treatment device comprises an invisible electricity supply box, a medical interventional treatment instrument and an interventional device dustproof disinfecting box, a rechargeable battery is arranged in the invisible power supply box, the upper side of the rechargeable battery is provided with a battery electric quantity detecting chip, the right upper side of the battery electric quantity detecting chip is provided with a charging reminding lamp, the right side of the invisible electricity supply box is provided with a charging interface, a charging interface dustproof sealing cover is arranged on the charging interface, the lower side of the invisible electricity supply box is provided with a fixing base plate, the left side of the fixing bottom disc is provided with a pushing rod dismounting and mounting ring, a device pushing rod is arranged on the pushing rod dismounting and mounting ring, and the left lower side of the fixing base plate is provided with device universal wheels. The medical oncology medical interventional treatment device has the advantage that the functions are complete, the use is convenient, during the traditional Chinese medicine oncology medical interventional treatment, the operation is simple and convenient, time and labor are saved, and the work difficulty of medical staff is lightened.

The invention provides a biomedical degradable Mg-Zn-Zr-Sc alloy and a preparation method thereof. The alloy comprises the following components in percentage by mass: greater than or equal to 0.5% and less than or equal to 2% of Zn, greater than or equal to 0.3% and less than or equal to 0.8% of Zr, greater than 0% and less than or equal to 10% of Sc, and the balance of Mg. By utilizing the characteristics of favorable compatibility and high degradability of Mg in organisms, the Zn, Zr and Sc are reasonably added to further regulate and optimize the mechanical properties and corrosion resistance of Mg; and the alloy is prepared by a casting technique with lower cost. The Mg-Zn-Zr-Sc alloy does not have precipitated phase, and thus, is beneficial to inhibiting the couple corrosion, so the corrosion mode is uniform corrosion; the alloy has excellent corrosion resistance and favorable mechanical properties, and can be used in the fields of degradable bone plates, bone nails, vessel interventional therapy stents and other biological materials.

The invention discloses a bending catheter with a controllable head and used for interventional therapy. A head portion of a multi-cavity catheter is connected with a main catheter soft head, the tail portion of the multi-cavity catheter is connected with an extending pipe through a connection piece, a handle is arranged outside the extending pipe, a handle sliding device is movably connected in the handle and is matched with the extending pipe, the upper end and the lower end of the sliding device are extended to the outside of the casing of the handle, a drawing wire is respectively connected with the upper side and the lower side of the sliding device, the other ends of the drawing wires penetrate through auxiliary cavities on the same side of the multi-cavity catheter and the main catheter soft head to be fixedly connected on the head portion of the main catheter soft head, and other end of the extending pipe extends to the outside of the handle to be connected with a connector. Compared with the prior art, the bending catheter has the advantages of being safe, reliable and simple in production process, is capable of meeting other performance requirements of catheters in vessels, achieves universalness of the operation process of doctors, reduces risk of patients in operation, and simultaneously achieves multipurpose performance.

The invention relates to a tumor interventional dose drainage treatment device, and belongs to the technical field of medical apparatuses and instruments. The tumor interventional dosing drainage treatment device comprises an intervention device storage cabinet, a hidden battery box, a drainage cabinet, and a dosing cabinet. The lower side of the intervention device storage cabinet is provided with a device fixing chassis. The device fixing chassis is internally provided with a charging wire storage cabin. The charging wire storage cabin is provided with a wire cabin door. The wire cabin door is connected with the charging wire storage cabin through a wire cabin door hinge. The charging wire storage cabin is internally provided with a wire winding roller. The wire winding roller is connected with the charging wire storage cabin through a wire roller rotating shaft. The wire winding roller is provided with a battery charging wire. The device is complete in functions and convenient in use. When the device performs interventional therapy of an oncology department and dosing, operation is simple, and the device saves time and efforts, and working difficulty of medical staff is reduced.

The invention relates to treatment instruments, in particular to an interventional treatment instrument made from a composite material and used for treating cerebral aneurysm embolism. Bead-like diamond spring coils of the treatment instrument can be coiled to form a space structure conforming to the arterial aneurysm through connecting points of diamonds and plays an arterial aneurysm stuffing role, meanwhile PU nanometer electrically-spun wires between the diamond spring coils can isolate blood flows, promote thrombosis in the arterial aneurysm and achieve arterial aneurysm closing purpose. The effective areas of the spring coils re increased through diamond support frameworks made of nickel-titanium memory alloy composite wires, and the embolism effect of the arterial aneurysm is improved. The PU nanometer electrically-spun wires among the diamond support frameworks are mixed with blood to form membranous substance, the arterial aneurysm can be closed, and thrombosis can be promoted. The using efficiency of the spring coils is improved, and the embolism effect is strengthened.

The invention provides an absorbable vascular stent, which is made of biodegradable materials, and the biodegradable materials include polylactic acid stereocomplexes, and the polylactic acid stereocomplexes are D-polylactic acid and L-polylactic acid. A mixture of lactic acid, or a polymer of D-polylactic acid and L-polylactic acid, the polylactic acid stereocomplex has at least one melting temperature above 200°C. The polylactic acid stereocomplex has good mechanical strength, biocompatibility and biodegradability, and the stent made by processing it also has good mechanical strength, biocompatibility and biodegradability, and is used for vascular The interventional treatment of obstructive diseases has a good supporting effect, and side effects such as thrombosis and restenosis will not occur. Experiments show that the bending strength of the absorbable vascular stent provided by the present invention can reach more than 140 MPa, and the tensile strength can reach more than 60 MPa.

The invention relates to a medicine coated balloon and a preparation method thereof. The coating is prepared from the following raw materials in parts by weight: 5-9 parts of a medicine, 1-5 parts of excipient and 1-15 parts of a solvent, wherein the medicine is at least one of taxanes and macrolides; the excipient is at least one of iopromide, polyvinylpyrrolidone, polysorbate and polyethylene glycol; and the solvent is at least one of water, methanol, ethanol, acetone, isopropanol, acetonitrile, ethyl acetate and methyl formate. According to the method, by optimizing the composition of coating raw materials, the proportion of raw materials and the process parameter in the coating preparation method, the coating cannot be easily separated before reaching the target site and can quickly release the medicine when reaching the target site, the target tissue can be promoted to absorb the medicine in the coating, the medicine duration in the target tissue can be improved, and the vessel restenosis rate after interventional therapy can be reduced.