The invention relates to an intra-cavity lesion positioner in capsule endoscopy. The intra-cavity lesion positioner comprises a capsule endoscope for detecting and discovering a lesion portion and is characterized by further comprising a capsule positioner, the capsule positioner is connected with the capsule endoscope through a remote control disconnecting and connecting device, the capsule positioner comprises a capsule shell, an automatic parking and positioning device, a positioning signal transmitter, a signal transmitter remote control switch and a battery, the automatic parking and positioning device is used for fixedly parking the capsule positioner on the lesion portion, the positioning signal transmitter is electrically connected with the battery and the signal transmitter remote control switch, and the signal transmitter remote control switch receives an instruction and controls the positioning signal transmitter to transmit positioning signals. The intra-cavity lesion positioner is ingenious in structure and convenient to operate, an intra-cavity minimal lesion can be accurately positioned in a laparoscopic minimally invasive operation is performed, operation efficiency is improved, positioning errors are avoided, operation errors are reduced, the capsule endoscope and the capsule positioner are mutually dragged, and tumbling of the capsule endoscope in an intestinal tube and examination blind areas are decreased.