24 results about "Lower Gastrointestinal Tract" patented technology

The invention discloses an endoscopic gastrointestinal tract image detection and recognition system and method based on artificial intelligence, and belongs to the technical field of medical image detection. Comprising an image acquisition module, an image preprocessing module, a feature extraction module, a lesion detection module, a lesion recognition module, a model training module, a result output module, a data storage module, a man-machine interaction module and a quality evaluation module, wherein the image acquisition module is used for acquiring image data in the gastrointestinal tract and transmitting the image data to the image preprocessing module; the image preprocessing module is used for preprocessing the image data. Through cooperative work of multiple modules, a whole-process intelligent detection and recognition system from image collection to result output is constructed, all the modules are clear in division of labor, data transmission is efficient, accurate processing and analysis of gastrointestinal tract images under an endoscope can be achieved, and the defects of traditional manual diagnosis and an existing AI diagnosis technology are effectively overcome.

Systems and methods for objective evaluation of a stool sample to determine whether a patient's lower gastrointestinal tract is sufficiently clean to undergo a successful gastrointestinal visualization procedure with favorable visualization. A method includes collecting a stool sample from a patient and assessing the stool sample to determine whether an intestine of the patient is sufficiently clean for the patient to undergo a successful lower gastrointestinal tract visualization procedure.

Provided are methods for preventing or delaying the need for surgical intervention in a patient having familial adenomatous polyposis (FAP) and an at least partially intact lower gastrointestinal tract. Also provided are methods for preventing or delaying the formation of neoplasia and / or cancer in a patient having FAP. The methods comprise administering an effective amount of a pharmaceutical therapy that comprises eflornithine and sulindac to a patient having FAP and an intact lower gastrointestinal tract.

Described herein is a controlled release pet food composition comprising: a matrix comprising: a fibrous component comprising a high solubility fiber source and a low solubility fiber source, and a polyphenol source; wherein the matrix is adapted to deliver the polyphenol source to the lower gastrointestinal (GI) tract of a mammal upon uptake by the mammal. Methods of making and using these compositions are also described.

Orally administered pharmaceutical compositions comprising incretin or its analogues or derivatives are presented, which allow for prolonged glycemic control. The formulations presented herein incorporate a self-emulsifying drug delivery system (SEDDS). Advantageously, such formulations provide protection in the upper gastrointestinal tract from proteolytic conditions while allowing for efficient drug release and absorption in the lower gastrointestinal tract.

The present invention relates to methods of stabilising proteins and peptides in the lower gastrointestinal tract. Pharmaceutical compositions which comprise as active ingredient a protein or a peptide; 5-aminolevulinic acid (5-ALA) or a pharmaceutically acceptable salt thereof; and optionally a pH-modulating component and / or an enzyme inhibitor are described

The anchoring method of the gastrointestinal tract inner sleeve comprises the steps that the gastrointestinal tract sleeve is arranged outside the anchoring device in a sleeving mode, so that the anchoring holes are aligned with the negative pressure holes one by one; when the gastrointestinal tract sleeve is conveyed to a pre-anchoring position in the gastrointestinal tract, the negative pressure source is started, gastrointestinal tract tissues are adsorbed into the negative pressure holes in the negative pressure cylinder through the anchoring holes in the gastrointestinal tract sleeve under the action of negative pressure, and when the gas pressure in the negative pressure cylinder is reduced to a certain threshold value, the normally-closed constant pressure valve is opened, so that the gastrointestinal tract sleeve is anchored in the gastrointestinal tract. The gas in the cylindrical needle pushing part flows into the negative pressure cylinder, and the cylindrical needle pushing part slides in the axial direction of the negative pressure cylinder to push the mechanical latch to puncture and be adsorbed into gastrointestinal tract tissues, so that the anchoring of the gastrointestinal tract sleeve is realized, the anchoring operation of a plurality of anchoring points of the gastrointestinal tract sleeve can be completed at one time, and the anchoring efficiency of the gastrointestinal tract sleeve is improved. One-by-one adsorption and puncture are avoided, and the method is efficient and convenient.

The invention discloses polysaccharide-based gastrointestinal tract tissue marking hydrogel as well as a preparation method and application thereof. The invention provides a preparation method of gastrointestinal tract tissue labeling hydrogel by utilizing the property that polysaccharide is subjected to Schiff base reaction with oxidized dextran after being grafted with polyaniline. Compared with the existing commercial marking liquid, the marking hydrogel disclosed by the invention has a better marking effect, and overcomes the defects that the conventional marking liquid is easy to coagulate and easy to leak during injection and the like. The polysaccharide-based gastrointestinal tract tissue marking hydrogel prepared by the invention has good biocompatibility, injectability, controllable degradability and excellent stability, and can be used for accurate positioning of gastrointestinal tract pathological tissues or specific parts under an endoscope and treatment of cancerous tissues.

To provide an oral composition and a method for producing the same, enabling efficient generation of monomeric glutamic acid in a lower digestive tract.SOLUTION: A method for producing γ-oligoglutamic acid is provided, comprising: (1) hydrolyzing γ-polyglutamic acid in an acidic or alkaline aqueous solution to obtain an aqueous solution containing a hydrolysate; and (2) neutralizing the aqueous solution containing the hydrolysate obtained in step (1) and removing a precipitate of the formed salt. An oral composition, containing γ-oligoglutamic acid is provided.SELECTED DRAWING: None

The present invention relates to a method for stabilizing proteins and peptides in the lower gastrointestinal tract. A pharmaceutical composition is described that comprises as an active ingredient a protein or peptide; 5-aminolevulinic acid (5-ALA) or a pharma- ceutical acceptable salt thereof; and, optionally, a pH adjusting component and / or an enzyme inhibitor.

The invention discloses a mandarin fish feed additive as well as a preparation method and application thereof, belongs to the technical field of aquaculture, and solves the problems that a conventional feed in the prior art is serious in water pollution, hypoxia stress of fish larvae, low in immunity, dysfunctional in gastrointestinal tracts and the like, and low in fry survival rate. The mandarin fish feed additive comprises the following components in percentage by mass: 45%-56% of enzymolysis fresh minced fillet, 8%-12% of gradient activated zeolite powder, 10%-20% of soybean meal or / and cottonseed meal, 2%-4% of an immunopotentiator, 1.5%-2% of compound probiotics, 6%-8% of fish oil or / and krill oil and 4%-5% of a premix. When the mandarin fish feed additive is used for culturing mandarin fish, the activity of serum peroxidase of the mandarin fish can be improved, the activity of glutathione peroxidase is improved, and the content of malondialdehyde is reduced; the selenium deposition of the liver can be increased, and the intestinal flora can be optimized; the survival rate of the mandarin fish can be improved.

Described herein are controlled release pet food compositions comprising: a matrix comprising: a fiber component comprising a high solubility fiber source and low solubility fiber source, and a polyphenol source; wherein the matrix is adapted to deliver the polyphenol source tot he lower gastrointestinal (GI) tract of a mammal after ingestion by the mammal. Methods of making and using these compositions are also described.

The present invention relates to a solid oral dosage form for sustained release in the lower gastrointestinal tract comprising an antibody or a functional fragment thereof in a depot layer (2) covering an inert core unit (1), a sustained release layer (3) covering the depot layer and a delayed release layer (4) covering the sustained release layer, preferably prepared by pharmaceutical stratification; an oral multiparticulate drug delivery system comprising a plurality of such solid oral dosage forms; and the use of the solid oral dosage form in targeted topical treatment in the lower gastrointestinal tract of a patient.

Orally administrable pharmaceutical compositions comprising an incretin or analog or derivative thereof are presented that allow for extended control of blood glucose. Formulations presented herein comprise a self-emulsifying drug delivery system (SEDDS). Advantageously such formulations afford protection from the proteolytic conditions in the upper gastrointestinal tract while allowing for effective drug release and absorption in the lower gastrointestinal tract.

To provide an endoscope device for acquiring lower gastrointestinal tract images and a method of controlling the same.SOLUTION: The invention belongs to the field of medical imaging equipment and automation control technology, and particularly relates to an endoscope device associated with imaging of the lower gastrointestinal tract using an endoscope, and to a method of controlling the endoscope device. The method includes the steps of: acquiring an image of the lower gastrointestinal tract from an image sensor; acquiring environmental information related to a distal end portion; sensing at least one first body part from the image based on a pre-trained model; calculating relative position information between the first body part and the distal end portion of the endoscope device; generating a first control signal for steering in correspondence with the first body part based on the environmental information and the relative position information; and transmitting the first control signal to a drive unit.SELECTED DRAWING: Figure 1

A feed additive composition for ruminants contains a choline salt, shows high protection in the rumen, and is also superior in dissolution in the lower gastrointestinal tract, and the like. The feed additive composition for ruminants contains:(A) at least one selected from hydrogenated oil and wax, each having a melting point of higher than 50° C. and lower than 90° C.,(B) 0.01-6 wt % of a surfactant,(C) 10-60 wt % of a choline salt,(D) 1-40 wt % of L-lysine or a salt thereof,(E) a hygroscopic agent, and(F) 0.1-3 wt % of a stearic acid metal salt, and the like, all weight percentages being with respect to the composition.

The present invention relates to a composition for use in treating a condition of the lower gastrointestinal tract, e.g. ulcerative colitis, wherein the composition comprises: a) a carrier comprising: a1) water in an amount of more than 10% to 30% by weight of the carrier; and a2) monoacylglycerol lipid in an amount of 70% to 90% by weight of the carrier, wherein the monoacylglycerol lipid comprises monolinolein or monoolein, or combinations thereof; and b) a pharmaceutically active agent, wherein the composition forms a lipid cubic phase at a temperature of 36° C. to 39° C. The composition is particularly suitable for rectal administration, for example, as an enema. Also disclosed is a composition, methods for preparing the compositions, and kits for making the compositions.

Described herein is a controlled release pet food composition comprising: a matrix comprising: a fibrous component comprising a high solubility fiber source and a low solubility fiber source, and a polyphenol source; wherein the matrix is adapted to deliver the polyphenol source to the lower gastrointestinal (GI) tract of a mammal upon uptake by the mammal. Methods of making and using these compositions are also described.

Systems and methods for objective evaluation of a stool sample to determine whether a patient's lower gastrointestinal tract is sufficiently clean to undergo a successful gastrointestinal visualization procedure with favorable visualization. A method includes collecting a stool sample from a patient and assessing the stool sample to determine whether an intestine of the patient is sufficiently clean for the patient to undergo a successful lower gastrointestinal tract visualization procedure.

The present invention relates to a composition for treating a lower gastrointestinal tract condition, such as ulcerative colitis, where the composition comprises: a) a carrier comprising: a1) water in an amount of more than 10% to 30% by weight of the carrier; and a2) a monoacylglycerol glyceride in an amount of from 70% to 90% by weight of the carrier wherein the monoacylglycerol glyceride comprises glyceryl monolinoleate or glyceryl monooleate or a combination thereof; and b) a pharmaceutically active agent, wherein the composition forms a cubic lipid phase at a temperature of 36 DEG C to 39 DEG C. The composition is particularly suitable for rectal administration, for example as an enema. A composition, a method for preparing the composition, and a kit for making the composition are also disclosed.

The invention provides an endoscope device for obtaining a lower gastrointestinal tract image and a control method. The invention belongs to the technical field of medical imaging equipment and automatic control, and particularly relates to an endoscope device for shooting images of a lower gastrointestinal tract by using an endoscope. A control method of an endoscope device according to an embodiment of the present specification may include: acquiring an image of a lower gastrointestinal tract from an image sensor; obtaining environmental information on the front end part; sensing at least one first body part from the image based on a pre-trained model; calculating relative position information between the first body part and the front end part of the endoscope device; generating a first control signal for steering corresponding to the first body part based on the environmental information and the relative position information; and transmitting the first control signal to a driving unit.

The present invention relates to a solid oral dosage form for sustained release in the lower gastrointestinal tract, comprising antibodies or functional fragments thereof in a depot layer (2) covering an inert core unit (1), a sustained release layer (3) covering the depot layer, and a delayed release layer (4) covering the sustained release layer, preferably prepared by drug layering; an oral multiparticulate drug delivery system comprising a plurality of the solid oral dosage forms; and the use of the solid oral dosage form in the targeted local treatment in the lower gastrointestinal tract of a patient.

Provided are a medical image device and an automated control technique, particularly, an endoscopic device for capturing an image of a lower gastrointestinal tract using an endoscope and a method of controlling the endoscopic device. The method of controlling an endoscopic device includes acquiring an image of a lower gastrointestinal tract from an image sensor, acquiring environment information with respect to a front-end portion of the endoscopic device, detecting at least one first body part from the image, based on a pre-trained model, calculating relative position information between the at least one first body part and the front-end portion of the endoscopic device, generating, based on the environment information and the relative position information, a first control signal for steering the front-end portion to correspond to the at least one first body part, and transmitting the first control signal to a driver.