System for release in lower gastrointestinal tract

a technology for releasing systems and gastrointestinal tracts, applied in the direction of powder delivery, medical preparations, capsule delivery, etc., can solve the problems of unfailingly realizing colon-specific delivery of drugs, and difficult to unfailingly deliver drugs colon-specifically
US20050249800A1Inactive Publication Date: 2005-11-10KUDO YUMIO +2
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
KUDO YUMIO
Publication Date
2005-11-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

A system whereby a substance which is orally taken and to be delivered into the lower digestive tract is selectively delivered into the lower digestive tract. More particularly, a system which makes it possible to surely and quickly deliver the aimed substance to the lower digestive tract without being affected by pH change in the digestive tract due to change in bacterial flora. Compositions disintegrating in the lower digestive tract characterized by containing a compound <A>, which has a molecular weight of 1000 or less and has a disulfide bond, and a polymer <B>, which has a molecular weight exceeding 1000 and is digested by enteric bacteria and / or undergoes softening, swelling or dissolution due to a decrease in pH; molded products with the use of these compositions; and preparations with the use of these molded products.
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Description

TECHNICAL FIELD

[0001] The present invention relates to a system that orally uptakes a material desired to be delivered to a lower part of the gastrointestinal tract and delivers it selectively to the lower part of gastrointestinal tract. More specifically, the present invention relates to a system that unfailingly and quickly delivers an objective material selectively to a lower part of gastrointestinal tract without being influenced by a change in pH in the gastrointestinal tract due to a variation in the bacterial flora. Also, the present invention relates to a composition that disintegrates at a lower part of gastrointestinal tract, comprising a compound having a molecular weight of 1,000 or less and having a disulfide bond and a polymer having a molecular weight of above 1,000 and having a property of being decomposed by enterobacteria, and / or a property of being softened, swelled or dissolved due to a decrease in pH, to a formed product comprising such a composition, and to ...

Claims

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