105 results about "Coacervate" patented technology

The present invention is drawn to an adhesive or binder composition comprising, —a cationic polyelectrolyte, —an anionic polyelectrolyte, —a mineral salt selected from the group consisting of alkaline metal or alkaline earth metal halogenides, —a particulate mineral filler, —a water-soluble polyphenol comprising at least one polyhydroxylated aromatic ring structure, and —water It is also drawn to the use of such a composition as an adhesive, binder, coating or sealant in the construction industry.

The invention relates to coacervate-forming polymers having defined structural formulae. The invention also relates solutions comprising the coacervate-forming polymers and methods of making solutions comprising the coacervate-forming polymers. The invention also relates to polymer coacervates, comprising the coacervate-forming polymers within the coacervates, including polymer coacervates comprising cargo compounds, and methods for making such polymer coacervates. The coacervates of the invention are capable of penetrating into cells and thereby delivering cargo compounds into cells. The invention further relates to compositions, including pharmaceutical compositions, comprising the polymer coacervates. The invention also relates to uses of the coacervate-forming polymers, including medical uses.

A stimulation fluid to prevent coacervate formation in a subterranean formation. The stimulation fluid generally comprises nanobubbles, a cationic component, and an anionic component. The cationic component may be a biocide, scale control additive, clay control additive, water control or friction reducing polymer, surfactant, or a combination of cationic components. The anionic component may be a surfactant, scale inhibitor, chelant, water control or friction reducing polymer, or a combination of anionic components.

The present invention relates to an isolated peptide comprising the amino acid sequence of Formula (I): (O)n-K-(O)m-Z; wherein K is lysine optionally modified with a self-immolative moiety Z is tryptophan or is absent; O is GHGX1Y (SEQ ID NO: 1); G is glycine, H is histidine, Y is tyrosine; each X1 is independently selected from alanine, glycine, serine, asparagine, histidine (H), arginine (R), aspartic acid, tyrosine, and proline; n is 0 – 5; m is 0 – 5; n+m is 3, 4, 5, 6, 7 or 8, and optionally, wherein not all of the X1 residues are proline (P). Such peptide is a coacervate forming peptide. The present invention also relates to methods of preparing coacervate compositions comprising the isolated peptide, optionally also comprising one or more biomacromolecules (payloads). The present invention further relates to the coacervate compositions per se, and their uses, e.g. in methods of treatment or diagnosis.

The invention discloses a preparation method of a micron-sized cell-matrix co-polymer biological material. The preparation method comprises the following steps: firstly, inducing SHED cells in an ultra-low adsorption plate by using an alpha-MEM culture medium containing serum, GlutaMAXI, vitamin C and the like to form micron-sized spheres (SHED spheres); secondly, taking human dentin, and carrying out mechanical crushing, EDTA (Ethylene Diamine Tetraacetic Acid) demineralization, grinding and sterilization to prepare 1-100 microns of dentin matrix particles (DDMPs); and finally, by taking the GelMA hydrogel as a carrier, entrapping SHED spphere and DDMPs, and carrying out 405nm photo-crosslinking for 30 seconds to form the hydrogel. The co-polymer can significantly promote angiogenesis and osteogenesis coupling regeneration in a bone defect model, and is suitable for oral cavity and cranio-maxillofacial bone repair.

The present invention proposes a method and use for stabilizing a simple agglomerate for pH and salt and with adjustable size. In phosphoric acid buffer solutions with different salt concentrations and pH values, the polyacrylic acid hydroxypropyl group condensation body has specific stability; hydrophobic thermal response blocks are introduced into a hydroxypropyl acrylate monomer through reversible addition-fragmentation chain transfer polymerization to regulate and control the size of a condensation body, and a phase separation behavior is shown at different temperatures; a hydrophobic block without thermal response is introduced to regulate and control the size of the aggregate, and no thermal response behavior is shown. Continuous regulation and control of the size of the aggregate from the micron level to the nano level are achieved, and the requirements of different application scenes are met. The hydroxypropyl polyacrylate condensation body can be used for packaging various dyes and drugs; high-efficiency enzyme protection is achieved, formed aggregates can protect glucose oxidase, and the retention rate of enzyme activity reaches 85% or above after treatment is conducted for 3 hours at 60 DEG C; as a micro-reactor for the reaction of generating p-nitrobenzaldehyde phenylhydrazone from p-nitrobenzaldehyde and phenylhydrazine, the reaction rate is greatly improved.

A non-sulfate shampoo is disclosed. The shampoo incorporates at least one non-sulfate surfactant selected from a taurate salt and a sarcosinate salt, and in addition incorporates a complexation compound. The shampoo produces a coacervate upon dilution with water and in use to shampoo hair. The shampoo provides mild non-irritating treatment of the hair and does not irritate skin or eyes.

The present invention relates to a functionalized artificial cell based on a composite coacervate, preparation and application thereof, and relates to the field of biomedicine technology. The preparation method is as follows: a positively charged solution and a negatively charged solution are mixed, the positively charged solution being a polylysine solution or an ε-polylysine hydrochloride solution, and the negatively charged solution being a deoxyribonucleic acid solution; a coacervate droplet suspension containing functional components is obtained by liquid-liquid phase separation; phospholipids and PEGylated phospholipids are dissolved in an organic solvent and then subjected to vacuum rotary evaporation until the organic solvent evaporates to obtain a lipid membrane; the coacervate droplet suspension is added to the lipid membrane for hydration until the lipid membrane is completely dissolved, thereby obtaining a functionalized artificial cell; at least one of the positively charged solution, the negatively charged solution and the phospholipid solution contains a functional component. The functionalized artificial cell based on the composite coacervate constructed by the present invention has a cell membrane-like and cytoplasm-like structure, and has good physiological stability and biocompatibility.

A stimulation fluid to prevent coacervate formation in a subterranean formation. The stimulation fluid generally comprises nanobubbles, a cationic component, and an anionic component. The cationic component may be a biocide, scale control additive, clay control additive, water control or friction reducing polymer, surfactant, or a combination of cationic components. The anionic component may be a surfactant, scale inhibitor, chelant, water control or friction reducing polymer, or a combination of anionic components.

The invention belongs to the technical field of algal polysaccharide extraction, and discloses a modification extraction method of algal asparagus polysaccharide and a method for preparing a lutein coating by using the algal asparagus polysaccharide. The modified extraction method comprises the following steps: extracting gracilaria lemaneiformis powder with a weak base solution, enabling lactide and polysaccharide to be subjected to grafting reaction through a redox initiation system under the assistance of ultrasonic waves, and then separating out a first polysaccharide component with high emulsibility and a second polysaccharide component with high gel property through graded alcohol precipitation. The two obtained functional components are used for coating xanthophyll, specifically, the first polysaccharide component emulsifies a xanthophyll oil phase to form a pre-emulsion, the second polysaccharide component is compounded with gelatin, a composite coacervate is formed on an oil drop interface by adjusting the pH value, and finally drying and curing are conducted. According to the method, two modified polysaccharides with definite functions can be synchronously obtained, the prepared xanthophyll coating is high in encapsulation efficiency, good in storage and processing stability and excellent in water dispersibility, and the problems that xanthophyll is unstable and difficult to apply are effectively solved.

TITLE: Coacervate Cleansing Composition with Mineral Particle. The disclosure relates to compositions comprising (a) at least one amphoteric surfactant, (b) at least one glycolipid, (c) at least one cationic polymer at a concentration of approximately 0.05% to approximately 2%; (d) at least one mineral particle, and (e) at least one cosmetically acceptable solvent, in which the cleansing system is substantially free of phenoxyethanol, and in which the pH of the composition is between approximately 4 and approximately 8, and in which the weight ratio of a to b is approximately 0.4 to approximately 4, and in which the combined concentration of a and b is approximately 10% to approximately 20% of the total weight of the composition. The compositions may be used as rinse-off compositions to cleanse the skin and deposit mineral particles. Figure for abstract: none

The invention discloses a special membrane material for targeted trapping of macrobrachium larvae in water and a preparation method of the special membrane material, and belongs to the field of water environment biological pollution prevention and control. The membrane material is of a multi-layer composite structure and comprises a nanofiber membrane base material layer, an interface adhesion layer and a functional modification layer. The interface adhesion layer is bionic coacervate gel formed by curing hydrophobic polyelectrolyte and phytic acid; the functional modification layer is covalently grafted with a bionic adhesion protein active peptide fragment and a macrobrachium larva chemical pheromone. The material actively attracts larvae to approach through chemical pheromones, high-strength adhesion capture is achieved through bionic peptide fragments rich in aromatic and cationic amino acids, and trapping is integrated. The preparation method comprises the steps of electrostatic spinning of a base material, surface activation, gel coating, functional modification and the like. The material disclosed by the invention has high selectivity and high capture rate on the larvae of the Limnoperna fortunei, is environment-friendly, long-acting and stable, and is suitable for green prevention and treatment of fouling of the larvae of the Limnoperna fortunei in facilities such as water pipelines and pump stations.

The present invention refers to nutraceutical compositions, to plant extracts and complex coacervates comprising them. The present invention further refers to uses thereof.

A method of breaking down at least one component of a substrate can include providing a catabolic nanocompartment that includes a liquid coacervate phase, at least one catalyst within the coacervate phase, and an aqueous phase surrounding the coacervate phase. The method can include contacting the catabolic nanocompartment with the substrate including the at least one component such that the catalyst degrades the at least one component and forms degradation products of the at least one component.

The invention discloses a macrophage immune activation method based on aggregate mediated magnesium ion delivery. The method comprises the following steps: in a buffer environment containing magnesium ions, preparing a biomolecular aggregate formed by compounding polyarginine and polyadenylic acid through liquid-liquid phase separation, and enriching the magnesium ions by the aggregate through multivalent chelation; diluting the aggregate loaded with high-concentration magnesium ions in a cell culture medium to obtain a biomolecular aggregate suspension; and sequentially adding the target cell suspension and the biomolecular aggregate suspension into a cell culture dish, fully mixing, and then transferring the cell culture dish into a carbon dioxide cell incubator for standing culture. According to the method, the biomolecular aggregate loaded with the high-concentration magnesium ions is co-cultured with the cells, and the high-concentration magnesium ions are delivered into the cells in a short time, so that the immune level of the cells is improved, and the activity and safety of the cells are ensured.

The present application relates to a kind of mussel-based composite coacervate based on mussel adhesive protein and its preparation method and purposes, the mussel-based composite coacervate includes mussel adhesive protein and anionic polyelectrolyte material;The mass ratio of mussel adhesive protein and anionic polyelectrolyte material is (0.05~4):1;The oxidation rate of dopa residue in the mussel adhesive protein in the composite coacervate is 0.1%~70.0%.The present application realizes the accurate control of the preparation of the composite coacervate formed by regulating the concentration, mass ratio and system pH of mussel adhesive protein and anionic polyelectrolyte material, and then improves its performance and effect as tissue adhesive, wound repair dressing, acute hemostatic material, local drug delivery carrier and drug release system field or bone tissue repair, cartilage repair and tissue filling and support field.

The present invention relates to plant-based coacervate core-shell microcapsules wherein the shell comprises Moringa oleifera extract, as well as to methods and uses thereof.

The invention provides a rain wash resistant and long-acting antibacterial liquid-liquid condensed phase and a preparation method and application thereof.The liquid-liquid condensed phase comprises polyethyleneimine, sodium deoxycholate and metal chloride salt, the concentration of the polyethyleneimine is 0.5 g / L-5 g / L, and the molecular weight of the polyethyleneimine is 600-25000; the concentration of the sodium deoxycholate is 0.5 mM to 50 mM.

The invention relates to the technical field of biology, and discloses a polyelectrolyte aggregate high-strength hydrogel based on thermal induction crosslinking and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing a solution; (2) forming a polyelectrolyte aggregate; (3) forming a precursor; (4) thermally induced crosslinking; and (5) post-treatment. The preparation method of the polyelectrolyte aggregate high-strength hydrogel based on thermally induced crosslinking provided by the invention adopts a two-step process: firstly forming a polyelectrolyte aggregate, and then carrying out heat treatment on the aggregate to induce the aggregate to strengthen; heat-induced endogenous crosslinking is adopted, namely endogenous chemical crosslinking such as Maillard reaction between chitosan and sodium hyaluronate is initiated by heating, so that the mechanical property order of magnitude is improved.

The invention discloses a preparation method of a double-protein aggregate for packaging and stabilizing spice essential oil, the double-protein aggregate and application of the double-protein aggregate. According to the process, ovalbumin and lysozyme are used as raw materials, stock solutions of the ovalbumin and the lysozyme are mixed in proportion, then pH adjustment and NaCl concentration adjustment are conducted, pulsed electric field treatment is introduced, protein is promoted to be subjected to liquid-liquid phase separation under the synergistic effect to form a composite condensate, and the composite condensate is used for packaging and stabilizing spice essential oil. Through multi-dimensional synergistic regulation, the performance of the composite coagulator is remarkably improved, the embedding rate of the emulsion to the spice essential oil reaches 90% or above, the particle size increase is smaller than or equal to 10% after the emulsion is refrigerated for 6 months at 4 DEG C, the layering rate is smaller than or equal to 5%, the release rate of irritant peculiar smell components in the spice essential oil can be effectively reduced, the sensory characteristics of the spice essential oil can be greatly improved, and the flavor of the spice essential oil can be improved. The application range in the fields of food, health care products and the like is expanded.

The present invention relates to a coating composition comprising a coacervate including a cationic polyelectrolyte and an anionic polyelectrolyte, ceramic particles, and water. It also relates to a method for forming a coating using such a composition, and a coating obtained by such a method.

The invention provides a lignin-based aqueous phase aggregate, a preparation method thereof, a pesticide composition and application of the pesticide composition. The lignin-based aqueous phase aggregate has full-biomass-based components, is natural and harmless, does not need to synthesize polyelectrolyte or a small-molecular surfactant, and eliminates the ecological risk of synthetic components; the preparation process does not depend on an emulsifier, a cross-linking agent or an organic solvent, toxic risks of organic solvent residues on pesticide application personnel and crops are eliminated, the preparation process is simple, and complex steps such as shear emulsification and ultrasonic treatment are not needed; the lignin-based aqueous phase aggregate disclosed by the invention keeps stable in a wide pH, ionic strength and temperature range, does not need to depend on salt ions to adjust phase separation, and can tolerate complex environmental changes; the lignin-based aqueous phase aggregate disclosed by the invention has self-bacteriostatic activity and can be applied as a protective bactericide; the lignin-based aqueous phase aggregate has high encapsulation efficiency on various pesticides, and can play a synergistic role after encapsulating a bactericide.

The invention relates to a liquid-liquid phase separation mediated condensate carrier and application thereof. Specifically, the invention provides a delivery carrier, which contains (a) a polypeptide and (b) a polynucleotide, wherein the polypeptide has a sequence as shown in (LRLLRWC) n, or the polypeptide has a sequence as shown in (LRLLR) nWC, and n is an integer greater than or equal to 1.

1. Name of the designed product: condensation bead (windmill type). 2. Use of the designed product: for daily washing. 3. Design points of the designed product: in shape. 4. Picture or photo that best shows the design points: perspective view.

A solid state composition comprising a coacervate-forming pair of materials consisting of silk fibroin and a silk-complementary material and methods of making and using the same are disclosed. A coacervate-based adhesive composition and methods of making and using the same are disclosed. The composition includes a coacervate formed by mixing a freeze-dried silk fibroin solution and tannic acid. The tannic acid is present in an amount sufficient to initiate complexing and / or cross-linking of the adhesive composition. The adhesive has many useful applications, but one particularly valuable application is expected to involve adhesive application directly to the skin or outer surface of marine animals, such as sharks.

The invention provides a liquid-liquid condensed phase microcapsule as well as a preparation method and application thereof, and belongs to the technical field of pesticides. The liquid-liquid condensed phase micro-capsule is a liquid-liquid condensed phase liquid drop wrapped by an interfacial film; the interfacial film comprises sodium polylipoate; the liquid-liquid condensed phase liquid drops comprise sodium lipoate and a cationic surface active agent, and the concentration of the sodium lipoate is 5-100 mM; and the concentration of the cationic surface active agent is 5-50 mM. The interfacial film of the liquid-liquid condensed phase microcapsule can effectively obstruct interaction between adjacent liquid drops, avoid spontaneous fusion of the liquid drops and guarantee the structural stability of the microcapsule in the long-term storage and transportation process. The liquid-liquid condensed phase microcapsule can entrap hydrophobic drug molecules to form a water-based carrier pesticide, and the wetting, spreading and deposition of the pesticide on hydrophobic leaf surfaces can be improved.

1. Name of the design product: condensation beads (four cavity-surrounding ball) 2. Use of the design product: the design product is used for washing clothes, and can also be used for washing dishes in a dishwasher. 3. Design points of the design product: in shape. 4. Picture or photo that best indicates the design points: perspective view.