One aspect of the present invention relates to a method of
coating a surface, comprising sequentially depositing on a surface, under pH-controlled conditions, alternating
layers of polymers to provide a
coated surface, wherein a first
polymer is selected from the group consisting of
pH dependent cationic polyelectrolytes and neutral polymers, and a second
polymer is selected from the group consisting of anionic polyelectrolytes, thereby permitting or preventing
cell adhesion to said
coated surface. In certain embodiments, the aforementioned method provides a
coated surface to which
cell adhesion is permitted. In certain embodiments, the aforementioned method provides a coated surface to which
cell adhesion is prevented. Another aspect of the present invention relates to a method of rendering a surface cytophilic, comprising the step of
coating a surface with a
polyelectrolyte multilayer film, which film swells to less than or equal to about 150% of its original thickness when exposed to an
aqueous medium. Another aspect of the present invention relates to a method of rendering a surface cytophobic, comprising the step of
coating a surface with a
polyelectrolyte multilayer film, which film swells to greater than or equal to about 200% of its original thickness when exposed to an
aqueous medium.