22 results about "Bioprocess" patented technology

To provide sterilization of fluid-guiding elements by ultra violet (UV) light, and more particularly to provide use of such fluid-guiding elements for bioprocessing applications.SOLUTION: There is disclosed an ultra-violet (UV) light sterilizable fluid-guiding element (100, 200, 300, 400, 500) configurable to form a part of a normally closed bioprocessing fluid system, at least a portion of the element being formed from a material which is transmissive to UV light, the at least one portion of the element including one or more surfaces (134) configured to contact and guide fluids within the closed system. The element further includes at least one UV light emitting diode (LED) (154) mounted in, on, or adjacent the at least one portion and has sufficient light output to sterilize at least the one or more surfaces (134).SELECTED DRAWING: Figure 1

The invention refers to a processing chamber (100) shaped concentric around a center axis (101). The processing chamber (100) comprises a conical frustum shaped first body section (1) with a first base side (11) and a second base side (12). The second base side (12) opens into a second body section (2). The second body section extends along the center axis (101) with a first end of the second body section (2) pointing away from the first body section (1). The first end of the second body section (2) opens into a third body section (3). The third body section extends along the center axis (101) with a first end of the third body section (3) pointing in a direction away from the second body section (2) and wherein the first end of the third body section (3) is tapering into a second end (30) of the processing chamber (100).

The application discloses a kind of based on carbon source-sink and biological process's preferential protection area demarcation method, comprising: obtaining the multi-source remote sensing data of research area, generates the ecological resistance surface of research area;Based on circuit theory extraction ecological corridor and ecological node, construct the static ecological network of source-corridor-node structure;For the spatio-temporal heterogeneity characteristics of ecological source, the supply and demand of carbon fixation service of ecological source are calculated;Carbon fixation service as important ecological resources, according to the characteristics of biological migration from low resource habitat to high resource habitat, compare the supply and demand ratio of carbon fixation service between ecological source, to determine the trend of ecological corridor, calculate the flow radius of ecological source carbon sink supply area, according to flow radius determine the biological flow relationship between ecological source, divide ecological source into carbon source protection area and carbon sink protection area.

The present disclosure relates to skincare compositions that include sunflower sprout extract for treating skin conditions. More specifically, novel aspects are directed to a metabolomics guided, bioprocess engineered sunflower sprout extract obtained from sunflower seeds germinated in a controlled environment where free fatty acids are broken down to create energy within cells which is important for vitality. Incorporation of the metabolomics guided bioprocess engineered sunflower sprout extract as an active in a skincare composition, working through epigenetic pathways, results in enhanced human gene expression as well as increased protein and lipid production in manner correlated with anti-aging effects. The skincare composition comprises an enhanced extract obtained from plant seeds germinated in an environment that includes an effective amount of sucrose and enriched levels of oxygen, and a cosmetically acceptable carrier.

The present disclosure provides surfactant-based compositions, methods, kits, and systems for use in cell permeabilization, analytical and diagnostic assays, polypeptide stabilization, viral inactivation, and bioprocess workflows. In certain aspects, permeabilization buffers comprising defined concentrations of nonionic surfactants in polar protic solvents permeabilize diverse cell types while preserving intracellular targets and compatibility with downstream detection chemistry and nucleic acid amplification. Related compositions include loading, blocking, running, and mountant buffers, as well as polypeptide stabilization and viral inactivation solutions formulated with the surfactants. In additional aspects, the surfactants are used in lateral flow devices, bead-based assays, and lipid nanoparticle workflows, including determination of encapsulation efficiency. The disclosure further provides methods and systems in which data generated from surfactant-containing workflows are analyzed by machine-learning processes to determine attributes of buffer performance and recommend protocol parameters.

A skincare composition and a method for ameliorating the effects of aging. The skincare composition comprises an enhanced extract obtained from plant seeds germinated in an environment that includes an effective amount of sucrose and enriched levels of oxygen, and cosmetically acceptable carrier.

A computer implemented method for determining anomalies in a bioprocess, wherein the bioprocess is performed in a plurality of bioprocess cycles in series, each cycle corresponding to a separate instance of at least a portion of the bioprocess, the plurality of bioprocess cycles comprising a current bioprocess cycle and at least one previous bioprocess cycle, the method comprising: collecting process data for the current bioprocess cycle; providing reference data for the current bioprocess cycle and for the at least one previous bioprocess cycle of the plurality of bioprocess cycles, the reference data corresponding to the process data; communicating to a user deviation and / or conformity between the current bioprocess cycle and a corresponding reference bioprocess cycle, based on the process data and the reference data.

This item is a mixer assembly used to perform bioprocessing procedures such as mixing cell cultures and related substances.

The invention relates to a method of transferring a microbial bioprocess from a multi-use bioreactor (1) to a single-use bioreactor (2), wherein the source bioprocess is a batch or fed-batch microbial bioprocess and the source bioprocess arrangement (3) comprises a source bioreactor (5) with a stirrer and the source bioreactor (5) is the multi-use bioreactor (1) which has at least 1000 L production volume of a microbial culture producing a maximum heat of at least 25,000 W and / or the stirrer of the source bioreactor (5) is driven with a maximum torque of at least 120 Nm, wherein the target bioprocess is a continuous microbial bioprocess and the target bioprocess arrangement (4) comprises a target bioreactor (6) and the target bioreactor (6) is the single-use bioreactor (2) which has a production volume of a microbial culture of at most 50 % of the production volume of the source bioreactor (5) and of at most 800 L, the microbial culture of the target bioreactor (6) produces a maximum heat of at most 20,000 W during the target bioprocess and / or the target bioreactor (6) comprises a stirrer driven with a maximum torque of at most 100 Nm, wherein an average amount of the bioproduct produced per time of performance of the target bioprocess by the target bioreactor (6) is at least 90 %, preferably at least 100 %, of an average amount of the bioproduct produced per time of performance of the source bioprocess by the source bioreactor (5).

A flow distribution device for bioprocess systems, comprising: a flow distribution manifold (12; 112) comprising: at least four fluid connection conduits (14), wherein each fluid connection conduit (14) comprises a first end (18) for fluid connection and an opposite second end (20), and wherein at least three of the fluid connection conduits comprise a membrane (19a) and a valve seat (19b), which membrane (19a) can be put in at least two different positions in relation to the valve seat (19b) for allowing or preventing fluid flow between the first end (18) and the second end (20) of the fluid connection conduit (14); and a central common compartment (30) to which the second ends (20) of each of the fluid connection conduits (14) are connected, whereby the first ends (18) of each of the fluid connection conduits (14) can be in fluid communication with the central common compartment (30) and wherein the fluid connection conduits (14) are entering the central common compartment (30) from at least three different directions; wherein said flow distribution device (10) further comprises at least three membrane actuation members (41) which are provided in connection with one membrane (19a) of the flow distribution manifold (12; 112) each, wherein each of said membrane actuation members (41) is configured for actuating the membrane (19a) to be in at least two different positions in relation to the valve seat (19b), wherein a first position of the membrane (19a) allows flow between the first end (18) and the second end (20) of the fluid connection conduit (14) and a second position of the membrane (19a) prevents flow between the first end (18) and the second end (20) of the fluid connection conduit (14).

The present invention relates to a method for remotely configuring credentials for a bioprocess control system of a bioprocess system in a cloud environment, comprising steps of: requesting, from a user of the bioprocess control system, start of the bioprocess control system; launching, in the cloud environment, a custom launcher for configuring credentials for the bioprocess control system; obtaining, by the custom launcher, credential information from a secret management system; performing, by the custom launcher, configuration of the bioprocess control system with the credential information, and starting, by the custom launcher, the bioprocess control system using the configuration of the bioprocess control system.

The application provides a high-moisture beer lees preservation method for animal feed, and relates to the technical field of animal feed. The high-moisture beer lees preservation method for animal feed specifically comprises the following steps: S1. Pre-isolation layer laying; S2. Step-by-step filling and pressure gradient generation; S3. One-way pressure difference exhaust; S4. Subarea ripening and barrier switching; and S5. In-situ solidification and nutrition locking. The technology combines physical processes and biological processes, drives the activation of bacterial agents through the moisture gradient, controls oxygen through gravity hydraulic pressure, and divides zones through switchable physical barriers, thereby avoiding the dependence on intelligent devices, inhibiting mold growth, effectively prolonging the storage time, slowing down the loss of raw material nutrients, standardizing the operation, providing a stable cross-season supply solution for the breeding feed supply chain, being lower in cost, and being less likely to lose nutrients.

A computer implemented method for determining anomalies in a bioprocess in real-time, the method comprising: collecting, in real-time, process data for a current bioprocess, providing reference data relating to a reference bioprocess, the reference data corresponding to the process data; communicating to a user, in real-time, deviation and / or conformity between the current bioprocess and the reference bio process based on the process data and the reference data.

The present invention relates to a method for operating a biological process arrangement (1) to perform at least one repetition of a biological process, wherein the biological process arrangement (1) includes at least one replaceable electronic component (8), and wherein a process control system (7) controls the biological process arrangement (1) using a digital model (10). The method proposes that a replaceable electronic component (8) is removed and replaced by a new electronic component (9), the process control system (7) automatically detects the removal of the replaceable electronic component (8), automatically detects the presence of the new electronic component (9), and retrieves the digital representation (11) of the new electronic component (9) based on communication with the new electronic component (9). The process control system (7) derives a functional relationship between the replaceable electronic component (8) and the new electronic component (9) from the digital representation (11) of the replaceable electronic component (8) and the new electronic component (9). Based on the functional relationship, the process control system (7) replaces the digital representation (11) of the replaceable electronic component (8) with the digital representation (11) of the new electronic component (9), thereby updating the digital model (10), and the process control system (7) controls the biological process arrangement (1) to perform the biological process based on the updated digital model (10).

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for a computing platform that supports bioprocess design, execution, analysis, and technology transfer. One of the methods includes receiving, by a bioinformatics platform from a production facility, a facilities specification that represents properties and capabilities of each item of equipment of a plurality of items of equipment at the production facility. A selection of a recipe to be transferred to the production facility as a production plan is received. A matching process is performed between unit operations of the selected recipe and equipment represented by the facilities specification to convert each equipment-agnostic unit operation of the recipe into an equipment-specific production task to be performed by a particular item of equipment in the production facility. A production plan is generated having a plurality of equipment-specific production tasks for the production facility.

A flow cell assembly for use in a bioprocess including a housing and a glass body. The housing includes an inlet tube connector and an outlet tube connector and a holding structure for immovably holding the glass body. The glass body is a universal single-piece glass body surrounding a measurement channel. The measurement channel has an inlet end and an outlet end defining a medium flow direction, and a defined dimension along an optical measurement axis perpendicular to the medium flow direction. The inlet end and outlet end of the measurement channel are in fluid communication with the inlet tube connector and the outlet tube connector of the housing, respectively. The housing or the glass body includes an aligning structure for aligning a probe head. The housing or the glass body includes a fixing structure for immovably fixing the aligned probe head relative to the glass body.

The present disclosure provides surfactant-based compositions, methods, kits, and systems for use in cell permeabilization, analytical and diagnostic assays, polypeptide stabilization, viral inactivation, and bioprocess workflows. In certain aspects, permeabilization buffers comprising defined concentrations of nonionic surfactants in polar protic solvents permeabilize diverse cell types while preserving intracellular targets and compatibility with downstream detection chemistry and nucleic acid amplification. Related compositions include loading, blocking, running, and mountant buffers, as well as polypeptide stabilization and viral inactivation solutions formulated with the surfactants. In additional aspects, the surfactants are used in lateral flow devices, bead-based assays, and lipid nanoparticle workflows, including determination of encapsulation efficiency. The disclosure further provides methods and systems in which data generated from surfactant-containing workflows are analyzed by machine-learning processes to determine attributes of buffer performance and recommend protocol parameters.