The present invention relates to a method for operating a continuous downstream process, in particular a continuous
viral inactivation process or an in-line
dilution process, using a
bioprocess assembly (1), comprising a compensating vessel (2) having a first fluid inlet (3) for introducing a concentrate
stream, in particular a product or buffer concentrate
stream, into said compensating vessel (2), at least one second fluid inlet (4) for introducing a
diluent stream, in particular a product or buffer
diluent stream, into said compensating vessel (2), and a fluid outlet (5) for leading a liquid stream out of said compensating vessel (2), the
bioprocess assembly (1) comprising a transport
assembly (6) for
fluid transport, the transport assembly (6) being assigned to the first and second fluid inlets (3) and (4), respectively, for transporting at least one liquid stream to the compensating vessel (2) and the fluid outlet (5) for transporting a liquid stream from said compensating vessel (2), and the
bioprocess assembly (1) comprising an
electronic process control device (7). It is proposed that the
electronic process control device (7) adapts the filling level in the compensation container (2) by open-loop and / or closed-
loop control of said transport assembly (6) so that it does not fall below a predefined minimum filling level in the compensation container (2).