126results about How to "Less effective" patented technology

A method and system for controlling an apparatus including receiving data indicative of an actual state of the apparatus, defining a first viewpoint relative to at least one of the environment and the apparatus, determining a first predicted state of the apparatus at time T, determining a first predicted state of the environment at time T, producing a first virtualized view from the first viewpoint, sending a first control signal to the apparatus after producing the first virtualized view, defining a second viewpoint relative to at least one of the apparatus and the environment, determining a second predicted state of the apparatus at time T+delta T, determining a second predicted state of the environment at time T+delta T, producing the second virtualized view from the second viewpoint, sending a second control signal to the apparatus after producing the second virtualized view, and changing the actual state of the apparatus based on the first control signal.

A light conversion device and high-intensity, solid-state light source utilize wavelength conversion elements with a thermal conductivity greater than 1 watt per meter per degree Kelvin (W/m-K). Exemplary materials that have high thermal conductivity include monocrystalline solids, polycrystalline solids, substantially densified ceramic solids, amorphous solids or composite solids. The light conversion device and high-intensity, solid-state light source have at least one heat sink that is in direct thermal contact with the wavelength conversion element. The heat sink quickly dissipates heat generated within the wavelength conversion element in order to prevent the wavelength conversion element from overheating and undergoing thermal quenching of the wavelength conversion and light emission.

The present invention is directed to oral, therapeutically effective extended release pharmaceutical compositions of 3-hydroxy-N-methylmorphinan, including delayed onset, extended release dosage forms and the use thereof.

An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

An electrostimulation device (e.g., 100) consists of a single paddle (e.g., 102) and at least one lead (e.g., 110) for connecting the electrostimulation device to a pulse generator. The paddle has at least one electrode (e.g., 106) for providing electrical stimulation. The electrode(s) is provided in an area (A) of the paddle and a ratio of the width of the area to the length of the area is greater than 0.5. The present invention also relates to a paddle (e.g.,102) implantable in a vertebra.

A four wheel drive system for bilaterally symmetric vehicles has separate controlled drive speed and direction for each wheel. Each drive system is operable to independently drive each wheel. The rear wheels of the vehicle are steering wheels which are connected with the vehicle frame for independent rotation about a vertical axis. Steering and driving of the wheels is controlled by a controller. The combination of controlled steering for the rear wheels through many degrees about their vertical axes and individual power to all four wheels provides the vehicle with a zero turning radius for improved mobility as well as improved traction on unstable surfaces.

The invention relates to a non-human multicellular organism carrying a dominant lethal genetic system, the lethal effect of which is conditional, wherein the lethal effect of the lethal system occurs in the natural environment of the organism.

A method for etching an ultra-shallow channel includes using an etch process that is selective for one material to etch a different material in order to achieve a very precise channel depth in the different material. Channels as shallow as 10 nm can be fabricated in silicon with precision of 5 nm or better using the method. Stepped channels can be fabricated where each segment is a different depth, with the segments being between 10 nm and 1000 nm in depth. The method is applied to create a fluidic channel which includes a channel substrate to which is bonded a lid substrate to confine fluids to the fluidic channels so fabricated.

The present invention relates to specific CSF1R ECD fusion molecules that exhibit improved therapeutic properties. The invention also relates to polypeptide and polynucleotide sequences, vectors, host cells, and compositions comprising or encoding such molecules. The invention also relates to methods of making and using the CSF1R ECD fusion molecules. The invention further relates to methods of treatment using the CSF1R ECD fusion molecules. For example, certain CSF1R ECDs of the invention may be used to treat rheumatoid arthritis (RA) or multiple sclerosis (MS).

A gripper assembly for anchoring a tractor within a downhole passage and for assisting movement of the tractor within the passage. The gripper assembly includes an elongated mandrel and flexible toes that can be radially displaced to grip onto the surface of the passage. The toes are displaced by the interaction of a driver slidable on the mandrel and a driver interaction element on the toes. In one embodiment, the toes are displaced by the interaction of rollers and ramps that are longitudinally movable with respect to one another. In another embodiment, the toes are displaced by the interaction of toggles that rotate with respect to the toes.

Apparatus for inserting an instrument (1) in a flexible body cavity is disclosed. The apparatus includes a sheath (3) having an inner chamber (31) for accommodating the instrument (1) and an outer chamber (41) surrounding the inner chamber, thereby defining an enclosed space between the inner chamber and the outer chamber Fluid pressure is temporarily applied to thse enclosed space so as to expand the outer chamber to facilitate insertion of the instrument in the body cavity. In another embodiment the inner chamber is expandable to have a diameter equal to or greater than the diameter of the outer chamber, and wherein the outer chamber incorporates one or more lines of weakness for facilitating release and expansion of the inner chamber and withdrawal of the instrument from the inner chamber. In yet another embodiment the sheath includes at its distal end a convex lens for use by a camera in obtaining images of said body cavity. A flexible housing for receiving the instrument may be provided with a relatively rigid intermediate part between the housing and the sheath for guiding the instrument from said housing to said sheath.

The present invention relates to the enhancement of radiation sensitivity by using photodynamic therapy.

Improved molecular vaccines comprise nucleic acid vectors that encode a fusion polypeptide that includes polypeptide or peptide physically linked to an antigen. The linked polypeptide is one that (a) promotes processing of the expressed fusion polypeptide via the MHC class I pathway and/or (b) promotes development or activity of antigen presenting cells, primarily dendritic cells. These vaccines employ one of several types of nucleic acid vectors, each with its own relative advantages: naked DNA plasmids, self-replicating RNA replicons and suicidal DNA-based on viral RNA replicons. Administration of such a vaccine results in enhance immune responses, primarily those mediated by CD8+ cytotoxic T lymphocytes, directed against the immunizing antigen part of the fusion polypeptide. Such vaccines are useful against tumor antigens, viral antigens and antigens of other pathogenic microorganisms and can be used in the prevention or treatment of diseases that include cancer and infections.

The invention relates to the manufacture technical field of polysilicon ingot furnaces, and aims to provide a closed cooling system of a gas cooled polysilicon ingot furnace. The system comprises a heat exchange platform positioned on a supporting column and used for placing a crucible, wherein a cooling gas channel is arranged in the heat exchange platform; a gas inlet and a gas outlet at two ends of the cooling gas channel are respectively connected with a cooling gas inlet pipeline and a cooling gas outlet pipeline; and the heat exchange platform, the cooling gas inlet pipeline, the cooling gas outlet pipeline, a cooling gas power pump group and a cooler form a closed circulation loop of the cooling gas. Compared with the cooling method of radiation cooling and water cooling, the system related by the invention has strong gas cooling control capacity and high industrial controllability; the gas is fed into the heat exchange platform evenly, so that the whole temperature of the heatexchange platform is even, which is in favor of even nucleation of a silicon melt at the bottom of the crucible; and the reducing speed of the temperature at the bottom of the crucible can be precisely controlled during the crystal growth.

Integrated membrane treatment systems for treatment of an aqueous solution. In embodiments, components, such as an MBR, are integrated with means to recover energy from the system, for example from an RO concentrate, to operate the other components. In embodiments including biological treatment, RO is integrated with other components, such as an MBR with the ROs ability to remove inorganic nitrogen enabling biological treatment to be performed with only partial nitrification and the MBR operated without active pH control. In embodiments, RO is integrated with a chlorine generator to convert chlorides present in the RO concentrate for an in-situ source of oxidizing biocides for disinfection purposes. Chloramines may be generated in-situ from residual ammonia and chlorides in the RO reject. In embodiments, carrier media is employed in a membrane tank to enhance removal of residual organics by the MBR and to also improve effectiveness of membrane scouring.

An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes at the distal ends of the guide tubes allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered to ablate nerves outside of the media.

A multi-chamber container (60) includes a first chamber (2) having a side wall (3) terminating at a first chamber upper end (5). A first chamber opening (6) is disposed in the first chamber upper end (5). The first chamber side wall (3) is formed from an inner circumference portion (62) and an outer circumference portion (63). The multi-chamber container (60) includes a second chamber (10) having a side wall (11) terminating at a second chamber side wall upper end (13) which has a second chamber opening (14). A hinge (61) is disposed intermediate each chamber inner and outer side wall interface portion (66). The chambers (2) and (10) are moveable about the hinge (61) between a first position where the inner circumference side wall portions (62) and (64) are spaced apart, and a second position where the inner circumference side wall portions (62) and (64) of the chambers are adjacent.

A liquid-gas phase reactor system including a slinger located in an upper section (headspace region) of a reaction vessel. The slinger comprises an upper horizontal surface including a plurality of vertically raised vanes extending radially outward along a curved path which effectively distribute liquid about the reactor vessel. A method for conducting an oxidation reaction using a liquid-gas phase reactor system is also disclosed. The disclosed reactor system and method have a broad range of applications but are particularly suited for the production of terephthalic acid.

Training the inspiratory muscles using a training device includes evaluating the endurance of the inspiratory muscles of the patient, including the time to the onset of exhaustion, setting parameters of the training device, directing an monitoring endurance training sessions using the training device, providing feedback to the patient during the training and repeating the testing, setting, directing and providing steps as periodically.