1106 results about "Gastrointestines" patented technology

Provided are a method and a system for Medical auxiliary diagnostic for gastritis. The medical auxiliary diagnostic system includes: a sampling system collecting and storing medical images, and including a first dataset and a second dataset; a user device connected to the sampling system, and reading medical images from the sampling system or uploading medical images; and an image analysis system connected to both the sampling system and the user device to analyze medical images based on requests from the user device, thereby generating auxiliary images for assisting in diagnosis. The image analysis system performs deep learning based on the first dataset and the second dataset. Based on the results of the deep learning, the image analysis system performs inferences on a target image to generate auxiliary diagnostic images for assisting in identifying precancerous lesions. Both the first and second datasets include upper gastrointestinal endoscopic images.

The invention relates to the technical field of medical systems, in particular to an intelligent gastrointestinal postoperative intestinal obstruction diagnosis and intervention decision-making system and method, and the system comprises a data preprocessing module, a multi-modal data fusion module, a gastrointestinal function recovery model construction module, a self-adaptive progressive reinforcement learning optimization module AHRL and a diagnosis and intervention recommendation module. The self-adaptive progressive reinforcement learning optimization module optimizes an intervention strategy layer by layer through a five-layer progressive algorithm from the steps of dynamic adjustment of feature weights, recursive state propagation, layered accumulation optimization, symptom similarity matrix generation, progressive weight reverse feedback and the like, deep fusion of key symptoms by multi-modal data is achieved, and the accuracy of the key symptoms is improved. And the intervention scheme is updated in real time according to the patient state change. In the intervention decision recommendation module, the system generates personalized diagnosis suggestions based on the optimized strategy, carries out real-time risk assessment, and provides continuous and dynamic intervention support for the patient.

The invention discloses a probiotic-polyphenol nanoparticle colon-targeted co-delivery system as well as a preparation method and application thereof, and belongs to the field of biological medicines. The FCPs and hyaluronic acid (HA) are combined through non-covalent interaction, so that the hydrogel has colon targeting property and mucosal adhesion at the same time, and delivery of probiotics is facilitated. The hydrogel (HF) based on polysaccharide has good biocompatibility, and can be used for effectively encapsulating the probiotics and the natural products. Then, the PDA-TH NPs and BA are incorporated into the polysaccharide chain network of HF, and finally the BA-HF-PDAT targeted co-delivery system is constructed. The BA (at) HF-PDAT targeted co-delivery system can protect BA from serious gastrointestinal stress, and is jointly assembled with PDT-TH NPs to realize dual slow release of thymol (Thy), so that the treatment effect of BA and Thy is improved, and the BA (at) HF-PDAT targeted co-delivery system contributes to treatment of clostridium difficile infection (CDI).

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The invention provides a drug-loaded callicarpa nudiflora-derived extracellular vesicle as well as a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations. The drug-loaded callicarpa nudiflora-derived extracellular vesicle has relatively high encapsulation efficiency and drug loading rate and good gastrointestinal tract stability and biocompatibility, can target a colitis disease part to reduce adverse reaction of a drug and improve the curative effect, solves the problem that the drug is insoluble in water, and can be used for preparing the drug-loaded callicarpa nudiflora-derived extracellular vesicle. The invention provides a novel drug delivery strategy for treating the ulcerative colitis, and is expected to become an effective strategy for clinically treating the ulcerative colitis, thereby achieving the effects of synergistically treating the ulcerative colitis and improving the effectiveness and safety of drug delivery.

The discovery and application of immune checkpoint inhibitors (ICI) have significantly promoted cancer treatment. However, the response rate is still low in gastrointestinal (GI) cancers. To explore novel adjuvant treatment options, we performed fecal microbiota transplantation (FMT) of healthy donors on 10 GI cancer patients with resistance to anti-PD-(L) 1 treatment. The combination of FMT and anti-PD1 treatment was well tolerated and no serious adverse reaction was observed. Two out of 10 patients restored clinical responsiveness to anti-PD1 after FMT. Clinical benefits were shown to be associated with better colonization of co-occurred immunogenic microbes from donors, alongside activated immune status reflected by the peripheral immune cell population. Moreover, we identified microbial signatures of ICI responsiveness and validated in an independent cohort. Our study demonstrates the feasibility of FMT as a potential adjuvant therapy for ICI irresponsive GI cancer patients and laid a foundation for LBP / consortia development to enhance ICI efficacy.

The invention provides a halite-containing probiotic preparation for improving gastrointestinal environment and a preparation method, the halite-containing probiotic preparation comprises the following components in parts by weight: 60-70 parts of a probiotic composition, the probiotic composition comprises lactobacillus casei Zhang, animal bifidobacterium subsp. Lactis V9, lactobacillus plantarum P-01, animal bifidobacterium subsp. Lactis B-01 and casei paracasei LC-11, the weight ratio is 3: 2: 2: 1: 1. 1.2 to 3.5 parts of nanoscale refined halite; 10 to 15 parts of a microcapsule embedding material; 0.6 to 1.2 parts of an antioxidant system; 15 to 30 parts of auxiliary materials; the probiotic preparation disclosed by the invention has the characteristics of obvious strain combination advantage, nano-scale halite protection and synergism, accurate release of a multi-layer microcapsule structure, synergistic effect of an antioxidant system and the like, the survival rate of probiotics, gastrointestinal tract tolerance and intestinal colonization capacity are remarkably improved, and a new technical scheme is provided for improving gastrointestinal health.

The invention belongs to the technical field of biological medicines, and particularly relates to a postbiotic hydrogel for relieving alcoholic gastric ulcer as well as a preparation method and application thereof. The metagen hydrogel for relieving the alcoholic gastric ulcer, provided by the invention, is mainly prepared from metagen of rhamnobacter and modified lactoferrin; the lactobacillus rhamnosus is lactobacillus rhamnosus JM023. Tests prove that when the postbiotic hydrogel is applied to an alcoholic gastric ulcer rat model, the occurrence of gastric ulcer can be inhibited by inhibiting oxidative stress and inflammatory response and improving protection factor secretion; and the alcoholic gastric ulcer is relieved by regulating and controlling the expression of oxidation, inflammation, cell apoptosis and tissue repair related metabolic pathways and regulating gastrointestinal flora. The metagen hydrogel disclosed by the invention has the effect of effectively relieving gastric ulcer symptoms caused by alcohol, and is suitable for being developed and applied as a medicine or a health-care product for relieving alcoholic gastric ulcer.

Embodiments of devices and methods for collecting gastrointestinal samples using a capsule-shaped device that is swallowed are provided.

S-Beta-hydroxybutyric acid compositions for oral delivery are effective in rapidly raising blood ketone levels without causing acute acidosis or gastrointestinal (GI) distress when consumed in sufficiently dilute form and / or as a gel or suspension. By limiting added beta-hydroxybutyrate salts containing alkali or alkaline earth metal ions, beta-hydroxybutyric acid solutions, gels, or suspensions can deliver exogenous ketone bodies without significantly altering electrolyte balance. Although aqueous beta-hydroxybutyric acid solutions are moderately acidic with a pH of about 3.5 to 4, when diluted with sufficient water, the water acts as a pseudo buffering agent that offsets otherwise harsh acidic effects when consumed orally. Gels and suspensions can also ameliorate acidic effects by partially encapsulating the beta-hydroxybutyric acid. Beta-hydroxybutyric acid can be pure S-beta-hydroxybutyric acid or a non-racemic mixture enriched with S-beta-hydroxybutyric acid relative to R-beta-hydroxybutyric acid.

The present disclosure provides batteries that have a reduced risk or no risk of esophageal or gastrointestinal damage in a conductive aqueous environment, such as when accidentally swallowed. The batteries are, in some embodiments, nominally 9V, 3V or 1.5V coin or button cell-type batteries.

The invention relates to the technical field of beverage production processes, and discloses a production process of a vegetable beverage containing active organic iron extracted from brassica rapa leaf, and the production process comprises the following steps: S1, a raw material preparation stage, S2, a component extraction stage, S3, a filtration and concentration stage, S4, a preparation stage, and S5, a packaging stage. An iron supplement product is developed, iron of the iron supplement product is derived from natural active organic iron in the brassica rapa leaf raw material, and the iron in the form is more easily absorbed and utilized by a human body, so that the bioavailability of the iron is effectively improved, and side effects are reduced; compared with a traditional inorganic iron supplement, the prepared nutritional beverage can significantly reduce or avoid gastrointestinal discomfort and other side effects, so that the product is safer and suitable for long-term use.

The invention discloses a polyphenol-mediated high-internal-phase Pickering emulsion as well as a preparation method and application thereof, and belongs to the crossing field of food science and biological medicine application. The preparation method of the high-internal-phase Pickering emulsion comprises the following steps: respectively dissolving polyphenol, food-grade aldehydes, proteins, peptides or amino acids in water, then mixing the three solutions, and carrying out magnetic stirring under a normal-temperature dark condition to obtain a mixed system; then centrifuging, and freeze-drying the precipitate to obtain polyphenol composite nanoparticles; and dissolving the polyphenol composite nanoparticles in water to obtain a nanoparticle suspension, mixing the nanoparticle suspension with vegetable oil, and performing high-speed dispersion to obtain the polyphenol-mediated high-internal-phase Pickering emulsion. The polyphenol-mediated high-internal-phase Pickering emulsion has good biocompatibility, is stable in digestion of gastrointestinal tracts, and has a very excellent application prospect in the industries of medicines and health care products.

The invention discloses a gastrointestinal tumor image multi-attribute classification method and device based on multi-modal fusion, and a medium. The method comprises the following steps: constructing a multi-modal gastrointestinal tumor data set; performing hierarchical operation on the data set; constructing an image feature extraction network, and respectively extracting EUS image and WLE image features in the data set by using the image feature extraction network; constructing a multi-attribute classification network, performing multi-attribute classification training on the tumor attributes by using the image features, and after the training is completed, predicting the tumor image to be detected by using the network to obtain the tumor attributes after network prediction completion; and performing cross-modal attention fusion and tumor property classification under lesion attribute guidance, and finally outputting tumor property classification of the to-be-detected tumor image. According to the method, through cross-modal attention fusion operation, the model learns complementary contents in the EUS mode and the WLE mode, the attributes of tumor deletion are supplemented, and the properties of the tumor of the patient are classified by utilizing the supplemented attribute data, so that the method is used for assisting a diagnosis result.

The invention provides a probiotic composition for promoting ethanol metabolism as well as a probiotic agent and application thereof, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: compounding lactobacillus mucus A21252, plant lactobacillus A21352, casei paracasei A21151 and lactobacillus reuteri A21325 to obtain a probiotic composition, and matching the probiotic composition with auxiliary materials (resistant dextrin, xylooligosaccharide, erythritol, L-arabinose, lemon fruit powder and corn oligopeptide powder) to obtain the probiotic agent. The probiotic agent not only can quickly improve the hangover alleviating speed, has the effects of alleviating hangover, protecting liver and eliminating gastrointestinal dysfunction caused by alcoholism, but also can reduce discomfort caused by excessive drinking. The probiotic agent is simple and convenient to process, low in cost and wide in market prospect.

Provided are compositions and methods of using compositions including probiotics for treatment and prevention of a variety of pain disorders, neurological disorders, and / or physiological disorders. The compositions include one or more bacterium capable of producing γ-Aminobutyric acid (GABA). The bacterium is selected from Bifidobacterium adolescentis, Limosilactobacillus reuteri, and Lactiplantibacillus plantarum.

The present disclosure relates to the use of 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea or 1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea, or a pharmaceutically acceptable salt thereof, in combination with a MAPKAP kinase inhibitor for the treatment of cancers, including c-KIT-mediated cancers, such as GIST.

Compositions and methods for detecting gastrointestinal diseases are provided. The present invention relates to compositions and methods for detecting and treating gastrointestinal diseases. The present invention relates to the use of an agent for determining intestinal alkaline phosphatase (iAP) activity and the amount of iAP in a child for the preparation of a kit for use in a method for determining the prognosis of inflammatory bowel disease (IBD) in said child.

The invention relates to a feeding intolerance burst risk early warning method and device based on multi-modal dynamic monitoring. The method comprises the steps that a gastrointestinal tract peristaltic wave image sequence under the abdominal skin surface of a patient is collected; collecting borborygmus data; collecting physical sign physiological data of the patient; monitoring behavior and posture data of the patient in real time; tracking the infinitesimal displacement and deformation of the gastrointestinal wall in the gastrointestinal tract peristaltic wave image sequence, and extracting and quantifying the speed, direction and wave crest and trough change rate of the peristaltic wave and the regularity index of the peristaltic wave; calculating a physiological deviation degree between the fusion feature at the current moment and an expected normal mode generated by the physiological feature baseline model of the patient; and inputting the physiological deviation degree, the change rate of the physiological deviation degree in the time dimension and the accumulated deviation duration into a conditional variation risk assessment model, and outputting a potential spatial distance. Through the non-invasive and highly quantified feeding intolerance risk model, the early recognition capability and clinical intervention efficiency of feeding intolerance are remarkably improved.

The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and / or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.

The invention discloses an intelligent lavage and drainage system for gastrointestinal surgery in the technical field of gastrointestinal surgery, and the system comprises an information collection module which is used for collecting gastrointestinal pressure information of a patient and recording and storing the pressure information; the data analysis and processing module is used for establishing a pressure model and a pressure threshold value by utilizing a machine learning algorithm based on the collected pressure information; the intelligent control module is used for controlling the flow speed and flow of the lavage fluid and the drainage fluid in different time periods according to the pressure information; and the early warning module is used for monitoring abnormal conditions of the gastrointestinal tract, automatically starting a drainage function and sending out an alarm signal when monitoring that the pressure information exceeds a preset pressure threshold value. By analyzing the relevance between various characteristic information and gastrointestinal tract environment information of the patient, the lavage and drainage parameters are automatically adjusted according to individual differences of the patient, and a more personalized treatment scheme can be provided, so that the treatment effect is improved.

An apparatus for detecting and treating gastrointestinal pathology. The apparatus includes a wireless capsule, where the wireless capsule includes at least one of: an optical imaging system, a thermal imaging system, or a camera. The camera is a narrow band imaging system, a white light imaging system, or both.

Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

The invention belongs to the technical field of biological medicines, and discloses a traditional Chinese medicine composition for treating microsatellite stability (MSS) type tumors by a sensitization immune checkpoint inhibitor. The traditional Chinese medicine composition provided by the invention comprises radix scutellariae, rhizoma zingiberis, Chinese herbaceous peony, liquorice root and Chinese date, can increase CD8 + T cell infiltration, promote the CD8 + T cell to secrete cytokines and improve the immunosuppression of MSS type tumors, and further breaks through the conventional range of anti-tumor treatment of immune examination inhibitors; meanwhile, the traditional Chinese medicine composition can also improve adverse reaction of gastrointestinal tracts caused by tumor treatment by an immune examination inhibitor, and the life quality of patients is improved.

Different animal model tests prove that the bacteroides fragilis, especially viable bacteria, lysate, inactivated bacteria, extracts and the like of the bacteroides fragilis ZY-312 with the preservation number of CGMCC No.10685 and the bacteroides fragilis NCTC 9343 have the effects of improving and treating the functional gastrointestinal diseases, especially functional dyspepsia and irritable bowel syndrome. For functional dyspepsia, bacteroides fragilis can effectively improve weight loss, anorexia, visceral hypersensitivity and gastric motility disorder caused by functional dyspepsia. For irritable bowel syndrome, bacteroides fragilis can effectively improve diarrhea symptoms and reduce intestinal sensitivity.

The invention provides donepezil sustained-release microspheres and a preparation method, a pharmaceutical preparation and application thereof. The preparation method comprises the following steps: forming a water phase (containing a surfactant, an osmotic pressure regulator and water, and regulating the pH value with a pH regulator); forming an oil phase (comprising donepezil, a carrier material and an organic solvent); and adding the oil phase into the water phase, dispersing to form a pre-emulsion, performing membrane emulsification on the pre-emulsion to form an emulsion, and finally curing, washing and freeze-drying the emulsion to obtain the donepezil sustained-release microspheres. The preparation process is stable and controllable, the batch-to-batch repeatability is good, the surface of the microsphere is smooth and complete, the particle size distribution is uniform, the size is controllable, the microsphere has high drug loading capacity, long-term stable release can be realized, the injectability is excellent, the administration frequency can be reduced, and the adverse reaction of gastrointestinal tracts can be reduced.

The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to said compound(s) for use as in a method of treating a skin disorder; eye disease; ear disease; mouth, throat and respiratory disease; gastrointestinal disease; liver, gallbladder and pancreatic disease; urinary tract and kidney disease; disease of male genitale organs and female genitale organs; disease of the hormone system; metabolic disease; cardiovascular disease; blood disease; lymphatic disease; disorder of the central nervous system; brain disorder; musculoskeletal system disease; allergy disorder; pain; infectious disease; inflammatory disorder; injury; immunology disorder; cancer; hereditary disease; or edema.