1185 results about "Respiratory disease" patented technology

The invention discloses a pediatric abnormal breathing detection method and system based on a physiological signal, and relates to the technical field of medical information processing, and the method comprises the steps: collecting a multi-modal physiological signal, employing wavelet decomposition and a soft threshold function to eliminate noise, and outputting a preprocessing signal group in combination with morphological opening and closing operation; calculating a time domain feature, a frequency domain feature and a nonlinear feature of the preprocessed signal group, organizing the features into a three-layer pyramid structure, analyzing time sequence similarity by adopting an attention mechanism, and outputting a fusion feature sequence; and carrying out preliminary anomaly detection on the fused feature sequence, carrying out classification based on an age grouping threshold, extracting context feature vectors of windows before and after an abnormal point, and carrying out secondary discrimination to realize accurate identification and graded early warning of the respiratory anomaly. The respiration monitoring system with high reliability, high adaptability and intelligent learning ability is constructed, and comprehensive technical support is provided for early recognition, real-time early warning and intelligent diagnosis of children respiratory system diseases.

The invention provides a small sample respiratory disease pattern recognition method based on a diffusion model. The method comprises the following steps: firstly, for common respiratory disease types, collecting and classifying data of three respiratory modes: normal respiration, pause respiration and deep respiration which respectively correspond to respiratory diseases such as normal respiration, obstructive apnea and asthma in medicine; secondly, learning an internal distribution rule of data by using a radio frequency diffusion model, and generating diversified and high-quality radio frequency time sequence data on the basis of limited real samples so as to expand a data set; and thirdly, combining the generated data with real data, extracting an accurate respiration signal through a one-dimensional time sequence extraction algorithm, and converting a time sequence into a two-dimensional image by utilizing a Gramian Angle Field (GAF) method, so that the time dependency relationship of the time sequence is intuitively presented in the image. And finally, a convolutional neural network (CNN)-Transform deep learning model is adopted to carry out feature extraction and classification on the image data, and then multi-scale feature analysis and breathing mode recognition are carried out. According to the method, the recognition precision and generalization ability of the model are remarkably improved under the small sample condition, and an accurate and reliable solution is provided for non-contact breathing mode recognition.

The invention relates to the field of intelligent assistance, and particularly discloses an intelligent assistance system for child pneumology department disease diagnosis, which obtains doctor inquiry record information of a to-be-diagnosed child, and in response to existence of auxiliary examination items, obtains auxiliary examination information of the auxiliary examination items of the to-be-diagnosed child, and sends the auxiliary examination information to the to-be-diagnosed child. Carrying out segmentation processing and global semantic coding aggregation on doctor inquiry record information by adopting an artificial intelligence-based image recognition and data analysis technology, and carrying out implicit semantic feature extraction on auxiliary examination information; and intelligently obtaining an auxiliary diagnosis result of the respiratory disease type of the child to be diagnosed according to a cross-modal semantic joint feature between a global semantic aggregation feature of the doctor inquiry record information and an auxiliary examination implicit semantic feature, and displaying the result. Therefore, the accuracy and comprehensiveness of auxiliary diagnosis of children respiratory diseases can be remarkably improved.

Introduced here are pressure-mitigation apparatuses able to mitigate the pressure applied to a human body by the surface of an object. A controller device can be fluidically coupled to a pressure-mitigation device that includes a series of selectively inflatable chambers. When a pressure-mitigation device is placed between a human body and a surface, the controller device can continuously, intelligently, and autonomously circulate air through the chambers of the pressure-mitigation device. As further discussed below, the controller device may cause the chambers to be selectively inflated, deflated, or any combination thereof. Such an approach is useful in a variety of contexts. For example, pressure-mitigation apparatuses may be used to improve treatment of patients suffering from respiratory illnesses and patients who are partially or completely immobilized for extended durations (e.g., as part of a medical procedure).

The invention belongs to the technical field of sleep respiratory disease detection, and relates to a sleep apnea identification method based on a hybrid neural network, which comprises the following steps of: sensing human sleep in a bed surrounding environment by using a millimeter wave radar, and positioning a thoracic cavity position by adopting spatial two-dimensional analysis; the problem that interference exists in radar sign signal extraction of different targets at the same distance is solved. And a respiration signal Shannon entropy is constructed as an iterative index of the whale optimization algorithm, and the index is minimized to realize iterative optimization of variational mode extraction parameters, so that different respiration states are matched with different parameters, and thus a dominant frequency narrowband respiration signal is accurately extracted. A breathing time-frequency energy diagram obtained by data processing is used as input, and a CNN network and a bidirectional long-short-term memory module are used together to construct a feature extraction module, so that the method can recognize the change trend of frequency along with time, capture more comprehensive features, and recognize target sleep apnea more accurately. In addition, the hybrid network enables accurate classification of unmanned scenarios, apnea, hypopnea, and normal respiration.

The invention relates to the field of biological medicine, and discloses a method and system for analyzing cough sound by using disease characteristics to diagnose respiratory diseases, and the method comprises the steps: deploying a six-microphone annular array to achieve the precise positioning and triggering of a sound source; self-adaptive spectral subtraction and Wiener filtering cascade are adopted to enhance the audio; segmenting a cough segment based on energy envelope; fusing the Mel-cepstrum, the linear prediction residual error, the harmonic energy ratio and the transient zero-crossing rate to construct a pathological feature matrix; extracting local, medium-range and global time sequence features through a three-branch parallel convolutional network; inputting a disease specific classifier to discriminate asthma, pneumonia and laryngitis respectively, and applying a feature decoupling regular term to improve interpretability. The system correspondingly realizes the modularized processing flow. According to the method, the cough sound collection quality and the disease subtype recognition accuracy in a complex environment are improved, meanwhile, the thermodynamic diagram is output to assist clinical decision making, and the diagnosis credibility and practicability are enhanced.

The invention relates to the field of prevention and treatment of respiratory diseases, and discloses a preparation method of a human respiratory syncytial virus preventive mRNA vaccine. The main components of the mRNA vaccine comprise mRNA for coding an antigen and lipid nanoparticles. According to the mRNA sequence provided by the invention, an independently researched and developed 5 'UTR / 3' UTR sequence and a codon optimization mode are adopted, and efficient translation of target protein can be realized. According to the mRNA vaccine provided by the invention, RSV F protein is selected as an antigen, and the RSV F protein sequence is optimally designed, so that stable pre-fusion conformation RSV F protein can be expressed, and after a mouse is immunized, the mouse can be induced to generate high-level RSV F protein specific binding antibody titer and neutralizing antibody titer.

The invention relates to the technical field of medical equipment, in particular to a wearable sputum excretion assistive device which is light in weight, easy to wear and designed for patients with respiratory system diseases, and the integration of lung sound recognition and sputum excretion functions can be achieved through a distributed electronic stethoscope and a vibration tapping head integrated on the wearable assistive device. The sputum excretion device is suitable for patients needing long-term sputum excretion management. The auxiliary tool mainly comprises a distributed electronic stethoscope, a flexible and rigidity-variable electromagnetic tapping head array, a vest type wearable backpack and an auxiliary tool hard backpack shell. During working, firstly, the vest type wearable backpack is adjusted to be in the size suitable for a patient and fixed to the back of the patient, secondly, lung sound data of the patient are captured in real time through the distributed electronic stethoscope, and the lung area needing sputum excretion nursing is recognized according to the processing result of the lung sound data. And calculating again and sending a detailed instruction to the flexible and rigidity-variable electromagnetic tapping head array, and adjusting the rigidity and tapping frequency of each tapping unit according to the received instruction. Finally, after single-time sputum excretion nursing is completed, lung sound recognition is repeatedly carried out, the treatment effect is evaluated according to the latest lung sound data, the tapping strategy is automatically adjusted, and the optimal treatment effect is achieved. The blank in the application field can be filled, and the nursing pressure of medical staff is relieved.

The invention relates to a sodium channel regulator for inhibiting Nav1.8, and provides a compound as shown in a formula I which can be used as the sodium channel regulator for inhibiting Nav1.8, and an isomer of the compound, or a pharmaceutically acceptable salt of the compound, the invention also provides a pharmaceutical composition containing the compound and the isomer thereof, or the pharmaceutically acceptable salt thereof and a carrier or excipient, and a pharmaceutical application of the pharmaceutical composition as a NaV1.8 inhibitor (such as pain, respiratory diseases, neurological disorders, mental diseases and the like).

A robust nasal organoid culture system and fully characterized 2D and 3D in vitro produced organoids are provided, as well as methods of using the organoids. The nasal organoids comprise a population of differentiated nasal epithelial cells having cellular heterogeneity and molecular markers similar to mature nasal epithelial tissue. Improved methods for producing two-dimensional and three-dimensional nasal organoids are also provided. These methods generally require a two-phase culture system, i.e., amplification and differentiation culture. The provided nasal organoids are suitable for reproducing nasal tissue complexity, for mimicking respiratory diseases, studying barrier function and drug delivery, high throughput drug screening, and assessing the effects of pathogens and environmental toxins on nasal respiratory epithelium.

Provided herein are elastin-like polypeptides, endosomal escape peptides, and compounds comprising an elastin-like polypeptide chemically or recombinantly conjugated to one or more endosomal escape peptides. Also provided herein are compositions comprising a compound provided herein and an agent, methods of delivering an agent, and methods of treating or preventing a disease (e.g., a cardiovascular disease, a lung or respiratory disease, a musculoskeletal disease, a hematological disease, an immune disorder, an infectious disease, a genetic disease, cancer, a neurological disease, a psychiatric disorder, a metabolic disorder, or an inflammatory disease).

The present invention relates to a pharmaceutical composition comprising a weak acid drug, with the use of a bicarbonate salt to achieve a high incorporation of the drug into the liposome and a better therapeutic efficacy. Also disclosed is a method for treating a respiratory disease using the pharmaceutical composition disclosed herein.

The present invention relates to novel compounds which are capable of inhibiting semicarbazide-sensitive amine oxidase and myeloperoxidase. These compounds are useful for the treatment of a variety of inflammatory indications, e.g., autoimmune diseases, respiratory disease, fibrosis, vasculitis, neurological diseases or disorders, and the complications resulting from infectious disease, obesity, diabetes / metabolic syndrome and / or cardiovascular disease in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.

The invention discloses a single-channel air supply type mine ventilation device, and relates to the technical field of mine ventilation devices. The single-channel air supply type mine ventilation device comprises a ventilation pipe, one side of the ventilation pipe is fixedly connected with an air extracting pump, one end of the air extracting pump is fixedly connected with an air supply pipe, the outer surface of the air supply pipe is fixedly connected with a connecting pipe, the outer surface of the connecting pipe is provided with an air outlet groove, and one end of the connecting pipe is fixedly connected with a removing mechanism. According to the mine ventilation device, when the mine is ventilated through the clearing mechanism and the air supply type ventilation device, air needs to be exhausted from the outside to enter the mine, but during air exhausting, dust and cotton fibers can enter the ventilation device from the outside and can shield the ventilation position, and the dust at the ventilation opening is cleared away through the clearing mechanism during air supply; the concentration of suspended particles in air can be reduced by removing dust, the quality of air in a mine is improved, and the risks of respiratory diseases and other health problems of workers are reduced.

The present invention relates to a pharmaceutical composition comprising a weak acid drug, with the use of a bicarbonate salt to achieve a high incorporation of the drug into the liposome and a better therapeutic efficacy. Also disclosed is a method for treating a respiratory disease using the pharmaceutical composition disclosed herein.

The invention discloses a respiratory disease oxygen precise conveying system based on a sensor, and relates to the technical field of medical equipment, and the system comprises a sensing module which integrates multiple sensors to collect and process airway and physiological data of a patient; the disease matching module identifies disease types through database comparison; the dynamic adaptation module calculates exclusive oxygen concentration based on a multi-mode fusion initial algorithm; the conveying module executes adjustment; the closed-loop feedback module continuously fine-tunes the oxygen concentration through a closed-loop stepped fine-tuning algorithm to form a closed-loop link, so that accurate dynamic control of oxygen delivery is realized; according to the invention, multi-sensor collaborative acquisition and disease precise matching are combined with a dynamic algorithm and closed-loop feedback, so that individuation and dynamic oxygen delivery are realized, the system avoids misjudgment by relying on a standardized database, and the oxygen concentration, flow and pressure are ensured to be adjusted in real time along with physiological indexes of a patient through multi-parameter collaborative adjustment and stepped fine adjustment; the treatment comfort, the effectiveness and the long-term adaptability are improved.

The invention discloses a respiratory infectious disease multi-pathogen nucleic acid detection kit based on a fluorescent PCR detection technology and application of the respiratory infectious disease multi-pathogen nucleic acid detection kit. The invention provides two detection kits aiming at 20 and 6 respiratory tract detection, the two kits can specifically detect respiratory tract pathogens, the detection sensitivity is high, the whole detection system is short in time consumption and simple and convenient in use process, and detection results of 20 pathogenic microorganisms can be reported within 40 min at the shortest; the whole set of detection kit and the detection method are high in sensitivity and good in specificity; the normal-temperature storage and transportation of the reagent can be realized.

Methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.

The invention discloses an equipment invariance enhanced multi-modal deep learning model and application thereof, and the model comprises an input module, a coding module, a modal fusion module, a classification module, an equipment adversarial branch module, an output module and a final total loss function. Extracting features through a coding module to obtain audio features and text features; after the audio features and the text features are processed by the modal fusion module to obtain final joint representation, the classification module processes the final joint representation to obtain classification results and corresponding probabilities, and the classification results and the corresponding probabilities are output by the output module; the equipment confrontation branch module enables an audio encoder to confront an equipment classification head in a training stage; and finally, introducing the total loss function in a training stage to optimize the model. The model provided by the invention has the capability of realizing high-accuracy identification on various respiratory system diseases on the premise of not depending on acquisition equipment of a specific brand, and shows excellent generalization performance and robustness in multi-equipment and multi-center data.

The present disclosure provides a compound of formula H having excellent PDE4B inhibitory activity, and a pharmaceutical composition thereof and a use thereof. The compound provided by the present disclosure can be used for effectively treating PDE4-related diseases and disorders, including but not limited to inflammatory respiratory diseases, inflammatory bowel diseases, inflammatory joint diseases, inflammatory skin diseases, inflammatory eye diseases, and diseases or cancers of the peripheral or central nervous system.

The invention discloses an intimate contact person traceability device based on droplet detection and a traceability method thereof, and belongs to the circuit system field, the human respiration field and the respiratory tract disease traceability technical field, the intimate contact person traceability device comprises a droplet detection module, an intimate contact person traceability module and a rear end system which are electrically connected with each other, the spittle detection module detects spittle signals to judge physical contact conditions among individuals, the close contact person traceability module records geographic positions and time when the spittle signals are obtained, spittle spreading conditions of main spreading modes of respiratory diseases can be obviously embodied, and a rear-end system has a function of filtering a large amount of redundant information. According to the method, the search range can be accurately limited at a specific time point and a space position, close contact persons and secondary close contact persons can be found out more quickly, and an epidemic prevention department can lock high-risk crowds and regions in the shortest time and effectively control the illness state within the minimum range.

The invention relates to the technical field of children respiratory diseases, and discloses an intelligent diagnosis auxiliary system and method for children respiratory diseases. The intelligent diagnosis auxiliary system comprises a physiological data acquisition module, an environmental data acquisition module, a children data analysis module and an auxiliary early warning module. According to the system, a child physiological risk coefficient is obtained by analyzing a child sleep coefficient, a child motion coefficient and a child symptom coefficient, meanwhile, all activity sites of a current child in a week and risk values in the sites are obtained, and a child environment risk coefficient is obtained through comprehensive calculation; the child physiological risk coefficient and the child environment risk coefficient are synthesized to obtain a comprehensive risk coefficient, and if the comprehensive risk coefficient exceeds a set threshold value, a part issued by a patient with the largest similar value with the comprehensive risk coefficient of the current child and the same age is taken to be displayed to a doctor. Therefore, the doctor can quickly judge and diagnose the pathogenesis of the child patient.

The present disclosure relates to a cleaner station, to which a cleaner may be coupled, and a method of controlling the same, and more particularly, to a cleaner station and a method of controlling the same, in which the cleaner station has a dust bag and a dust collection device for emptying a dust bin of the cleaner, and the cleaner station includes a bag compressing member and a bag joining device, which may reduce a volume of the dust bag by discharging air in the dust bag and compressing the dust bag, and seal the dust bag to prevent dust from scattering at the time of removing the dust bag, such that user convenience may be improved during the process of removing the dust bag, diseases such as respiratory diseases caused by dust spoilage and scattering may be prevented, and hygiene may be improved.

The invention discloses a cutting and polishing device for mold machining, and relates to the technical field of cutting and polishing devices.The cutting and polishing device comprises a cutting and polishing mechanism, the cutting and polishing mechanism is provided with a collecting mechanism, the collecting mechanism comprises a porous shell, a collecting box and a rectangular hole, and a box plate is additionally arranged at an opening of the collecting box; a perforated plate is additionally arranged in the collecting box, an annular filtering net piece is fixed in the perforated plate, a round pipe is fixed to the surface of the perforated plate, and fan blades are additionally arranged at the other end of the round pipe. The device can directly clean metal chippings, abrasive particles and dust driven in the high-speed rotating process of the cutting disc and the grinding wheel, so that the concentration of the metal chippings, abrasive particles and dust in the environment is reduced to a great extent, the probability of causing respiratory diseases of workers is reduced, the body health of the workers is guaranteed, and the working efficiency is improved. And meanwhile, the cleaning and maintaining cost is reduced, and the use efficiency of the cutting and polishing device is improved.

Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

The invention particularly relates to a respiratory disease diagnosis device and method, and the device comprises a respiratory sound signal collection unit which is used for obtaining a current respiratory sound signal; the breathing sound signal preprocessing unit is used for performing segmentation processing and denoising processing on the current breathing sound signal to obtain a preprocessed breathing sound signal; the feature extraction unit is used for extracting multi-modal features of the preprocessed breath sound signals; and the detection unit is used for inputting the multi-modal features into a preset deep learning network model to obtain a respiratory system disease detection result. Therefore, through multi-modal feature extraction, dynamic fusion and an efficient classification strategy, the problems of relatively low feature identification degree, relatively low disease classification accuracy and the like in the process of researching disease diagnosis based on the breath sound signals in related technologies are solved, and the detection performance of chronic respiratory system diseases based on the breath sound signals is remarkably improved.

The invention discloses a method for treating chicken chronic respiratory diseases by using MG-sEV-miRNA-200, and belongs to the technical field of exosomes, and the method comprises the following steps: step 1, constructing an MG infected cell model, and carrying out fluorescence quantitative analysis on gga-miR-200a-3p in cells / exosomes in different time periods of infection; step 2, carrying out overexpression on the miR-200 in the ACE II cells, and extracting an exosome (MG-sEV-miRNA-200) rich in the miR-200; step 3, constructing a cell model for exosome treatment, and carrying out RNA-seq sequencing to identify an exosome treatment target and a pathway rich in gga-miR-200a-3p; step 4, constructing a chick embryo model infected by MG, and injecting MG-sEV-miRNA-200 to intervene in respiratory diseases caused by MG; 5, evaluating the curative effect; mG-sEV is taken as a medium, miRNA can be protected from being influenced by RNA enzyme activity, the gga-miR-200a-3p-rich MG-sEV has the advantages of low immunogenicity, low cytotoxicity, relatively high stability, relatively high biocompatibility and the like, and the MG-sEV rich in gga-miR-200a-3p can be used for remarkably relieving lung inflammation injury caused by MG infection and reducing the bacterium carrying amount of MG in lung tissues; the method has a wide application prospect in the treatment of chicken chronic respiratory diseases.

The invention relates to the technical field of virus detection, in particular to a primer probe combination for bovine respiratory disease syndrome pathogen identification and application and a kit thereof. When the bovine viral diarrhea virus is identified, the nucleotide sequence of the upstream primer of the used primer probe group is as shown in SEQ ID No.1, the nucleotide sequence of the downstream primer is as shown in SEQ ID No.2, and the nucleotide sequence of the probe is as shown in SEQ ID No.3. The primer probe combination provided by the invention can be used for identifying and diagnosing eight common pathogens capable of causing the bovine respiratory disease syndrome at one time through a two-tube reaction system by using a fluorescent quantitative PCR method, can also be used for identifying a mixed infected sample, has the advantages of accurate identification, high sensitivity, simplicity in operation, short time consumption and the like, and can be used for detecting the bovine respiratory disease syndrome. And an effective technical means can be provided for pathogen diagnosis and disease prevention of the bovine respiratory disease syndrome in China.

The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to said compound(s) for use as in a method of treating a skin disorder; eye disease; ear disease; mouth, throat and respiratory disease; gastrointestinal disease; liver, gallbladder and pancreatic disease; urinary tract and kidney disease; disease of male genitale organs and female genitale organs; disease of the hormone system; metabolic disease; cardiovascular disease; blood disease; lymphatic disease; disorder of the central nervous system; brain disorder; musculoskeletal system disease; allergy disorder; pain; infectious disease; inflammatory disorder; injury; immunology disorder; cancer; hereditary disease; or edema.

The utility model discloses a fuel gas heat conduction oil boiler, which relates to the technical field of oil boilers, and comprises a base, the upper side of the base is fixedly connected with a water suction pump, the input end of the water suction pump is fixedly connected with a water suction pipe, the output end of the water suction pump is fixedly connected with a plurality of supporting legs, and the upper side of the base is fixedly connected with a water inlet pipe. A boiler body is fixedly connected to the upper ends of the supporting legs, an air outlet valve is fixedly connected to the upper side of the outer wall of the boiler body, and a safety valve is fixedly connected to the upper side of the outer wall of the boiler body. Through the mutual cooperation of a filtering adsorption plate, a sliding groove, a push block, a sliding block, a limiting rod, a first spring, a first connecting plate and a U-shaped inserting plate, the filtering adsorption plate can be detached and replaced, the filtering effect of the device is improved, the emission of harmful substances in waste gas can be effectively reduced, the health of surrounding residents and workers can be protected, and the practicability is high. And respiratory system diseases or other health problems caused by inhalation of harmful gas are avoided.