374 results about "Endocrine system" patented technology

The invention discloses a probe set for detecting whole exons of extended genetic diseases. The probe set for detecting the whole exons of the extended genetic diseases comprises a standard whole exonprobe set, a whole genome copy number variation probe, and a mitochondrial loop full-length probe, and the genetic diseases comprise 6161 genetic diseases; the standard whole exon probe set can detect the genetic diseases caused by whole exon mutation, the genetic diseases comprise nervous system diseases, metabolic system diseases, endocrine system diseases, digestive system diseases, skeletal system diseases, urinary system diseases, immune system diseases, cardiovascular system diseases, blood system diseases, integument system diseases, ophthalmic system diseases, ear system diseases, respiratory system diseases, and genital system diseases; and the density of the mitochondrial probe is 6X; test samples comprise blood, fresh tissue, FFPE samples, and saliva. The invention discloses using method and kit and application of the probe set for detecting the whole exons of the extended genetic diseases.

The present invention relates to immunogenic compositions for modulating the immune system, comprising a therapeutically effective quantity of two or more immuno-active antigenic agents with pathogen-associated molecular patterns (PAMPs) and / or danger-associated molecular patterns (DAMPs) and one or more physiologically acceptable carriers, excipients, diluents or solvents. The immunogenic compositions according to the present invention are used for producing medicaments for preventing and / or treating, and for preventing and / or treating infectious diseases, auto-immune diseases, allergic diseases, inflammation, arthritis, inflammatory diseases, transplant rejection, affections caused by vascular disorders, diseases caused by haemorrhagic or ischaemic cardiovascular accidents, ischaemia, heart attack and haemorrhagia leading to tissue destruction, heart, kidney, respiratory or liver insufficiency, cancer, malign and benign tumours and neoplasia. The present invention further relates to methods for inducing the regeneration of cells, tissues, organs and organic systems such as the circulatory, nervous and endocrine systems. Finally, the present invention relates to methods for restoring immune response in an animal, in particular a human being.

The invention provides an anion polyamide fiber and a preparing method for the fiber, and provides a polyamide fiber that can release anions and the making way for the fiber, which comprises the making of the anion mother particles and anion polyamide fiber. Wherein, sodium powder, toturmaline, verdelite, and opal powder particles are taken as anion generating agent, after surface treatment, they are molten with polyamide chips in proper proportion to make anion mother particles. Then they are mixed with polyamide raw materials by a mixer in proper proportion, and are spun into anion fibers by hi-speed spinning on a chinlon spinning machine. The invention is of a simple process, easy to implement, fills the blank in the field both at home and abroad. According to practice, the concentration of anions surrounding a person wearing a garment made of the fibers from the invention is obviously increased. A clothing of the fibers from the invention can fully neutralize and balance the anions for the free radicals generated during the metabolism of a body, maintain the immunity function and normal state of the incretion system of a body, and is beneficial for health.

The invention relates to a micro-needle transdermal delivery patch with high penetration efficiency, and belongs to a medicament and equipment integrated patch product. The micro-needle transdermal delivery patch can painlessly and efficiently deliver medicament waiting delivery matters to the subcutaneous part, and achieves treatment, beautifying and health-care effects. In addition, under the stimulation of external force, heat, light, electricity, magnetic field, electric field and the like, the penetration effect can be accelerated, so that the micro-needle delivery patch has a curative effect which is not achieved in a common medicinal patch, the application range of the medicinal patch is expanded, and the curative effect of medicaments are improved. The invention relates to the structural design of the novel micro-needle transdermal delivery patch and the core technology of the implementation process, and the patch can be used for treating skin and shallow skin diseases and can also be used for treatment and related nursing operation of deep tissues and endocrine system diseases. The micro-needle delivery patch product conforms to the tide of future medical treatment, really realizes the advanced treatment concepts of painless delivery and happy treatment, is a novel patch product, and particularly has a broad market prospect for special crowds such as old people and children.

The invention specifically discloses composite whitening and banishing essence and a preparation method thereof. The composite whitening and banishing essence comprises the following raw materials in percent by weight: 1 to 25 percent of Chinese herb active site extract, 0.1 to 10 percent of ethylhexyl ferulate, 0.1 to 5 percent of vitamin C ethyl ether, 0.05 to 3 percent of nicotinamide, 10 to 40 percent of grease, 1 to 6 percent of emulsifier, 1 to 15 percent of moisturizing agent, 0.1 to 1.5 percent of preservative, 0.1 to 0.5 percent of essence and the balance of deionized water. By virtue of the composite whitening and banishing essence, the activity of tyrosinase can be effectively inhibited, oxygen free radicals are efficiently eliminated, forming of melanin is prevented, and the formed melanin is decomposed and faded; meanwhile, an endocrine system of a human body can be regulated, and injuries to the skin caused by chemical components such as hormone are repaired, so that effects of treating both symptoms and root causes comprehensively and quickly are achieved.

Novel analogs of 1 alpha ,25-dihydroxyvitamin D3 which are selective agonists for the genomic responses or agonists or antagonists for the rapid cellular responses in a wide array of diseases in which 1 alpha ,25-dihydroxyvitamin D3 or its prodrugs are involved. Novel analogs have general formulae represented by compounds of groups I-V. A method for treatment and prevention of diseases connected with the endocrine system.

The invention relates to the use of selected (R)-2-[(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and / or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinological systems, gastrointestinal, urogenital, metabolic and seizure disorders, where the above mechanisms have been described as playing a pathological role.

The invention discloses a pressure regulating type smart watch for measuring pulse condition. The pressure regulating type smart watch comprises a watch band assembly and a watch movement assembly, wherein the watch band assembly comprises a raised contact surface and a pulse sensor; the watch movement assembly comprises a watch band scroll, a micro stepping motor, a watch gear, a stepping motor driving unit, an A / D (Analog / Digital) conversion unit, a CPU (Central Processing Unit), a wireless interface unit, a storage unit and a touch screen; the watch band is used for adjusting the pressure born by the pulse sensor under the action of the micro stepping motor; the pulse sensor is used for measuring pulse condition characteristic parameters. The pressure regulating type smart watch has the advantages that the measurement is easily realized; through logic operation of the CPU unit, pulse condition indexes are obtained, and health indicators comprising health conditions of a digestion system, a blood circulation system and an endocrine system are indirectly reckoned. The invention also discloses a pressure regulating type method for measuring the pulse condition. According to the pressure regulating type smart watch and the pressure regulating type method disclosed by the invention, pulse condition data can be stored for a long term; wireless communication and control over the smart watch can be realized; the pulse conditions indexes and the health indicators are displayed on the touch screen, so the health states of human bodies are conveniently and timely grasped.

The invention discloses a eurycoma longifolia extract product and an application thereof. The invention is characterized in that a eurycoma longifolia active component is extracted with an ultrasonic distillation technology or a membrane separation technology; and the active component is applied in the field of beverages, such as that the active component can be prepared into coffee, tea, and the like. The extracted active component provided by the invention has higher purity, and the prepared beverage can more efficiently improve human testosterone level. The beverage also has the functions of kidney clearing, diuresis, sterilizing, inflammation eliminating, body blood circulation enhancing, metabolism enhancing, endocrine system improving, and body immune function enhancing. The beverages are suitable for daily applications.

An application of the algin oligose in preparing medicine, food additive, helth-care food, or feed additive for preventing and treating tumor and intestinal infection, elongating life, and beautifying skin is disclosed.

The invention relates to a feed for improving the survival rate of weaned newborn rabbits. The feed comprises the following components in percentage by weight: 15 to 23 percent of wheat shorts, 10 to 18 percent of wheat bran, 6 to 10 percent of pomace, 3 to 6 percent of puffed soybean flour, 4 to 9 percent of chrysanthemum powder, 18 to 23 percent of clover particles, 8 to 15 percent of oat grass, 1 to 3 percent of soybean meal, 4 to 7 percent of maize germ flour, 4 to 9 percent of rice bran cake, 0.1 to 0.2 percent of sodium sulfate, 0.3 to 0.5 percent of calcium hydrophosphate, 0.06 to 0.1 percent of sodium bicarbonate, 0.20 to 0.25 percent of edible salt, 0.10 to 0.15 of choline chloride, 0.10 to 0.15 percent of L-lysine, 0.10 to 0.15 percent of DL-methionine, 0.05 to 0.08 percent of rabbit multi-vitamin, 0.10 to 0.15 percent of disinfectant, 0.01 to 0.05 percent of soybean fiber, 0.20 to 0.25 percent of metal trace elements, and 0.02 to 0.05 percent of xylooligosaccharide. The feed can improve the stress resistance of the rabbit, has stronger palatability, uses the sodium bicarbonate as buffer, contributes to normal work of endocrine system in stress state, and can neutralize acid generated in a pomace metabolizing process; and reasonable energy ratio of amino acid can improve the digestion absorption rate of the feed.

The invention is a health product for diabetes, relating to the field of health products, prepared of Oyster Shell extract, Se-enriched yeast, Cr-enriched yeast, L-zinc aspartate, L- magnesium aspartate, linolenic acid powder, alpha- Thioctic Acid, Bitter Melon P.E, P. tataricum Linn extract, Fructus lycii P.E, Dwarf Lilyturf Tuber extract, Cortex Mori extract, Fructus Corni extract, and Fenugreek P.E, and it can promote insulin function to be normal, synthetically supplement nutrition deficient in the diets of patients suffering from diabetes, prevent complication of diabetes, protect brain, eyes, and heart, promote cooperation of immune system, nerve system and endocrine system and synthetically regulate blood sugar to be stable.

The invention provides a two-hybrid yeast for detecting estrogen-like compounds in environmental samples and a preparation method thereof, wherein the yeast contains pGBKT7-ER yeast expression plasmids and pGAD424-GRIP1 yeast expression plasmids, wherein the pGBKT7-ER yeast expression plasmids contain estrogen receptor genes, and the pGAD424-GRIP1 yeast expression plasmids contain estrogen receptor coactivated factor genetic fragments with the sequence of SEQ ID No.2. The invention also provides a bioassay method for detecting the estrogen-like compounds in the environment, which comprises: co-culturing two-hybrid yeast cells and a sample to be detected, adding a reaction liquid of o-nitrobenzene-beta-D-galactopyranoside for reaction, and calculating the concentration of the estrogen-like compounds according to the detected absorbance value of supernatant at 420 nanometers after the reaction stops. The invention adopts the two-hybrid yeast of recombinant estrogen receptor genes for test, and is more close to the actual action conditions of an endocrine system of a mammal; constructed yeast cell genes have stable character and are easy to culture and screen; the screening process of the whole estrogen-like effect is simple to operate; and the required quantity of the sample is small, and the cost is low.

A Chinese medicine for treating mastoplasia is prepared from 10 Chinese-medicinal materials including dandelion herb, Chinese angelica root, seaweed, ground beetle, etc. Its preparing process is also disclosed.

The electro-enhanced solid-phase microextraction (EE-SPME) method involves extraction that is performed with an SPME fiber, preferably made of polydimethylsiloxane (PDMS), in the presence of an applied electric potential for a predetermined period of time. Polar analytes are extracted onto the fiber, which is the stationary phase. The solid-phase microextraction fiber is then inserted into an injection port of a gas chromatograph coupled with a mass spectrometer. The polar analytes are desorbed in the injection port, and are analyzed by GC-MS to detect and quantify the individual components. The method is particularly useful for the detection of trace amounts of plasticizers, such as phthalate esters and bisphenol A, that are known to disrupt the endocrine system of humans and animals above known levels

The invention discloses a drug with an adamantane structure, a derivative and an analogue thereof with new activities for preventing tumor and the like and new indication and also relates to application of compounds as anti-tumor drugs and the like. The drugs comprise the following structures: the derivatives and the analogue produced by the adamantane structure, a compound with a new structure produced by taking the adamantane structure as a fundamental structure or a structural fragment, various compounds which are obtained by simplifying or augmenting and modifying a parent nucleus structure of the compound with the new structure and have structures the same as or different from the parent nucleus structure and similarity or correlativity with the compound with respect to bioactivity, as well as inorganic acid salts, organic acid salts, inorganic alkali salts, organic alkali salts or a compound salt of the derivatives and the analogue with the structure and prodrugs thereof. The drugs with anti-tumor pharmacological activity and taken as anti-tumor drugs can be applied in combination with other known anti-tumor drugs and also be used for treating tumor associated diseases or other diseases accompanied by tumor diseases in combination with other drugs, including diseases caused by virus, bacteria and fungus, neurological diseases, endocrine system diseases, immunologic system diseases and the like.

The invention discloses a yellow-tea preparation process. The yellow-tea preparation process includes the steps of picking of fresh leaves; withering of the fresh leaves; water removing; light rolling; heaping for yellowing; primary baking, cooling and secondary baking; fragrance raising and re-drying; quality testing, weighing and packaging. Huoshan yellow shoots are taken as raw materials, so that the yellow tea prepared by the unique process has the advantages of being attractive in appearance and high in quality, yellow-bright and clear in liquor color, fragrant and mellow in taste, durable in brew and sweet in aftertaste and moist in throat; Huoshan local herbal medicine like dendrobium huoshanense, Huoshan ganoderma lucidum, bulb mite, Longhan pinellia ternate, tuceahoe, eucommia ulmoides, platycodon grandiflorum and clinopodium polycephalum are added, so that efficacy of dehumidification and detoxification, lung moistening and cough relieving, heat clearing and nerve soothing, dampness excreting and diuresis inducing, spleen benefiting and stomach harmonizing and nerve calming is achieved, and auxiliary efficacy for cough haemoptysis, chronic bronchitis, tiredness and nerve exhaustion, neurasthenia, restless sleep and the like is realized; meanwhile, moderating effects on immune system, endocrine system, central nervous system, circulatory system and urinary system to different degrees are achieved.

The invention discloses a making process of Litsea coreana, which comprises the following operation steps of: picking bud leaves; spreading till bud leaves are cool; primarily baking; baking again; and storing and converting. The Litsea coreana manufactured by adopting the process is oleosus in colour and lustre, full-bodied in endoplasm aroma, mellow in taste and red in soup colour; furthermore, the Litsea coreana has special coffee fragrance; if being drunk for a long time, the Litsea coreana is beneficial to improving the functions of the hemopoietic system and the endocrine system; the Litsea coreana disclosed by the invention has the health-care functions on cranial nerve and heart and cerebral vessels and has multiple effects of quenching thirst, cooling, helping digestion, relieving flatulence, detoxifying, diminishing swelling, refreshing, educating, improving eyesight, invigorating stomach, dissipating stasis, relieving pain, checking diarrhea, stopping hiccup and the like.

Methods for modulating the endocrine system of a mammal are provided. In the subject methods, a positive allosteric modulator of AMPA receptors of the hypothalamus are administered to the host. The subject methods find use in applications where it is desired to increase the baseline circulatory level of a growth hormone in a mammalian host. The subject methods also find use in applications where it is desired to increase the circulatory level of DHEA in a mammalian host. Finally, another subject method also finds use in applications where it is desired to decrease the circulatory level of cortisol in a mammalian host.

The invention discloses a preparation technology of a green tea. The preparation technology comprises the following steps: picking fresh leaves; withering the picked fresh leaves; performing fixation; spreading the fresh leaves after fixation so that the fresh leaves after the fixation are cooled, and performing resurgence on the cooled fresh leaves; rolling the fresh leaves after resurgence; primarily baking the rolled fresh leaves, spreading the baked fresh leaves so that the baked fresh leaves are cooled, and baking the cooled fresh leaves once more; enhancing fragrance, and stoving the fresh leaves after fragrance enhancement; and testing quality, weighing the weight of each pack of the green tea, and packaging the green tea. According to the preparation technology disclosed by the invention, Huoshan Huangya is used as raw materials, so that the green tea prepared by using a unique technology has the characteristics of being rich, strong, fresh and refreshing in taste; besides, Huoshan local Chinese herbal medicines of Huoshan dendrobium, Huoshan glossy ganoderma, Anhui fritillaria thunbergii, Longhan pinellia tubers, wolfiporia extensa, eucommia ulmoides, platycodon roots and clinopodium herb are added, so that the green tea has the efficacies of removing dampness, removing toxin, moistening lung for arresting cough, clearing heat, soothing the nerves, resolving dampness, promoting diuresis, benefitting spleens, regulating the function of the stomach, quieting the heart and soothing the nerves, and has auxiliary curative effects on diseases of cough, hemoptysis, chronic bronchitis, weariness, spiritlessness, neurataxia, restless sleep and the like. Besides, the green tea has the effect of regulating an immune system, an endocrine system, a central nervous system, a circulatory system and a urinary system in different degrees, so that the green tea prepared by using the preparation technology disclosed by the invention has better health care efficacies than other green teas.

This invention provides a combination of microRNAs for evaluating the physiological and / or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum / plasma of a subject; and a method for evaluating the physiological and / or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum / plasma of a subject; and a kit for evaluating the physiological and / or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum / plasma of a subject; and a biochip for evaluating the physiological and / or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum / plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute / chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute / chronic infectious diseases caused by various pathogenic microorganisms; other acute / chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

A compound preparation for human external use and its application belong to the technical field of human preparations. The lectin and the white fungus polysaccharide are used as active components, and the relative weight ratio between the two active components contained in the preparation is: 0.5-1.0 parts of the lectin and 1.5-3.0 parts of the white fungus polysaccharide. Said lectin is preferably kidney bean lectin. The dosage form is preferably a gel solution. 100ml of the gel solution contains 0.5-1.0 grams of plant lectin, 1.5-3.0 grams of tremella polysaccharide, 0.8-0.9 grams of NaCl, and pH buffers, stabilizers, and preservatives. The preparation is mainly used for external use by humans during sexual behavior, and it also has the functions of contraception, prevention and treatment of sexually transmitted diseases and lubrication; it can also be used as skin care products. Its principle of action is brand new and will not affect the human endocrine system; it can interfere and prevent HIV and other pathogens from invading normal cells in the body; it is extremely safe.

The invention discloses a pressed candy with functions of adjusting and improving the human endocrine system and a preparation method thereof, and belongs to the field of food processing. The pressed candy with the functions of adjusting and improving the human endocrine system mainly comprises following raw materials: maca powder, natto powder, noni primary pulp, moringa oleifera leaf primary pulp, resistant dextrin, compound amino acid, multi-vitamins as well as mineral substances, sweetening agent, acidity condiment and edible powdered flavor. The preparation method is that primary pulp is firstly blended, and then is evenly mixed with partial raw materials, effective components of raw materials are fully dissolved out, and finally the effective components are dried through atomization to prepare powder, and the powder is mixed with partial raw materials evenly, is screened by a 200-mesh screen, and then is pressed through a multiple rotary tablet press to obtain pressed candies. The pressed candy interacts in such as aspects of improving human sexual function, enhancing human immunity, reducing blood pressure and sugar, resisting fatigue, delaying senility and the like, has good taste, security and non-toxic side effect and simple production process, is convenient to eat and easy to produce, and keeps effective components of raw materials furthest.

The invention discloses lucid ganoderma tea, lucid ganoderma teabag and a processing technology thereof. The lucid ganoderma tea comprises the following four components in parts by weight: 50-60 parts of inonotus obliquus powder, 10-20 parts of phellinus igniarius powder, 10-20 parts of phellinus linteus powder and 5-30 parts of lucid ganoderma extract. Thus, the lucid ganoderma tea disclosed by the embodiment of the invention has perfect mouthfeel, can give full play to the medicinal effect and healthcare effect of lucid ganoderma, improves the body immunity, and realizes an effect of adjusting and protecting the central nervous system, digestive system, endocrine system and respiratory system and the organs such as liver, prostate and the like.

The invention provides a human body endocrine system health risk early warning system, which comprises a human body health scanning system, an endocrine system health risk early warning data processor and an endocrine system health risk early warning result display, wherein the human body health scanning system is used for scanning and evaluating the function values of each tissue and organ of a human body endocrine system; the endocrine system health risk early warning data processor uses a human body endocrine system health risk early warning model for performing human body endocrine system health risk early warning; the output end of the human body health scanning system is connected with the input end of the endocrine system health risk early warning data processor; and the output end of the endocrine system health risk early warning data processor is connected with the endocrine system health risk early warning result display. The organ function of the endocrine system is comprehensively scanned in a short time; the organ function of the endocrine system is evaluated; and the human body tissue energy change and the organ functional change are discovered in time. The potential risk factors and the disease development direction are predicted through combining endocrine system clinical index data, and the health risk of the endocrine system realizes early-stage early warning.

A urine test for diagnosing lung cancer has been developed that uses an artificial nose such as a colorimetric sensor arrays to identify metabolic profiles in urine headspace gas. Cancer cells excrete unique compounds that are a byproduct of their metabolism. The compounds are excreted through a patient's endocrine system by filtration through the kidneys and other organs and are ultimately excreted through the urine. Some of these cancer cell by-products excrete in the urine are small volatile organic compounds (VOCs). Once the urine has exited the body, these VOCs may be outgassed to the environment. Experimental research has determined that a colorimetric sensor array as disclosed is capable of reliably identifying patients with lung cancer based after exposure to the VOCs of the urine headspace gas.

The invention relates to a feed for improving the milking capacity of lactation female rabbits, which comprises the following components: 11%-13% of corn, 4%-6% of wheat middling, 8%-12% of bran, 12%-16% of sunflower meal, 7%-9% of apple pomace, 2%-4% of gluten, 1%-4% of sugarcane molasses, 6%-9% of wheat, 14%-19% of alfalfa meal, 5%-9% of oat grass meal, 1%-3% of soybean oil, 4%-9% of extruded soybean, 0.5%-3% of fiber powder, 0.6%-1.3% of calcium hydrogen phosphate, 0.6%-1.3% of calcium carbonate stone powder, 0.06%-0.1% of sodium bicarbonate, 0.25% of salt, 0.19% of lysine, 0.1% of methionine, 0.1% of disinfectant, 0.5% of liver sanguinin, 0.1% of choline chloride, 0.2% of metal trace element, 0.04% of xylo-oligosaccharide and 0.07% of vitamin. The feed can improve the anti-stress capability of rabbits and has stronger palatability; the sodium bicarbonate is used as a buffering agent to be beneficial to normal operation of the endocrine system under the stress state and generate acid in the metabolic process of the apple pomace neutralization; and the reasonable amino acid energy ratio can improve the digestibility of the feed.

Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.