50 results about "Endocrine system" patented technology

The invention discloses an endocrine health monitoring method and system based on artificial intelligence. The method comprises the following steps: S1, generating a preprocessed standard physiological signal data set; s2, constructing an initial physiological state map based on the preprocessed standard physiological signal data set to form an initial physiological state map; s3, expanding and refining the preliminary physiological state atlas, constructing a multilayer heterogeneous physiological state atlas, and forming a combined physiological state atlas comprehensively reflecting various physiological interaction mechanisms; s4, outputting graph embedding representation reflecting the states of the endocrine glands and the dynamic linkage relation of the endocrine glands; and S5, on the basis of the graph embedding representation, analyzing and judging the linkage state of each gland in the endocrine system by using a preset anomaly judgment strategy, detecting a node or edge relationship with an abnormal mode, and outputting an anomaly monitoring result serving as anomaly early warning information. The endocrine health monitoring precision can be improved.

The invention relates to the field of animal consumer goods, and particularly discloses application of glucan in preparation of animal products for relieving pet stress syndromes. Pet experiments find that beta-1, 3 / alpha-1, 3-glucan can improve the stress syndromes of the indoor cats, specifically, abnormal behaviors of the cats are corrected, and abnormity of multiple systems of organisms such as the immune system, the endocrine system and the urinary system is improved. And when the method is applied to pets, the life quality of the pets can be remarkably improved, more emotional support is provided for pet owners, and the method has practical popularization and application values.

Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

The invention relates to the technical field of data analysis, can be applied to business system platforms of financial science and technology, medical treatment and health and the like, and discloses a human body state characteristic value analysis method, device and equipment and a medium. Performing system state analysis on an endocrine system, a circulatory system and a respiratory system of the user according to the physical examination data to obtain a system state characteristic value set, constructing a physiological index vector and a disease course characteristic vector according to the physical examination data, and constructing a complication incidence matrix according to case data; performing complication association analysis on the user according to the physiological index vector, the disease course feature vector and the complication association matrix to obtain a complication feature value, analyzing a criticality feature value of the user according to a system state feature value set and the complication feature value to obtain a hazard feature value set, and performing weighted summation on the hazard feature value set to obtain a complication feature value set; and obtaining a human body state characteristic value. And the accuracy of human body state characteristic value analysis is improved.

The invention discloses application of mangiferin in preparation of a protective agent for testicular sertoli cells and preparation of a medicine for treating male infertility diseases, and relates to the technical field of medicine application. Wherein the mangiferin can play a role in protecting the sertoli cells, and the protection role is reflected in ways of improving the cell viability of the sertoli cells, inhibiting the apoptosis of the sertoli cells, inhibiting the oxidative stress of the sertoli cells, inhibiting the inflammatory response of the sertoli cells and the like; meanwhile, mangiferin can be used for treating male infertility diseases in ways of relieving weight loss, repairing testis, improving endocrine system functions, inhibiting oxidative stress of testis tissues, inhibiting inflammatory response of the testis tissues and the like. Wherein the mangiferin can inhibit the inflammatory reaction mainly by inhibiting the activation of NLRP3 inflammasome to inhibit the NLRP3 pathway, so that the inflammation and even pyroptosis of testicular sertoli cells are remarkably reduced to improve spermatogenesis, and the male infertility disease is well treated.

The technology described herein is directed to probiotic microbes engineered to secrete at least one enteroendocrine modulating polypeptide, which can be a sweet protein. In some embodiments, the probiotic microbe secretes the enteroendocrine modulating polypeptide in the distal colon. Also described herein are nucleic acids or vectors comprising a coding sequence for the enteroendocrine modulating polypeptide. Also described herein are compositions comprising the engineered probiotic microbe. Methods of using such probiotic microbes and compositions are also disclosed, including methods for modulating enteroendocrine cells and methods for treating metabolic diseases.

The invention relates to the technical field of biological medicine, and discloses rapamycin-loaded microemulsion gel as well as a preparation method and application thereof. The preparation method of the microemulsion gel comprises the following steps: dissolving N, N-dimethyl octadecyl carboxymethyl chitosan in a water phase, then adding an oil phase, a cosurfactant and rapamycin, and stirring to obtain rapamycin-loaded microemulsion; the preparation method comprises the following steps: dissolving a high polymer material in a PBS solution, heating until the high polymer material is completely dissolved, then adding dopamine, stirring for reaction, and finally dialyzing and freeze-drying to obtain the adhesive. And adding a gel matrix containing a thickening agent and an adhesive into the microemulsion, and stirring to obtain the rapamycin-loaded microemulsion gel. According to the prepared microemulsion gel, transdermal drug delivery of hydrophobic drugs is achieved, testis are coated with the microemulsion gel loaded with rapamycin, the blocking effect of damp-heat stress on differentiation and development of testis interstitial cells can be relieved, and the functionality of a male reproduction endocrine system is recovered.

The invention discloses a medicinal and edible composition formula capable of resisting aging and improving sexual function. The invention belongs to the technical field of anti-aging. The medicinal and edible composition formula disclosed by the invention has remarkable anti-aging and sexual function improving effects; cell aging can be effectively delayed, the metabolic capability of a body is enhanced, and an endocrine system is regulated, so that a young state and a good sexual function are kept; according to the formula, natural medicinal and edible food materials are adopted, so that the safety is extremely high, and the side effect is extremely small; the formula is beneficial to improving the psychological state and life quality, enhancing the immunity of the body, improving the resistance of the body and reducing the occurrence of diseases.

The invention belongs to the field of traditional Chinese medicines, and provides application of a valerian extract in preparation of a medicine for preventing and treating climacteric syndrome. Pharmacological experiments show that the valerian extract has a regulation effect on a hypothalamic-pituitary-neuroendocrine system, and has important significance in regulating postmenopausal endocrine conditions of middle-aged and old women and improving anxiety, insomnia, dysphoria and other climacteric symptoms related to FSH (follicle stimulating hormone) and LH (luteinizing hormone). In addition, the valerian extract has a good regulation effect on secretion of related sex hormones and hypothalamus neurotransmitters of climacteric rats, and has a certain correction effect on the central monoamine neurotransmitter disorder state of the climacteric rats. The traditional Chinese medicine composition can improve clinical symptoms of climacteric syndrome.

The invention discloses a dynamic intelligent monitoring and early warning system based on endocrine gland functions, and relates to the technical field of endocrine monitoring, and the dynamic intelligent monitoring and early warning system comprises the following steps: obtaining hypothalamus, pituitary and target gland three-layer hormone concentration data, and carrying out timestamp alignment; after wavelet denoising, the deviation degree of each parameter relative to the health baseline is quantified; establishing an original differential equation set to simulate a hormone axis regulation and control relationship, and calculating a hierarchical weight; a fourth-order Runge-Kutta method is adopted to discretely solve a dynamic weight value; fusing the weight and the abnormality to generate a risk index, and dynamically adjusting an early warning line in combination with a hyperbolic threshold function; according to the threshold breakthrough duration and trend, three-level response of data review, targeted monitoring and drug intervention is triggered. According to the method, a hierarchical coupling differential equation is constructed by simulating a multi-stage regulation mechanism of an endocrine system, so that the recognition sensitivity of early signals of endocrine disorder is improved.

The invention relates to the field of aquatic product muscle quality regulation and control. A method for improving muscle quality of fish by regulating intestinal microenvironment through a neuroendocrine system is characterized by comprising the following steps: 1) sterilizing a temporary rearing pond, injecting aerated water to 2 / 3 of the height of the temporary rearing pond, and regulating dissolved oxygen in the water to be 5.0-8.0 mg / L, water temperature to be 16-24 DEG C, pH to be 7.2-8.0 and ammonia nitrogen content to be lower than 0.5 mg / L by using an aerator; (2) adding a mixed input of 50-100 mg / L of lactobacillus brevis MN047 and 20-50 mg / L of lotus rhizome node extract into the water, and stirring to enable the mixed input to be uniformly dispersed; (3) putting fresh and alive freshwater fishes into the temporary rearing pond according to the rearing density of 20-30kg / m < 3 >, and fasting the fishes during temporary rearing; (4) temporary rearing; 5) waiting for detection in a refrigerator at-80 DEG C; (6) determining; and 7) analyzing the data. According to the method, the stress reaction can be relieved after fish stress, neurotransmitters are secreted, intestinal microbial flora is regulated, and then muscle quality deterioration caused by the stress reaction is relieved.

Disclosed are novel compounds that are antagonists of the human GPR39 protein. Disclosed are pharmaceutical compositions of antagonists of the human GPR39 protein and methods of use. In particular, disclosed herein are methods of using the antagonists to treat diseases or conditions, including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, blood disorders, neurological disorders, and respiratory diseases.

A small molecule compound SPAM1 for up-regulating neuropeptide PACAP and receptor PAC1-R thereof, a method for preparing the same and use of the same; the SPAM1 has a structure of formula (I), wherein R=none, H2O or HCl; SPAM1 has small molecular weight, and can efficiently cross biological barriers including a blood-brain barrier, a blood-testis barrier etc; SPAM1 up-regulates the expression of the neurotransmitter / neuromodulator PACAP secreted by hypothalamus-pituitary and the specific receptor thereof, and acts on the glands downstream of the gonadal axis and the adrenal axis, thereby exerting comprehensive regulation effects; and SPAM1 specifically targets the PAC1-R1, and only acts on cells and tissues of nervous and endocrine systems naturally expressing the PAC1-R, thereby producing fewer side effects. Accordingly, SPAM1 is a novel small molecule compound medicament for effectively treating and preventing function decline and disorders of nervous, endocrine and immune systems closely related to neuropeptide PACAP.

The present invention provides a composition for treating hyperglycemia caused by SARS-CoV-2 infection, a preparation method, an application and a medicine, and relates to the field of pharmaceutical compositions. The composition comprises, by weight, 10-40 parts of rhein, 15-60 parts of magnolol, 2.5-10 parts of quercetin, 10-40 parts of licorice chalcone and 10-20 parts of formononetin. The composition of the present invention has the effect of treating hyperglycemia caused by SARS-CoV-2 infection. OGTT and ITT experimental results show that the composition can significantly improve fasting blood sugar and glucose tolerance in mice, effectively reduce the adverse effects of SARS-CoV-2 infection on the endocrine system, and improve the quality of life of patients.

The present application relates to the field of animal consumer goods, and specifically discloses the use of glucan in the preparation of animal products for relieving pet stress syndrome. Through pet experiments, it is found that beta-1,3 / alpha-1,3-glucan can improve the stress syndrome of room cats, specifically by correcting the abnormal behavior of cats and improving the abnormalities of multiple systems of the body such as the immune system, endocrine system and urinary system. When applied to pets, it can significantly improve the quality of life of pets and provide more emotional support for pet owners, and has practical value for popularization and application.

This invention presents a disposable male hydrogel patch designed to delay ejaculation and prolong erection time while minimizing the impact on sexual pleasure. The patch features an ergonomically designed backing with specific curvatures, a drug-loaded strip divided into central and side zones, and an optional hydrogel coating for sustained drug release. The central zone contains a drug mixture that inhibits the dorsal nerve of the penis, while the side zones promote vasodilation related to erection. The backing includes the adjustment hole for adaptive fitting and is made of a multi-layer composite that integrates breathability, waterproofing, moisture absorption, and fixation. The drug-loaded strip incorporates herbal extracts and synthetic compounds to target the nervous system, vascular system, and endocrine system. Discrete protruding arrays at the coronal sulcus recess enhance drug delivery. This novel, multi-angle approach comprehensively improves sexual function and quality of life, making it a significant innovation in male sexual health.

Based on the questionnaire information and health records, it is possible to search / analyze the user's cardiovascular diseases and / or disease history, and recommend customized health functional foods according to the search / analysis results. In addition, it is convenient to provide posts registered by other members, SNS posts, etc., and support sharing the provided posts, SNS posts, etc. with acquaintances. Moreover, it is possible to search for various information such as definitions / causes / related functions / related foods / TIP / TALK for cardiovascular diseases, and search for relevant departments by keywords for age, main symptoms, and secondary symptoms, or support a service that displays the location information of the departments searched in order of proximity to the user on an electronic map through a location-based service. Also, it is possible to search or be recommended for disease names, pharmaceutical ingredients, pharmaceuticals, types of health functional foods, sales information, etc. related to disease factors (nervous system, digestive / metabolic system, reproductive system, muscular system, sensory system, cardiovascular system, endocrine system, immune system, others), and support functions for creating purchase information (image, product name, consumer price, discount rate, selling price, quantity) and product reviews of the searched / recommended health functional foods.

The invention discloses a nano material for targeted regulation of intracellular pH value and a preparation method and application thereof. In order to solve the problem of cell dysfunction caused by pH value imbalance in cells, the nano vesicles based on biomimetic modification of the cell membranes are provided, pH buffer salt is entrapped by the cell membranes of target cells, and the target cells are specifically recognized. The target cells comprise related cells of a motor system, an endocrine system or a digestive system. The pH buffer salt is a phosphate compound, a carbonate compound, a citrate compound or a succinate compound. The preparation method comprises the following steps: extracting a targeted cell membrane through a differential centrifugation method, carrying out ultrasonic fusion on the targeted cell membrane and a buffer salt solution to prepare the nano material, applying the nano material to preparation of drugs for type 2 diabetes, type 2 inflammatory bowel disease or osteoporosis, specifically targeting corresponding target cells, releasing a regulator, and regulating the intracellular pH value of the target cells.

The invention discloses a quaternary ammonium surfactant with a fluorocarbon-silicon-carbon double hydrophobic chain and a preparation method thereof, wherein the preparation method is by N-((dimethylamino) methyl)-4,4,5,5,6,6,6-heptafluoro-3,3-bis(trifluoromethyl) hexanoamide, 3-chloropropylmethyldimethoxysilane, potassium iodide and solvent in a reaction vessel, heating and stirring are completely dissolved to raw material, temperature reaction is continued afterwards, solvent and water are removed by decompression distillation after the reaction terminates, and washed with ethanol until washings do not change color, to obtain a quaternary ammonium surfactant with a fluorocarbon-silicon-carbon double hydrophobic chain;The surfactant is free of perfluorooctanoic acid (PFOA) and perfluorohexanesulfonic acid (PFHxS) substances, possesses environmentally friendly characteristics, will not have an impact on human nervous system, immune system, endocrine system and genetic information etc., can effectively produce foam, with good heat stability, it is possible to improve the foaming performance and the burning resistance of foam fire extinguishing agent. Wetting agent aspect can reduce aqueous solution surface tension, wets low-energy surface.

The invention relates to a method and device for measuring and calculating the physiological age of a human endocrine system, electronic equipment and a storage medium. The method comprises the following steps: acquiring endocrine system indexes of a to-be-detected object, wherein the endocrine system indexes comprise a blood routine detection index, a blood biochemical detection index and a human whole body system scanner detection index of the to-be-detected object; acquiring a physiological age prediction model; and processing the endocrine system indexes by using the physiological age prediction model to obtain a target physiological age of the tested object. A physiological age analysis model is established based on blood endocrine related indexes and human whole body system scanner (eagle model) detection indexes, the physiological age of the human endocrine system is analyzed, and the aging degree of the body endocrine system is evaluated.

The invention relates to the technical field of curative effect monitoring, in particular to a threatened abortion patient drug curative effect monitoring and personalized medication recommendation system, which comprises a data acquisition module for acquiring physiological data and fetal heart rate information of a threatened abortion patient in real time; the microbiome analysis module is used for analyzing the intestinal microbiome composition of the patient, detecting the microflora change of the endocrine system by collecting the excrement sample of the patient, and predicting the metabolic effect of the medicine on the patient; the drug curative effect evaluation module comprehensively analyzes the data from the data acquisition module and the microbiome analysis module, evaluates the curative effect of the threatened abortion patient after using the drug, and evaluates the influence of the drug on the fetus health in combination with the fetal heart rate and the heart rate variability data; the personalized drug use recommendation module is used for providing personalized drug dosage and use scheme recommendation according to an evaluation result of the drug curative effect evaluation module; the treatment scheme is automatically adjusted, and it is ensured that the medicine plays a role in the optimal treatment range, so that the treatment effect is optimized.

The invention is suitable for the technical field of camellia oil application, and provides application of camellia oil in prevention and treatment of ovarian function decline. The invention reveals that the camellia oil has good prevention and improvement effects on the ovarian function decline for the first time. A series of rigorous scientific experiments prove that the camellia oil can effectively improve weight loss and reproductive hormone disorder caused by mouse ovarian function decline induced by cyclophosphamide, repair ovarian tissue damage and inhibit ovarian granular cell apoptosis, so that normal development of ovaries is promoted, the ovarian index is increased, and the effect of preventing and treating ovarian diseases is achieved. The number of atresia follicles is reduced, the pregnancy rate and the litter size are increased, and the occurrence of ovarian function decline is effectively prevented and improved. The discovery provides a scientific basis for preventing and improving ovarian function decline by using the camellia oil, and avoids tissue hyperplasia and canceration risks caused by strong stimulation of an endocrine system, reproductive organs and mammary gland by exogenous hormones in a hormone therapy.

The invention discloses a herba epimedii, rhodiola rosea and ginseng capsule for invigorating kidney and strengthening yang and a preparation method thereof, and mainly relates to the technical field of pharmaceutical preparations containing traditional herbal medicines. Compared with the prior art, the technical problem to be solved by the invention is to provide the kidney-tonifying and yang-strengthening capsule with small liver burden, epimedium, rhodiola rosea, ginseng, medlar, cinnamon, rehmannia and schisandra chinensis are taken as main raw materials, and auxiliary materials including inulin, a lubricant, a binder and a protective agent are added to complete a capsule filling step. The burdens on the liver and the kidney are reduced through the ways of regulating an endocrine system, enhancing the antioxidant capacity, regulating the activity of immune cells, improving energy metabolism and the like, and a better protection effect is achieved.

A composition containing a combination of at least one fiber and at least one probiotic can be orally administered to a subject in an amount effective to modulate the association of intestinal bacteria to cholesterol levels in blood in the subject. The method can achieve at least one outcome of improving cholesterol levels in blood, preventing and / or treating cardiovascular, circulating, endocrine and / or nervous system conditions and / or diseases.

In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine / threonine kinase receptor of the TGF-beta family and an extracellular domain of a type II serine / threonine kinase receptor of the TGF-beta family. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type II receptor selected from: ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type I receptor selected from: ALK1, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. Optionally the soluble complex is a heterodimer. In certain aspects, such soluble polypeptide complexes may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumors, cancerous cells, and / or cells of hematopoietic lineages, including red blood cells. In certain aspects, such soluble polypeptide complexes can be used to improve muscle formation, bone formation, hematopoiesis, metabolic parameters, and disorders associated with these tissues, cellular networks, and endocrine systems.

The invention discloses a medicinal and edible formula. The invention belongs to the technical field of medicine and food homology formulas, various components in the formula cooperate with one another, and from multiple targets of regulating a cardiovascular system, an endocrine system and an immune system, relieving mental stress, supplementing nutrition and the like, damage to a body caused by overfatigue is comprehensively improved instead of relieving a single symptom; the raw materials in the formula are easy to obtain on the market, can be used by people in various forms (such as powder, pills, tea bags and the like), are convenient and rapid, and are easily accepted by the public; the selected raw materials are all medicinal and edible substances, are high in safety after being eaten for a long time and have no obvious toxic or side effect, and adverse reactions possibly caused by traditional medicine prevention are avoided.

The invention provides a tea composition with effects of reducing fat and body weight as well as a preparation method and application of the tea composition, and belongs to the technical field of tea. The tea composition consists of the following components in parts by weight: 1-12 parts of sophora flowers, 1-12 parts of large-leaf white tea, 1-12 parts of old dark tea, 1-7 parts of roses, 1-12 parts of cyclocarya paliurus, 1-9 parts of mulberry leaf tea and 1-9 parts of lotus leaf tea. The tea composition obtained through scientific compatibility can regulate viscera and endocrine and accelerate metabolism, and has the advantages of being obvious in lipid-lowering and weight-losing effect, stable in effect and the like. The invention further provides a preparation method and application of the tea composition, and provides tea soup capable of reducing fat and weight. The obtained tea soup is rich in fragrance, pure in taste and long in aftertaste, and has good lipid-lowering and weight-losing effects.

Described herein are methods and compositions for treatment of diabetes and / or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

The invention belongs to the technical field of new application of medicines, and provides application of hippocampus multi-penis pills in preparation of medicines for improving or treating polycystic ovarian syndrome. In a clinical test, the hippocampus multi-penis pill is applied to a patient with the spleen-kidney yang deficiency type polycystic ovarian syndrome, the treatment effect is remarkable, the ovarian function of the patient can be effectively improved, and the endocrine system and the body metabolism function can be adjusted. Clinical test results show that the hippocampus multi-penis pill has a certain application prospect in preparation of medicines for improving or treating polycystic ovarian syndrome.

Disclosed herein are novel compounds that are antagonists of the human GPR39 protein. Pharmaceutical compositions and methods of use of antagonists of human GPR39 protein are disclosed. In particular, disclosed herein are methods of treating diseases or conditions, including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic disorders, gastrointestinal and liver disorders, hematological disorders, neurological disorders, and respiratory disorders, using the antagonists.