14 results about "Endocrine system" patented technology

The invention relates to the technical field of biological medicine, and discloses rapamycin-loaded microemulsion gel as well as a preparation method and application thereof. The preparation method of the microemulsion gel comprises the following steps: dissolving N, N-dimethyl octadecyl carboxymethyl chitosan in a water phase, then adding an oil phase, a cosurfactant and rapamycin, and stirring to obtain rapamycin-loaded microemulsion; the preparation method comprises the following steps: dissolving a high polymer material in a PBS solution, heating until the high polymer material is completely dissolved, then adding dopamine, stirring for reaction, and finally dialyzing and freeze-drying to obtain the adhesive. And adding a gel matrix containing a thickening agent and an adhesive into the microemulsion, and stirring to obtain the rapamycin-loaded microemulsion gel. According to the prepared microemulsion gel, transdermal drug delivery of hydrophobic drugs is achieved, testis are coated with the microemulsion gel loaded with rapamycin, the blocking effect of damp-heat stress on differentiation and development of testis interstitial cells can be relieved, and the functionality of a male reproduction endocrine system is recovered.

Disclosed are novel compounds that are antagonists of the human GPR39 protein. Disclosed are pharmaceutical compositions of antagonists of the human GPR39 protein and methods of use. In particular, disclosed herein are methods of using the antagonists to treat diseases or conditions, including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, blood disorders, neurological disorders, and respiratory diseases.

The present application relates to the field of animal consumer goods, and specifically discloses the use of glucan in the preparation of animal products for relieving pet stress syndrome. Through pet experiments, it is found that beta-1,3 / alpha-1,3-glucan can improve the stress syndrome of room cats, specifically by correcting the abnormal behavior of cats and improving the abnormalities of multiple systems of the body such as the immune system, endocrine system and urinary system. When applied to pets, it can significantly improve the quality of life of pets and provide more emotional support for pet owners, and has practical value for popularization and application.

The invention relates to a method and device for measuring and calculating the physiological age of a human endocrine system, electronic equipment and a storage medium. The method comprises the following steps: acquiring endocrine system indexes of a to-be-detected object, wherein the endocrine system indexes comprise a blood routine detection index, a blood biochemical detection index and a human whole body system scanner detection index of the to-be-detected object; acquiring a physiological age prediction model; and processing the endocrine system indexes by using the physiological age prediction model to obtain a target physiological age of the tested object. A physiological age analysis model is established based on blood endocrine related indexes and human whole body system scanner (eagle model) detection indexes, the physiological age of the human endocrine system is analyzed, and the aging degree of the body endocrine system is evaluated.

Described herein are methods and compositions for treatment of diabetes and / or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

Disclosed herein are novel compounds that are antagonists of the human GPR39 protein. Pharmaceutical compositions and methods of use of antagonists of human GPR39 protein are disclosed. In particular, disclosed herein are methods of treating diseases or conditions, including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic disorders, gastrointestinal and liver disorders, hematological disorders, neurological disorders, and respiratory disorders, using the antagonists.

The invention relates to a graphene material with magnetic properties for cleaning contaminated water containing Cr(VI) heavy metal, bisphenol a (BPA), which interferes with the normal functioning of the endocrine system in the body, and disease-causing microorganisms.

The invention relates to the technical field of biological medicines, and discloses application of rapamycin in preparation of a medicine for protecting male reproductive function from damp-heat stress injury. The invention also discloses application of the rapamycin derivative in preparation of a medicine for protecting male reproductive function from damp-heat stress injury. The rapamycin derivative is everolimus, temsirolimus or defolimus. The invention discloses the new application of the rapamycin in preparing the medicine for treating the damp-heat stress caused by the high-temperature and high-humidity environment for the first time, and the action mechanism of the rapamycin is that the rapamycin inhibits an mTOR (mammalian Target of Rapamycin) pathway and activates cell protective autophagy. Animal experiments show that the rapamycin can significantly improve the testosterone concentration of a damp-heat stress model, effectively recover the protein expression of PDGFRalpha and 3beta-HSD, reverse the development process of damaged testicular interstitial cells, and provide a brand new drug choice with a clear action mechanism for preventing and treating the influence of damp-heat stress on a male reproductive endocrine system.

The invention discloses a composition for promoting gonad maturation of wild sal-family large yellow croakers and application of the composition, and belongs to the technical field of aquaculture. Through scientific proportioning of gonadotropin releasing hormone (GnRH) or analogues, polypeptide gonadotropin (FSH, LH) and auxiliary hormone (dopamine receptor antagonist), multi-target activation of an endocrine system of wild parent fish is realized, and synchronous maturation of gonads is promoted. Meanwhile, culture environment parameters such as illumination period, water temperature and salinity are optimized, an ecological environment suitable for sexual maturity is built, stress is reduced, the health of the parent fish is guaranteed, efficient, synchronous and safe sexual maturity of the parent fish is achieved, the breeding efficiency and the fry quality are remarkably improved, an artificial breeding technology of the Pseudosciaena crocea of the sal family is promoted to stride towards the scientization, standardization and industrialization direction, and the economic benefit is increased. And sustainable development of marine fishery resource protection and culture industry is promoted.

Described herein are methods and compositions for treatment of diabetes and / or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

A composition containing a combination of at least one fiber and at least one probiotic can be orally administered to a subject in an amount effective to regulate gut bacteria association with cholesterol levels in the blood of the subject. The method can achieve at least one result that is improvement of cholesterol levels in the blood, prevention and / or treatment of cardiovascular, circulatory, endocrine system and / or nervous system conditions and / or diseases.

Described herein are methods and compositions for treating diabetes and / or obesity. Bitter taste oligopeptide molecules formulated for enteral delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract that involve hormones involved in gastric emptying and inhibition of appetite, such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY). As a novel way of treating diabetes with limited side effects, the described invention uses the body's own endocrine system to treat diabetes, which is an advantage over existing therapies that can only provide disease management without a cure or require more aggressive approaches such as surgical intervention.

The application relates to the field of water product muscle quality regulation. A method for improving fish muscle quality by regulating the intestinal microenvironment of a neuroendocrine system, characterized by comprising the following steps: 1) after sterilizing the temporary culture pond, injecting aeration water to 2 / 3 of the height of the temporary culture pond, adjusting the dissolved oxygen in the water to 5.0-8.0 mg / L by using an oxygenator, maintaining the water temperature at 16-24 DEG C, the pH value at 7.2-8.0, and the ammonia nitrogen content below 0.5 mg / L; 2) adding 50-100 mg / L of lactobacillus panis MN047 and 20-50 mg / L of lotus node extract mixture into the water, and stirring to uniformly disperse the mixture; 3) according to the breeding density of 20-30 kg / m 3 Fresh and live freshwater fish is put into the temporary culture pond, and the fish is fasted during temporary culture; 4) temporary culture; 5) waiting in a refrigerator at-80 DEG C; 6) measurement; 7) data analysis. The method can relieve the stress reaction of fish after stress, secrete neurotransmitters, regulate intestinal microbial flora, and then relieve the deterioration of muscle quality caused by stress reaction.

The application discloses a traditional Chinese medicine composition for regulating a brain-gut axis, which is characterized by being prepared from raw medicinal materials in the following proportions by weight: 10-20 parts of marigold, 8-16 parts of day day flower, 6-12 parts of perilla, 4-8 parts of ophiopogon, 2-4 parts of polygonatum, 2-4 parts of dried tangerine or orange peel, 2-4 parts of anemarrhena, 2-4 parts of poria, and 2-4 parts of licorice. According to the mechanism of the brain-gut axis, the traditional Chinese medicine composition can safely and effectively treat diseases of multiple systems such as the digestive system, the nervous system and the endocrine system.