40 results about "Endocrine system" patented technology

The invention relates to the field of animal consumer goods, and particularly discloses application of glucan in preparation of animal products for relieving pet stress syndromes. Pet experiments find that beta-1, 3 / alpha-1, 3-glucan can improve the stress syndromes of the indoor cats, specifically, abnormal behaviors of the cats are corrected, and abnormity of multiple systems of organisms such as the immune system, the endocrine system and the urinary system is improved. And when the method is applied to pets, the life quality of the pets can be remarkably improved, more emotional support is provided for pet owners, and the method has practical popularization and application values.

Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

The invention relates to the technical field of data analysis, can be applied to business system platforms of financial science and technology, medical treatment and health and the like, and discloses a human body state characteristic value analysis method, device and equipment and a medium. Performing system state analysis on an endocrine system, a circulatory system and a respiratory system of the user according to the physical examination data to obtain a system state characteristic value set, constructing a physiological index vector and a disease course characteristic vector according to the physical examination data, and constructing a complication incidence matrix according to case data; performing complication association analysis on the user according to the physiological index vector, the disease course feature vector and the complication association matrix to obtain a complication feature value, analyzing a criticality feature value of the user according to a system state feature value set and the complication feature value to obtain a hazard feature value set, and performing weighted summation on the hazard feature value set to obtain a complication feature value set; and obtaining a human body state characteristic value. And the accuracy of human body state characteristic value analysis is improved.

The invention discloses application of mangiferin in preparation of a protective agent for testicular sertoli cells and preparation of a medicine for treating male infertility diseases, and relates to the technical field of medicine application. Wherein the mangiferin can play a role in protecting the sertoli cells, and the protection role is reflected in ways of improving the cell viability of the sertoli cells, inhibiting the apoptosis of the sertoli cells, inhibiting the oxidative stress of the sertoli cells, inhibiting the inflammatory response of the sertoli cells and the like; meanwhile, mangiferin can be used for treating male infertility diseases in ways of relieving weight loss, repairing testis, improving endocrine system functions, inhibiting oxidative stress of testis tissues, inhibiting inflammatory response of the testis tissues and the like. Wherein the mangiferin can inhibit the inflammatory reaction mainly by inhibiting the activation of NLRP3 inflammasome to inhibit the NLRP3 pathway, so that the inflammation and even pyroptosis of testicular sertoli cells are remarkably reduced to improve spermatogenesis, and the male infertility disease is well treated.

The technology described herein is directed to probiotic microbes engineered to secrete at least one enteroendocrine modulating polypeptide, which can be a sweet protein. In some embodiments, the probiotic microbe secretes the enteroendocrine modulating polypeptide in the distal colon. Also described herein are nucleic acids or vectors comprising a coding sequence for the enteroendocrine modulating polypeptide. Also described herein are compositions comprising the engineered probiotic microbe. Methods of using such probiotic microbes and compositions are also disclosed, including methods for modulating enteroendocrine cells and methods for treating metabolic diseases.

The invention relates to the technical field of biological medicine, and discloses rapamycin-loaded microemulsion gel as well as a preparation method and application thereof. The preparation method of the microemulsion gel comprises the following steps: dissolving N, N-dimethyl octadecyl carboxymethyl chitosan in a water phase, then adding an oil phase, a cosurfactant and rapamycin, and stirring to obtain rapamycin-loaded microemulsion; the preparation method comprises the following steps: dissolving a high polymer material in a PBS solution, heating until the high polymer material is completely dissolved, then adding dopamine, stirring for reaction, and finally dialyzing and freeze-drying to obtain the adhesive. And adding a gel matrix containing a thickening agent and an adhesive into the microemulsion, and stirring to obtain the rapamycin-loaded microemulsion gel. According to the prepared microemulsion gel, transdermal drug delivery of hydrophobic drugs is achieved, testis are coated with the microemulsion gel loaded with rapamycin, the blocking effect of damp-heat stress on differentiation and development of testis interstitial cells can be relieved, and the functionality of a male reproduction endocrine system is recovered.

The invention belongs to the field of traditional Chinese medicines, and provides application of a valerian extract in preparation of a medicine for preventing and treating climacteric syndrome. Pharmacological experiments show that the valerian extract has a regulation effect on a hypothalamic-pituitary-neuroendocrine system, and has important significance in regulating postmenopausal endocrine conditions of middle-aged and old women and improving anxiety, insomnia, dysphoria and other climacteric symptoms related to FSH (follicle stimulating hormone) and LH (luteinizing hormone). In addition, the valerian extract has a good regulation effect on secretion of related sex hormones and hypothalamus neurotransmitters of climacteric rats, and has a certain correction effect on the central monoamine neurotransmitter disorder state of the climacteric rats. The traditional Chinese medicine composition can improve clinical symptoms of climacteric syndrome.

The invention discloses a dynamic intelligent monitoring and early warning system based on endocrine gland functions, and relates to the technical field of endocrine monitoring, and the dynamic intelligent monitoring and early warning system comprises the following steps: obtaining hypothalamus, pituitary and target gland three-layer hormone concentration data, and carrying out timestamp alignment; after wavelet denoising, the deviation degree of each parameter relative to the health baseline is quantified; establishing an original differential equation set to simulate a hormone axis regulation and control relationship, and calculating a hierarchical weight; a fourth-order Runge-Kutta method is adopted to discretely solve a dynamic weight value; fusing the weight and the abnormality to generate a risk index, and dynamically adjusting an early warning line in combination with a hyperbolic threshold function; according to the threshold breakthrough duration and trend, three-level response of data review, targeted monitoring and drug intervention is triggered. According to the method, a hierarchical coupling differential equation is constructed by simulating a multi-stage regulation mechanism of an endocrine system, so that the recognition sensitivity of early signals of endocrine disorder is improved.

Disclosed are novel compounds that are antagonists of the human GPR39 protein. Disclosed are pharmaceutical compositions of antagonists of the human GPR39 protein and methods of use. In particular, disclosed herein are methods of using the antagonists to treat diseases or conditions, including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, blood disorders, neurological disorders, and respiratory diseases.

A small molecule compound SPAM1 for up-regulating neuropeptide PACAP and receptor PAC1-R thereof, a method for preparing the same and use of the same; the SPAM1 has a structure of formula (I), wherein R=none, H2O or HCl; SPAM1 has small molecular weight, and can efficiently cross biological barriers including a blood-brain barrier, a blood-testis barrier etc; SPAM1 up-regulates the expression of the neurotransmitter / neuromodulator PACAP secreted by hypothalamus-pituitary and the specific receptor thereof, and acts on the glands downstream of the gonadal axis and the adrenal axis, thereby exerting comprehensive regulation effects; and SPAM1 specifically targets the PAC1-R1, and only acts on cells and tissues of nervous and endocrine systems naturally expressing the PAC1-R, thereby producing fewer side effects. Accordingly, SPAM1 is a novel small molecule compound medicament for effectively treating and preventing function decline and disorders of nervous, endocrine and immune systems closely related to neuropeptide PACAP.

The present application relates to the field of animal consumer goods, and specifically discloses the use of glucan in the preparation of animal products for relieving pet stress syndrome. Through pet experiments, it is found that beta-1,3 / alpha-1,3-glucan can improve the stress syndrome of room cats, specifically by correcting the abnormal behavior of cats and improving the abnormalities of multiple systems of the body such as the immune system, endocrine system and urinary system. When applied to pets, it can significantly improve the quality of life of pets and provide more emotional support for pet owners, and has practical value for popularization and application.

This invention presents a disposable male hydrogel patch designed to delay ejaculation and prolong erection time while minimizing the impact on sexual pleasure. The patch features an ergonomically designed backing with specific curvatures, a drug-loaded strip divided into central and side zones, and an optional hydrogel coating for sustained drug release. The central zone contains a drug mixture that inhibits the dorsal nerve of the penis, while the side zones promote vasodilation related to erection. The backing includes the adjustment hole for adaptive fitting and is made of a multi-layer composite that integrates breathability, waterproofing, moisture absorption, and fixation. The drug-loaded strip incorporates herbal extracts and synthetic compounds to target the nervous system, vascular system, and endocrine system. Discrete protruding arrays at the coronal sulcus recess enhance drug delivery. This novel, multi-angle approach comprehensively improves sexual function and quality of life, making it a significant innovation in male sexual health.

Based on the questionnaire information and health records, it is possible to search / analyze the user's cardiovascular diseases and / or disease history, and recommend customized health functional foods according to the search / analysis results. In addition, it is convenient to provide posts registered by other members, SNS posts, etc., and support sharing the provided posts, SNS posts, etc. with acquaintances. Moreover, it is possible to search for various information such as definitions / causes / related functions / related foods / TIP / TALK for cardiovascular diseases, and search for relevant departments by keywords for age, main symptoms, and secondary symptoms, or support a service that displays the location information of the departments searched in order of proximity to the user on an electronic map through a location-based service. Also, it is possible to search or be recommended for disease names, pharmaceutical ingredients, pharmaceuticals, types of health functional foods, sales information, etc. related to disease factors (nervous system, digestive / metabolic system, reproductive system, muscular system, sensory system, cardiovascular system, endocrine system, immune system, others), and support functions for creating purchase information (image, product name, consumer price, discount rate, selling price, quantity) and product reviews of the searched / recommended health functional foods.

The invention discloses a nano material for targeted regulation of intracellular pH value and a preparation method and application thereof. In order to solve the problem of cell dysfunction caused by pH value imbalance in cells, the nano vesicles based on biomimetic modification of the cell membranes are provided, pH buffer salt is entrapped by the cell membranes of target cells, and the target cells are specifically recognized. The target cells comprise related cells of a motor system, an endocrine system or a digestive system. The pH buffer salt is a phosphate compound, a carbonate compound, a citrate compound or a succinate compound. The preparation method comprises the following steps: extracting a targeted cell membrane through a differential centrifugation method, carrying out ultrasonic fusion on the targeted cell membrane and a buffer salt solution to prepare the nano material, applying the nano material to preparation of drugs for type 2 diabetes, type 2 inflammatory bowel disease or osteoporosis, specifically targeting corresponding target cells, releasing a regulator, and regulating the intracellular pH value of the target cells.

The invention discloses a quaternary ammonium surfactant with a fluorocarbon-silicon-carbon double hydrophobic chain and a preparation method thereof, wherein the preparation method is by N-((dimethylamino) methyl)-4,4,5,5,6,6,6-heptafluoro-3,3-bis(trifluoromethyl) hexanoamide, 3-chloropropylmethyldimethoxysilane, potassium iodide and solvent in a reaction vessel, heating and stirring are completely dissolved to raw material, temperature reaction is continued afterwards, solvent and water are removed by decompression distillation after the reaction terminates, and washed with ethanol until washings do not change color, to obtain a quaternary ammonium surfactant with a fluorocarbon-silicon-carbon double hydrophobic chain;The surfactant is free of perfluorooctanoic acid (PFOA) and perfluorohexanesulfonic acid (PFHxS) substances, possesses environmentally friendly characteristics, will not have an impact on human nervous system, immune system, endocrine system and genetic information etc., can effectively produce foam, with good heat stability, it is possible to improve the foaming performance and the burning resistance of foam fire extinguishing agent. Wetting agent aspect can reduce aqueous solution surface tension, wets low-energy surface.

The invention relates to a method and device for measuring and calculating the physiological age of a human endocrine system, electronic equipment and a storage medium. The method comprises the following steps: acquiring endocrine system indexes of a to-be-detected object, wherein the endocrine system indexes comprise a blood routine detection index, a blood biochemical detection index and a human whole body system scanner detection index of the to-be-detected object; acquiring a physiological age prediction model; and processing the endocrine system indexes by using the physiological age prediction model to obtain a target physiological age of the tested object. A physiological age analysis model is established based on blood endocrine related indexes and human whole body system scanner (eagle model) detection indexes, the physiological age of the human endocrine system is analyzed, and the aging degree of the body endocrine system is evaluated.

The invention discloses a herba epimedii, rhodiola rosea and ginseng capsule for invigorating kidney and strengthening yang and a preparation method thereof, and mainly relates to the technical field of pharmaceutical preparations containing traditional herbal medicines. Compared with the prior art, the technical problem to be solved by the invention is to provide the kidney-tonifying and yang-strengthening capsule with small liver burden, epimedium, rhodiola rosea, ginseng, medlar, cinnamon, rehmannia and schisandra chinensis are taken as main raw materials, and auxiliary materials including inulin, a lubricant, a binder and a protective agent are added to complete a capsule filling step. The burdens on the liver and the kidney are reduced through the ways of regulating an endocrine system, enhancing the antioxidant capacity, regulating the activity of immune cells, improving energy metabolism and the like, and a better protection effect is achieved.

A composition containing a combination of at least one fiber and at least one probiotic can be orally administered to a subject in an amount effective to modulate the association of intestinal bacteria to cholesterol levels in blood in the subject. The method can achieve at least one outcome of improving cholesterol levels in blood, preventing and / or treating cardiovascular, circulating, endocrine and / or nervous system conditions and / or diseases.

In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine / threonine kinase receptor of the TGF-beta family and an extracellular domain of a type II serine / threonine kinase receptor of the TGF-beta family. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type II receptor selected from: ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type I receptor selected from: ALK1, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. Optionally the soluble complex is a heterodimer. In certain aspects, such soluble polypeptide complexes may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumors, cancerous cells, and / or cells of hematopoietic lineages, including red blood cells. In certain aspects, such soluble polypeptide complexes can be used to improve muscle formation, bone formation, hematopoiesis, metabolic parameters, and disorders associated with these tissues, cellular networks, and endocrine systems.

The invention provides a tea composition with effects of reducing fat and body weight as well as a preparation method and application of the tea composition, and belongs to the technical field of tea. The tea composition consists of the following components in parts by weight: 1-12 parts of sophora flowers, 1-12 parts of large-leaf white tea, 1-12 parts of old dark tea, 1-7 parts of roses, 1-12 parts of cyclocarya paliurus, 1-9 parts of mulberry leaf tea and 1-9 parts of lotus leaf tea. The tea composition obtained through scientific compatibility can regulate viscera and endocrine and accelerate metabolism, and has the advantages of being obvious in lipid-lowering and weight-losing effect, stable in effect and the like. The invention further provides a preparation method and application of the tea composition, and provides tea soup capable of reducing fat and weight. The obtained tea soup is rich in fragrance, pure in taste and long in aftertaste, and has good lipid-lowering and weight-losing effects.

Described herein are methods and compositions for treatment of diabetes and / or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

The invention belongs to the technical field of new application of medicines, and provides application of hippocampus multi-penis pills in preparation of medicines for improving or treating polycystic ovarian syndrome. In a clinical test, the hippocampus multi-penis pill is applied to a patient with the spleen-kidney yang deficiency type polycystic ovarian syndrome, the treatment effect is remarkable, the ovarian function of the patient can be effectively improved, and the endocrine system and the body metabolism function can be adjusted. Clinical test results show that the hippocampus multi-penis pill has a certain application prospect in preparation of medicines for improving or treating polycystic ovarian syndrome.

Disclosed herein are novel compounds that are antagonists of the human GPR39 protein. Pharmaceutical compositions and methods of use of antagonists of human GPR39 protein are disclosed. In particular, disclosed herein are methods of treating diseases or conditions, including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic disorders, gastrointestinal and liver disorders, hematological disorders, neurological disorders, and respiratory disorders, using the antagonists.

The invention relates to a graphene material with magnetic properties for cleaning contaminated water containing Cr(VI) heavy metal, bisphenol a (BPA), which interferes with the normal functioning of the endocrine system in the body, and disease-causing microorganisms.

The invention relates to a composition with a hypoglycemic effect, and belongs to the field of medicines or health care products. The invention provides a composition with a hypoglycemic effect. The composition is prepared from the following raw materials in parts by weight: 8 to 12 parts of fructus mume, 8 to 12 parts of radix astragali seu hedysari, 8 to 12 parts of radix puerariae, 2.4 to 3.6 parts of lotus plumule, 5.6 to 8.4 parts of fructus gardeniae, 8 to 12 parts of fructus lycii, 5.6 to 8.4 parts of rhizoma dioscoreae and 2.4 to 3.6 parts of radix panacis quinquefolii. According to the traditional Chinese medicine, all the medicines are used together, the upper jiao, the middle jiao and the lower jiao are considered, the effects of tonifying qi and yin, promoting the production of body fluid to quench thirst, nourishing yin and clearing heat are achieved together, compared with a single or simple medicine pair in the literature, all the components can generate more synergistic effects, the chronic endocrine system diabetes is comprehensively treated from multiple aspects, the illness state is more comprehensively improved, and the effect of treating chronic endocrine system diabetes is achieved through the mutual synergistic effects. The curative effect is enhanced, adverse reactions are reduced, and the application range is wider.

The present invention may be an invention that can search for / analyze a disease of interest and / or disease history of a user on the basis of questionnaire information and health records, and recommends customized health functional foods according to the search / analysis results. In addition, the present invention may be an invention that provides support to make it easy to receive posts, SNS posts, etc. registered by other members and share the received posts, SNS posts, etc. with acquaintances. In addition, the present invention may be an invention that can search for various information such as definitions / causes / related functionality / related foods / TIP / TALK, etc. about the disease of interest and supports a service in which location information about searched medical departments is displayed on an electronic map in order of proximity to a user through a location-based service and a search of related medical departments using keywords about age, cardinal symptoms, and accessory symptoms. In addition, the present invention may be an invention that searches and receives recommendations for disease names related to disease factors (nervous system, digestive / metabolic system, reproductive system, muscular system, sensory system, cardiovascular system, endocrine system, immune system, etc.), medicinal ingredients, medicines, types of health functional foods, sales information, etc., and supports purchase information (image, product name, consumer price, discount rate, selling price, quantity) about the searched / recommended health functional foods, and functions related to writing product reviews.

The invention relates to the technical field of biological medicines, and discloses application of rapamycin in preparation of a medicine for protecting male reproductive function from damp-heat stress injury. The invention also discloses application of the rapamycin derivative in preparation of a medicine for protecting male reproductive function from damp-heat stress injury. The rapamycin derivative is everolimus, temsirolimus or defolimus. The invention discloses the new application of the rapamycin in preparing the medicine for treating the damp-heat stress caused by the high-temperature and high-humidity environment for the first time, and the action mechanism of the rapamycin is that the rapamycin inhibits an mTOR (mammalian Target of Rapamycin) pathway and activates cell protective autophagy. Animal experiments show that the rapamycin can significantly improve the testosterone concentration of a damp-heat stress model, effectively recover the protein expression of PDGFRalpha and 3beta-HSD, reverse the development process of damaged testicular interstitial cells, and provide a brand new drug choice with a clear action mechanism for preventing and treating the influence of damp-heat stress on a male reproductive endocrine system.

The present invention relates to a composition with hypoglycemic effect and its preparation method and use, belonging to the field of medicine or health care products. The present invention provides a composition with hypoglycemic effect, which is prepared from the following raw materials in weight ratio: 8-12 parts of black plum, 8-12 parts of astragalus, 8-12 parts of kudzu root, 2.4-3.6 parts of lotus seed heart, 5.6-8.4 parts of gardenia, 8-12 parts of wolfberry, 5.6-8.4 parts of yam, and 2.4-3.6 parts of American ginseng. The present invention also provides a preparation method and use of the composition. The present invention uses all medicines together, taking into account the upper, middle and lower three energizers, and together they have the effects of invigorating qi and nourishing yin, promoting body fluid and quenching thirst, nourishing yin and clearing heat. Compared with the single or simple drug pair in the literature, more synergistic effects may be produced between the components, and chronic endocrine system diabetes is comprehensively treated from multiple angles, and the condition is improved more comprehensively, and the synergistic effects between each other are utilized to enhance the efficacy, reduce adverse reactions, and have a wider scope of application.

The invention discloses a composition for promoting gonad maturation of wild sal-family large yellow croakers and application of the composition, and belongs to the technical field of aquaculture. Through scientific proportioning of gonadotropin releasing hormone (GnRH) or analogues, polypeptide gonadotropin (FSH, LH) and auxiliary hormone (dopamine receptor antagonist), multi-target activation of an endocrine system of wild parent fish is realized, and synchronous maturation of gonads is promoted. Meanwhile, culture environment parameters such as illumination period, water temperature and salinity are optimized, an ecological environment suitable for sexual maturity is built, stress is reduced, the health of the parent fish is guaranteed, efficient, synchronous and safe sexual maturity of the parent fish is achieved, the breeding efficiency and the fry quality are remarkably improved, an artificial breeding technology of the Pseudosciaena crocea of the sal family is promoted to stride towards the scientization, standardization and industrialization direction, and the economic benefit is increased. And sustainable development of marine fishery resource protection and culture industry is promoted.

The invention discloses a bath lotion for male sexual hypofunction and a preparation method thereof, and relates to the technical field of physiotherapy bath lotion. The traditional Chinese medicine shampoo comprises the following raw materials in parts by weight: 40-60 parts of a traditional Chinese medicine composition, 1-1.5 parts of clove essential oil, 5-8 parts of glycerol, 3-5 parts of a ginseng extracting solution, 10-15 parts of a surfactant, 0.2-0.5 part of a thickening agent and the balance of deionized water. The traditional Chinese medicine composition contains various components such as semen cuscutae extract, radix morindae officinalis extract, cornu cervi pantotrichum extract, fructus psoraleae extract, herba epimedii extract, herba cistanche extract, fructus lycii extract and radix angelicae sinensis extract, and the traditional Chinese medicine components can be absorbed through skin and act on an endocrine system or a nervous system of a human body; the effect of improving male sexual hypofunction is achieved.