25 results about "Endocrine system" patented technology

The invention relates to the field of animal consumer goods, and particularly discloses application of glucan in preparation of animal products for relieving pet stress syndromes. Pet experiments find that beta-1, 3 / alpha-1, 3-glucan can improve the stress syndromes of the indoor cats, specifically, abnormal behaviors of the cats are corrected, and abnormity of multiple systems of organisms such as the immune system, the endocrine system and the urinary system is improved. And when the method is applied to pets, the life quality of the pets can be remarkably improved, more emotional support is provided for pet owners, and the method has practical popularization and application values.

Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.

The invention relates to the technical field of data analysis, can be applied to business system platforms of financial science and technology, medical treatment and health and the like, and discloses a human body state characteristic value analysis method, device and equipment and a medium. Performing system state analysis on an endocrine system, a circulatory system and a respiratory system of the user according to the physical examination data to obtain a system state characteristic value set, constructing a physiological index vector and a disease course characteristic vector according to the physical examination data, and constructing a complication incidence matrix according to case data; performing complication association analysis on the user according to the physiological index vector, the disease course feature vector and the complication association matrix to obtain a complication feature value, analyzing a criticality feature value of the user according to a system state feature value set and the complication feature value to obtain a hazard feature value set, and performing weighted summation on the hazard feature value set to obtain a complication feature value set; and obtaining a human body state characteristic value. And the accuracy of human body state characteristic value analysis is improved.

The technology described herein is directed to probiotic microbes engineered to secrete at least one enteroendocrine modulating polypeptide, which can be a sweet protein. In some embodiments, the probiotic microbe secretes the enteroendocrine modulating polypeptide in the distal colon. Also described herein are nucleic acids or vectors comprising a coding sequence for the enteroendocrine modulating polypeptide. Also described herein are compositions comprising the engineered probiotic microbe. Methods of using such probiotic microbes and compositions are also disclosed, including methods for modulating enteroendocrine cells and methods for treating metabolic diseases.

The invention relates to the technical field of biological medicine, and discloses rapamycin-loaded microemulsion gel as well as a preparation method and application thereof. The preparation method of the microemulsion gel comprises the following steps: dissolving N, N-dimethyl octadecyl carboxymethyl chitosan in a water phase, then adding an oil phase, a cosurfactant and rapamycin, and stirring to obtain rapamycin-loaded microemulsion; the preparation method comprises the following steps: dissolving a high polymer material in a PBS solution, heating until the high polymer material is completely dissolved, then adding dopamine, stirring for reaction, and finally dialyzing and freeze-drying to obtain the adhesive. And adding a gel matrix containing a thickening agent and an adhesive into the microemulsion, and stirring to obtain the rapamycin-loaded microemulsion gel. According to the prepared microemulsion gel, transdermal drug delivery of hydrophobic drugs is achieved, testis are coated with the microemulsion gel loaded with rapamycin, the blocking effect of damp-heat stress on differentiation and development of testis interstitial cells can be relieved, and the functionality of a male reproduction endocrine system is recovered.

The invention belongs to the field of traditional Chinese medicines, and provides application of a valerian extract in preparation of a medicine for preventing and treating climacteric syndrome. Pharmacological experiments show that the valerian extract has a regulation effect on a hypothalamic-pituitary-neuroendocrine system, and has important significance in regulating postmenopausal endocrine conditions of middle-aged and old women and improving anxiety, insomnia, dysphoria and other climacteric symptoms related to FSH (follicle stimulating hormone) and LH (luteinizing hormone). In addition, the valerian extract has a good regulation effect on secretion of related sex hormones and hypothalamus neurotransmitters of climacteric rats, and has a certain correction effect on the central monoamine neurotransmitter disorder state of the climacteric rats. The traditional Chinese medicine composition can improve clinical symptoms of climacteric syndrome.

The invention discloses a dynamic intelligent monitoring and early warning system based on endocrine gland functions, and relates to the technical field of endocrine monitoring, and the dynamic intelligent monitoring and early warning system comprises the following steps: obtaining hypothalamus, pituitary and target gland three-layer hormone concentration data, and carrying out timestamp alignment; after wavelet denoising, the deviation degree of each parameter relative to the health baseline is quantified; establishing an original differential equation set to simulate a hormone axis regulation and control relationship, and calculating a hierarchical weight; a fourth-order Runge-Kutta method is adopted to discretely solve a dynamic weight value; fusing the weight and the abnormality to generate a risk index, and dynamically adjusting an early warning line in combination with a hyperbolic threshold function; according to the threshold breakthrough duration and trend, three-level response of data review, targeted monitoring and drug intervention is triggered. According to the method, a hierarchical coupling differential equation is constructed by simulating a multi-stage regulation mechanism of an endocrine system, so that the recognition sensitivity of early signals of endocrine disorder is improved.

Disclosed are novel compounds that are antagonists of the human GPR39 protein. Disclosed are pharmaceutical compositions of antagonists of the human GPR39 protein and methods of use. In particular, disclosed herein are methods of using the antagonists to treat diseases or conditions, including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, blood disorders, neurological disorders, and respiratory diseases.

The present application relates to the field of animal consumer goods, and specifically discloses the use of glucan in the preparation of animal products for relieving pet stress syndrome. Through pet experiments, it is found that beta-1,3 / alpha-1,3-glucan can improve the stress syndrome of room cats, specifically by correcting the abnormal behavior of cats and improving the abnormalities of multiple systems of the body such as the immune system, endocrine system and urinary system. When applied to pets, it can significantly improve the quality of life of pets and provide more emotional support for pet owners, and has practical value for popularization and application.

This invention presents a disposable male hydrogel patch designed to delay ejaculation and prolong erection time while minimizing the impact on sexual pleasure. The patch features an ergonomically designed backing with specific curvatures, a drug-loaded strip divided into central and side zones, and an optional hydrogel coating for sustained drug release. The central zone contains a drug mixture that inhibits the dorsal nerve of the penis, while the side zones promote vasodilation related to erection. The backing includes the adjustment hole for adaptive fitting and is made of a multi-layer composite that integrates breathability, waterproofing, moisture absorption, and fixation. The drug-loaded strip incorporates herbal extracts and synthetic compounds to target the nervous system, vascular system, and endocrine system. Discrete protruding arrays at the coronal sulcus recess enhance drug delivery. This novel, multi-angle approach comprehensively improves sexual function and quality of life, making it a significant innovation in male sexual health.

The invention relates to a method and device for measuring and calculating the physiological age of a human endocrine system, electronic equipment and a storage medium. The method comprises the following steps: acquiring endocrine system indexes of a to-be-detected object, wherein the endocrine system indexes comprise a blood routine detection index, a blood biochemical detection index and a human whole body system scanner detection index of the to-be-detected object; acquiring a physiological age prediction model; and processing the endocrine system indexes by using the physiological age prediction model to obtain a target physiological age of the tested object. A physiological age analysis model is established based on blood endocrine related indexes and human whole body system scanner (eagle model) detection indexes, the physiological age of the human endocrine system is analyzed, and the aging degree of the body endocrine system is evaluated.

In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of a type I serine / threonine kinase receptor of the TGF-beta family and an extracellular domain of a type II serine / threonine kinase receptor of the TGF-beta family. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type II receptor selected from: ActRIIA, ActRIIB, TGFBRII, BMPRII, and MISRII. In some embodiments, the disclosure provides soluble polypeptide complexes comprising an extracellular domain of a type I receptor selected from: ALK1, ALK2, ALK3, ALK4, ALK5, ALK6, and ALK7. Optionally the soluble complex is a heterodimer. In certain aspects, such soluble polypeptide complexes may be used to regulate (promote or inhibit) growth of tissues or cells including, for example, muscle, bone, cartilage, fat, neural tissue, tumors, cancerous cells, and / or cells of hematopoietic lineages, including red blood cells. In certain aspects, such soluble polypeptide complexes can be used to improve muscle formation, bone formation, hematopoiesis, metabolic parameters, and disorders associated with these tissues, cellular networks, and endocrine systems.

Described herein are methods and compositions for treatment of diabetes and / or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

The invention belongs to the technical field of new application of medicines, and provides application of hippocampus multi-penis pills in preparation of medicines for improving or treating polycystic ovarian syndrome. In a clinical test, the hippocampus multi-penis pill is applied to a patient with the spleen-kidney yang deficiency type polycystic ovarian syndrome, the treatment effect is remarkable, the ovarian function of the patient can be effectively improved, and the endocrine system and the body metabolism function can be adjusted. Clinical test results show that the hippocampus multi-penis pill has a certain application prospect in preparation of medicines for improving or treating polycystic ovarian syndrome.

Disclosed herein are novel compounds that are antagonists of the human GPR39 protein. Pharmaceutical compositions and methods of use of antagonists of human GPR39 protein are disclosed. In particular, disclosed herein are methods of treating diseases or conditions, including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic disorders, gastrointestinal and liver disorders, hematological disorders, neurological disorders, and respiratory disorders, using the antagonists.

The invention relates to a graphene material with magnetic properties for cleaning contaminated water containing Cr(VI) heavy metal, bisphenol a (BPA), which interferes with the normal functioning of the endocrine system in the body, and disease-causing microorganisms.

The present invention may be an invention that can search for / analyze a disease of interest and / or disease history of a user on the basis of questionnaire information and health records, and recommends customized health functional foods according to the search / analysis results. In addition, the present invention may be an invention that provides support to make it easy to receive posts, SNS posts, etc. registered by other members and share the received posts, SNS posts, etc. with acquaintances. In addition, the present invention may be an invention that can search for various information such as definitions / causes / related functionality / related foods / TIP / TALK, etc. about the disease of interest and supports a service in which location information about searched medical departments is displayed on an electronic map in order of proximity to a user through a location-based service and a search of related medical departments using keywords about age, cardinal symptoms, and accessory symptoms. In addition, the present invention may be an invention that searches and receives recommendations for disease names related to disease factors (nervous system, digestive / metabolic system, reproductive system, muscular system, sensory system, cardiovascular system, endocrine system, immune system, etc.), medicinal ingredients, medicines, types of health functional foods, sales information, etc., and supports purchase information (image, product name, consumer price, discount rate, selling price, quantity) about the searched / recommended health functional foods, and functions related to writing product reviews.

The invention relates to the technical field of biological medicines, and discloses application of rapamycin in preparation of a medicine for protecting male reproductive function from damp-heat stress injury. The invention also discloses application of the rapamycin derivative in preparation of a medicine for protecting male reproductive function from damp-heat stress injury. The rapamycin derivative is everolimus, temsirolimus or defolimus. The invention discloses the new application of the rapamycin in preparing the medicine for treating the damp-heat stress caused by the high-temperature and high-humidity environment for the first time, and the action mechanism of the rapamycin is that the rapamycin inhibits an mTOR (mammalian Target of Rapamycin) pathway and activates cell protective autophagy. Animal experiments show that the rapamycin can significantly improve the testosterone concentration of a damp-heat stress model, effectively recover the protein expression of PDGFRalpha and 3beta-HSD, reverse the development process of damaged testicular interstitial cells, and provide a brand new drug choice with a clear action mechanism for preventing and treating the influence of damp-heat stress on a male reproductive endocrine system.

The invention discloses a composition for promoting gonad maturation of wild sal-family large yellow croakers and application of the composition, and belongs to the technical field of aquaculture. Through scientific proportioning of gonadotropin releasing hormone (GnRH) or analogues, polypeptide gonadotropin (FSH, LH) and auxiliary hormone (dopamine receptor antagonist), multi-target activation of an endocrine system of wild parent fish is realized, and synchronous maturation of gonads is promoted. Meanwhile, culture environment parameters such as illumination period, water temperature and salinity are optimized, an ecological environment suitable for sexual maturity is built, stress is reduced, the health of the parent fish is guaranteed, efficient, synchronous and safe sexual maturity of the parent fish is achieved, the breeding efficiency and the fry quality are remarkably improved, an artificial breeding technology of the Pseudosciaena crocea of the sal family is promoted to stride towards the scientization, standardization and industrialization direction, and the economic benefit is increased. And sustainable development of marine fishery resource protection and culture industry is promoted.

Described herein are methods and compositions for treatment of diabetes and / or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

A composition containing a combination of at least one fiber and at least one probiotic can be orally administered to a subject in an amount effective to regulate gut bacteria association with cholesterol levels in the blood of the subject. The method can achieve at least one result that is improvement of cholesterol levels in the blood, prevention and / or treatment of cardiovascular, circulatory, endocrine system and / or nervous system conditions and / or diseases.

Described herein are methods and compositions for treating diabetes and / or obesity. Bitter taste oligopeptide molecules formulated for enteral delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract that involve hormones involved in gastric emptying and inhibition of appetite, such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY). As a novel way of treating diabetes with limited side effects, the described invention uses the body's own endocrine system to treat diabetes, which is an advantage over existing therapies that can only provide disease management without a cure or require more aggressive approaches such as surgical intervention.

The application relates to the field of water product muscle quality regulation. A method for improving fish muscle quality by regulating the intestinal microenvironment of a neuroendocrine system, characterized by comprising the following steps: 1) after sterilizing the temporary culture pond, injecting aeration water to 2 / 3 of the height of the temporary culture pond, adjusting the dissolved oxygen in the water to 5.0-8.0 mg / L by using an oxygenator, maintaining the water temperature at 16-24 DEG C, the pH value at 7.2-8.0, and the ammonia nitrogen content below 0.5 mg / L; 2) adding 50-100 mg / L of lactobacillus panis MN047 and 20-50 mg / L of lotus node extract mixture into the water, and stirring to uniformly disperse the mixture; 3) according to the breeding density of 20-30 kg / m 3 Fresh and live freshwater fish is put into the temporary culture pond, and the fish is fasted during temporary culture; 4) temporary culture; 5) waiting in a refrigerator at-80 DEG C; 6) measurement; 7) data analysis. The method can relieve the stress reaction of fish after stress, secrete neurotransmitters, regulate intestinal microbial flora, and then relieve the deterioration of muscle quality caused by stress reaction.

The application discloses a traditional Chinese medicine composition for regulating a brain-gut axis, which is characterized by being prepared from raw medicinal materials in the following proportions by weight: 10-20 parts of marigold, 8-16 parts of day day flower, 6-12 parts of perilla, 4-8 parts of ophiopogon, 2-4 parts of polygonatum, 2-4 parts of dried tangerine or orange peel, 2-4 parts of anemarrhena, 2-4 parts of poria, and 2-4 parts of licorice. According to the mechanism of the brain-gut axis, the traditional Chinese medicine composition can safely and effectively treat diseases of multiple systems such as the digestive system, the nervous system and the endocrine system.

The invention relates to the technical field of medical data processing, in particular to a male reproductive hormone level analysis method and system.The male reproductive hormone level analysis method comprises the following steps that physiological data in the resting state and the motion state are collected, response differences are calculated, metabolic regulation capacity is analyzed, hormone detection intervals are adjusted, hormone abnormality is detected, and an offset relation is constructed; and extracting a ratio trend label, identifying an instability period, establishing a prediction path, and generating a hormone concentration prediction sequence. According to the method, the adaptability of hormone state recognition to individual basic states is achieved by combining metabolic regulation capacity judgment and abnormal interval dynamic adjustment, the expressive power of the overall regulation characteristics of an endocrine system is enhanced by means of multi-hormone migration relation modeling, periodic behavior forms are divided by means of a ratio trend label, and the accuracy of hormone state recognition is improved. According to the method, the typing capability on the change trend of the hormone ratio is improved, and the continuous recognition and dynamic evaluation capability on the change trend of a complex hormone sequence is improved through hopping feature extraction and stable sequence construction.