191 results about "Circulatory system" patented technology

The present invention relates generally to improved systems and methods for removing undesirable material residing in vessels. More specifically, the present invention relates to systems and methods for using at least one cannula to remove substantially en bloc, from a site of obstruction or interest, undesirable material without fragmentation and without excessive fluid loss.

A method of operating an implantable blood pump including connecting the implantable blood pump to a primary controller, the primary controller being configured to operate the implantable blood pump, and a secondary controller. The secondary controller synchronizes its own motor drive signals to a frequency and phase of the primary controller's motor drive signals, without actively contributing power to the implantable blood pump. An imminent or actual disconnection event is detected in which the primary controller is disconnected from the implantable blood pump. Uninterrupted operation of the implantable blood pump is continued with the secondary controller.

The present invention relates generally to improved systems and methods for removing undesirable material residing in vessels. More specifically, the present invention relates to systems and methods for using at least one cannula to remove substantially en bloc, from a site of obstruction or interest, undesirable material without fragmentation and without excessive fluid loss.

The invention discloses an automatic liquid supplementing device used in the TGV electroplating process and an electroplating system and method. The automatic liquid supplementing device comprises an electroplating cavity, an external tank body, a circulating system, a potential applying assembly, a conductivity sensor and a control module. The external tank body is divided into a left cavity (provided with a soluble anode) and a right cavity (communicated with the electroplating cavity) through an ionic membrane, and the cation concentration of the right cavity is the same as that of the electroplating cavity; the potential applying assembly can adjust the potential difference of the left and right chambers according to electroplating working conditions; the conductivity sensor detects the conductivity of the electroplating liquid in real time, the control module determines the cation consumption based on the conductivity, and the flow velocity and potential difference of the circulating system are adjusted in a closed-loop mode. According to the method, automatic, continuous and accurate supplement of positive ions is achieved through the synergistic effect of concentration difference diffusion and potential difference in combination with closed-loop control, the problems that in the prior art, manual supplement is tedious, concentration fluctuation is large, supplement lags behind and the like are solved, and the stability of the electroplating liquid, the TGV hole filling yield and the uniformity of a plating layer are effectively improved.

The utility model provides a nasal cavity irrigation circulation system, and relates to the field of medical instruments. The system comprises at least one flushing pump, at least one suction pump, a flushing pipeline system and a circulating pipeline system, in the flushing mode, the flushing pump pumps first liquid through the first liquid supply pipeline and supplies the first liquid to the nasal cavity on one side, and the suction pump discharges the liquid pumped out of the nasal cavity on the other side to the dirty liquid box through the first discharge pipeline. In the circulation mode, the flushing pump pumps second liquid through the second liquid supply pipeline and supplies the second liquid to the nasal cavity on one side, and the suction pump discharges the liquid pumped out of the nasal cavity on the other side to the circulation box through the second discharge pipeline; through an independent pipeline system in the system, switching between a flushing mode and a circulating mode can be achieved; the problem that in the process that a patient uses circulating equipment, excessive nasal endocrine and attached pathogens of the patient are prone to being attached to the pipeline in the equipment, and the pipeline is not thoroughly disinfected through disinfectant is solved.

This invention relates to the field of biopharmaceutical manufacturing technology, and discloses a BCMA-targeting nanobody, its preparation method, and its application. The nanobody comprises a heavy chain single-domain binding domain, a helical conformation-constrained peptide chain, and an amphiphilic self-assembled polypeptide sequence. The helical conformation-constrained peptide chain forms a steric barrier between the binding domain and the polypeptide sequence through physical length, maintaining the monomeric conformation of the polypeptide sequence in a free state. When the binding domain is anchored at the receptor binding interface, the conformation-constrained peptide chain increases the local effective concentration of the polypeptide sequence within the confined space, inducing intermolecular topological assembly. This invention utilizes a kinetic phase transition mechanism to generate a binding state jump, maintaining the conformational activity of the composition in the circulatory system, reducing off-target toxicity, and prolonging the residence time at the receptor interface.

The invention relates to a preparation method of a placenta trophoblast-derived transporter and application of the placenta trophoblast-derived transporter in a medicine for treating spontaneous abortion, which comprises the following steps of: taking out a placenta of a suckling mouse, cutting the placenta into fine tissue blocks, resuspending by using digestive juice, digesting in a water bath kettle at 37 DEG C for 20 minutes, and then stopping digestion by using 1640 culture containing high-temperature heat-inactivated fetal calf serum; diluting and neutralizing collagenase digestive juice according to 5 times of volume; and centrifuging the collagenase digestive juice for multiple times to obtain a precipitate, namely the exosome. And carrying out density gradient centrifugation on the coarse migration body by using Optiprep as a density medium, washing, precipitating and centrifuging by using PBS on an ultra-high-speed centrifuge by using a horizontal rotor to obtain the placental trophoblast source migration body. The invention finds that the generation of the placental trophoblast cell source migration body is related to the physiological process of pregnancy for the first time, and the placental trophoblast cell source migration body can enter the circulatory system and reach the placenta through in-vitro supplementation.

A piston assembly for a fluid circulation system includes a piston housing separated by a piston (70) into a first chamber and a second chamber. A piston (70) fluidly separates the first chamber from the second chamber and is movable to vary the volume of the first and second chambers. At least one chamber includes two fluid ports spaced apart from each other. When the piston (70) moves to one side of the first chamber, a passage (82a) on the piston communicates the two fluid ports while maintaining a seal of the first chamber from the second chamber. A piston (70) for a piston assembly is also disclosed. A piston (70) provides a bypass passage through the two fluid ports while allowing pressurization of each chamber.

Provided is an extracorporeal circulation system, which includes an arterial sheath, an inflow tube, a handle, an outflow tube, and a venous sheath that are connected in sequence. The arterial sheath is used for connecting to a carotid artery, and the venous sheath is used for connecting to a vein. The handle includes a housing, as well as a flow controller, a blood filter, and a one-way check valve that are arranged in the housing and are communicated in sequence. The flow controller is connected to the end of the inflow tube away from the arterial sheath, and the one-way check valve is connected to the end of the outflow tube away from the venous sheath. The flow controller includes one body element with a flow-through channel and a flow control element. At least part of the flow control element is received in the body element and is movably connected to the flow-through channel. The flow control element reduces or increases the circulation area of the flow-through channel under an external force. Reverse blood flow from the carotid artery to the femoral vein can be established by using the extracorporeal circulation system of the present invention, thereby preventing a falling thrombus from entering the brain during surgery.

The present disclosure features imaging media including a contrast agent encapsulated within a biodegradable nanoparticle matrix. The particles are sized such that they avoid excretion via urinary excretion (e.g., at least 5 nm in diameter) during an imaging procedure or an image-guided procedure. Instead, the particles are predominantly removed from circulation by the reticuloendothelial system of the liver. This results in a buildup of contrast agent in the liver, allowing for a highly specific imaging modality for liver imaging. Further, the bulk of the imaging media is excreted into the bowel, reducing in-vivo toxicity of the imaging media. Finally, because of their size, the nanoparticles of the imaging media have a higher circulation half-life.

A therapeutic compression garment, including: a body portion; and a spine portion, wherein the bands extending from either the body portion and / or spine portion attach the body and spine portions together when the body and spine portions are wrapped around a body limb, and wherein the spine portion is releasably attached onto the body portion such that the spine portion is positionable at different locations on the body portion.

Methods and apparatus disclosed herein relate to graphical representation of patient hemodynamic state. In various embodiments, one or more measured physiological parameters of a patient may be analyzed. Based on the analysis, a graphical user interface (GUI) may be rendered. The GUI may include a figure-eight schematic (222, 1222) that represents a circulatory system of the patient. The figure-eight schematic may include: a first loop (224, 1224) that represents pulmonary circulation of the patient; a second loop (226, 1226) that represents systemic circulation of the patient; and a central object (228, 1228) that connects the first and second loops represents a heart of the patient. In various embodiments, each of the first and second loops includes multiple arc fragments, with each arc fragment being shaped to convey one or more of the measured physiological parameters of the patient.

The invention provides an ART offspring circulatory system defect prediction method and system and a storage medium. The method comprises the following steps: acquiring parental clinical data, gene data and embryo monitoring image data of a to-be-predicted ART offspring; extracting an embryonic development event time node based on the image data, calculating a deviation with a preset standard model, generating a multi-scale space-time distortion parameter matrix, and converting the multi-scale space-time distortion parameter matrix into a development asynchronism scalar; analyzing parental data by using a circulatory system defect related gene-clinical index knowledge graph, constructing a weighted feature network, developing an asynchronous scalar to adjust an edge weight, and calculating initial feature propagation centrality of each node; inputting the space-time distortion parameter matrix into an embryo channel of a double-flow interactive attention network, and inputting the initial feature propagation centrality and other parental clinical data into a parental channel; and fusing the two-channel features through an interactive attention layer to generate context sensing fusion features, and outputting the risk probability of occurrence of circulatory system defects of ART offspring based on the features.

The present application relates to the technical field of peritoneal dialysis, in particular to a multi-bag independent control and intelligent circulation system of peritoneal dialysis equipment. The present application determines the correction residual amount based on the basic backflow residual amount and the basic perfusion residual amount adjusted by the flushing effect of the backflow of waste liquid, and the weight change of each drug liquid bag before and after dialysis circulation and the theoretical ultrafiltration amount. The characteristic correction residual amount is determined based on the state parameter difference of each drug liquid bag dialysis cycle and several dialysis cycles before it. The target flushing amount after each drug liquid bag dialysis cycle is determined based on the characteristic correction residual amount and the concentration gradient difference of the adjacent two circulation drug liquids, and the next drug liquid bag output target flushing amount is controlled to flush the pipeline with the drug liquid, and the generated flushing waste liquid is guided to the previous drug liquid bag to start the next drug liquid bag dialysis cycle. The present application realizes dynamic and accurate quantification of pipeline residual, combines physical correction and personalized habit calibration, and improves the pipeline flushing effect.

Disclosed in the present invention are a disposable continuous oxygenation mechanical perfusion circulation system for ex-vivo organs and a working method. A circulation pipeline of the circulation system is provided with a deoxygenated return line and an oxygenated perfusion line; an output end of a low-temperature organ storage container is connected to the deoxygenated return line, and a pump tube and an oxygenator are arranged in the deoxygenated return line; an organ adapter sleeve assembly is detachably mounted on an organ tray assembly; the organ tray assembly is arranged in a cavity of the low-temperature organ storage container; and an output end of the oxygenator is connected to the oxygenated perfusion line, an automatic bubble separator mounted on the oxygenated perfusion line is connected to an input end of the organ adapter sleeve assembly, and a pressure sensor is mounted on the oxygenated perfusion line. The present invention has the following advantages: the ability to provide an automatic bubble removal function; having an oxygenation function in addition to a low-temperature mechanical perfusion function; being lightweight and being convenient for portable transport of a perfusion apparatus; and having higher safety and reliability.

The invention discloses a novel bismuth-based chelate CT contrast agent and a preparation method and application thereof. The synthesis method comprises the following steps: reacting 2, 6-pyridine dimethyl carbinol with thionyl chloride to obtain 2, 6-bis (chloromethyl) pyridine; the preparation method comprises the following steps: carrying out a heating reaction on 2-(4-methylphenyl)-1, 2, 4-triazine-2-ketone, N, N ', N'-tri (p-toluenesulfonyl) diethylenetriamine and an inorganic base in a solvent, and carrying out concentrated sulfuric acid deprotection to obtain an intermediate pyclen; the preparation method comprises the following steps: heating and reacting pyrene and halogenated carboxylic ester in a polar organic solvent under an alkaline condition, and hydrolyzing to obtain a ligand product; and heating and chelating the ligand product and a bismuth agent to prepare the target bismuth-based chelate. Laboratory large-scale preparation of the small-molecule bismuth-based chelate CT contrast agent is achieved, and the prepared nonionic contrast agent has low osmotic pressure, high stability, high water solubility and good biological safety and is used for CT imaging of digestion, urinary and circulatory systems.

The application discloses application of Gastrodia elata extract in preparation of a feed additive for resisting Aeromonas hydrophila infection, and belongs to the technical field of water animal disease prevention and treatment. The application first finds that the Gastrodia elata extract has a significant effect of inhibiting Aeromonas hydrophila infection. After the Gastrodia elata extract is added into water animal feed as a feed additive and is fed to the water animal, the Gastrodia elata extract is absorbed into blood circulation system through a digestive tract, up-regulates intestinal immunoglobulin gene expression, improves serum immunoglobulin level, enhances intestinal barrier function, improves animal activity, effectively resists Aeromonas hydrophila infection, reduces disease occurrence, and improves yield and quality of animal breeding. Therefore, the Gastrodia elata extract has a good application prospect.

The utility model relates to the technical field of carbon dioxide laser treatment, in particular to a carbon dioxide laser therapeutic instrument which comprises a machine shell, one side of the top end of the machine shell is in threaded connection with a light guide arm, a touch control screen is embedded in the top end of the machine shell, and a laser power source is installed in the machine shell. A control panel is installed in the machine shell and located on one side of the laser power source, and a circulating cooling mechanism is further arranged in the machine shell. The water tank is made of transparent acrylic, the water level of the water tank can be observed through the front window of the machine shell, when water needs to be added, the funnel is inserted into the water inlet, the water filling function is achieved through the funnel, the ventilation valve is arranged on the water tank and has the function of ventilation and watertightness, and the situation that water cannot be injected due to the fact that a water tank circulation system is a closed system is prevented. Meanwhile, drainage can be completed through the water outlet, and the problem that according to an existing therapeutic apparatus, water injection and drainage are not convenient to conduct in a closed water tank in a closed machine box is solved.

A parathyroid gland perfusion preservation device is provided, which relates to the field of human organ preservation technologies. The device includes a parathyroid gland preservation box, a perfusion liquid circulation system and a control system. The parathyroid gland preservation box defines a space for placing parathyroid glands. The perfusion liquid circulation system is connected to the parathyroid glands stored in the parathyroid gland preservation box through inlet pipes, indwelling needles and a reflux pipe to supply perfusion liquid to the parathyroid glands. The control system is electrically connected to components of the perfusion liquid circulation system, and configured to receive a working state signal of the components of the perfusion liquid circulation system, and send a control instruction to the components of the perfusion liquid circulation system according to the working state signal. The device can achieve in vitro preservation of parathyroid glands, and can effectively protect the parathyroid glands.

The invention relates to the field of hardware etching automatic adding, and discloses a hardware etching automatic adding system and a circulation control method thereof.The hardware etching automatic adding system comprises a circulation system and a control system, the circulation system comprises a working cylinder and a sampling box, and liquid medicine circularly flows between the working cylinder and the sampling box; the control system comprises a main controller, a sensor module and a liquid adding pump set, the sensor module is used for detecting the copper ion concentration in the sampling box and the ion concentration and oxidation intensity of hydrochloric acid, the sensor module outputs signals to the main controller, and the main controller controls the liquid adding pump set to pump water, hydrochloric acid and an oxidizing agent into the working cylinder. Therefore, real-time monitoring and accurate adjustment of liquid medicine parameters are realized, and manual intervention and medicine loss are reduced.

This invention proposes an online monitoring method for the quality of traditional Chinese medicine (TCM) extraction, belonging to the field of TCM extraction technology. It addresses the current problem that quality testing in TCM extraction processes largely relies on manual sampling followed by laboratory analysis, which suffers from issues such as discrete sampling, delayed results, and the inability to reflect changes in the extraction process in real time. The method includes: activating the extraction tank circulation system to circulate the herbal solution within a closed pipeline; continuously acquiring spectral data of the herbal solution using a near-infrared spectral probe installed on the circulation pipeline; simultaneously acquiring flow rate, liquid level, and equipment status signals; intelligently identifying clogging events of the extraction tank's side filter or filter based on flow rate and tuning fork switch status, and automatically marking corresponding noise periods; after removing noise data, preprocessing and feature extraction of the effective spectral data, and using the least squares method to fit a continuous trend curve of the content of active ingredients changing over time. This invention achieves real-time quality monitoring of the extraction process, significantly improving the accuracy and reliability of monitoring results.

A method for capturing dislodged vegetative growth during a surgical procedure is provided. The method includes maneuvering, into a circulatory system, a first cannula having a distal end and an opposing proximal end, such that the first cannula is positioned to capture the vegetative growth en bloc. A second cannula is positioned in fluid communication with the first cannula, such that a distal end of the second cannula is situated in spaced relation to the distal end of the first cannula. A suction force is provided through the distal end of the first cannula so as to capture the vegetative growth. Fluid removed by the suction force is reinfused through the distal end of the second cannula. Subsequent to becoming dislodged, the vegetative growth is captured by the first cannula. A method for capturing a vegetative growth during removal of a pacemaker lead is also provided.

The invention discloses a quickly-started fire escape and fire-avoiding cabin and a use method thereof, and relates to the technical field of fire-fighting emergency escape equipment, and the quickly-started fire escape and fire-avoiding cabin comprises an expandable fire-avoiding cabin equipment box body; a fire-avoiding cabin rapid opening supporting assembly, a positive pressure oxygen supply breathing system, a human body breathing waste gas absorption circulating system, an emergency survival material storage assembly, a power battery and a communication lighting system are integrated in the box body. A multi-panel movable unfolding structure is adopted in the fire-avoiding cabin equipment box body, the fire-fighting fire-avoiding cabin is of a foldable structure, and second-level rapid unfolding is achieved through a safety linkage mechanism and an inflation supporting frame. According to the invention, when a building fire escape channel is blocked, a closed safe fire-avoiding space can be quickly built, and by matching with a positive pressure breathing guarantee module, an emergency survival material module and an external communication module, quick risk avoiding, safety protection and long-acting rescue waiting are realized; the device is convenient to store, small in occupied space and capable of being flexibly arranged in various places such as high-rise buildings and residences, and the problems that an existing fire risk avoiding device is slow in unfolding, incomplete in protection and poor in adaptability are solved.

To provide a liquid dispensing head that can stably dispense liquid in a liquid circulation system. [Solution] The liquid discharge head of the embodiment comprises a plurality of pressure chambers communicating with the nozzle, a plurality of upstream resistance passages, an upstream common liquid chamber, an upstream liquid port, a plurality of downstream resistance passages, a downstream common liquid chamber, a downstream liquid port, and a bypass passage. The bypass passage connects the upstream common liquid chamber and the downstream common liquid chamber at the other end of the arrangement direction of the plurality of pressure chambers. The upstream common liquid chamber branches and connects to each of the upstream resistance passages in the order of the arrangement direction of the pressure chambers, and connects to one end of the bypass passage beyond the last upstream resistance passage. At the points where the upstream common liquid chamber branches into the plurality of upstream resistance passages, the inlet of the upstream resistance passage widens toward the downstream side of the liquid circulation flowing through the upstream common liquid chamber.

An embodiment includes a cardioplegia delivery system having a console, controller, and disposables. The console, in conjunction with the disposables, combines blood from the heart-lung machine and crystalloid from the IV-bag in a specified ratio and then adds in a drug (arrest agent and / or additive). The electro-mechanical console incorporates a blood / crystalloid pump, temperature controllable water circulation system, pressure and temperature monitors, a sensor interface with the disposables, an arrest agent pump, an additive pump and ultra-sonic air detection sensors. The system monitors and controls the blood-crystalloid ratio, drug concentration, flow rate, pressure, temperature, and delivery route of the cardioplegia solution delivered to the patient. The system is a software-controlled system with a graphical user interface controller. The controller is utilized to initiate / stop cardioplegia delivery, monitor delivery parameters and view / save relevant case information and data.

The application provides a preparation method of an endothelium matrix vascular prosthesis. The method comprises the following steps: injecting a cell suspension into the inner wall of the vascular prosthesis to adhere, then supplying a culture medium under a perfusion circulation system to simulate an in-vivo vascular environment, so that an endothelium tissue is formed on the inner wall of the vascular prosthesis, and finally, the endothelium tissue vascular prosthesis is subjected to a decellularization treatment to obtain the endothelium matrix vascular prosthesis. The method can provide elasticity and mechanical properties for the vascular prosthesis by using a cell internal growth technology, and meanwhile, the adhesion and growth of cells are induced by using the topological structure of the vascular prosthesis. The method improves the biocompatibility of the vascular prosthesis while performing the endothelium matrix treatment on the vascular prosthesis, and finally, a biological vascular prosthesis with high elasticity, high mechanical strength and high biocompatibility is obtained.

The embodiment of the application discloses a kind of vein bionics microfluidic chip and its preparation and application method of simulating multi-organ interconnection.The chip includes a chip main body, and its microfluid channel system integrates at least three organ simulation units: a lung simulation chamber for culturing lung cells to simulate upstream organs that can produce systemic effects;An upstream colon cancer cell culture chamber for three-dimensional culture of colon cancer cells to simulate tumor primary lesions;And a downstream liver cell culture chamber for three-dimensional co-culture of liver cells and vascular endothelial cells to simulate the target organ of liver, and the three simulation chambers are communicated with each other by a vein bionics microfluid network, which simulates the complex blood circulation system of human body (including pulmonary circulation and systemic circulation), can realize the signal molecule transmission between organs, and simulate the invasion and metastasis process of colon cancer cells to the target organ of liver via the circulatory system after being affected by upstream lung signals.

The application discloses a preparation method of a far-infrared moisture-absorbing and heat-generating blanket, and particularly relates to the technical field of blanket manufacturing, which comprises the following steps: pretreating fiber materials, giving the mixed fibers with far-infrared function, moisture-absorbing and heat-generating treatment of the mixed fibers, weaving the mixed fibers into a fabric, and post-finishing the fabric; the far-infrared moisture-absorbing and heat-generating capability is given to the blanket, after the human body absorbs far-infrared rays, the water molecules in the human body can resonate, the vibration energy level of the water molecules can be activated, and then the blood circulation of the human body can be accelerated; long-term use of the blanket can help to improve the microcirculation system of the human body, enhance metabolism, and improve the immunity of the human body; for example, for some people with weak physique and easy to feel cold in hands and feet, use of the blanket can promote the expansion of peripheral blood vessels, make the body warmer, and enhance the self-regulation ability of the body; the thermal effect of the far-infrared rays can also play a certain physiotherapy role.

The invention belongs to the field of medical instruments, and particularly relates to a DSA bulb tube cooling system which comprises a bulb tube, a cooling oil pipeline, a heat exchanger and an external cooling unit. An original heat exchange part which is directly formed by a water circulation pipeline and a cooling oil pipeline is changed into a heat exchange part I which is formed by the water circulation pipeline, the cooling oil pipeline and a heat exchange pipeline II and a heat exchange part II which is formed by the water circulation pipeline and a refrigerant pipeline, and the refrigerant pipeline is used for carrying out heat exchange cooling treatment on the water circulation pipeline. And after the temperature of the refrigerant is raised through the evaporation box, the refrigerant enters the cooling box through the heat exchange pipeline II to pre-cool the water circulation system at the first time after heat exchange with cooling oil, so that the heat capacity and the heat dissipation efficiency of the system are improved. Meanwhile, the invention further discloses a using method of the DSA bulb tube cooling system, and the normal operation temperature of the DSA bulb tube is maintained.

A system for extracorporeal blood circulation, with an oxygenator (10) comprising a heat exchanger (11) designed to heat or cool blood from a patient's extracorporeal blood circulation; a reservoir (20) designed to store a heat exchange medium and connected to the heat exchanger (11); and a thermoelectric heating / cooling device (14); wherein the thermoelectric heating / cooling device (14) is connected to the reservoir (20) by means of a further heat exchanger (23) and is designed to heat or cool the heat exchange medium in the reservoir (20) by means of the further heat exchanger (23).