25 results about "Heart disorder" patented technology

The invention relates to the technical field of health monitoring, in particular to an electrocardiograph monitoring intelligent diagnosis system based on deep learning and multi-modal fusion technology, which is characterized in that a multi-modal synchronous sensing unit synchronously acquires ECG, PCG and PPG data streams with aligned timestamps, and an edge intelligent diagnosis unit operates a lightweight model with the parameter smaller than 1MB, so that the ECG monitoring intelligent diagnosis system is obtained. The cloud fusion analysis unit is used for dynamically fusing multi-source data by adopting a cross-modal attention mechanism to generate a ventricular fibrillation probability PVF, and the dynamic collaborative decision-making unit is used when R is equal to III or Cilt, and the cloud fusion analysis unit is used for dynamically fusing the multi-source data by adopting a cross-modal attention mechanism to generate a ventricular fibrillation probability PVF; deep diagnosis, PVFgt, is triggered within 5 seconds at 0.9; and when 0.95, a third-level audible and visual alarm is triggered, and the closed-loop optimization unit continuously optimizes the model by distilling and compressing the misdiagnosis sample. According to the intelligent diagnosis system for electrocardiograph monitoring, rapid edge diagnosis is achieved through a lightweight model, critical cases can respond rapidly through cloud cooperation, and the accuracy and timeliness of heart disease diagnosis are improved.

Embodiments of the present disclosure utilize DNNs for ECG interpretation, where original ECG waveforms are directly ingested by the DNNs using paired interpretation labels for training, without the need for explicatory feature extraction or rule-based criteria.

Electrocardiogram-based deep learning for cardiac prediction is described. An electrocardiogram analysis module may include a data preprocessor configured to normalize an electrocardiogram to generate a standardized input for an electrocardiogram-based cardiac prediction. The electrocardiogram analysis module may further include a deep learning model including a neural network and at least one dense layer, the deep learning model trained to identify features associated with a cardiac condition that reflect underlying cardiac changes that result from or predispose development of the cardiac condition, and generate a cardiac prediction based on the identified features.

The disclosure provides systems, methods, and non-transitory computer readable media for non-invasively assessing cardiac pressure and efficiency. An example computer implemented method includes: receiving patient-specific image data of a cardiac chamber of a patient, the patient-specific image data acquired from an imaging modality over a cardiac cycle; receiving patient-specific vitals data; deriving non-invasive cardiac parameters from the patient-specific image data and the patient-specific vitals data; applying the non-invasive cardiac parameters to a trained model to generate: a total energy output for blood flow out of the cardiac chamber during the cardiac cycle, and a total energy input for blood flow into the cardiac chamber during the cardiac cycle; and generating, in real time, based on a ratio of the total energy output to the total energy input, a patient-specific cardiac efficiency value for the cardiac chamber, the patient-specific cardiac efficiency value classifying a severity of a heart disease of the patient.

Methods and apparatuses, including devices and systems, for remote and detection and / or diagnosis of acute myocardial infarction (AMI). In particular, described herein are handheld and adhesive devices having an electrode configuration capable of recording three orthogonal ECG lead signals in an orientation-specific manner, and transmitting these signals to a processor. The processor may be remote or local, and it may automatically or semi-automatically detect AMI, atrial fibrillation or other heart disorders based on the analyses of the deviation of the recorded 3 cardiac signals with respect to previously stored baseline recordings.

Systems, methods and associated devices for locking a tensioning element, such as a bridging element, suture, wire or string, during a medical procedure, such as placement of a medical implant in a subject are provided herein. The systems, methods and devices described herein are particularly useful for delivery and deployment of heart implants for reshaping a heart valve annulus for treatment of a heart disorder, such as mitral valve regurgitation.

A method of treating or preventing a heart condition selected from the group consisting of acute myocarditis and acute pericarditis in a human subject in need thereof, the method comprising administering an effective amount of cannabidiol (CBD) to the subject.

Disclosed is a method of characterizing a cardiac lesion using an image comprising: a black blood image generated from signals acquired during black blood late gadolinium enhanced magnetic resonance acquisition (ACQ1); a bright blood image is generated from signals acquired during bright blood late gadolinium enhanced magnetic resonance acquisition, the bright blood acquisition step (ACQ2) being different from the inversion recovery sequence. The method comprises: computer segmenting the bright blood image to generate localization data defining a set of at least one wall of the cardiac muscle; the computer extracts the set of at least one wall characterizing a cardiac lesion from the set of at least one wall defining the myocardium from the positioning data of the set of at least one wall according to the black blood image and the positioning data.

The application discloses a biomarker, a kit and application for diagnosing ventricular repolarization prolongation caused by cold exposure, and comprises one or more of the following applications: A1) application in preparing a product for diagnosing ventricular repolarization prolongation caused by cold exposure; A2) application in preparing a product for screening ventricular repolarization prolongation caused by cold exposure; A3) application in preparing a product for treating ventricular repolarization prolongation caused by cold exposure; A4) application in preparing a product for evaluating ventricular repolarization prolongation caused by cold exposure; A5) application in preparing a product for distinguishing ventricular repolarization prolongation caused by cold exposure from other heart diseases; and the miRNA marker is hsa-miR-125b-5p, and the nucleotide sequence is shown as SEQ ID No. 1. The expression amount of the hsa-miR-125b-5p marker provided by the application in the plasma of a ventricular repolarization prolongation caused by cold exposure group is significantly higher than that of a control group, has good diagnostic efficiency for ventricular repolarization prolongation caused by cold exposure, and indicates that the hsa-miR-125b-5p is a potential biomarker for ventricular repolarization prolongation caused by cold exposure.

The invention belongs to the field of gene drugs, and particularly relates to snoRNA Gm25215 as well as a simulant and application thereof. The invention further discloses the application of the snoRNA Gm25215 serving as the biomarker in preparation of a product for detecting myocardial cell ferroptosis or DIC. When doxorubicin cardiotoxicity occurs, the snoRNA expression activity is increased, so that the application of the snoRNA as a biomarker in preparation of detection products is provided. According to the characteristics of the snoRNA, the snoRNA is named as FERSNO, ferroptosis of myocardial cells is remarkably inhibited by knocking down the FERSNO, the FERSNO simulant and the application of the FERSNO simulant in preparation of drugs for preventing and / or treating heart diseases are provided, the FERSNO simulant is preferably an FERSNO inhibitor, and the application of the FERSNO simulant in preparation of drugs for preventing and / or treating heart diseases in preparation of drugs for preventing and / or treating heart diseases in preparation of drugs for preventing and / or treating heart diseases in preparation of drugs for preventing and / or treating heart diseases in preparation of drugs for preventing and / or treating heart diseases in preparation of drugs for preventing and / or treating heart diseases in preparation of drugs for preventing and / or treating heart diseases in preparation of drugs for preventing and / or treating heart diseases. The reduction of FERSNO expression effectively alleviates the problems of poor prognosis of patients with doxorubicin cardiotoxicity and heart disease treatment. The nucleotide sequence of the FERSNO is as shown in SEQ ID NO. 1.

The invention relates to cellular microcompartments, each microcompartment successively comprising the following layers, which are organised around at least one lumen: —at least one inner layer of human cells undergoing cardiac differentiation, expressing at least one gene chosen from PDGFRα, MESP-1, NKX2-5, GATA4, MEF2C, TBX20, ISL1 and TBX5, —at least one intermediate layer of isotonic aqueous solution, and—at least one outer hydrogel layer. The invention also relates to the cardiac tissues obtained from said microcompartments and the use thereof, particularly in the treatment of heart disease.

The garment suitable for hosting a management and functioning logic and sensors / electrodes positioned in predetermined areas of the human body suitably is stabilized by the innovative characteristics of the garment itself and aimed at visualizing the state of health of the heart muscle. The sensors feature a new type of layout in order to minimize artifacts during vectorcardiogram generation. The entire apparatus communicates in real time with the Internet and exploits the architectures of Artificial Intelligence in order to improve the predictive performance of any heart disease.

A system for processing electrocardiogram (ECG) signals is disclosed. A receiving module receives ECG signals corresponding to at least one channel. The ECG signal for each channel includes a plurality of beats. A beat processing module, for each channel: calculates an instantaneous heart rate (IHR) for each beat; forms a plurality of beat groups from the plurality of beats, each beat group including a set of beats of the plurality of beats; calculates an average heart rate (AHR) for each beat group based upon the IHR of the set of beats; and generates a representative beat for each beat group based upon the set of beats. A feature extraction module extracts, for each channel, a set of features based upon the plurality of representative beats. A classifier generates an indicator indicating a risk associated with a cardiac disease based upon the set of features for the at least one channel.

An information processing system (1) according to an embodiment comprises a determination unit (102) that inputs pulse information relating to the heartbeat of a subject and attribute information pertaining to the subject to a trained model and thereby generates a determination result indicating the presence / absence and the degree of heart disease in the subject. The trained model is trained using, for a plurality of providers who provide training data, pulse information relating to the heartbeat of the provider, attribute information pertaining to the provider, and diagnosis information indicating the state of cardiac function of the provider.

The application discloses functions and application of lysine-deficient protein kinase 2 inhibitors in inhibiting ventricular remodeling, and belongs to the field of gene functions and application.The application determines the interrelation between the expression of WNK2 and ventricular remodeling, and the research result shows that in a model of pathological ventricular remodeling, the expression of WNK2 is significantly higher than that of a normal group;inhibition of WNK2 expression significantly reduces ventricular remodeling including myocardial hypertrophy, fibrosis and heart function reduction, and promotion of WNK2 overexpression significantly aggravates the ventricular remodeling process and worsens heart function.WNK2 can be used as a drug target for screening drugs for protecting heart function, resisting myocardial fibrosis and / or preventing, relieving and / or treating ventricular remodeling and related heart diseases, and an inhibitor of WNK2 can be used for developing drugs for protecting heart function, inhibiting ventricular remodeling and preventing, relieving and / or treating diseases related to ventricular remodeling, thereby providing an effective new approach for clinical treatment of ventricular remodeling.

Method and apparatus for performing automatic cardiac diagnosis. The apparatuses described herein may be handheld devices which enables self-recording of cardiac signals by the patient, including entering relevant data by patients regarding their cardiac history, including cardiac disease risk factors, and / or current conditions and symptoms. Based on recorded cardiac signals, cardiac risk factors and the current symptoms, the apparatus may calculates a cardiac risk score and may provide simplified diagnostic information and actionable instructions to the patient.

The invention discloses an in-aorta catheter and a ventricular assist device, and belongs to the technical field of medical instruments. The catheter in the aorta comprises a multi-cavity catheter body, a first cavity and a second cavity which are isolated from each other are arranged in the catheter body, a blood inlet is formed in the proximal end of the first cavity and communicated with blood in the aorta, and medium fluid flows in the second cavity and is not communicated with the blood. A bleeding part is arranged on the multi-cavity tube body and comprises a bleeding hole formed in the tube wall and a bag-shaped film located on the side, close to the heart, of the bleeding hole. When the thin film is in the first state, the thin film is not filled with the medium and covers the sealed bleeding hole, and when the thin film is in the second state, the filled medium bulges and opens the bleeding hole to enable blood to flow out. The ventricular auxiliary device further comprises a diaphragm pump and a control host, and the control host drives the diaphragm pump to suck or pump blood and controls the saccular film to expand or contract. Accurate control of blood flow is achieved through the controllable bag-shaped thin film, and effective auxiliary circulation support is provided for patients with heart diseases.

A system for diagnosing a heart condition comprises an imaging system (102) arranged to acquire two images of the heart at respective points in the cardiac cycle, and locating means, which may be manually operated or automatic, for locating a series of pairs of points on the images. Each pair of points indicates the respective positions of a single part of the heart in the two images. The system further comprises a processor (108) arranged to calculate from the positions of said pairs of points a value of at least one parameter of the deformation of the heart. It may further be arranged to compare the value of the at least one parameter with reference data to generate a diagnostic output.

The application provides a heart state risk prediction model training system, which comprises a data acquisition and preprocessing module, a multi-modal data adaptive fusion module, an attention mechanism-based deep prediction network and a risk prediction and visualization output module. The data acquisition and preprocessing module is used for acquiring multi-modal physiological signal data and preprocessing the data. The multi-modal data adaptive fusion module is used for receiving the preprocessed multi-modal physiological signal data, adaptively weighting and fusing the features of different modalities through a gating fusion mechanism and outputting a fused feature vector. The attention mechanism-based deep prediction network is used for receiving the fused feature vector, extracting time sequence features through a hybrid neural network and outputting a heart disease risk probability. The risk prediction and visualization output module is used for converting the heart disease risk probability into an understandable risk level and visually displaying the risk level. In the above technical solution, the individual differences of different populations and long-term health monitoring requirements are met.

Cardiac conditions such as valvular regurgitation can be treated using implantable clip devices. Some clip devices include two or more separate clips that, after individual attachment to native valve leaflet portions, are then coupled to each other. The finished arrangement can serve to maintain leaflet portions that are held in or near coaptation with each other by the clips.

Cardiac conditions such as valve regurgitation can be treated using implantable clip devices. Some clip devices include two or more separate clips, which are individually attached to the natural valve leaflets and then connected to each other. The completed placement can serve to maintain the valve leaflets held in close or near-close contact with each other by the clips.

A method of machine-assisted setting up of a procedure for tricuspid valve implantation in a patient with a heart, comprising: (a) identifying a conduction system location on an image data set of said heart, said image acquired using data collection from outside the heart; and (b) providing machine-assisted guidance of a tricuspid valve implantation and / or selection based on a risk to the conduction system from valve implantation.

The present disclosure describes a composition comprising vitamin C, vitamin E, zinc, copper, lutein, zeaxanthin, and coenzyme Q10, and any of the pharmaceutically acceptable salts thereof.The composition is useful in methods for treating conditions associated with vision loss, including age-related macular degeneration, and for supporting heart health.

Systems and methods are provided for selecting a patient for intervention relating to genetically predicted lipoprotein (a) (“Lp(a)”) levels. A method may obtain or having obtained a biological sample from the patient. A method may perform or having performed sequencing on the biological sample, comprising. A method may acquire reads for the patient. A method may mask at least one portion of a gene LPA at a reference genome to facilitate alignment of the reads to a reference genome. A method may determine a pseudocount of copy number within the gene LPA at a genome of the patient. A method may in an event that the pseudocount is not an expected amount, selecting the patient for the intervention. A method may in an event that the pseudocount is an expected amount, omitting selection of the patient for the intervention.

The embodiment of the invention relates to the technical field of electric stethoscopes, in particular to a device for collecting heart sounds, the heart sounds of parts needing to be collected are collected by arranging a plurality of heart sound collecting pieces, so that the heart sounds of a plurality of areas of a plurality of hearts can be obtained at the same time, the situation that the heart sounds reflecting abnormal heart sounds are omitted is avoided, and the states of the hearts are obtained in real time. According to the heart sound collecting device, the multiple heart sound collecting pieces are arranged on the supporting piece, and the positions of the heart sound collecting pieces on the supporting piece can be adjusted, so that when the supporting piece is arranged on the heart of a patient, the relative positions of the heart sound collecting pieces and the heart can be adjusted, and the positions of the heart sound collecting pieces can be adjusted according to the heart positions of different patients; therefore, the heart sound accuracy is improved. The signal analysis part is in communication connection with the multiple heart sound collection parts and used for receiving, analyzing and processing the signals from the heart sound collection parts so that abnormal information in the heart sound signals can be conveniently extracted, and a doctor can accurately and objectively diagnose whether a patient has heart diseases or not.