Carbon-11 labeled N-methyldopamine hydrochloride and preparation method thereof

Abstract

The invention relates to a radioactive compound labeling technology in the field of positron imaging agents, in particular to a method for synthesizing carbon-11 labeled N-methyldopamine hydrochloride. The preparation method comprises the following steps of: A, fully reacting 200 to 300mCi of carbon-11 methyl iodide (II) with 3 to 6mg of dopamine hydrochloride (III) dissolved and neutralized by excessive 0.1mol/L sodium bicarbonate solution at the temperature of between 70-85DEG C, and cooling to room temperature to obtain reaction liquid; and B, blowing the reaction liquid in the step A to dryness, separating, collecting a substance with a radioactive component, wherein the radioactive component is the carbon-11 labeled N-methyldopamine hydrochloride (I). The carbon-11 labeled N-methyldopamine hydrochloride has strong affinity with a dopamine transporter and a norepinephrine transporter, can early discover the change of cardiac sympathetic nerves, and provides a strong evidence for early diagnosis and treatment of heart disease; and the preparation method is simple and practicable, good in repeatability, low in synthetic cost and stable in yield.

Description

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AI Technical Summary

Benefits of technology

This patented method allows for better detection of abnormalities associated with specific neurotransmitters called adrenal medulla or vasospinal cord receptors. It involves injecting certain substances into these tissues through small holes made in their skulls during surgery under conscious control from outside the body. These substance molecules have been labelled with different types of dyes like fluorescein, rhodopsin, cyanines, etc., allowing them to become visible when exposed to light at appropriate wavelengths. By measuring changes caused by these compounds, researchers may diagnose and treat disease more accurately without invasive procedures.

Problems solved by technology

This patented technical problem addressed in this patents relates to developing new compounds capable of detecting specific substances related to neuronal functions during normal or abnormal processes associated with inflammations caused by stress stimuli. These novel chemical entities should ideally provide superior sensitivity and accuracy compared to existing techniques.

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