The invention discloses application of a miR-6809-5p inhibitor, and belongs to the technical field of biological
medicine.The inventor finds that expression of miR-6809-5p in
plasma of a PD patient is abnormally increased in the research of PD
pathogenesis, and further
cell experiments find that the expression of miR-6809-5p is abnormally increased in the
plasma of the PD patient. By inhibiting the expression of the miR-6809-5p, the adverse effects of MPP + on
cell viability,
apoptosis, ROS, p-alpha-syn and TH
protein can be effectively improved, and the miR-6809-5p has a remarkable
treatment effect on PD. MPP + is an
active metabolite of
neurotoxin MPTP, can be selectively absorbed by
dopaminergic neurons through
dopamine transporter (DAT)
protein to trigger degeneration death of the
dopaminergic neurons, and is widely applied to construction of PD
cell models to research
pathogenesis of PD and
drug evaluation. The miR-6809-5p inhibitor disclosed by the invention is used for preparing a
medicine for treating the Parkinson's
disease, and the
nucleotide sequence of the miR-6809-5p inhibitor is as follows: UGAUCCUUUCUUUCCUUGCCA.