43 results about "Single photon emission" patented technology

This invention discloses a radioactive molecular probe for targeting CSPG4 / NG2, its preparation method, and its application. The radioactive molecular probe comprises the structure shown in Formula I or Formula II. The technical solution of this invention uses a radioactive molecular probe to specifically recognize CSPG4 / NG2 in vivo through the target polypeptide portion, thereby achieving specific nuclear medicine positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging diagnosis of CSPG4 / NG2 positive tumors or CSPG4 / NG2 positive lesions, such as autoimmune diseases and cardiovascular and cerebrovascular diseases, thereby realizing early diagnosis and efficacy evaluation of malignant tumors.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

1. The name of the design product: single photon emission and X-ray computed tomography system. 2. The use of the design product: functional and structural imaging, a nuclear medicine molecular imaging device integrating SPECT / CT multiple modalities three-dimensional medical image imaging and processing functions. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

1. The name of the design product: Single photon emission and X-ray computed tomography system host shell. 2. The use of the design product: used as a single photon emission and X-ray computed tomography system host shell. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to a deviation acquisition method and device of a single photon emission computed tomography system, equipment and a medium, which can improve the deviation estimation accuracy of the system. The method comprises the following steps: controlling a target object to move to a first target position through a translation stage, and determining an actual detection position of the target object recognized by a system probe under a current pose; obtaining a first expected pose deviation; the first expected pose deviation represents the deviation between the expected pose and the current pose of the system probe; determining an expected detection position of the target object according to the first target position and the first expected pose deviation, and obtaining a first position difference between the expected detection position and the actual detection position; and according to the first position difference corresponding to each first expected pose deviation, determining the actual pose deviation between the expected pose and the current pose of the system probe.

Disclosed are electrically driven single-photon emitters and their fabrication methods. The single-photon emitter comprises a substrate, an active layer on the substrate, a spacer between the substrate and the active layer, a first electrode connected to the active layer, and a second electrode between the substrate and the spacer and vertically spaced apart from the active layer across the spacer. The substrate includes a deformable polymer. The substrate has a first dent where a portion of a top surface of the substrate is concavely recessed. The active layer has a second dent at a position which is aligned with the first dent and where a portion of a top surface of the active layer is concavely recessed.

The present invention provides a compound as represented by formula I or a pharmaceutically acceptable salt, precursor compound, isotope compound, stereoisomer or tautomer thereof. The compound has high affinity and strong targeting specificity for melanoma, low non-specific uptake in livers and kidneys, and a high tumor / non-tumor ratio. In addition, the probe precursor of the present invention can selectively chelate different radioactive diagnostic or therapeutic nuclides, and is used in single-photon emission computed tomography for early diagnosis of major diseases such as malignant tumors and Parkinson's disease, guiding the selection of a treatment regimen, efficacy monitoring, and radioactive therapy. The compound is simple to synthesize, has easily available raw materials and good stability, and can be promoted and applied as a novel melanoma-targeted radiopharmaceutical.

The invention provides a compound shown as a formula I, or a pharmaceutically acceptable salt thereof, or a precursor compound and an isotope compound thereof, or a stereoisomer and a tautomer thereof. The compound has high affinity with melanoma, strong targeting specificity, low non-specific uptake in liver and kidney, and high tumor / non-tumor ratio. Besides, the probe precursor can be selectively chelated with different radioactive diagnosis or treatment nuclides, and is used for early diagnosis of malignant tumors, Parkinson's diseases and other major diseases through single photon emission computed tomography, and guidance of treatment scheme selection, curative effect monitoring and radioactive treatment. The compound has the advantages of simple synthesis, easily available raw materials and good stability, and can be popularized and applied as a novel melanoma targeted radiopharmaceutical. # imgabs0 #

The application provides a polarization single photon source based on an anisotropic Dirac cavity, and relates to the technical field of solid-state single photon sources.The polarization single photon source based on the anisotropic Dirac cavity comprises: an anisotropic Dirac microcavity, which comprises: a C6 symmetry broken cavity photonic crystal located on the inside; a C6 symmetry cladding photonic crystal surrounding the outside of the C6 symmetry broken cavity photonic crystal; and a quantum dot coupled with the anisotropic Dirac microcavity to realize the deterministic emission of linearly polarized single photons.In the application, a single InAs / GaAs quantum dot is coupled with an anisotropic Dirac photonic crystal microcavity, the polarization selection Purcell enhancement effect of the microcavity is utilized, the deterministic single photon emission with high linear polarization degree and high single photon purity is realized, and the application can be used as a core quantum bit carrier in the fields of quantum communication, quantum calculation and quantum precision measurement.

A method for performance by a controller, that comprises selecting, based on a received heralding signal, a comb spectral mode of a frequency comb 204; and causing, based on the selection, a reconfigurable mode selection apparatus 206 to permit the selected comb spectral mode 210 to be incident on a non-linear photonic element 212; wherein the received heralding signal is representative of the detection of a first photon 106 of a frequency-correlated photon pair 110, the heralding signal indicating a frequency of the heralded second photon 108 of the frequency-correlated photon pair from among a plurality of possible frequencies; and wherein the non-linear photonic element 212 is further arranged to receive the heralded second photon 108 and to produce an output photon 214 having a frequency based on the frequency of the heralded second photon 108 and the selected comb spectral mode 210; and wherein, in the event of a contemporaneous detection of two frequency-correlated photon pairs, selecting a comb spectral mode that complements the heralded second photon of the two heralded second photons for which the non-linear photonic element 212 has a greater conversion efficiency.

The application discloses a kind of two-way spin angular momentum and momentum direction controllable single photon emitter and method thereof.The application independently controls the spin angular momentum of emitting photon by the internal structure of each nano scattering unit, and is irrelevant to the phase of scattered light;The momentum direction of emitting photon is controlled by the position of each nano scattering unit, and is related to the phase of scattered light, two kinds of control do not affect each other, and the control of the spin angular momentum and momentum direction of emitting photon can be independently designed;Two sets of super surface structures corresponding to two emitting photons are combined to form a two-way single photon emitter, and single photon emission is realized, and the spin angular momentum and momentum direction of each emitting photon can be independently controlled by the corresponding super surface structure;The maximum emission angle can reach 53°, and the phase-independent scheme makes the spin angular momentum insensitive to the accurate position of single photon source relative to the super surface, so high-precision single photon source positioning and alignment technology is no longer needed.

For dosimetry, a miniaturized nuclear imaging system with a solid-state detector is used to determine the activity and / or injected dose of radiopharmaceuticals. By being sized to scan a syringe or vial, the solid-state detector can be used to determine the injected dose with higher accuracy than current dose calibrators and with less frequent use of calibration or normalization sources. The miniaturized nuclear imaging system reconstructs activity in the same way as a nuclear imaging system that scans patients, and therefore can be used to calibrate a dose model. A tissue mimicking phantom with a solid-state dosimeter measures the dose from a radiopharmaceutical that is used to calibrate the dose model.

The utility model relates to a single photon emission tomography device. The single photon emission tomography device comprises a rack; the first probe module comprises a first driving mechanism, a first rotary table and a first probe, the first rotary table is rotationally connected to the rack, and the first probe is connected to the first rotary table; the second probe module comprises a second rotary table and a second probe, the second rotary table is rotationally connected to the rack, and the second probe is connected to the second rotary table; the first driving mechanism is used for driving the first probe to move in the first direction, the second direction and the third direction and is used for driving the first rotary table to rotate around the axial direction of the rack, any two of the first direction, the second direction and the third direction are perpendicular, and one of the directions is the axial direction of the rack. The single photon emission tomography equipment can have a larger axial scanning visual field, so that the scanning requirement of a larger axial size is met, the number of times of moving a sickbed in the scanning process is reduced, the scanning process is simplified, and the scanning time is shortened.

A method for performance by a controller, that comprises selecting, based on a received heralding signal, a comb spectral mode of a frequency comb 204; and causing, based on the selection, a reconfigurable mode selection apparatus 206 to permit the selected comb spectral mode 210 to be incident on a non-linear photonic element 212; wherein the received heralding signal is representative of the detection of a first photon 106 of a frequency-correlated photon pair 110, the heralding signal indicating a frequency of the heralded second photon 108 of the frequency-correlated photon pair from among a plurality of possible frequencies; and wherein the non-linear photonic element 212 is further arranged to receive the heralded second photon 108 and to produce an output photon 214 having a frequency based on the frequency of the heralded second photon 108 and the selected comb spectral mode 210; and wherein, in the event of a contemporaneous detection of two frequency-correlated photon pairs, selecting a comb spectral mode that complements the heralded second photon of the two heralded second photons for which the non-linear photonic element 212 has a greater conversion efficiency.

The preparation method of the AlGaN-based cation vacancy defect single-photon emission source of the present invention belongs to the fields of semiconductor technology and quantum information technology. Through group theory analysis combined with first-principles calculations, it is confirmed that the neutral cation vacancy of AlGaN is suitable for single-photon emission. The specific implementation includes the following key steps: p-type AlGaN growth, preparation of cation vacancies by surface electron irradiation, pulsed laser irradiation and other methods combined with nitridation treatment and thermal annealing treatment. The present invention also provides an AlGaN-based cation vacancy defect single-photon emission source prepared by the above method. The present invention provides an optional single-photon source solution for the field of quantum communication, and at the same time has guiding significance for the design of single-photon sources based on semiconductor material defects. The process is simple, the industrial preparation method of the semiconductor material AlGaN on which it is based is mature, the photon energy is suitable for low-loss propagation in optical fibers, and it has broad application prospects.

For single photon emission computed tomography (SPECT) detectors, embedded capacitive material (ECM) is used in printed circuit boards (PCB) with semiconductor detectors. High voltage (HV) filtering and / or blocking capacitors are formed from ECM. ECM is less disruptive to radiation or emissions to be detected by the semiconductor detectors compared to surface mounted capacitors.

Direction estimation for radioactive source localization in single photon emission computed tomography. For radioactive source positioning, the SPECT system uses a spectral, low spatial resolution detector to position a (first) point of interaction (POI) within a 3D detector sensor material ("3D detector" or "3D spectral detector"), which in turn can be used to estimate the general direction of the emission source. By detecting the depth of the 3D POI and emissions within a specified energy range, the processor may determine a direction toward the source. Shielding is not required, since detected emissions from other directions may be discarded. Different shields may be used to assist in directivity determination, such as different thickness profiles or material types of detector sides, allowing directional determination by strength.

This application relates to a motion control method, device, medical scanning system, and storage medium for a probe. The motion control method includes: planning the distribution of path points in the initial motion path of the probe based on the posture information of the object being detected and a preset scanning range; determining a path optimization target corresponding to the preset scanning parameters; adjusting the path parameters of each path point in the initial motion path according to the path optimization target, so that the target motion path corresponding to the adjusted path parameters satisfies the path optimization target; and controlling the probe to move relative to the object being detected during scanning in a single-photon emission computed tomography (SPECT) system according to the target motion path to obtain detection data. This method can combine the posture information of the object being detected and the scanning requirements to achieve accurate and satisfactory motion path planning and adjustment, thereby reducing the application difficulty of motion planning.

Systems and methods for generating synthetic computed tomography (CT) images, such as generating synthetic time-resolved four-dimensional CT or single-photon emission CT images of the human respiratory system, are described. Generating a synthetic CT image includes processing at least one output from a physics-based lung simulation model in combination with at least one generative learning model. The output from the physics-based lung simulation model provides additional information that improves clinical decision-making without additional patient exposure to radiation-intensive imaging procedures.

The present disclosure relates to a deviation acquisition method for a single-photon emission computed tomography system, which includes: controlling a target object to move to a first target position through a translation stage, and determining an actual detection position of the target object detected by a system detector in a current pose; obtaining at least one first expected pose deviation; determining at least one expected detection position of the target object based on the first target position and the at least one first expected pose deviation, and obtaining at least one first position difference between the at least one expected detection position and the actual detection position; and determining an actual pose deviation between the expected pose and the current pose of the system detector based on the at least one first position difference corresponding to the at least one first expected pose deviation.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

Methods of fabricating single photon emitters (SPEs) including nanoindentation of hexagonal boron nitride (hBN) host materials and annealing thereof, devices formed from such methods, and chips with a single photon emitter. A substrate with a layer of hBN is provided. Nanoindentation is performed on the layer of hBN to produce an array of sub-micron indentations in the layer of hBN. The layer of hBN is annealed to activate SPEs near the indentations. Devices include a substrate with an SPE produced in accordance with the methods. Chips include a substrate, an hBN layer, and an SPE including an indentation on the hBN layer, in which the substrate is not damaged at the indentation.

A method for determining a single-photon emitter based on deep learning, performed by at least one electronic device, may include: acquiring input data based on a single-photon point light source image; generating determination information expected values by inputting the input data to a trained artificial neural network model; and determining whether an emitter providing the single-photon point light source image is a single-photon emitter or a non-single-photon emitter, based on the determination information expected values.

The present invention discloses a three-way single-photon emitter with controllable spin angular momentum and momentum direction, and a method thereof. The present invention independently controls the spin angular momentum of the emitted photons through the internal structure of each nano-scattering unit, in a scheme that is independent of the scattered light phase; controls the momentum direction of the emitted photons through the position of each nano-scattering unit, in a scheme that is dependent on the scattered light phase. Since these two schemes do not affect each other, the control of the spin angular momentum and momentum direction of the emitted photons can be independently designed; two sets of metasurface structures corresponding to the three-way emitted photons are combined in a set manner to form a three-way single-photon emitter, which can realize three-way single-photon emission, and the spin angular momentum and momentum direction of the photons emitted in each path can be independently controlled; the emission angle can reach a maximum of 53°, and the phase-independent scheme makes the spin angular momentum insensitive to the precise position of the single-photon source relative to the metasurface, eliminating the need for high-precision single-photon source positioning and alignment technology.

To correct motion in Single Photon Emission Computed Tomography (SPECT) imaging, additional modality information is used to depict different regions in a patient. Motion is determined in these different regions as reflected in the SPECT data. These region motions are used for motion correction. Statistical measurements of SPECT data for different regions may be used to weight region motion.

The invention discloses a single-photon water body attenuation coefficient measuring instrument and a measuring method. The single-photon water body attenuation coefficient measuring instrument comprises a single-photon emission source, a telescopic measuring tube and a single-photon counter, the telescopic measuring pipe is provided with a containing cavity used for containing a tested water body, a first water inlet hole communicated with the containing cavity and used for discharging the tested water body and a first water outlet hole communicated with the containing cavity and used for discharging the tested water body, and a first light inlet window and a second light inlet window which are oppositely arranged are arranged on the two sides of the containing cavity. The single-photon emission source is arranged on the outer side of the first light-transmitting window; the single-photon counter is arranged on the outer side of the second light-transmitting window, and the single-photon emission source, the telescopic measuring tube and the single-photon counter are all arranged in the camera obscura. The single photon source is adopted to measure the attenuation coefficient of the water body, pure water calibration is not needed any more, and the use convenience of the instrument is improved.

Systems and methods for generating synthetic computed tomography (CT) images, such as generating synthetic time-resolved four-dimensional CT or single-photon emission CT images of the human respiratory system, are described. Generating a synthetic CT image includes processing at least one output from a physics-based lung simulation model in combination with at least one generative learning model. The output from the physics-based lung simulation model provides additional information that improves clinical decision-making without additional patient exposure to radiation-intensive imaging procedures.

The application belongs to the technical field of medical imaging, and provides a single photon emission computed tomography image correction method and device, electronic equipment and storage medium, wherein the method comprises: acquiring multi-energy window scanning data obtained through single photon emission computed tomography, wherein the multi-energy window scanning data comprises main energy window scanning data and at least one scattering window scanning data; reconstructing a main energy window image using the main energy window scanning data, and reconstructing a scattering window image using the scattering window scanning data; calculating an attenuation coefficient image using the main energy window image and the scattering window image; and correcting the main energy window image using the attenuation coefficient image to obtain a single photon emission computed tomography image.

The application belongs to the technical field of single photon emitters, and relates to a radiation enhancement type single photon emitter and a preparation method, which comprise an hBN thin layer and an emitter; the emitter is arranged above the hBN thin layer, and the emitter is located within a range of 10 nm above the surface of the hBN thin layer. By utilizing the hyperbolic dispersion characteristics of the hBN thin layer, Purcell enhancement and enhancement of photon coupling output power can be realized in a wide band range. The problems of low photon coupling output efficiency and Purcell effect enhancement in the existing single photon emitter are solved. Therefore, the application range of the single photon emitter in photonics and quantum optics is expanded. Compared with the existing single photon emitter, the application has a simple structure, does not need a complex manufacturing process, and reduces manufacturing cost.

A method and system for engineering C-Band telecom-wavelength quantum defects centers, such as carbon-boron vacancy (CB-VB) and silicon-boron vacancy (SiB-VB) complex centers, in hexagonal boron nitride (h-BN), the method including growing a h-BN thin epilayer, or a semi-bulk thick layer, using a semiconductor epitaxial growth processing tool, doping one or more of said h-BN thin epilayer, or said semi-bulk thick layer, with carbon or silicon impurities during the growing to create defect complexes comprising (CB-VB) and (SiB-VB), controlling a growth rate and V / III ratio during the growing, and producing h-BN wafers and thin epilayers with the (CB-VB) and (SiB-VB) quantum defect centers as single photon emitters in the conventional band of telecom wavelengths as well as qubits.