53 results about "Single photon emission" patented technology

This disclosure provides systems, methods and apparatuses for single photon emitters based on nanoribbons. A single photon emitter includes: a substrate; at least one nanostructure disposed on the substrate; and a nanoribbon disposed over at least one apex of the at least one nanostructure. The nanoribbon may include a transition metal dichalcogenide (TMD). A method of manufacturing a single photon emitter includes: growing a transition metal dichalcogenide (TMD) nanoribbon on a first substrate; collecting the TMD nanoribbon on a polymer film; stacking the TMD nanoribbon and polymer film on a second substrate having nanostructures with the TMD nanoribbon disposed over an apex of the at least one nanostructure; and removing the polymer film.

The invention belongs to the technical field of single-photon emitters, and relates to a radiation-enhanced single-photon emitter and a preparation method thereof. The radiation-enhanced single-photon emitter comprises an hBN thin layer and an emitter; the emitter is disposed over the hBN thin layer, and the emitter is located within a range of 10 nm over the surface of the hBN thin layer. By using the hyperbolic dispersion characteristic of the hBN thin layer, the enhancement of the Purcell and the enhancement of the photon coupling output power can be realized in a broadband range. The single-photon emitter solves the problems that in an existing single-photon emitter, the photon Pelsel effect is enhanced, and the photon coupling output efficiency is low. Therefore, the application range of the material in photonics and quantum optics is expanded. Compared with an existing single-photon emitter, the single-photon emitter is simple in structure, does not need a complex manufacturing process, and reduces the manufacturing cost.

1. Name of the Design Product: Single Photon Emission Computed Tomography Equipment. 2. Use of the Design Product: For nuclear medicine SPECT / CT scanning and imaging, capable of evaluating the metabolic levels and functional activities of various organs in the living body. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Combined State Diagram 1.

The invention discloses a molecular imaging probe targeting poly ADP ribose polymerase as well as a preparation method and application of the molecular imaging probe. The molecular imaging probe is represented by the following formula Ia or Ib. The compound disclosed by the invention can be used as a PARP-targeted positron emission, single photon emission or nuclear magnetic resonance imaging probe, and has a great application prospect in imaging treatment of PARP expression abnormity related diseases such as tumors. # imgabs0 #

Theranostic agents incorporating a chelating moiety that can chelate a radioactive metal isotope and a PSMA-targeting moiety are disclosed herein. The theranostic agents, which can be used to treat and / or detect cancers associated with increased PSMA expression, have the formula:and include complexes, anions or salts thereof. R1 includes a chelating moiety; a is 0 or 1; n is an integer from 12 to 21; and R2 includes a prostate specific membrane antigen (PSMA)-targeting moiety. Optionally, the chelating moiety is chelated to a metal atom, where the metal atom is a positron or single photon emitting metal isotope, or an alpha, beta, or Auger emitting metal isotope.

This invention discloses a radioactive molecular probe for targeting CSPG4 / NG2, its preparation method, and its application. The radioactive molecular probe comprises the structure shown in Formula I or Formula II. The technical solution of this invention uses a radioactive molecular probe to specifically recognize CSPG4 / NG2 in vivo through the target polypeptide portion, thereby achieving specific nuclear medicine positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging diagnosis of CSPG4 / NG2 positive tumors or CSPG4 / NG2 positive lesions, such as autoimmune diseases and cardiovascular and cerebrovascular diseases, thereby realizing early diagnosis and efficacy evaluation of malignant tumors.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

1. The name of the design product: single photon emission and X-ray computed tomography system. 2. The use of the design product: functional and structural imaging, a nuclear medicine molecular imaging device integrating SPECT / CT multiple modalities three-dimensional medical image imaging and processing functions. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

1. The name of the design product: Single photon emission and X-ray computed tomography system host shell. 2. The use of the design product: used as a single photon emission and X-ray computed tomography system host shell. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to a deviation acquisition method and device of a single photon emission computed tomography system, equipment and a medium, which can improve the deviation estimation accuracy of the system. The method comprises the following steps: controlling a target object to move to a first target position through a translation stage, and determining an actual detection position of the target object recognized by a system probe under a current pose; obtaining a first expected pose deviation; the first expected pose deviation represents the deviation between the expected pose and the current pose of the system probe; determining an expected detection position of the target object according to the first target position and the first expected pose deviation, and obtaining a first position difference between the expected detection position and the actual detection position; and according to the first position difference corresponding to each first expected pose deviation, determining the actual pose deviation between the expected pose and the current pose of the system probe.

Disclosed are electrically driven single-photon emitters and their fabrication methods. The single-photon emitter comprises a substrate, an active layer on the substrate, a spacer between the substrate and the active layer, a first electrode connected to the active layer, and a second electrode between the substrate and the spacer and vertically spaced apart from the active layer across the spacer. The substrate includes a deformable polymer. The substrate has a first dent where a portion of a top surface of the substrate is concavely recessed. The active layer has a second dent at a position which is aligned with the first dent and where a portion of a top surface of the active layer is concavely recessed.

The present invention provides a compound as represented by formula I or a pharmaceutically acceptable salt, precursor compound, isotope compound, stereoisomer or tautomer thereof. The compound has high affinity and strong targeting specificity for melanoma, low non-specific uptake in livers and kidneys, and a high tumor / non-tumor ratio. In addition, the probe precursor of the present invention can selectively chelate different radioactive diagnostic or therapeutic nuclides, and is used in single-photon emission computed tomography for early diagnosis of major diseases such as malignant tumors and Parkinson's disease, guiding the selection of a treatment regimen, efficacy monitoring, and radioactive therapy. The compound is simple to synthesize, has easily available raw materials and good stability, and can be promoted and applied as a novel melanoma-targeted radiopharmaceutical.

The invention provides a compound shown as a formula I, or a pharmaceutically acceptable salt thereof, or a precursor compound and an isotope compound thereof, or a stereoisomer and a tautomer thereof. The compound has high affinity with melanoma, strong targeting specificity, low non-specific uptake in liver and kidney, and high tumor / non-tumor ratio. Besides, the probe precursor can be selectively chelated with different radioactive diagnosis or treatment nuclides, and is used for early diagnosis of malignant tumors, Parkinson's diseases and other major diseases through single photon emission computed tomography, and guidance of treatment scheme selection, curative effect monitoring and radioactive treatment. The compound has the advantages of simple synthesis, easily available raw materials and good stability, and can be popularized and applied as a novel melanoma targeted radiopharmaceutical. # imgabs0 #

The application provides a polarization single photon source based on an anisotropic Dirac cavity, and relates to the technical field of solid-state single photon sources.The polarization single photon source based on the anisotropic Dirac cavity comprises: an anisotropic Dirac microcavity, which comprises: a C6 symmetry broken cavity photonic crystal located on the inside; a C6 symmetry cladding photonic crystal surrounding the outside of the C6 symmetry broken cavity photonic crystal; and a quantum dot coupled with the anisotropic Dirac microcavity to realize the deterministic emission of linearly polarized single photons.In the application, a single InAs / GaAs quantum dot is coupled with an anisotropic Dirac photonic crystal microcavity, the polarization selection Purcell enhancement effect of the microcavity is utilized, the deterministic single photon emission with high linear polarization degree and high single photon purity is realized, and the application can be used as a core quantum bit carrier in the fields of quantum communication, quantum calculation and quantum precision measurement.

A method for performance by a controller, that comprises selecting, based on a received heralding signal, a comb spectral mode of a frequency comb 204; and causing, based on the selection, a reconfigurable mode selection apparatus 206 to permit the selected comb spectral mode 210 to be incident on a non-linear photonic element 212; wherein the received heralding signal is representative of the detection of a first photon 106 of a frequency-correlated photon pair 110, the heralding signal indicating a frequency of the heralded second photon 108 of the frequency-correlated photon pair from among a plurality of possible frequencies; and wherein the non-linear photonic element 212 is further arranged to receive the heralded second photon 108 and to produce an output photon 214 having a frequency based on the frequency of the heralded second photon 108 and the selected comb spectral mode 210; and wherein, in the event of a contemporaneous detection of two frequency-correlated photon pairs, selecting a comb spectral mode that complements the heralded second photon of the two heralded second photons for which the non-linear photonic element 212 has a greater conversion efficiency.

The application discloses a kind of two-way spin angular momentum and momentum direction controllable single photon emitter and method thereof.The application independently controls the spin angular momentum of emitting photon by the internal structure of each nano scattering unit, and is irrelevant to the phase of scattered light;The momentum direction of emitting photon is controlled by the position of each nano scattering unit, and is related to the phase of scattered light, two kinds of control do not affect each other, and the control of the spin angular momentum and momentum direction of emitting photon can be independently designed;Two sets of super surface structures corresponding to two emitting photons are combined to form a two-way single photon emitter, and single photon emission is realized, and the spin angular momentum and momentum direction of each emitting photon can be independently controlled by the corresponding super surface structure;The maximum emission angle can reach 53°, and the phase-independent scheme makes the spin angular momentum insensitive to the accurate position of single photon source relative to the super surface, so high-precision single photon source positioning and alignment technology is no longer needed.

The invention relates to a tetramethylpiperidine oxide (Tempo l) functionalized metalloporphyrin nano-particle and a preparation method and application thereof, the preparation method of the Tempo l functionalized metalloporphyrin nano-particle is simple, various metal ions can be efficiently and stably chelated, and the tetramethylpiperidine oxide (Tempo l) functionalized metalloporphyrin nano-particle can be used as a metal ion chelating agent. Wide application prospects are realized in the fields of magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT) and fluorescence imaging; and the material has enhanced water dispersibility and bioavailability, higher imaging performance and efficient active oxygen scavenging ability, and is a good diagnosis and treatment integrated material.

For dosimetry, a miniaturized nuclear imaging system with a solid-state detector is used to determine the activity and / or injected dose of radiopharmaceuticals. By being sized to scan a syringe or vial, the solid-state detector can be used to determine the injected dose with higher accuracy than current dose calibrators and with less frequent use of calibration or normalization sources. The miniaturized nuclear imaging system reconstructs activity in the same way as a nuclear imaging system that scans patients, and therefore can be used to calibrate a dose model. A tissue mimicking phantom with a solid-state dosimeter measures the dose from a radiopharmaceutical that is used to calibrate the dose model.

A photon emitter includes a multi-layer film. The multi-layer film includes a first material layer and a second material layer, and the multi-layer film includes an interface surface between the first and second material layers. The first material layer includes silicon nitride. The multi-layer film is formed by positioning the silicon nitride over the second material layer and energetically activating the combination of the first material layer and the second material layer. The interface surface is operable to emit single photons.

The utility model relates to a single photon emission tomography device. The single photon emission tomography device comprises a rack; the first probe module comprises a first driving mechanism, a first rotary table and a first probe, the first rotary table is rotationally connected to the rack, and the first probe is connected to the first rotary table; the second probe module comprises a second rotary table and a second probe, the second rotary table is rotationally connected to the rack, and the second probe is connected to the second rotary table; the first driving mechanism is used for driving the first probe to move in the first direction, the second direction and the third direction and is used for driving the first rotary table to rotate around the axial direction of the rack, any two of the first direction, the second direction and the third direction are perpendicular, and one of the directions is the axial direction of the rack. The single photon emission tomography equipment can have a larger axial scanning visual field, so that the scanning requirement of a larger axial size is met, the number of times of moving a sickbed in the scanning process is reduced, the scanning process is simplified, and the scanning time is shortened.

A method for performance by a controller, that comprises selecting, based on a received heralding signal, a comb spectral mode of a frequency comb 204; and causing, based on the selection, a reconfigurable mode selection apparatus 206 to permit the selected comb spectral mode 210 to be incident on a non-linear photonic element 212; wherein the received heralding signal is representative of the detection of a first photon 106 of a frequency-correlated photon pair 110, the heralding signal indicating a frequency of the heralded second photon 108 of the frequency-correlated photon pair from among a plurality of possible frequencies; and wherein the non-linear photonic element 212 is further arranged to receive the heralded second photon 108 and to produce an output photon 214 having a frequency based on the frequency of the heralded second photon 108 and the selected comb spectral mode 210; and wherein, in the event of a contemporaneous detection of two frequency-correlated photon pairs, selecting a comb spectral mode that complements the heralded second photon of the two heralded second photons for which the non-linear photonic element 212 has a greater conversion efficiency.

The preparation method of the AlGaN-based cation vacancy defect single-photon emission source of the present invention belongs to the fields of semiconductor technology and quantum information technology. Through group theory analysis combined with first-principles calculations, it is confirmed that the neutral cation vacancy of AlGaN is suitable for single-photon emission. The specific implementation includes the following key steps: p-type AlGaN growth, preparation of cation vacancies by surface electron irradiation, pulsed laser irradiation and other methods combined with nitridation treatment and thermal annealing treatment. The present invention also provides an AlGaN-based cation vacancy defect single-photon emission source prepared by the above method. The present invention provides an optional single-photon source solution for the field of quantum communication, and at the same time has guiding significance for the design of single-photon sources based on semiconductor material defects. The process is simple, the industrial preparation method of the semiconductor material AlGaN on which it is based is mature, the photon energy is suitable for low-loss propagation in optical fibers, and it has broad application prospects.

For single photon emission computed tomography (SPECT) detectors, embedded capacitive material (ECM) is used in printed circuit boards (PCB) with semiconductor detectors. High voltage (HV) filtering and / or blocking capacitors are formed from ECM. ECM is less disruptive to radiation or emissions to be detected by the semiconductor detectors compared to surface mounted capacitors.

Direction estimation for radioactive source localization in single photon emission computed tomography. For radioactive source positioning, the SPECT system uses a spectral, low spatial resolution detector to position a (first) point of interaction (POI) within a 3D detector sensor material ("3D detector" or "3D spectral detector"), which in turn can be used to estimate the general direction of the emission source. By detecting the depth of the 3D POI and emissions within a specified energy range, the processor may determine a direction toward the source. Shielding is not required, since detected emissions from other directions may be discarded. Different shields may be used to assist in directivity determination, such as different thickness profiles or material types of detector sides, allowing directional determination by strength.

This application relates to a motion control method, device, medical scanning system, and storage medium for a probe. The motion control method includes: planning the distribution of path points in the initial motion path of the probe based on the posture information of the object being detected and a preset scanning range; determining a path optimization target corresponding to the preset scanning parameters; adjusting the path parameters of each path point in the initial motion path according to the path optimization target, so that the target motion path corresponding to the adjusted path parameters satisfies the path optimization target; and controlling the probe to move relative to the object being detected during scanning in a single-photon emission computed tomography (SPECT) system according to the target motion path to obtain detection data. This method can combine the posture information of the object being detected and the scanning requirements to achieve accurate and satisfactory motion path planning and adjustment, thereby reducing the application difficulty of motion planning.

The present invention discloses a single-photon emitter with controllable spin angular momentum and momentum direction, and a method thereof. The present invention comprises a metal substrate, nano-scattering units, a dielectric spacer, and a single-photon source. The present invention independently controls the spin angular momentum of the emitted photons through the internal structure of each nano-scattering unit, in a scheme that is independent of the scattered light phase; and controls the momentum direction of the emitted photons through the position of each nano-scattering unit, in a scheme that is dependent on the scattered light phase. Because these two schemes do not affect each other, the control of the spin angular momentum and momentum direction of the emitted photons can be independently designed, realizing a single-photon emitter in which both the spin angular momentum and momentum direction are independently controllable. The maximum emission angle can reach 53°, and the phase-independent scheme makes the spin angular momentum insensitive to the precise position of the single-photon source relative to the metasurface, eliminating the need for high-precision single-photon source positioning and alignment technology.

Systems and methods for generating synthetic computed tomography (CT) images, such as generating synthetic time-resolved four-dimensional CT or single-photon emission CT images of the human respiratory system, are described. Generating a synthetic CT image includes processing at least one output from a physics-based lung simulation model in combination with at least one generative learning model. The output from the physics-based lung simulation model provides additional information that improves clinical decision-making without additional patient exposure to radiation-intensive imaging procedures.

The present disclosure relates to a deviation acquisition method for a single-photon emission computed tomography system, which includes: controlling a target object to move to a first target position through a translation stage, and determining an actual detection position of the target object detected by a system detector in a current pose; obtaining at least one first expected pose deviation; determining at least one expected detection position of the target object based on the first target position and the at least one first expected pose deviation, and obtaining at least one first position difference between the at least one expected detection position and the actual detection position; and determining an actual pose deviation between the expected pose and the current pose of the system detector based on the at least one first position difference corresponding to the at least one first expected pose deviation.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

Methods of fabricating single photon emitters (SPEs) including nanoindentation of hexagonal boron nitride (hBN) host materials and annealing thereof, devices formed from such methods, and chips with a single photon emitter. A substrate with a layer of hBN is provided. Nanoindentation is performed on the layer of hBN to produce an array of sub-micron indentations in the layer of hBN. The layer of hBN is annealed to activate SPEs near the indentations. Devices include a substrate with an SPE produced in accordance with the methods. Chips include a substrate, an hBN layer, and an SPE including an indentation on the hBN layer, in which the substrate is not damaged at the indentation.