28 results about "Single photon emission" patented technology

This invention discloses a radioactive molecular probe for targeting CSPG4 / NG2, its preparation method, and its application. The radioactive molecular probe comprises the structure shown in Formula I or Formula II. The technical solution of this invention uses a radioactive molecular probe to specifically recognize CSPG4 / NG2 in vivo through the target polypeptide portion, thereby achieving specific nuclear medicine positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging diagnosis of CSPG4 / NG2 positive tumors or CSPG4 / NG2 positive lesions, such as autoimmune diseases and cardiovascular and cerebrovascular diseases, thereby realizing early diagnosis and efficacy evaluation of malignant tumors.

1. The name of the design product: single photon emission and X-ray computed tomography system. 2. The use of the design product: functional and structural imaging, a nuclear medicine molecular imaging device integrating SPECT / CT multiple modalities three-dimensional medical image imaging and processing functions. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

1. The name of the design product: Single photon emission and X-ray computed tomography system host shell. 2. The use of the design product: used as a single photon emission and X-ray computed tomography system host shell. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

Disclosed are electrically driven single-photon emitters and their fabrication methods. The single-photon emitter comprises a substrate, an active layer on the substrate, a spacer between the substrate and the active layer, a first electrode connected to the active layer, and a second electrode between the substrate and the spacer and vertically spaced apart from the active layer across the spacer. The substrate includes a deformable polymer. The substrate has a first dent where a portion of a top surface of the substrate is concavely recessed. The active layer has a second dent at a position which is aligned with the first dent and where a portion of a top surface of the active layer is concavely recessed.

The application provides a polarization single photon source based on an anisotropic Dirac cavity, and relates to the technical field of solid-state single photon sources.The polarization single photon source based on the anisotropic Dirac cavity comprises: an anisotropic Dirac microcavity, which comprises: a C6 symmetry broken cavity photonic crystal located on the inside; a C6 symmetry cladding photonic crystal surrounding the outside of the C6 symmetry broken cavity photonic crystal; and a quantum dot coupled with the anisotropic Dirac microcavity to realize the deterministic emission of linearly polarized single photons.In the application, a single InAs / GaAs quantum dot is coupled with an anisotropic Dirac photonic crystal microcavity, the polarization selection Purcell enhancement effect of the microcavity is utilized, the deterministic single photon emission with high linear polarization degree and high single photon purity is realized, and the application can be used as a core quantum bit carrier in the fields of quantum communication, quantum calculation and quantum precision measurement.

The application discloses a kind of two-way spin angular momentum and momentum direction controllable single photon emitter and method thereof.The application independently controls the spin angular momentum of emitting photon by the internal structure of each nano scattering unit, and is irrelevant to the phase of scattered light;The momentum direction of emitting photon is controlled by the position of each nano scattering unit, and is related to the phase of scattered light, two kinds of control do not affect each other, and the control of the spin angular momentum and momentum direction of emitting photon can be independently designed;Two sets of super surface structures corresponding to two emitting photons are combined to form a two-way single photon emitter, and single photon emission is realized, and the spin angular momentum and momentum direction of each emitting photon can be independently controlled by the corresponding super surface structure;The maximum emission angle can reach 53°, and the phase-independent scheme makes the spin angular momentum insensitive to the accurate position of single photon source relative to the super surface, so high-precision single photon source positioning and alignment technology is no longer needed.

For dosimetry, a miniaturized nuclear imaging system with a solid-state detector is used to determine the activity and / or injected dose of radiopharmaceuticals. By being sized to scan a syringe or vial, the solid-state detector can be used to determine the injected dose with higher accuracy than current dose calibrators and with less frequent use of calibration or normalization sources. The miniaturized nuclear imaging system reconstructs activity in the same way as a nuclear imaging system that scans patients, and therefore can be used to calibrate a dose model. A tissue mimicking phantom with a solid-state dosimeter measures the dose from a radiopharmaceutical that is used to calibrate the dose model.

The utility model relates to a single photon emission tomography device. The single photon emission tomography device comprises a rack; the first probe module comprises a first driving mechanism, a first rotary table and a first probe, the first rotary table is rotationally connected to the rack, and the first probe is connected to the first rotary table; the second probe module comprises a second rotary table and a second probe, the second rotary table is rotationally connected to the rack, and the second probe is connected to the second rotary table; the first driving mechanism is used for driving the first probe to move in the first direction, the second direction and the third direction and is used for driving the first rotary table to rotate around the axial direction of the rack, any two of the first direction, the second direction and the third direction are perpendicular, and one of the directions is the axial direction of the rack. The single photon emission tomography equipment can have a larger axial scanning visual field, so that the scanning requirement of a larger axial size is met, the number of times of moving a sickbed in the scanning process is reduced, the scanning process is simplified, and the scanning time is shortened.

For single photon emission computed tomography (SPECT) detectors, embedded capacitive material (ECM) is used in printed circuit boards (PCB) with semiconductor detectors. High voltage (HV) filtering and / or blocking capacitors are formed from ECM. ECM is less disruptive to radiation or emissions to be detected by the semiconductor detectors compared to surface mounted capacitors.

Direction estimation for radioactive source localization in single photon emission computed tomography. For radioactive source positioning, the SPECT system uses a spectral, low spatial resolution detector to position a (first) point of interaction (POI) within a 3D detector sensor material ("3D detector" or "3D spectral detector"), which in turn can be used to estimate the general direction of the emission source. By detecting the depth of the 3D POI and emissions within a specified energy range, the processor may determine a direction toward the source. Shielding is not required, since detected emissions from other directions may be discarded. Different shields may be used to assist in directivity determination, such as different thickness profiles or material types of detector sides, allowing directional determination by strength.

Systems and methods for generating synthetic computed tomography (CT) images, such as generating synthetic time-resolved four-dimensional CT or single-photon emission CT images of the human respiratory system, are described. Generating a synthetic CT image includes processing at least one output from a physics-based lung simulation model in combination with at least one generative learning model. The output from the physics-based lung simulation model provides additional information that improves clinical decision-making without additional patient exposure to radiation-intensive imaging procedures.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

Methods of fabricating single photon emitters (SPEs) including nanoindentation of hexagonal boron nitride (hBN) host materials and annealing thereof, devices formed from such methods, and chips with a single photon emitter. A substrate with a layer of hBN is provided. Nanoindentation is performed on the layer of hBN to produce an array of sub-micron indentations in the layer of hBN. The layer of hBN is annealed to activate SPEs near the indentations. Devices include a substrate with an SPE produced in accordance with the methods. Chips include a substrate, an hBN layer, and an SPE including an indentation on the hBN layer, in which the substrate is not damaged at the indentation.

To correct motion in Single Photon Emission Computed Tomography (SPECT) imaging, additional modality information is used to depict different regions in a patient. Motion is determined in these different regions as reflected in the SPECT data. These region motions are used for motion correction. Statistical measurements of SPECT data for different regions may be used to weight region motion.

Systems and methods for generating synthetic computed tomography (CT) images, such as generating synthetic time-resolved four-dimensional CT or single-photon emission CT images of the human respiratory system, are described. Generating a synthetic CT image includes processing at least one output from a physics-based lung simulation model in combination with at least one generative learning model. The output from the physics-based lung simulation model provides additional information that improves clinical decision-making without additional patient exposure to radiation-intensive imaging procedures.

The application belongs to the technical field of medical imaging, and provides a single photon emission computed tomography image correction method and device, electronic equipment and storage medium, wherein the method comprises: acquiring multi-energy window scanning data obtained through single photon emission computed tomography, wherein the multi-energy window scanning data comprises main energy window scanning data and at least one scattering window scanning data; reconstructing a main energy window image using the main energy window scanning data, and reconstructing a scattering window image using the scattering window scanning data; calculating an attenuation coefficient image using the main energy window image and the scattering window image; and correcting the main energy window image using the attenuation coefficient image to obtain a single photon emission computed tomography image.

The application belongs to the technical field of single photon emitters, and relates to a radiation enhancement type single photon emitter and a preparation method, which comprise an hBN thin layer and an emitter; the emitter is arranged above the hBN thin layer, and the emitter is located within a range of 10 nm above the surface of the hBN thin layer. By utilizing the hyperbolic dispersion characteristics of the hBN thin layer, Purcell enhancement and enhancement of photon coupling output power can be realized in a wide band range. The problems of low photon coupling output efficiency and Purcell effect enhancement in the existing single photon emitter are solved. Therefore, the application range of the single photon emitter in photonics and quantum optics is expanded. Compared with the existing single photon emitter, the application has a simple structure, does not need a complex manufacturing process, and reduces manufacturing cost.

This invention discloses a radiopharmaceutical targeting chondroitin sulfate proteoglycan 4 (CSPG4) with a linear polypeptide and its preparation method. The radiopharmaceutical comprises a CSPG4-targeting polypeptide, a radionuclide, and a bifunctional chelating agent. The radionuclide is labeled with the CSPG4-targeting polypeptide by the bifunctional chelating agent, wherein the targeting polypeptide has a linear structure consisting of 10 or 11 amino acids. This series of radiopharmaceuticals can achieve specific nuclear medicine positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging diagnosis of CSPG4-positive lesions, such as tumors, autoimmune diseases, cardiovascular diseases, and neurodegenerative diseases, in vivo.

The invention discloses a 3D material level measuring device and method based on quantum single photon detection, and belongs to the technical field of industrial measurement. The device comprises a single-photon transmitting and receiving unit, a light beam deflection motion unit, an integrated control module, an optical auxiliary assembly and a data output unit, a single-photon transmitting module covers a 1310-1550 nm human eye safe wave band, and a detection module is compatible with various single-photon-level devices such as a gated avalanche photodiode and a silicon photomultiplier. The light beam deflection motion unit can be a high-speed galvanometer, an electric holder or a combination of the high-speed galvanometer and the electric holder, the optical auxiliary assembly achieves interference resistance through light filtering, light splitting and light isolation, the integrated control module adopts an industrial master control chip and supports 0-80 m material level measurement and historical data local storage, and the data output unit is provided with 4-20 mA analog quantity and an RS485 Modbus protocol in a standard mode. 4G / 5G and Ethernet communication modules can be expanded and selected. According to the method, through the steps of synchronous triggering, global scanning, multi-stage anti-interference signal processing, three-dimensional point cloud reconstruction and data output, high-precision measurement of the material level height + / -2 mm to + / -8 mm within the range of 0-80 meters is achieved, and the volume calculation error is smaller than or equal to 0.8%. The technical problems of single-point measurement, weak anti-interference and existence of blind areas of a traditional level gage are solved, and the level gage is suitable for complex working conditions such as coal mines and chemical engineering, wide in protection range and remarkable in popularization value.

The application discloses a preparation method of a large-area hexagonal boron nitride ultraviolet single-photon source. ‑3 The system is first vacuumized to 10 ‑3 Pa below, and then heated to the reaction temperature and kept for a period of time; then, BCl3 and NH3 or BF3 and NH3 are introduced as two kinds of raw gas, and the graphite clamp is slightly decomposed by the high-temperature environment to provide a carbon source; the gas is mixed and chemically reacted to grow a large-area hexagonal boron nitride film with carbon defects; and the film peeled from the substrate is the hexagonal boron nitride ultraviolet single-photon source. The application successfully prepares the large-area hexagonal boron nitride ultraviolet single-photon emission source, characterizes the emission center with potential single-photon source characteristics, paves the way for the practical application of the hexagonal boron nitride material in quantum communication and optoelectronic application, and shows the stability and high-efficiency single-photon emission capacity of the material at room temperature.

A method and system for engineering C-Band telecom-wavelength quantum defects centers, such as carbon-boron vacancy (CB-VB) and silicon-boron vacancy (SiB-VB) complex centers, in hexagonal boron nitride (h-BN), the method including growing a h-BN thin epilayer, or a semi-bulk thick layer, using a semiconductor epitaxial growth processing tool, doping one or more of said h-BN thin epilayer, or said semi-bulk thick layer, with carbon or silicon impurities during the growing to create defect complexes comprising (CB-VB) and (SiB-VB), controlling a growth rate and V / III ratio during the growing, and producing h-BN wafers and thin epilayers with the (CB-VB) and (SiB-VB) quantum defect centers as single photon emitters in the conventional band of telecom wavelengths as well as qubits.

The invention provides a polarization single photon source based on an anisotropic Dirac cavity and a quantum key distribution device, and relates to the technical field of solid-state single photon sources. The polarization single photon source based on the anisotropic Dirac cavity comprises an anisotropic Dirac microcavity which comprises a C6 symmetrical broken cavity photonic crystal located on the inner side; the C6 symmetric cladding photonic crystal surrounds the outer side of the C6 symmetric broken cavity photonic crystal; and the quantum dot is coupled with the anisotropic Dirac microcavity so as to realize deterministic emission of the linear polarization single photon. According to the invention, the single InAs / GaAs quantum dot is coupled with the anisotropic Dirac photonic crystal microcavity, the polarization selection Purcell enhancement effect of the microcavity is utilized, deterministic single photon emission with high linear polarization degree and high single photon purity is realized, and the quantum dot can be used as a core quantum bit carrier in the fields of quantum communication, quantum calculation and quantum precision measurement.

1. The name of the design product: examination table shell. 2. The use of the design product: used as an examination table of single photon emission and X-ray computed tomography system. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The present invention relates to a single-photon generator and a manufacturing method thereof. Specifically, the single-photon generator may include metal nanoparticles having a chiral structure and a two-dimensional transition metal dichalcogenide monolayer, and emit circularly polarized single photons even without a separate external magnetic field or metamaterial. The single-photon generator of the present invention may generate a local magnetic field by utilizing the asymmetric electromagnetic field effect of chiral metal nanoparticles, and induce single-photon emission through local strain in a two-dimensional transition metal dichalcogenide monolayer coupled to the chiral metal nanoparticles. Accordingly, the single-photon emitter of the present invention can be implemented as a miniaturized quantum light source that generates single photons without requiring a strong magnetic field or a complex metamaterial, and thus can be applied to industrial fields such as quantum communication, quantum cryptography, and quantum computing.

Three-dimensional (3D) nanoarchitectured hexagonal boron nitride (hBN) is described with integrated solid-state single photon emitters (SPEs) from native defects generated during high-temperature chemical vapor deposition (CVD). The 3D hBN has a quasi-periodic gyroid minimal surface structure and is composed of a continuous 3D hBN sheet with built-in convex and concave curvatures that promote the formation of optically active and thermally robust native defects. The free-standing feature of the gyroid hBN with a nearly zero mean curvature can effectively eliminate the substrate disturbance and minimize lattice strain heterogeneity. As a result, naturally occurring defects with a narrow SPE spectral distribution can be created and activated as color centers in the 3D hBN, and the density of the SPEs can be tailored by CVD temperature.

A method and system for engineering C-Band telecom-wavelength quantum defects centers, such as carbon-boron vacancy (CB-VB) and silicon-boron vacancy (SiB-VB) complex centers, in hexagonal boron nitride (h-BN), the method including growing a h-BN thin epilayer, or a semi-bulk thick layer, using a semiconductor epitaxial growth processing tool, doping one or more of said h-BN thin epilayer, or said semi-bulk thick layer, with carbon or silicon impurities during the growing to create defect complexes comprising (CB-VB) and (SiB-VB), controlling a growth rate and V / III ratio during the growing, and producing h-BN wafers and thin epilayers with the (CB-VB) and (SiB-VB) quantum defect centers as single photon emitters in the conventional band of telecom wavelengths as well as qubits.

A system based upon artificial neural networks generates attenuation-corrected SPECT from non-attenuation-corrected SPECT (single photon emission computed tomography) without or with an intermediate step of attenuation map estimation. The system includes a SPECT scanner with CZT cameras for dynamic SPECT imaging. The system also includes a machine learning system including a 3D Dual Squeeze-and-Excitation Residual Dense Network for generating attenuation-corrected SPECT or attenuation maps from non-attenuation-corrected SPECT. The machine learning system reconstructs images from photopeak window and one or more scatter windows of the SPECT scanner are fed to the 3D Dual Squeeze-and-Excitation Residual Dense Network to generate attenuation-corrected SPECT or attenuation maps.

The application discloses a reconstruction method, system and device of single photon emission computed tomography, and the method comprises the following steps: acquiring multi-bed projection data, single-bed system matrix, reconstruction configuration parameters and scene parameters; performing reconstruction processing on the multi-bed projection data, the single-bed system matrix and the reconstruction configuration parameters to obtain an initial global image, a system matrix view and iterative control parameters; performing context processing on the scene parameters to obtain an application context; generating mathematical update logic of an iterative optimization algorithm based on the initial global image, the system matrix view, the iterative control parameters and the application context; calling a heterogeneous operator to perform operator operation according to the mathematical update logic to obtain operator calculation results; and iteratively updating the initial global image according to the operator calculation results, and obtaining a target global image when the iteration is terminated. The application improves the image reconstruction precision and hardware execution flexibility.