23 results about "Single-photon emission computed tomography" patented technology

The invention discloses an image correction method and system for an SPECT image and a related device, and relates to the field of image processing, and the method comprises the steps: obtaining an SPECT image and a CT image of the same patient, carrying out the alignment, extracting the function distribution characteristics of the SPECT image and the structural characteristics of the CT image through a preset deep learning model, and determining the artifact probability value of a pixel point in the SPECT image; classifying pixel points of the SPECT image through an artifact probability threshold, and generating a binary mask graph of the SPECT image according to a classification result; determining an artifact area of the SPECT image through the binary mask image, and correcting a pixel value of the artifact area through structural information of the CT image; and fusing the corrected artifact region with the non-artifact region of the SPECT image to obtain a corrected SPECT image. According to the method, the SPECT image is corrected by using the structural information of the CT image, and the correction accuracy of the SPECT image is improved.

Methods and systems are provided for calibrating a single photon emission computed tomography (SPECT) imaging system. In one example, a collimated line source for calibrating a SPECT system comprises a radioactive material aligned along a central axis of the collimated line source and a plurality of collimator plates arranged perpendicularly around the central axis, the collimator plates including a material that substantially absorbs photons striking the collimator plates. The collimator plates may absorb photons emitted by the radioactive material in non-perpendicular directions, which are not used for calibrating the SPECT imaging system, thereby reducing an amount of radiation released in an environment of the SPECT imaging system during calibration. Due to the reduced amount of radiation to which people in the environment are exposed, short time increments between patient examinations may be advantageously used to collect calibration data, reducing an overall amount of time used for calibration.

Assessment of transthyretin amyloid cardiomyopathy (ATTR-CM) can be performed by calculating a cardiac pyrophosphate activity (CPA) measurement from single-photon emission computed tomography (SPECT) images. SPECT images obtained using 99mTechnetium-pyrophosphate as a radiotracer can be analyzed to calculate CPA. Scan-specific thresholds for abnormal myocardial activity are identified based on left ventricular blood pool (LVBP) radiotracer counts, then radiotracer activity in regions of the myocardium with abnormal myocardial activity is determined. Finally, a CPA measurement can be calculated as a function of the mean radiotracer counts in such regions over the maximal LVBP radiotracer activity multiplied by the volume of involvement (e.g., the volume of abnormal activity). This CPA measurement can then be used as an assessment of ATTR-CM.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

The present invention provides a closed loop generation and / or infusion system comprising a radionuclide generator, an activity detector, a controller, a dose calibrator, a pump, eluant source and an automated elution system controlled by software and hardware for generation and infusion of a radionuclide for administering a dose of generated radionuclide into a subject for diagnosing a peripheral arterial disease in a subject suffering from or suspected of suffering from peripheral arterial disease and / or metabolic disease via Positron Emitting Tomography (PET) or Single-photon emission computed tomography (SPECT) imaging technologies. More particularly, the present invention provides methods of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease by performing quantitative assessment of blood flow in lower extremities or limbs of the subject; wherein the quantitative assessment is performed by analyzing one or more images and providing a severity score; and wherein the analysis of the one or more images is performed by using an automated system.

1. The name of the design product: single photon emission and X-ray computed tomography system. 2. The use of the design product: functional and structural imaging, a nuclear medicine molecular imaging device integrating SPECT / CT multiple modalities three-dimensional medical image imaging and processing functions. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The invention relates to the field of nuclear medicine, in particular to an imaging probe based on radionuclide labeling and application. The imaging probe based on radionuclide labeling provided by the invention comprises lanthanide nanocrystals, an amphiphilic block copolymer self-assembled by the lanthanide nanocrystals, and radionuclide ions labeled on the nanocrystals, and the imaging probe simultaneously realizes time-gated intensity imaging, life imaging and SPECT (Single Photon Emission Computed Tomography) imaging. The imaging probe based on radionuclide labeling is provided for the first time, the radionuclide labeling rate as high as 99.6% is achieved, the imaging probe not only supports time gating intensity imaging with high signal-to-background ratio, but also supports life imaging and SPECT imaging, and in-vivo biological distribution and metabolism tracking of radioactive nanoparticles are achieved.

The invention relates to a deviation acquisition method and device of a single photon emission computed tomography system, equipment and a medium, which can improve the deviation estimation accuracy of the system. The method comprises the following steps: controlling a target object to move to a first target position through a translation stage, and determining an actual detection position of the target object recognized by a system probe under a current pose; obtaining a first expected pose deviation; the first expected pose deviation represents the deviation between the expected pose and the current pose of the system probe; determining an expected detection position of the target object according to the first target position and the first expected pose deviation, and obtaining a first position difference between the expected detection position and the actual detection position; and according to the first position difference corresponding to each first expected pose deviation, determining the actual pose deviation between the expected pose and the current pose of the system probe.

The utility model discloses a multifunctional SPECT (Single Photon Emission Computed Tomography) performance measuring device, which relates to the medical equipment detection technology and comprises a spring buckle, a connecting piece, a telescopic rod and a circular truncated cone container, a spring buckle is arranged on the base, a clamping foot clamped on a medical bed is arranged in the spring buckle, the connecting piece is rotationally installed on the spring buckle, the telescopic rod is detachably installed in the connecting piece, the circular truncated cone container is detachably installed above the telescopic rod, and a containing cavity used for containing a radioactive source is formed in the circular truncated cone container. According to the device, multi-dimensional adjustment of the height and the direction of the radioactive source in the circular truncated cone container is achieved, the device is easy and convenient to adjust and operate, the loading and unloading time of the device is shortened, the radiation dose of operators is greatly reduced, and the device can measure multiple performance indexes such as inherent spatial resolution, inherent spatial linearity and fault spatial resolution of SPECT equipment.

For dosimetry, a miniaturized nuclear imaging system with a solid-state detector is used to determine the activity and / or injected dose of radiopharmaceuticals. By being sized to scan a syringe or vial, the solid-state detector can be used to determine the injected dose with higher accuracy than current dose calibrators and with less frequent use of calibration or normalization sources. The miniaturized nuclear imaging system reconstructs activity in the same way as a nuclear imaging system that scans patients, and therefore can be used to calibrate a dose model. A tissue mimicking phantom with a solid-state dosimeter measures the dose from a radiopharmaceutical that is used to calibrate the dose model.

The present invention relates to triglyceride analogs labeled with radioisotopes, or salts thereof, for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging. In addition, the present invention relates to compositions comprising the radiolabeled triglyceride analog, or a salt thereof, and methods for preparing the same. Further, methods of imaging using the radiolabeled triglyceride analog and uses of the radiolabeled triglyceride analog are disclosed herein. The invention also relates to an intermediate triglyceride analog for synthesis of the radiolabeled triglyceride analog.

The invention is suitable for the technical field of medical images, and provides a correction method and device for a single photon emission type computed tomography image, electronic equipment and a storage medium, and the method comprises the steps: obtaining a training sample set which comprises a plurality of training samples, each training sample comprises an uncorrected SPECT image, a CT image registered with the uncorrected SPECT image, an attenuation image obtained by converting the CT image, and a corrected SPECT image obtained by performing attenuation correction on the uncorrected SPECT image by using the attenuation image; the training sample set is used for training a first correction network and a first generation network, the first correction network is used for generating a corrected SPECT image according to the input uncorrected SPECT image, and the second generation network is used for generating a target image according to the input corrected SPECT image; and performing iterative cascade fine tuning on the trained first correction network and the first generation network by using the training sample set to obtain a second correction network and a second generation network.

For single photon emission computed tomography (SPECT) detectors, embedded capacitive material (ECM) is used in printed circuit boards (PCB) with semiconductor detectors. High voltage (HV) filtering and / or blocking capacitors are formed from ECM. ECM is less disruptive to radiation or emissions to be detected by the semiconductor detectors compared to surface mounted capacitors.

Direction estimation for radioactive source localization in single photon emission computed tomography. For radioactive source positioning, the SPECT system uses a spectral, low spatial resolution detector to position a (first) point of interaction (POI) within a 3D detector sensor material ("3D detector" or "3D spectral detector"), which in turn can be used to estimate the general direction of the emission source. By detecting the depth of the 3D POI and emissions within a specified energy range, the processor may determine a direction toward the source. Shielding is not required, since detected emissions from other directions may be discarded. Different shields may be used to assist in directivity determination, such as different thickness profiles or material types of detector sides, allowing directional determination by strength.

1. The name of the design product: digital single photon emission computed tomography imaging device. 2. The use of the design product: CT scan imaging for small animals. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

The invention relates to an acyclic chelating agent as well as a preparation method and application thereof. The acyclic chelating agent is a compound as shown in a formula I or a pharmaceutically acceptable salt of the compound as shown in the formula I. Compared with a common macrocyclic chelating agent, the non-cyclic chelating agent disclosed by the invention can be used for rapidly and efficiently marking radioactive metal nuclides under mild conditions, and is used for imaging such as PET (Polyethylene Terephthalate), SPECT (Single Photon Emission Computed Tomography) and MRI (Magnetic Resonance Imaging) or radionuclide treatment application research after being chelated with the radionuclides.

To correct motion in Single Photon Emission Computed Tomography (SPECT) imaging, additional modality information is used to depict different regions in a patient. Motion is determined in these different regions as reflected in the SPECT data. These region motions are used for motion correction. Statistical measurements of SPECT data for different regions may be used to weight region motion.

The application belongs to the technical field of medical imaging, and provides a single photon emission computed tomography image correction method and device, electronic equipment and storage medium, wherein the method comprises: acquiring multi-energy window scanning data obtained through single photon emission computed tomography, wherein the multi-energy window scanning data comprises main energy window scanning data and at least one scattering window scanning data; reconstructing a main energy window image using the main energy window scanning data, and reconstructing a scattering window image using the scattering window scanning data; calculating an attenuation coefficient image using the main energy window image and the scattering window image; and correcting the main energy window image using the attenuation coefficient image to obtain a single photon emission computed tomography image.

This disclosure provides, for example, benzo[c][1,2,5]thiadiazole compounds and methods for using these compounds, for example, to treat neurodegenerative diseases such as Parkinson's disease (PD), multiple system atrophy (MSA), and Lewy body dementia. This disclosure also provides the use of radioactive isotopes, for example... 11 C 18 F or 123 / 125 I. Methods for using radiolabeled benzo[c][1,2,5]thiadiazole compounds and the use of said radiolabeled compounds as positron emission tomography (PET) or single-photon emission computed tomography (SPECT) brain imaging agents for the diagnosis of neurodegenerative diseases and / or for monitoring the treatment of neurodegenerative diseases.

A system based upon artificial neural networks generates attenuation-corrected SPECT from non-attenuation-corrected SPECT (single photon emission computed tomography) without or with an intermediate step of attenuation map estimation. The system includes a SPECT scanner with CZT cameras for dynamic SPECT imaging. The system also includes a machine learning system including a 3D Dual Squeeze-and-Excitation Residual Dense Network for generating attenuation-corrected SPECT or attenuation maps from non-attenuation-corrected SPECT. The machine learning system reconstructs images from photopeak window and one or more scatter windows of the SPECT scanner are fed to the 3D Dual Squeeze-and-Excitation Residual Dense Network to generate attenuation-corrected SPECT or attenuation maps.

The utility model discloses a locking mechanism and a double-probe single photon emission computed tomography equipment probe, and relates to the technical field of mechanical structures, the locking mechanism comprises a driving piece, at least two locking pins, a locking pin sleeve and a sensing assembly, and the driving piece is used for driving each locking pin to move between an initial position and a locking position; the number of the lock pin sleeves is multiple, the lock pin sleeves correspond to the lock pins in a one-to-one mode, the lock pin sleeves are provided with installation bases used for allowing lock pin rings on the collimators to be embedded therein, and lock pin holes used for being communicated with inner holes of the lock pin rings are formed in the installation bases in a penetrating mode. When the lock pin is located at the initial position, a preset distance is reserved between the lock pin and the lock pin sleeve, and the locking mechanism is in an unlocking state. When the lock pin is in the locking position, the lock pin is inserted into the lock pin hole, and the locking mechanism is in a locking state. The sensing assembly is used for judging whether the locking mechanism is in a locking state or not. According to the utility model, the collimator is reliably mounted on the probe main body through the movement of the lock pin, and the collimator is simple and convenient to disassemble, assemble and replace.

The application discloses a reconstruction method, system and device of single photon emission computed tomography, and the method comprises the following steps: acquiring multi-bed projection data, single-bed system matrix, reconstruction configuration parameters and scene parameters; performing reconstruction processing on the multi-bed projection data, the single-bed system matrix and the reconstruction configuration parameters to obtain an initial global image, a system matrix view and iterative control parameters; performing context processing on the scene parameters to obtain an application context; generating mathematical update logic of an iterative optimization algorithm based on the initial global image, the system matrix view, the iterative control parameters and the application context; calling a heterogeneous operator to perform operator operation according to the mathematical update logic to obtain operator calculation results; and iteratively updating the initial global image according to the operator calculation results, and obtaining a target global image when the iteration is terminated. The application improves the image reconstruction precision and hardware execution flexibility.