38 results about "Single-photon emission computed tomography" patented technology

Presented herein are systems and methods that provide for improved detection and characterization of lesions within a subject via automated analysis of nuclear medicine images, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) images. In particular, in certain embodiments, the approaches described herein leverage artificial intelligence (AI) to detect regions of 3D nuclear medicine images corresponding to hotspots that represent potential cancerous lesions in the subject. The machine learning modules may be used not only to detect presence and locations of such regions within an image, but also to segment the region corresponding to the lesion and / or classify such hotspots based on the likelihood that they are indicative of a true, underlying cancerous lesion. This AI-based lesion detection, segmentation, and classification can provide a basis for further characterization of lesions, overall tumor burden, and estimation of disease severity and risk.

The invention relates to the technical field of medical image processing, and particularly provides a three-dimensional bone scanning total index calculation method, electronic equipment and a storage medium, and the method comprises the following steps: S1, carrying out focus segmentation on SPECT (Single Photon Emission Computed Tomography) tomographic bone scanning data to obtain a plurality of focus areas, each focus area corresponding to a bone metastasis focus; s2, performing skeleton segmentation and SPECT spatial conversion on the CT fault data to obtain a plurality of skeleton regions; s3, calculating a three-dimensional bone scanning index of each bone metastasis focus according to a proportional relation between the focus area and a bone area to which the focus area belongs, and then calculating a total three-dimensional bone scanning index according to all the three-dimensional bone scanning indexes; the method can effectively solve the problem of low acquisition precision of the total area of the bone region to which the focus belongs due to insufficient segmentation precision of the bone region.

The present invention relates to triglyceride analogs labeled with radioisotopes, or salts thereof, for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging. In addition, the present invention relates to compositions comprising the radiolabeled triglyceride analog, or a salt thereof, and methods for preparing the same. Further, methods of imaging using the radiolabeled triglyceride analog and uses of the radiolabeled triglyceride analog are disclosed herein. The invention also relates to an intermediate triglyceride analog for synthesis of the radiolabeled triglyceride analog.

The invention belongs to the technical field of radionuclide labeled radiochemistry and clinical nuclear medicine, and relates to a radionuclide labeled targeted CD44v6 antagonist as well as a preparation method and application thereof. The invention discloses a polypeptide radiopharmaceutical for CD44v6 targeting and a preparation method of the polypeptide radiopharmaceutical. The radiopharmaceutical is radionuclide-bifunctional chelating agent-CDA6, the radionuclide is labeled with polypeptide through the bifunctional chelating agent-CDA6, and the CDA6 polypeptide is of a straight chain structure composed of six amino acids. The radiopharmaceutical realizes specific nuclear medicine positron emission computed tomography (PET) or single photon emission computed tomography (SPECT) imaging diagnosis and / or radioactive therapy of CD44v6 positive tumors or CD44v6 positive lesions (autoimmune diseases, cardiovascular and cerebrovascular system diseases and the like) through specific recognition of the polypeptide CDA6 on CD44V6 in a living body.

The invention discloses an image correction method and system for an SPECT image and a related device, and relates to the field of image processing, and the method comprises the steps: obtaining an SPECT image and a CT image of the same patient, carrying out the alignment, extracting the function distribution characteristics of the SPECT image and the structural characteristics of the CT image through a preset deep learning model, and determining the artifact probability value of a pixel point in the SPECT image; classifying pixel points of the SPECT image through an artifact probability threshold, and generating a binary mask graph of the SPECT image according to a classification result; determining an artifact area of the SPECT image through the binary mask image, and correcting a pixel value of the artifact area through structural information of the CT image; and fusing the corrected artifact region with the non-artifact region of the SPECT image to obtain a corrected SPECT image. According to the method, the SPECT image is corrected by using the structural information of the CT image, and the correction accuracy of the SPECT image is improved.

1. Name of the Design Product: Single Photon Emission Computed Tomography Equipment. 2. Use of the Design Product: For nuclear medicine SPECT / CT scanning and imaging, capable of evaluating the metabolic levels and functional activities of various organs in the living body. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Illustrates the Design Key Points: Combined State Diagram 1.

Reducing noise and dose (radiation or contrast) for perfusion imaging in Computed Tomography Perfusion (CTP), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI) medical scanning devices by using a k-space based method. The time sequence of images from the scanner data set is converted as necessary, such as using a 2D Fast Fourier Transform (FFT), into a k-space having multiple timeframes. View-shared averaging is performed to reduce noise and preserve spatial and temporal resolutions of CTP, PET, SPECT and MRI data by progressively increasing the number of time frames for view-shared averaging for more distant regions of “k-space”, before converting the data, such as through a 2D FFT into a time sequence of noise reduced images.

Methods and systems are provided for calibrating a single photon emission computed tomography (SPECT) imaging system. In one example, a collimated line source for calibrating a SPECT system comprises a radioactive material aligned along a central axis of the collimated line source and a plurality of collimator plates arranged perpendicularly around the central axis, the collimator plates including a material that substantially absorbs photons striking the collimator plates. The collimator plates may absorb photons emitted by the radioactive material in non-perpendicular directions, which are not used for calibrating the SPECT imaging system, thereby reducing an amount of radiation released in an environment of the SPECT imaging system during calibration. Due to the reduced amount of radiation to which people in the environment are exposed, short time increments between patient examinations may be advantageously used to collect calibration data, reducing an overall amount of time used for calibration.

Assessment of transthyretin amyloid cardiomyopathy (ATTR-CM) can be performed by calculating a cardiac pyrophosphate activity (CPA) measurement from single-photon emission computed tomography (SPECT) images. SPECT images obtained using 99mTechnetium-pyrophosphate as a radiotracer can be analyzed to calculate CPA. Scan-specific thresholds for abnormal myocardial activity are identified based on left ventricular blood pool (LVBP) radiotracer counts, then radiotracer activity in regions of the myocardium with abnormal myocardial activity is determined. Finally, a CPA measurement can be calculated as a function of the mean radiotracer counts in such regions over the maximal LVBP radiotracer activity multiplied by the volume of involvement (e.g., the volume of abnormal activity). This CPA measurement can then be used as an assessment of ATTR-CM.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

The present invention provides a closed loop generation and / or infusion system comprising a radionuclide generator, an activity detector, a controller, a dose calibrator, a pump, eluant source and an automated elution system controlled by software and hardware for generation and infusion of a radionuclide for administering a dose of generated radionuclide into a subject for diagnosing a peripheral arterial disease in a subject suffering from or suspected of suffering from peripheral arterial disease and / or metabolic disease via Positron Emitting Tomography (PET) or Single-photon emission computed tomography (SPECT) imaging technologies. More particularly, the present invention provides methods of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease by performing quantitative assessment of blood flow in lower extremities or limbs of the subject; wherein the quantitative assessment is performed by analyzing one or more images and providing a severity score; and wherein the analysis of the one or more images is performed by using an automated system.

1. The name of the design product: single photon emission and X-ray computed tomography system. 2. The use of the design product: functional and structural imaging, a nuclear medicine molecular imaging device integrating SPECT / CT multiple modalities three-dimensional medical image imaging and processing functions. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The invention relates to the field of nuclear medicine, in particular to an imaging probe based on radionuclide labeling and application. The imaging probe based on radionuclide labeling provided by the invention comprises lanthanide nanocrystals, an amphiphilic block copolymer self-assembled by the lanthanide nanocrystals, and radionuclide ions labeled on the nanocrystals, and the imaging probe simultaneously realizes time-gated intensity imaging, life imaging and SPECT (Single Photon Emission Computed Tomography) imaging. The imaging probe based on radionuclide labeling is provided for the first time, the radionuclide labeling rate as high as 99.6% is achieved, the imaging probe not only supports time gating intensity imaging with high signal-to-background ratio, but also supports life imaging and SPECT imaging, and in-vivo biological distribution and metabolism tracking of radioactive nanoparticles are achieved.

The invention relates to a deviation acquisition method and device of a single photon emission computed tomography system, equipment and a medium, which can improve the deviation estimation accuracy of the system. The method comprises the following steps: controlling a target object to move to a first target position through a translation stage, and determining an actual detection position of the target object recognized by a system probe under a current pose; obtaining a first expected pose deviation; the first expected pose deviation represents the deviation between the expected pose and the current pose of the system probe; determining an expected detection position of the target object according to the first target position and the first expected pose deviation, and obtaining a first position difference between the expected detection position and the actual detection position; and according to the first position difference corresponding to each first expected pose deviation, determining the actual pose deviation between the expected pose and the current pose of the system probe.

The utility model discloses an SPECT multi-parallel-hole collimator, a collimator device and a detection device. The SPECT multi-parallel-hole collimator comprises three collimator positions, a calibration position, a first collimator position and a second collimator position which are transversely and continuously arranged, or the first collimator position, the second collimator position, or the zero collimator position, the first collimator position, and the second collimator position. The utility model relates to an SPECT (Single Photon Emission Computed Tomography) multi-parallel-hole collimator device, which comprises two SPECT multi-parallel-hole collimators which are oppositely arranged in parallel. The two PECT multi-parallel-hole collimators which are oppositely arranged in parallel further comprise a set of transverse guide rails, collimator transmission pieces and transmission mechanisms. A single photon emission computed tomography (SPECT) detection device comprises a multi-parallel-hole collimator device and two opposite detectors, each detector is fixed in a detector frame, and a transverse guide rail is fixed on the inner side of the detector frame. The utility model relates to an SPECT imaging method, which utilizes an SPECT detection device to implement detection and comprises a debugging step and a testing step.

Systems and methods for controlling motion of detectors having moving detector heads are provided. One system includes a gantry and a plurality of detector units mounted to the gantry, wherein the plurality of detector units are individually movable including translational movement and rotational movement. The system further includes a controller configured to control movement of the plurality of detector units to acquire Single Photon Emission Computed Tomography (SPECT) data, wherein the movement includes both the translational movement and the rotational movement coordinated to position the plurality of detector units adjacent to a subject.

The utility model discloses a multifunctional SPECT (Single Photon Emission Computed Tomography) performance measuring device, which relates to the medical equipment detection technology and comprises a spring buckle, a connecting piece, a telescopic rod and a circular truncated cone container, a spring buckle is arranged on the base, a clamping foot clamped on a medical bed is arranged in the spring buckle, the connecting piece is rotationally installed on the spring buckle, the telescopic rod is detachably installed in the connecting piece, the circular truncated cone container is detachably installed above the telescopic rod, and a containing cavity used for containing a radioactive source is formed in the circular truncated cone container. According to the device, multi-dimensional adjustment of the height and the direction of the radioactive source in the circular truncated cone container is achieved, the device is easy and convenient to adjust and operate, the loading and unloading time of the device is shortened, the radiation dose of operators is greatly reduced, and the device can measure multiple performance indexes such as inherent spatial resolution, inherent spatial linearity and fault spatial resolution of SPECT equipment.

The invention relates to a tetramethylpiperidine oxide (Tempo l) functionalized metalloporphyrin nano-particle and a preparation method and application thereof, the preparation method of the Tempo l functionalized metalloporphyrin nano-particle is simple, various metal ions can be efficiently and stably chelated, and the tetramethylpiperidine oxide (Tempo l) functionalized metalloporphyrin nano-particle can be used as a metal ion chelating agent. Wide application prospects are realized in the fields of magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT) and fluorescence imaging; and the material has enhanced water dispersibility and bioavailability, higher imaging performance and efficient active oxygen scavenging ability, and is a good diagnosis and treatment integrated material.

For dosimetry, a miniaturized nuclear imaging system with a solid-state detector is used to determine the activity and / or injected dose of radiopharmaceuticals. By being sized to scan a syringe or vial, the solid-state detector can be used to determine the injected dose with higher accuracy than current dose calibrators and with less frequent use of calibration or normalization sources. The miniaturized nuclear imaging system reconstructs activity in the same way as a nuclear imaging system that scans patients, and therefore can be used to calibrate a dose model. A tissue mimicking phantom with a solid-state dosimeter measures the dose from a radiopharmaceutical that is used to calibrate the dose model.

The present invention relates to triglyceride analogs labeled with radioisotopes, or salts thereof, for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging. In addition, the present invention relates to compositions comprising the radiolabeled triglyceride analog, or a salt thereof, and methods for preparing the same. Further, methods of imaging using the radiolabeled triglyceride analog and uses of the radiolabeled triglyceride analog are disclosed herein. The invention also relates to an intermediate triglyceride analog for synthesis of the radiolabeled triglyceride analog.

The invention is suitable for the technical field of medical images, and provides a correction method and device for a single photon emission type computed tomography image, electronic equipment and a storage medium, and the method comprises the steps: obtaining a training sample set which comprises a plurality of training samples, each training sample comprises an uncorrected SPECT image, a CT image registered with the uncorrected SPECT image, an attenuation image obtained by converting the CT image, and a corrected SPECT image obtained by performing attenuation correction on the uncorrected SPECT image by using the attenuation image; the training sample set is used for training a first correction network and a first generation network, the first correction network is used for generating a corrected SPECT image according to the input uncorrected SPECT image, and the second generation network is used for generating a target image according to the input corrected SPECT image; and performing iterative cascade fine tuning on the trained first correction network and the first generation network by using the training sample set to obtain a second correction network and a second generation network.

For single photon emission computed tomography (SPECT) detectors, embedded capacitive material (ECM) is used in printed circuit boards (PCB) with semiconductor detectors. High voltage (HV) filtering and / or blocking capacitors are formed from ECM. ECM is less disruptive to radiation or emissions to be detected by the semiconductor detectors compared to surface mounted capacitors.

Direction estimation for radioactive source localization in single photon emission computed tomography. For radioactive source positioning, the SPECT system uses a spectral, low spatial resolution detector to position a (first) point of interaction (POI) within a 3D detector sensor material ("3D detector" or "3D spectral detector"), which in turn can be used to estimate the general direction of the emission source. By detecting the depth of the 3D POI and emissions within a specified energy range, the processor may determine a direction toward the source. Shielding is not required, since detected emissions from other directions may be discarded. Different shields may be used to assist in directivity determination, such as different thickness profiles or material types of detector sides, allowing directional determination by strength.

A technetium [99mTc] injection preparation and a preparation method therefor and the use thereof. The preparation comprises component A and component B which are physically isolated from each other, wherein the component A comprises an active ingredient capable of being combined with a compound providing technetium [99mTc] to form a technetium [99mTc] drug, and the component B comprises a solvent capable of dissolving the technetium [99mTc] drug. The technetium [99mTc] injection preparation is suitable for single-photon emission computed tomography (SPECT) / CT imaging of prostate-specific membrane antigen (PSMA) positive lesions in prostate cancer patients.

1. The name of the design product: digital single photon emission computed tomography imaging device. 2. The use of the design product: CT scan imaging for small animals. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

A multi-modality imaging system allows for selectable photoelectric effect and / or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and / or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

The invention relates to an acyclic chelating agent as well as a preparation method and application thereof. The acyclic chelating agent is a compound as shown in a formula I or a pharmaceutically acceptable salt of the compound as shown in the formula I. Compared with a common macrocyclic chelating agent, the non-cyclic chelating agent disclosed by the invention can be used for rapidly and efficiently marking radioactive metal nuclides under mild conditions, and is used for imaging such as PET (Polyethylene Terephthalate), SPECT (Single Photon Emission Computed Tomography) and MRI (Magnetic Resonance Imaging) or radionuclide treatment application research after being chelated with the radionuclides.

To correct motion in Single Photon Emission Computed Tomography (SPECT) imaging, additional modality information is used to depict different regions in a patient. Motion is determined in these different regions as reflected in the SPECT data. These region motions are used for motion correction. Statistical measurements of SPECT data for different regions may be used to weight region motion.

The application belongs to the technical field of medical imaging, and provides a single photon emission computed tomography image correction method and device, electronic equipment and storage medium, wherein the method comprises: acquiring multi-energy window scanning data obtained through single photon emission computed tomography, wherein the multi-energy window scanning data comprises main energy window scanning data and at least one scattering window scanning data; reconstructing a main energy window image using the main energy window scanning data, and reconstructing a scattering window image using the scattering window scanning data; calculating an attenuation coefficient image using the main energy window image and the scattering window image; and correcting the main energy window image using the attenuation coefficient image to obtain a single photon emission computed tomography image.