392 results about "Computer tomographic" patented technology

A radiation therapy system that includes a radiation source that moves about a path and directs a beam of radiation towards an object and a cone-beam computer tomography system. The cone-beam computer tomography system includes an x-ray source that emits an x-ray beam in a cone-beam form towards an object to be imaged and an amorphous silicon flat-panel imager receiving x-rays after they pass through the object, the imager providing an image of the object. A computer is connected to the radiation source and the cone beam computerized tomography system, wherein the computer receives the image of the object and based on the image sends a signal to the radiation source that controls the path of the radiation source.

A stent is formed by encasing or encapsulating metallic rings in an inner polymeric layer and an outer polymeric layer. At least one polymer link connects adjacent metallic rings. The stent is drug loaded with one or more therapeutic agent or drug, for example, to reduce the likelihood of the development of restenosis in the coronary arteries. The inner and outer polymeric materials can be of the same polymer or different polymer to achieve different results, such as enhancing flexibility and providing a stent that is visible under MRI, computer tomography and x-ray fluoroscopy.

Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are disclosed.

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle.

The present disclosure provides a system and method for generating medical images. The method utilizes a novel algorithm to co-register Cone-Beam Computed Tomography (CBCT) volumes and additional imaging modalities, such as optical or RGB-D images.

A hybrid calibration method uses an calibration phantom (exterior reference) scanned simultaneously with the patient, and one or more known tissues of the subject (interior reference) to create a hybrid calibration reference that improves the measurement of tissue densities throughout the body. In addition, the calibration method is used to quantitatively define boundaries of tissue and organs for more accurate measurements of lengths, areas and volumes. Another aspect of the invention uses the calibrated images to quantitatively preset absolute window/levels for filming and image display, which provides standardized viewing for diagnostic purposes.

The present invention is a photodiode detector array for use in computerized tomography (CT) and non-CT applications. Specifically, the present invention is a high-density photodiode arrays, with low dark current, low capacitance, high signal to noise ratio, high speed, and low crosstalk that can be fabricated on relatively large substrate wafers. More specifically the photodiode array of the present invention is fabricated such that the PN-junctions are located on both the front side and back side surfaces of the array, and wherein the front side PN-junction is in electrical communication with the back side PN-junction. Still more specifically, the present invention is a photodiode array having PN-junctions that are electrically connected from the front to back surfaces and which can be operated in a fully depleted mode at low reverse bias.

A 2D or 3D velocity field is reconstructed from a cross-correlation analysis of image pairs of a sample, without first reconstructing images of the sample spatial structure. The method can be implemented via computer tomographic x-ray particle image velocimetry, using multiple projection angles, with phase contrast images forming dynamic speckle patterns. Estimated cross-correlations may be generated via convolution of a measured autocorrelation function with a velocity probability density function, and the velocity coefficients iteratively optimised to minimise the error between the estimated cross-correlations and the measured cross-correlations. The method may be applied to measure blood flow, and the motion of tissue and organs such as heart and lungs.

A method and a system are provided to prepare a plurality of cuttings or other rock fragments or other porous media, such as cuttings from a drilling interval or multiple intervals, for computer tomographic scanning at the same time. A method and system also are provided to allow organization of mass quantities of cuttings or other rock fragments obtained from intervals of a well to more accurately categorize the cuttings to assist selections thereof for more detailed digital rock analysis, such as using SEM and FIB-SEM systems, are provided. A method and system also are provided to allow characterization of facies occurrence frequency of a depth interval using drill cuttings or other rock fragments. Computerized systems, computer readable media, and programs for performing the methods are also provided.

A dynamic thresholding level set method combines two optimization processes, i.e., a level set segmentation and an optimal threshold calculation in a local histogram, into one process that involves a structure called a “propagating shell.” The propagating shell is a mobile 3-dimensional shell structure with a thickness that encompasses the boundary of an object, the boundary between two objects or the boundary between an object and a background. Because the local optimal threshold tends to shift to a value of a small region in a histogram, the shift can drive the propagating shell to an object boundary by pushing or pulling the propagating shell. The segmentation process is an optimizing process to find a balanced histogram with minimal threshold shift. When the histogram in the propagating shell is balanced, the optimal threshold becomes stable, and the propagating shell reaches a convergence location, i.e., an object boundary. This method can be applied to computer-aided organ and tumor volumetrics.

A contrast enhanced dynamic study of a subject is performed with a CT system. A series of undersampled image data sets are acquired during the study with successive data sets acquired at interleaved projection angles. More fully sampled image data sets are formed by transforming the x-ray attenuation projection data to k-space and then sharing peripheral k-space data between undersampled k-space data sets. Artifacts due to undersampling are thus reduced without significantly affecting the time resolution of a series of reconstructed images.

This invention pertains to a method of low-cost intraoperative all field simultaneous parallel microbeam single fraction few seconds duration 100 to 1,000 Gy and higher dose radiosurgery with micro-electro-mechanical systems (MEMS)-carbon nanotube based microaccelerators. It ablates cancer cells including the mesenchymal epithelial transformation associated cancer stem cells. Microbeam brachy-therapeutic radiosurgery is performed. Microaccelerators are configured for simultaneous parallel microbeam emission from varying angels to an isocentric tumor. Their additive dose rate at the isocentric tumor is in the range of 10,000 to 20,000 Gy/s. It eliminates most tumor recurrence and metastasis which enhances cancer cure rates. It also exposes cancer antigens which induces cancer immunity. Stereotactic breast core biopsy is combined with, positron emission tomography and computerized tomography and phase-contrast imaging. Parallel microbeam brachytherapy preserves normal breast appearance. Migration of normal stem cells from unirradiated valley regions heals the radiation damage to the normal tissue.

The present invention refers to a DC/AC power inverter control unit of a resonant-type power converter circuit (400), in particular a DC/DC converter, for supplying an output power for use in, for example, a high-voltage generator circuitry of an X-ray radio-graphic imaging system, 3D rotational angiography device or X-ray computed tomography device of the fan-or cone-beam type. More particularly, the present invention is directed to a resonant-type power converter circuit out which comprises an interphase transformer (406) connected in series to at least one series resonant tank circuit (403a and 403a′ or 403b and 403b′) at the output of two DC/AC power inverter stages (402a+b) supplying a multi-primary winding high-voltage transformer (404), wherein said interphase transformer (406) serves for removing the difference (DI) in the resonant output currents (₁ and ₂) of the DC/AC power inverter stages (402a+b). Furthermore, the present invention is dedicated to a control method which assures that the interphase transformer (406) is not saturated. This control method ensures zero current operation and provides for that input power losses can be minimized.

A method and apparatus are disclosed for high-sensitivity Single-Photon Emission Computed Tomography (SPECT), and Positron Emission Tomography (PET). The apparatus includes a two-dimensional (2D) gamma detector array that, unlike a conventional SPECT machine, moves to different positions in a three-dimensional (3D) volume space near an emission source and records a data vector g which is a measure of gamma emission field. In particular, the 3D volume space in which emission data g is measured extends substantially along a radial direction r pointing away from the emission source, and unlike a conventional SPECT machine, each photon detector element in the 2D gamma detector array is provided with a very large collimator aperture. Data g is related to the 3D spatial density distribution f of the emission source, noise vector n, and a system matrix H of the SPECT/PET apparatus through the linear system of equations g=Hf+n. This equation is solved for f by a method that reduces the effect of noise.

A marine device has a floating buoy containing electronics, a submerged payload containing electrical devices and electronics, a power source and a mooring line. At least a part of the power source is submerged and electrically connected to at least one of the submerged payload and the floating buoy, and the mooring line extends between the buoy and at least one of the power source submerged part, the submerged payload and a submerged anchor having a mass allowing it to stay under the water surface.