Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
711 results about "Positron emission tomography" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
<ul><li>PET scan images show bright spots where higher levels of chemical activity is present. This provides information about the functioning of organs.</li><li>A radiologist interprets the images and reports the findings.</li></ul>
Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
ActiveUS20070217963A1Efficient processingShort timeShaking/oscillating/vibrating mixersTransportation and packagingChemical reactionRadioactive decay
Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC +1
Devices Useful In Imaging
InactiveUS20090270725A1Convenient amountSurgical needlesVaccination/ovulation diagnosticsBiopsy methodsGamma imaging
Biopsy devices and methods useful with Positron Emission Tomography (PET) and Breast Specific Gamma Imaging (BSGI) are disclosed. A biopsy device including a flexible tube having a side aperture, and a PET or BSGI imageable material disposed within the flexible tube is disclosed. A biopsy method is disclosed that includes advancing a flexible tube having a PET or BSGI imageable material distally through the biopsy device. Various other embodiments and applications are disclosed.
Owner:DEVICOR MEDICAL PROD
Motion tracking system for real time adaptive imaging and spectroscopy
ActiveUS20070280508A1Improve performanceImprove accuracyImage analysisCharacter and pattern recognitionAdaptive imagingUsability
Current MRI technologies require subjects to remain largely motionless for achieving high quality magnetic resonance (MR) scans, typically for 5-10 minutes at a time. However, lying absolutely still inside the tight MR imager (MRI) tunnel is a difficult task, especially for children, very sick patients, or the mentally ill. Even motion ranging less than 1 mm or 1 degree can corrupt a scan. This invention involves a system that adaptively compensates for subject motion in real-time. An object orientation marker, preferably a retro-grate reflector (RGR), is placed on a patients' head or other body organ of interest during MRI. The RGR makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or “pose”, required to track the organ of interest. A camera-based tracking system observes the marker and continuously extracts its pose. The pose from the tracking system is sent to the MR scanner via an interface, allowing for continuous correction of scan planes and position in real-time. The RGR-based motion correction system has significant advantages over other approaches, including faster tracking speed, better stability, automatic calibration, lack of interference with the MR measurement process, improved ease of use, and long-term stability. RGR-based motion tracking can also be used to correct for motion from awake animals, or in conjunction with other in vivo imaging techniques, such as computer tomography, positron emission tomography (PET), etc.
Owner:UNIV OF HAWAII +3
Dedicated display for processing and analyzing multi-modality cardiac data
For diagnosis and treatment of cardiac disease, images of the heart muscle and coronary vessels are captured using different medical imaging modalities; e.g., single photon emission computed tomography (SPECT), positron emission tomography (PET), electron-beam X-ray computed tomography (CT), magnetic resonance imaging (MRI), or ultrasound (US). For visualizing the multi-modal image data, the data is presented using a technique of volume rendering, which allows users to visually analyze both functional and anatomical cardiac data simultaneously. The display is also capable of showing additional information related to the heart muscle, such as coronary vessels. Users can interactively control the viewing angle based on the spatial distribution of the quantified cardiac phenomena or atherosclerotic lesions.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC
Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
InactiveUS6562319B2BiocideOrganic chemistryPositron emission tomographyEpidermal growth factor receptor tyrosine kinase
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD +1
Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy
InactiveUS20020128553A1BiocideOrganic chemistryPositron emission tomographyEpidermal growth factor receptor tyrosine kinase
Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are disclosed.
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD +1
Multimodal silica-based nanoparticles
ActiveUS20140248210A1Ultrasonic/sonic/infrasonic diagnosticsPowder deliveryCellular componentDisease
The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo. In order to target a specific cell type, the nanoparticle may further be conjugated to a ligand, which is capable of binding to a cellular component associated with the specific cell type, such as a tumor marker. In one embodiment, a therapeutic agent may be attached to the nanoparticle. To permit the nanoparticle to be detectable by not only optical fluorescence imaging, but also other imaging techniques, such as positron emission tomography (PET), single photon emission computed tomography (SPECT), computerized tomography (CT), bioluminescence imaging, and magnetic resonance imaging (MRI), radionuclides / radiometals or paramagnetic ions may be conjugated to the nanoparticle.
Owner:SLOAN KETTERING INST FOR CANCER RES +1
Fluorination of proteins and peptides for F-18 positron emission tomography
Thiol-containing peptides can be radiolabeled with fluorine-18 (F-18) by reacting a peptide comprising a free thiol group with an F-18-bound labelling reagent which also has a group that is reactive with thiols. The resulting F-18-labeled peptides may be targeted to a tissue of interest using bispecific antibodies or bispecific antibody fragments having one arm specific for the F-18-labeled peptide or a low molecular weight hapten conjugated to the F-18-labeled peptide, and another arm specific to the targeted tissue. The targeted tissue is subsequently visualized by clinical positron emission tomography.
Owner:IMMUNOMEDICS INC
Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging
InactiveUS20060292073A1Maximum service lifeOrganic compound preparationSulfonic acid esters preparation1-amino-3-fluorocyclobutane-1-carboxylic acidCyclobutane
The radiolabeled non-natural amino acid 1-amino-3-cyclobutane-1-carboxylic acid (ACBC) and its analogs are candidate tumor imaging agents useful for positron emission tomography and single photon emission computed tomography due to their selective affinity for tumor cells. The present invention provides methods for stereo-selective synthesis of syn-ACBC analogs. The disclosed synthetic strategy is reliable and efficient and can be used to synthesize a gram quantity of various syn-isomers of the ACBC analogs, particularly, syn-[18F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC) and syn-[123I]-1-amino-3-iodocyclobutane-1-carboxylic (IACBC) acid analogs.
Owner:EMORY UNIVERSITY
Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
InactiveUS20080233018A1Isotope introduction to sugar derivativesSugar derivativesChemical synthesisConfocal
The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC
Micro CT scanners incorporating internal gain charge-coupled devices
ActiveUS7352840B1Improve rendering capabilitiesTake advantageTelevision system detailsRadiation/particle handlingCt scannersEngineering
The present invention provides internal gain charge coupled devices (CCD) and CT scanners that incorporate an internal gain CCD. A combined positron emission tomography and CT scanner is also provided.
Owner:RADIATION MONITORING DEVICES
PSMA-binding agents and uses thereof
ActiveUS8778305B2Satisfies long standing and unmetSharp contrastGroup 4/14 element organic compoundsIn-vivo radioactive preparationsProstate cancer cellAntigen
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Rubidium generator for cardiac perfusion imaging and method of making and maintaining same
ActiveUS20070140958A1Low pressure elutionFacilitates precision flow controlIn-vivo radioactive preparationsConversion outside reactor/acceleratorsFractographyRubidium
An 82Sr / 82Rb generator column is made using a fluid impervious cylindrical container having a cover for closing the container in a fluid tight seal, and further having an inlet for connection of a conduit for delivering a fluid into the container and an outlet for connection of a conduit for conducting the fluid from the container. An ion exchange material fills the container, the ion exchange material being compacted within the container to a density that permits, the ion exchange material to be eluted at a rate of at least 5 ml / min at a fluid pressure of 1.5 pounds per square inch (10 kPa). The generator column can be repeatedly recharged with 82Sr. The generator column is compatible with either three-dimensional or two-dimensional positron emission tomography systems.
Owner:OTTAWA HEART INST RES
Epidermal growth factor receptor binding compounds for positron emission tomography
A radiolabeled compound of a formula: is described. R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, halo, haloalkyl, carboxy, carbalkoxy and salts thereof; and A, B, C and D are each independently selected from the group consisting of a hydrogen and an electron withdrawing group, provided that at least one of A, B, C and D is [18]fluorine.
Owner:HADASIT MEDICAL RES SERVICES & DEVMENT +1
Method for reducing an electronic time coincidence window in positron emission tomography
ActiveUS20070106154A1Shorten the timeReducing random coincidencesUltrasonic/sonic/infrasonic diagnosticsInfrasonic diagnosticsGamma photonRadiation field
A method for acquiring PET images with reduced time coincidence window limits includes obtaining a preliminary image of a patient within a radiation field of view (FOV), determining the spatial location of the patient within the FOV based on the preliminary image, calculating a different time coincidence window based on the spatial location of the patient for each possible pair of oppositely disposed detectors, scanning the patient with a PET scanning system to detect a pair of gamma photons produced by an annihilation event, determining whether the detection of the pair of gamma photons occurs within the time coincidence window, accepting the detected event only if the detection of the gamma photons occurs within the time coincidence window, calculating the spatial location of accepted annihilation event, and adding the calculated spatial location of the annihilation event to a stored distribution of calculated annihilation event spatial locations representing the distribution of radioactivity in the patient.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC
Motion tracking system for real time adaptive imaging and spectroscopy
ActiveUS8121361B2Accurately determinedAccurately determineImage analysisCharacter and pattern recognitionAdaptive imagingSpectroscopy
Owner:UNIV OF HAWAII +3
Scintillation substances (variants)
ActiveUS20060086311A1Reduce manufacturing costHigh light yieldPolycrystalline material growthBy pulling from meltFractographyLutetium
Inventions relate to scintillation substances and they may be utilized in nuclear physics, medicine and oil industry for recording and measurements of X-ray, gamma-ray and alpha-ray, nondestructive testing of solid states structure, three-dimensional positron-emission tomography and X-ray computer tomography and fluorography. Substances based on silicate comprising lutetium and cerium characterised in that compositions of substances are represented by chemical formulae CexLu2+2y−xSi1−yO5+y, CexLiq+pLu2−p+2y−x−zAzSi1−yO5+y−p, CexLiq+pLu9.33−x−p−z□0.67AzSi6O26−p, where A is at least one element selected from group consisting of Gd, Sc, Y, La, Eu, Tb, x is value between 1×10−4 f.units and 0.02 f.units., y is value between 0.024 f.units and 0.09 f.units, z is value does not exceeding 0.05 f.units, q is value does not exceeding 0.2 f.units, p is value does not exceeding 0.05 f.units. Achievable technical result is the scintillating substance having high density, high light yield, low afterglow, and low percentage loss during fabrication of scintillating elements.
Owner:ZECOTEK HLDG INC
Modular System for Radiosynthesis with Multi-Run Capabilities and Reduced Risk of Radiation Exposure
InactiveUS20110150714A1Fast and efficient and compact and safe to operatorMinimize exposureIon-exchange process apparatusIon-exchanger regenerationRadiosynthesisRadiation exposure
Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC
Real time ultrasound monitoring of the motion of internal structures during respiration for control of therapy delivery
InactiveUS20060241443A1Organ movement/changes detectionChiropractic devicesHelical computed tomographyReal time ultrasound
A method of targeting therapy such as radiation treatment to a patient includes: identifying a target lesion inside the patient using an image obtained from an imaging modality selected from the group consisting of computed axial tomography, magnetic resonance tomography, positron emission tomography, and ultrasound; identifying an anatomical feature inside the patient on a static ultrasound image; registering the image of the target lesion with the static ultrasound image; and tracking movement of the anatomical feature during respiration in real time using ultrasound so that therapy delivery to the target lesion is triggered based on (1) movement of the anatomical feature and (2) the registered images.
Owner:CIVCO MEDICAL INSTR CO
Microfluidic radiosynthesis system for positron emission tomography biomarkers
InactiveUS20090036668A1Fast and efficient and compact mannerSmall amountGaseous chemical processesSugar derivativesHands freeEngineering
Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC
Method and system for scattered coincidence estimation in a time-of-flight positron emission tomography system
ActiveUS20060163485A1Material analysis by optical meansX/gamma/cosmic radiation measurmentTomographyCompanion animal
A method and system for controlling a positron emission tomography (PET) system is disclosed. The method includes acquiring image data and time-of-flight information from a PET system during an imaging scan. Further, the method includes performing scatter correction on the image data using the time-of-flight information.
Owner:GENERAL ELECTRIC CO
Biopsy Devices
InactiveUS20090270760A1Convenient amountSurgical needlesVaccination/ovulation diagnosticsBiopsy methodsGamma imaging
Biopsy devices and methods useful with Positron Emission Tomography (PET) and Breast Specific Gamma Imaging (BSGI) are disclosed. A biopsy device including a flexible tube having a side aperture, and a PET or BSGI imageable material disposed within the flexible tube is disclosed. A biopsy method is disclosed that includes advancing a flexible tube having a PET or BSGI imageable material distally through the biopsy device. Various other embodiments and applications are disclosed.
Owner:DEVICOR MEDICAL PROD
High power high yield target for production of all radioisotopes for positron emission tomography
InactiveUS20050061994A1Avoid low densitySuppress instabilityConversion outside reactor/acceleratorsNuclear monitoringCoolant flowInstability
A high power high yield target for the positron emission tomography applications is introduced. For production of Curie level of Fluorine-18 isotope from a beam of proton it uses about one tenth of Oxygen-18 water compared to a conventional water target. The target is also configured to be used for production of all other radioisotopes that are used for positron emission tomography. When the target functions as a water target the material sample being oxygen-18 water or oxygen-16 water is heated to steam prior to irradiation using heating elements that are housed in the target body. The material sample is kept in steam phase during the irradiation and cooled to liquid phase after irradiation. To keep the material sample in steam phase a microprocessor monitoring the target temperature manipulates the flow of coolant in the cooling section that is attached to the target and the status of the heaters and air blowers mounted adjacent to the target. When the target functions as a gas target the generated heat from the beam is removed from the target by air blowers and the cooling section. The rupture point of the target window is increased by a factor of two or higher by one thin wire or two parallel thin wires welded at the end of a small hollow tube which is held against the target window. One or two coils are used to produce a magnetic filed along the beam path for preventing the density depression along the beam path and suppression of other instabilities that can develop in a high power target.
Owner:AMINI BEHROUZ
Combined positron emission tomography and magnetic resonance tomography unit
InactiveUS7522952B2Save spaceShorten the timeMagnetic measurementsMaterial analysis by optical meansResonanceTomography
Owner:SIEMENS HEALTHCARE GMBH
Positron emission tomography detector for multilayer scintillation crystal
ActiveCN102707310AImprove detection efficiencyImprove spatial resolutionMeasurement with scintillation detectorsRadiation diagnosticsImaging qualityScintillation crystals
A positron emission tomography detector for a multilayer scintillation crystal comprises a plurality of layers of scintillation crystals, a photoelectric detector system and an algorithm system, wherein the multilayer scintillation crystals comprises n layers of array scintillation crystals and m layers of continuous scintillation crystals, both n and m are integers which are greater than or equal to 1, the sum of n and m is smaller than or equal to 10, the array scintillation crystals are formed by arraying strip-type scintillation crystals along the width and length directions, the continuous scintillation crystals are scintillation crystals which have uncut inner parts, the array scintillation crystals and the continuous scintillation crystals are sequentially coupled along the height direction of the strip-type scintillation crystals to form the multilayer scintillation crystals, and the bottoms of the continuous scintillation crystals are coupled with the photoelectric detector system. The positron emission tomography detector can more accurately obtain the position and the time of energy deposition of gamma photon in the scintillation crystal, and has higher detection efficiency of the gamma photon, the spatial resolution, the time resolution and the flexibility of a positron emission tomographic imaging system can be improved when the positron emission tomography detector is applied to the positron emission tomographic imaging system, and further, the imaging quality of the system can be improved.
Owner:RAYCAN TECH CO LTD SU ZHOU
Method and system for integrated radiological and pathological information for diagnosis, therapy selection, and monitoring
ActiveUS20140314292A1Ultrasonic/sonic/infrasonic diagnosticsImage enhancementSonificationCancers diagnosis
A method and system for integrating radiological and pathological information for cancer diagnosis, therapy selection, and monitoring is disclosed. A radiological image of a patient, such as a magnetic resonance (MR), computed tomography (CT), positron emission tomography (PET), or ultrasound image, is received. A location corresponding to each of one or more biopsy samples is determined in the at least one radiological image. An integrated display is used to display a histological image corresponding to the each biopsy samples, the radiological image, and the location corresponding to each biopsy samples in the radiological image. Pathological information and radiological information are integrated by combining features extracted from the histological images and the features extracted from the corresponding locations in the radiological image for cancer grading, prognosis prediction, and therapy selection.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC
Biomarkers for Alzheimer's disease
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Alzheimer's disease status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's or non-Alzheimer's dementia or normal. The biomarkers can be detected by SELDI mass spectrometry. In addition, the invention provides appropriate treatment interventions and methods for measuring response to treatment. Certain biomarkers of the invention may also be suitable for employment as radio-labeled ligands in non-invasive imaging techniques such as Positron Emission Tomography (PET).
Owner:VERMILLION INC
Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand
ActiveUS20110311447A1Low selectivityCompromise their utilityNervous disorderOrganic chemistryHuman useCombinatorial chemistry
Bipiperidinyl compounds and salts thereof are disclosed. The compounds include high affinity ligands for σ1 receptors. Some compounds are also highly selective for σ1 receptor compared to σ2 receptor. Compounds can comprise radioisotopes, including 18F or 11C. Radiolabeled compounds can be used as probes for imaging distribution of σ1 receptor in a subject such as a human using positron emission tomography (PET) scanning.
Owner:RGT UNIV OF CALIFORNIA +1
Medical imaging modality
InactiveUS20070100225A1Reliable detectionPrecise positioningDiagnostic recording/measuringTomographyImaging processingImage recording
A medical imaging modality with a PET detector ring for Positron Emission Tomography connected on the data side to a PET image processing unit is to be structured in such a way that, on the basis of the images generated in the modality, a reliable detection and precise localization of metabolism anomalies, especially of malign tissue with tumor incidence is possible. The modality is further intended to offer good access to the patient, so that operative or minimally-invasive interventions on the patient can be undertaken and checked alongside the image recording. To this end there is provision, in accordance with the invention, for an ACT recording device for angiographic computer tomography connected on the data side to an ACT image processing unit to be arranged adjacent to the PET detector, whereby a common display unit for display of PET images and / or ACT images generated in the relevant image processing unit is assigned to the PET image processing unit and the ACT image processing unit.
Owner:SIEMENS AG
Psma-binding agents and uses thereof
ActiveUS20110142760A1Satisfies long standingSharp contrastUrea derivatives preparationGroup 4/14 element organic compoundsAntigenProstate cancer cell
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com