Systems and methods for reducing
motion artifacts in cone-beam
computed tomography (CBCT) image reconstruction of a subject. The method includes accessing CBCT data and model-based CT (MBCT) data of the subject acquired with cone-beam CT and conventional
CT imaging systems, respectively, accessing
breathing amplitude
signal data of the subject acquired with the CBCT data and the MBCT data, and generating a
breathing motion model and motion model data based on the MBCT data and corresponding
breathing amplitude
signal data. The method also includes cross-calibrating the breathing amplitude
signal data, wherein cross-calibrating the breathing amplitudes includes simulating CBCT projection images using the MBCT data and determining at least one breathing amplitude corresponding to the MBCT data that provides a corresponding simulated CBCT projection to an actual
projection image, providing a correspondence between the breathing amplitudes corresponding to the MBCT data and the CBCT data. The method further includes reconstructing the CBCT data using the breathing motion model based on the MBCT data and the breathing amplitude corresponding to the MBCT data.