The invention is directed
biopsy site markers and methods of marking a
biopsy site, so that the location of the
biopsy cavity is readily visible by conventional imaging methods, particularly by
ultrasonic imaging. The
biopsy site markers of the invention have high
ultrasound reflectivity, presenting a substantial
acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the
biopsy site marker of the invention have a
high contrast of
acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform
surface contour to enhance the
acoustic signature. The markers have a characteristic form which is recognizably artificial during
medical imaging. The
biopsy site marker may be accurately fixed to the biopsy site so as to
resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.