90 results about "In vivo bildgebung" patented technology

A catheter for in vivo imaging comprising a monolithic outer sheath terminating in a monolithic atraumatic tip having a guidewire lumen. The catheter for in vivo imaging comprising a rotary drive shaft that passes through a central lumen of the monolithic outer sheath to impart rotary motion.

The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.

Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.

The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 inhibitor labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging agents, together with kits for the preparation of the radiopharmaceuticals. Also described are chelator conjugates of the caspase-3 inhibitor, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the diagnostic imaging and or therapy monitoring in vivo of various disease states where caspase-3 is involved.

The invention provides a family of fluorescent compounds. The compounds are substituted silaxanthenium compounds that can be chemically linked to one or more biomolecules, such as a protein, nucleic acid, and therapeutic small molecule. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications. The dyes are particularly useful for in vitro, in vivo and ex vivo imaging applications.

The present disclosure is directed to methods of non-invasively imaging cell nuclei. More particularly, the present disclosure is directed to methods of imaging cell nuclei in vivo using ultraviolet photoacoustic microscopy (UV-PAM), in which ultraviolet light is used to excite unlabeled DNA and RNA in cell nuclei to produce photoacoustic waves.

A device, a system and a method for in-vivo examination. A method for in-vivo examination includes substantially emptying a subject's colon from content, and inserting an autonomous in-vivo imaging device into the subject's gastrointestinal tract. An in-vivo examination kit includes an autonomous in-vivo imaging device, a wireless receiver, an antenna set, a laxative, and optionally a stimulant and an instructions leaflet.

The invention relates to a nano particle carrier having tumor and tumor-associated macrophage targeting multiple functions, which can be used for tumor therapy and in vivo imaging and positioning. The carrier is a liposome nano particle mediated by a tumor focus induction-activated cell-penetrating peptide, can be specifically enriched on the tumor focus through a circulating system after being subjected to intravenous injection, and simultaneously has the functions of molecule imaging and carrying multiple biomacromolecules and medicines. Concretely, by using a TAT cell-penetrating peptide of closed active center amino acid of a Legumain specificity-identified enzyme digestion substrate to connect PEG-modified liposome nano particles, after the circulating system reaches the tumor focus position, Legumain expressed by tumor and tumor-associated macrophage can separate the enzyme digestion substrate from the TAT active center, thereby realizing the enrichment on the tumor focus. The nano particle can pack various biomacromolecules or medicines, and has the functions of killing tumor, in vivo tumor tracing and performing early prevention on tumor.

The invention relates to a fluorescent-CT bimodal imaging probe and a preparation method thereof, specifically relates to a fluorescent-CT bimodal iodine doped carbon quantum dot prepared by a one-step hydrothermal carbonization method and application of the fluorescent-CT bimodal iodine doped carbon quantum dot in biomedical images, and belongs to the field of biomedical materials. The specific scheme is as follows: dissolving iodixanol and glycine in an aqueous solution according to a certain mass ratio to serve as precursors, putting the solution in a hydrothermal reaction kettle with polytetrafluoroethylene lining, heating up to 120-200 DEG C to react for 4 hours, dialyzing and freeze drying nigger-brown reaction liquid to remove residues and water to obtain black powdery nanoparticles, namely iodine doped carbon quantum dots. The iodine doped carbon quantum dot prepared by the method has such excellent properties as stable fluorescence, efficient X-ray attenuation capacity and good biocompatibility, and is successfully applied to live cell fluorescent imaging in vitro and CT imaging in vivo. The method has the advantages of simple operation, environmental protection and easy mass production.

Disclosed are a composition including hydrophilic nanoparticles that have a monosaccharide-phosphate or a derivative thereof adhered to the surface thereof, a colloidal solution of the composition dispersed in water, and a magnetic resonance imaging contrast agent including the colloidal solution. According to the present invention, nanoparticles having biocompatibility and excellent water-dispersibility can be prepared by modifying the surface of inorganic nanoparticles. The prepared nanoparticles may be effectively used in a variety of applications including, for example, in vivo imaging applications such as an MRI contrast agent, nano-electronic convergence technologies such as a quantum dot light emitting device, biomedical applications such as hyperthermia, or the like. Moreover, compared to existing nanoparticles dispersed by a dispersion stabilizer known in the art, excellent dispersion stability and a relatively small hydrodynamic diameter may be attained.

Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a ⁸⁹Zr-Desferrioxamine-NCS labeling agent.

The present invention provides a method for carrying out bio-orthogonal polysaccharide labeling from a microbiome level. The method comprises: placing microbial flora in a culture medium added with afirst probe, and culturing to obtain a microbial flora labeled with the first probe, wherein the first probe is one or a variety of unnatural saccharides; and carrying out a bio-orthogonal reaction onthe microbial flora labeled with the first probe and a second probe to obtain a microbial flora labeled with the second probe, wherein the second probe is a chemical marker capable of being subjectedto a bio-orthogonal reaction with the first probe. According to the present invention, with the method, a variety of bacteria capable of being metabolized and labeled with unnatural saccharides can be rapidly screened in the high-throughput manner, the specific types of the unnatural saccharides for metabolizing and labeling different bacteria can be determined, the possibility can be provided for the in vivo imaging of the specific microbiome, and the powerful tool is provided for the exploring of the biological functions of the macromolecules containing the polysaccharide structure in the bacteria difficultly cultured separately.

An in vivo imaging system for viewing the interior of an organism includes a camera mounted to a sled body that is placed in the interior of the organism. The camera includes a lens, and a dome covers the lens. An image display device is provided to display images received from the camera. A cable communicates images to the image display device according to a viewing angle of the lens. A magnetic source body placed on the exterior of the organism magnetically attracts the sled body to hold the sled body in place in the interior of the organism.

The invention discloses a tree polymer target contrast agent and preparation method thereof, and the contrast agent is nanoparticle, which has the structure as follows: a target radical T is located on the outerest end; a hydrophilic polyethylene glycol chain is used as a connecting arm; a tree polymer PAMAM is located in the central nucleus; paramagnetic metal X is imaged in vivo; the general formula thereof is PAMAM-PEG[(n)]-T/X. The preparation method has the steps of: PEG with different molecular masses is reacted with the target radical for preparing a product with a target radical on one end and a amino on the other end: NH[2]-PEG[(n)]-T; NH[2]-PEG[(N)]-T is reacted with PAMAM-COOH with molar ratio 32:1 for preparing a macromolecular ligand; T-PEG[(N)]-PAMAM; The ligand is chelated with paramagnetic metallic ion solution for preparing PAMAM- PEG[(N)]-T/X. The preparation method provided by the invention has the advantages of simple operation, mild and safe condition and wide application. And the prepared contrast agent has small cell toxicity, high relaxivity, and very good imaging effect for white mouse in vivo; obvious target property for imaging of tumor - bearing nude mouse in vivo.

The invention discloses a hydrophobic drug nanometer capsule of pH response of near-infrared fluorescent trace and a preparation method of the hydrophobic drug nanometer capsule and belongs to the technical field of preparation of nanometer materials. The hydrophobic drug nanometer capsule is applied to research of in-vivo imaging, cancer treatment and drug trace. The hydrophobic drug nanometer capsule of pH response of near-infrared fluorescent trace, which is wrapped with hydrophobic anticancer drugs and Ag2s nanometer particles, responds to pH (degraded in the acidic environment) and is in the diameter of 70-150 nm, has stable dispersibility in water phase, emits stable and strong near-infrared second-district fluorescent light under excitation of 808 nm, and can be used for tracing drug in real time in the blood circulation and the tumor position. The preparation method of the hydrophobic drug nanometer capsule is novel and simple, a drug carrier has cancer cell target and pH response characteristics as compared with a reported drug transport carrier and can emit near-infrared second-district fluorescent light, fluorescent signals are strong and can be used for tracing drug in real and identifying curative effect.

Provided herein are methods for detecting, quantifying, differentiating, diagnosing and imaging pathogenic bacteria or condition associated therewith using substrates for bacterial enzymes. Fluorescent, luminescent or colorimetric signals emitted by substrates or enzyme products in the presence of the bacteria are compared to controls to detect and locate the pathogenic bacteria. Provided is a method for screening therapeutic agents to treat the pathophysiological conditions by measuring a signal emitted from the substrates or products in the presence and absence of the potential therapeutic agent and a diagnostic method for detecting a mycobacterial infection in a subject by contacting biological samples with a substrate and imaging for signals emitted from a mycobacterial beta-lactamase product. Also provided are fluorogenic substrates or substrates comprising a colored dye or a chemical reagent effective to induce a color or pH change.

The present invention provides a novel method of labelling biological targeting molecules (BTMs) of interest with radioiodine. Also provided are novel radioiodinated BTMs prepared using the method, as well as radiopharmaceutical compositions comprising such radioiodinated BTMs. The invention also provides radioiodinated intermediates useful in the method, as well as in vivo imaging methods using.