50 results about "Chemical marker" patented technology

Pharmaceutical dosage forms with external or internal features to complicate counterfeiting and support authentication are described. External features include surface texture, surface markings defined by patterns of physical or chemical markers, or complex interlocking shapes. Internal features also include physical or chemical markers in two or three-dimensional patterns observable after sectioning, or after breaking along designed fracture lines. Methods of manufacture using solid freeform fabrication (SFF) techniques such as three-dimensional printing (3DP) are described. Method of authentication using dosage form patterns and batch codes are also described.

Disclosed are fibers which contain identification fibers. The identification fibers can contain a one or more of chemical markers and one or more distinct features, or taggants, which may vary among the fibers or be incorporated throughout all of the fibers. The chemical markers and distinct features can be representative of specific supply chain information. The supply chain information can be used to track the fibers from manufacturing through intermediaries, conversion to final product, and / or the consumer. The disclosed embodiments also relate to the method for making and characterizing the fibers. Characterization of the fibers can include identifying chemical markers and distinct features and correlating the chemical markers and distinct features to manufacturer-specific taggants to determine supply chain information.

The device measures glucose concentration in blood without any extraction of blood. The device is a non-invasive method for measuring glucose Radio Frequency and Antenna Circuits and Systems. The device is a wearable device that can non-invasively measure blood glucose levels in an instantaneous manner and continuous manner.

The invention concerns a method for authenticating different objects or substances to be identified comprising at least two phases: during an initial phase, selecting a plurality of chemical markers, assigning to and incorporating in each of the objects or substances a combination of markers, establishing an identification and / or authentication code (blocks 2, 11), storing in memory data or code for identifying and / or authenticating all the objects or substances and annex data; during an identification and / or authentication phase: a spectrophotometric analysis so as to determine a specific scanned code of the presence or absence of the markers (blocks 3, 4), identifying the object or the substance by comparing the scanned code and the identification and / or authentication codes (block 6). The invention is particularly applicable to fighting against counterfeiting, to automatic sorting, and the like.

The invention discloses a kit and a method for detecting hepatitis B virus surface antigen (HBsAg). The detection kit is used for marking hepatitis B virus surface antibody (HBsAb) by using metalloporphyrin obtained by using water-soluble A3B type metalloporphyrin to mark the HBsAb. The detection kit and the detection method have the advantages that: (1) free metalloporphyrin molecules are separated from a coupled substance easily after an A3B type metalloporphyrin complex is coupled with the HBsAb to obtain a high-purity labelled antibody, so that non-specific adsorption background signals are reduced when the HBsAg is detected by chemical luminescence immunodetection, and detection sensitivity is greatly improved; (2) the method is simple, convenient and quick; automation is realized easily; and specificity of immunoreaction, high sensitivity of chemical luminescence reaction and stability of a chemical marker are achieved; and (3) a new method is provided for detecting the HBsAg quickly and accurately, and preventing and treating the hepatitis B virus.

The disclosure relates to a process and composition for determining the quantity of a vitamin added to a foodstuff such as a beverage. The process involves (a) combining a predetermined amount of a chemical marker with a composition which is a carrier in combination with a predetermined amount of a vitamin to obtain a vitamin composition; (b) adding the vitamin composition to a foodstuff to obtain a vitamin fortified beverage; (c) quantitatively determining the amount of the chemical marker in the vitamin fortified foodstuff; and (d) correlating the quantitatively determined amount of the chemical marker in the vitamin fortified foodstuff with the predetermined amount of vitamin in the vitamin composition.

The invention discloses a method and probe for detecting miRNA (Ribonucleic Acid) and / or a target molecule with an aptamer. The probe comprises a gold nanoparticle-H1 compound, a gold nanoparticle-H2 compound and a target recognition compound, wherein the gold nanoparticle-H1 compound and the gold nanoparticle-H2 compound are respectively formed by bonding neck ring DNA (Deoxyribonucleic Acid) H1 and H2 to gold nanoparticles; and the target recognition compound comprises at least one of a carboxyl magnetic microsphere-DNA / 2 compound for recognizing miRNA, and DNA3 for recognizing target molecules. The method disclosed by the invention does not need chemical markers, shows visible color change with naked eyes, is simple in operation and wide in application range and can be applied to detection on target molecules with the aptamer.

Disclosed are fibers which contain identification fibers. The identification fibers can comprise one or more chemical markers, or taggants, which may vary among the fibers or be incorporated throughout all of the fibers. The disclosure also relates to the method for making and characterizing the fibers. Characterization of the fibers can include identifying chemical markers and correlating the chemical markers and a taggant chemical marker amounts of at least one of the chemical markers to manufacturer-specific taggants to determine supply chain information. The supply chain information can be used to track the fibers from manufacturing through intermediaries, conversion to final product, and / or the consumer.

This invention relates to a testing system arrangement for assessing the level of a biochemical marker, comprising a disposable device (2) with a sample inlet (4) and a at least one visible detection compartment (5A, 5B), for detection of said bio-chemical marker, a mobile unit (8) including a digital camera arranged to capture a digital picture (60) of said at least one visible detection compartment (5A, 5B), software run on a processor for analysing said picture (60) to assess said level and means arranged to present the result (70) of said assessment in a display (8A) of or connected to, said mobile unit (8), wherein said disposable device (2) is arranged with at least one reference surface (12) having a predetermined colour setting that is known to said software to enable exact assessment of the colour within said detection compartment (5A, 5B) by the use of said reference surface (12) within said digital picture as a basis reference.

A device having an air sampler, an electrospray apparatus, and a fluorescence excitation and detection system. The air sampler is capable of moving air suspected of containing a biological or chemical aerosol particle into a chamber. The electrospray apparatus is capable of spraying a charged solution into the chamber to coat the aerosol particles with a coating. The solution has a fluorescent-labeled biological or chemical marker capable of specific binding to the aerosol particle. The fluorescence system is capable of detecting fluorescence of the fluorescent label in the coating. A method of detecting the aerosol particle by: moving air suspected of containing the aerosol particle into a chamber; spraying the charged solution into the chamber with an electrospray apparatus, such that a coating of the solution is formed around the particle; exciting the fluorescent label; and detecting fluorescence of the fluorescent label.

The claimed invention relates to an enhanced mobile health detection and monitoring system utilizing non-invasive saliva screening of real-time health metrics coupled with remote deep analysis of body characteristics. Health information is derived from a combination of local chemical markers which are optically collected, locally reported and broadcast over a ‘cloud based’ internet data distribution system. The disclosed system, method and related device derives personal health and wellness information by combining saliva with disposable wellness indicators which are subsequently analyzed for pharmaceutical indicators as well as DNA, RNA and protein biomarkers to provide comprehensive wellness information.

The invention discloses an application of a general fluorescence labeling probe on a PCR-LDR gene SNP single nucleotide polymorphism chip. The application of the invention comprises the steps which are probe design, PCR product preparation, LDR product preparation and result detection, etc. The probe of the invention comprises a labeling probe and a testing probe, because the labeling probe is modified and the chemical labeling does not need to be directly carried out, the technical cost of the PCR-LDR combined chips can be reduced and the synthesis time of the probes can be saved, and the testing results reach the accuracy and the precision tested by the direct labeling technology.

Transcription factor is one important protein for gene regulation, is center of gene expression regulating passage and network, is important target of functional genome and protein block research and important target site of transcription treatment and medicine research owing to that many diseases are closely related to the abnormal expression and activation of transcription factor. The present invention proposes double stranded nucleic acid molecule coated in microporous plate to detect transcription factor protein. The process of analyzing transcription factor expression and activation level includes the following steps: preparing nucleic acid molecule; fixing the nucleic acid molecules to the pores of the microporous plate; incubation of cell or tissue extract containing transcription factor in the plate; incubation of transcription factor antibody in the plate; incubation of chemically marked transcription factor diantibody on the plate; and detecting and analyzing the chemical marker.

A method and composition for identifying chemically tagged petroleum products can be achieved by adding one or more chemicals to a selected petroleum product wherein the chemical is immune to extraction from the petroleum product by conventional inexpensive absorbents, cannot be removed by extraction with acids, bases, or immiscible solvents, cannot be easily oxidized, reduced or reacted with common agents, is difficult to disguise by masking with other agents, has a low polarity, and has a boiling point in the range of the petroleum product the chemical is being added to. The presence of the chemical is determined by using ion mobility spectroscopy.

The invention provides a bioluminescent detection probe based on a transcriptional activator like effector. The probe can achieve bioluminescence detection of microRNA (miRNA) without chemical labeling. The probe is a monomeric protein, and includes the following three parts: 1) a transcriptional activator like effector domain capable of specifically recognizing a DNA-miRNA hybrid chain; 2) a luciferase domain with bioluminescence; 3) a connecting region of the above two domains. The probe uses a single-stranded DNA coupled to the surface of a magnetic bead to hybridize with the miRNA to be tested, and a DNA-miRNA hybrid chain produced by hybridization is specifically recognized by the bioluminescent probe formed by the transcriptional activator like effector and the luciferase domain to achieve high sensitivity detection of the miRNA. The probe has the advantages of being low in cost, intuitive in result and convenient to use.

The present invention provides a method for carrying out bio-orthogonal polysaccharide labeling from a microbiome level. The method comprises: placing microbial flora in a culture medium added with afirst probe, and culturing to obtain a microbial flora labeled with the first probe, wherein the first probe is one or a variety of unnatural saccharides; and carrying out a bio-orthogonal reaction onthe microbial flora labeled with the first probe and a second probe to obtain a microbial flora labeled with the second probe, wherein the second probe is a chemical marker capable of being subjectedto a bio-orthogonal reaction with the first probe. According to the present invention, with the method, a variety of bacteria capable of being metabolized and labeled with unnatural saccharides can be rapidly screened in the high-throughput manner, the specific types of the unnatural saccharides for metabolizing and labeling different bacteria can be determined, the possibility can be provided for the in vivo imaging of the specific microbiome, and the powerful tool is provided for the exploring of the biological functions of the macromolecules containing the polysaccharide structure in the bacteria difficultly cultured separately.

Leak detection system and method for monitoring leaks in underground and aboveground storage tanks, pipelines or other containments, including single, double or triple wall containments are provided. A leak detection apparatus includes an oxidation chamber, a chemical marker concentrator, a mass spectrometer (MS) ion trap and a scroll vacuum pump. Vapor samples carrying marker chemicals introduced into a tank, pipeline, or other containment are injected at sample injection point into an oxidation chamber. Oxygen from an oxygen source is fed into oxidation chamber to destroy or oxidize contaminates such as hydrocarbons in the vapor without destroying or oxidizing the chemical markers. Effluent from the oxidation chamber is passed to an elongate conduit with a metal foil or screen suspended within the conduit. The marker chemicals are attracted by a chemical coating on the foil / screen and released by heating the metal. The released marker chemicals are fed into a mass spec ion trap for leakage analysis and results.

The invention discloses a method for deriving aldehyde pyrimidine, a method for detecting 5-aldehyde cytosine as well as application of an aldehyde pyrimidine derivative. The aldehyde pyrimidine derivative is prepared by mixing aldehyde pyrimidine and a Wittig reagent in an organic solvent and performing radiation by ultraviolet light, wherein the aldehyde pyrimidine is 5-aldehyde cytosine or 5-aldehyde uracil. The reaction condition is mild, efficient and rapid, application of the Wittig reagent in the field of epigenetics is effectively enlarged, and new though is provided for design of a chemical marker and a reaction type 5fC fluorescent probe of the aldehyde pyrimidine.

Systems and methods are provided for authenticating working fluids. The systems and methods include exposing at least a portion of a working fluid containing a UV-reactive chemical marker to light having wavelengths in the range of about 10-400 nm, thereby causing the chemical marker to generate a signal. The signal can be detected via a sensor system and compared to a reference signal that is associated with an authentic working fluid. An output may be generated to indicate whether the working fluid is the authentic working fluid.

Embodiments of the invention relate to methods and systems for the detection of Mycobacterium tuberculosis. Mycobacterium tuberculosis kills more than one million people each year. To better understand why M. tuberculosis is virulent and to discover chemical markers of this pathogen, we compared its lipid profile to that of the attenuated but related mycobacterium, Mycobacterium bovis Bacille Calmette Guerin (BCG). This strategy identified previously unknown compounds that are specific to M. tuberculosis, e.g. 1-tuberculosinyladenosine, N6-tuberculosinyladenosine, and various tuberculosinyladenosines having mycolic acids, produced by the Rv3378c enzyme.

The claimed invention relates to mobile computing monitoring of health statistics using chemically synthesized conjugate markers providing highly specific details of personal health states. Using portable computing and communications devices, commonly known as ‘smartphones’, personal health and wellness information is gathered from chemical markers and reported to the user. Chemical markers include chemicals which undergo a measurable color change when combined with body fluids such as saliva. Health information derived from chemical markers may be optically collected, locally reported and widely broadcast over a ‘cloud based’ internet data distribution system.