11 results about "Chemical marker" patented technology

The invention discloses a method for analyzing and identifying anti-inflammatory active ingredients of Xinhuang tablets based on a UPLC-Tripe-TOF-MS (Ultra Performance Liquid Chromatography-Tripe-TOF-Mass Spectrometry) spectrum-effect relationship. According to the method, an active extract is obtained from Xinhuang tablets through a dichloromethane liquid-liquid extraction method, a fingerprint spectrum of 10 batches of samples is established by using UPLC-Tripe-TOF-MS, a double-target evaluation system is constructed by combining an LPS-induced RAW264.7 cell inflammation model and COX-2 enzyme inhibition detection, and spectrum-effect relationship research is performed through gray correlation analysis and an OPLS-DA data mining technology. Four chemical components, namely indomethacin, 7-ketolithocholic acid, erucyl amide and pyranoapigenin, which are highly related to the anti-inflammatory activity are identified; the quality control method of the Xinhuang tablets based on the key chemical markers is established, a scientific basis is provided for quality evaluation and standardization of the traditional Chinese medicine compound Xinhuang tablets, and meanwhile a new thought is provided for development of anti-inflammatory drugs.

The application discloses an evaluation method for distinguishing different quality of momordica grosvenori of different origins. The application adopts high performance liquid chromatography to establish the fingerprint of momordica grosvenori, carries out gradient elution by taking water-acetonitrile as a mobile phase, and detects the wavelength of 203 nm to obtain the HPLC fingerprint of momordica grosvenori; the obtained chromatogram is introduced into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system to generate a control fingerprint, different origins of momordica grosvenori are distinguished through similarity comparison and / or chemical pattern recognition analysis; and chemical markers with VIP>1 such as 5-hydroxymethyl furfural, momordica grosvenori flavonoid, momordica grosvenori saponin V and momordica grosvenori saponin IIIA2 are screened. The application can effectively distinguish two main origins of green skin fruit and red hair fruit, overcomes the defects that traditional trait identification is subjective and it is difficult to distinguish similar appearance samples, and provides an objective, accurate and stable technical means for origin identification, quality consistency evaluation and authenticity identification of momordica grosvenori.

The present invention provides a method for determining the authenticity of a petroleum hydrocarbon allegedly comprising at least one specific chemical marker, as well as a method for determining adulteration of a petroleum hydrocarbon marked with at least one specific chemical marker. The methods claimed and described herein rely upon the use of specific chemical markers in combination with laser ionization at a wavelength of between about 300 nm and about 370 nm coupled with ion mobility spectrometry or with mass spectrometry.

A simulation device for obtaining the contents of chemical markers in oil at different positions inside a transformer belongs to the technical field of power equipment insulation state detection. The present invention aims to solve the problem that the oil samples inside existing transformers are affected by oil flow and temperature difference, resulting in significant differences in the contents of chemical markers at different positions, leading to inaccurate assessment of the insulation state of insulating paper. It includes: an oil sampling port is opened at the top of the oil tank, and an oil sampling probe samples and detects the content of chemical markers through the oil sampling port; the transformer oil heating module includes three temperature control units, which are arranged in the high-level area, middle-level area, and low-level area of the oil tank; the simulation circulation module uses a spiral stirrer installed on the inner side wall of the oil tank, and drainage ports are opened at the bottom and top of the oil tank, and an oil pipeline is connected between the drainage ports. A controllable flow rate pump is installed on the oil pipeline passage, and the spiral stirrer and the controllable flow rate pump are driven by a driving motor. The present invention is used to simulate the working state of a transformer and realize the simulation detection of the contents of chemical markers in oil at different positions.

The invention belongs to the technical field of traditional Chinese medicinal material fingerprint spectrum and primitive identification, and particularly relates to a construction method of flos magnoliae fingerprint spectrum and a primitive identification method. According to the method, volatile oil in flos magnoliae is taken as a detection object, and a stable and repeated gas phase detection means is firstly established and can be used for constructing a fingerprint spectrum of the flos magnoliae. Further, in combination with a multi-dimensional chemical pattern recognition technology (systematic clustering analysis / HCA, principal component analysis / PCA, partial least squares-discriminant analysis / OPLS-DA and VIP analysis), it is confirmed that myrcene and camphor in the atlas can be used as chemical markers for primitive identification. The method is simple and easy to operate, and has important significance for improving the quality control of the magnolia flower medicinal material.

To provide a landmine detection system and a landmine detection method that can improve the accuracy of detecting landmines that are placed on the ground and have metals containing iron on the outer surface, while reducing the risk of injury to an explorer, and can efficiently detect the landmines. [Solution] The mine detection system 1 comprises a first drone device 2 having a first drone 6, a first tank, and a first spraying device 10 that sprays an acidic first solution 52 that dissolves iron on the outer surface of the mine; a second drone device 4 having a second drone 20, a second tank, and a second spraying device 22 that sprays a second solution 54 that functions as a chemical marker that reacts to the iron ions dissolved by the first solution; and a third drone device 40 having a third drone 42 and a camera that captures images or videos of the reaction between the second solution and the iron ions.

The invention relates to a method and a corresponding system capable of verifying whether genuine SERS or SERRS chemical markers, which have a unique characteristic surface enhancement scattering feature, are present in a machine-readable mark applied to a valuable document by using a Raman spectrometer adapted to perform Raman spectroscopy analysis of the mark. The method according to the invention allows for rapid and reliable detection of the presence of SERS / SERRS chemical markers and is particularly suitable for verifying the authenticity of valuable documents, such as banknotes, by moving relative to the Raman spectrometer at a given speed, and possibly at a high speed, or by briefly exposing the Raman spectrometer.

According to the UPLC fingerprint spectrum detection method for the stone-eliminating and gallbladder-benefiting traditional Chinese medicine composition, a chemical mode recognition method is combined, 12 common peaks are calibrated in total, 8 common peaks are identified through a chemical reference substance, the similarity of 15 batches of stone-eliminating and gallbladder-benefiting traditional Chinese medicine composition fingerprints is 0.932 or above, and through analysis of HCA, PCA, OPLS-DA and the like and verification of a neural network model, the similarity of the fingerprint spectrums of the stone-eliminating and gallbladder-benefiting traditional Chinese medicine composition fingerprints is determined. 15 batches of stone-eliminating and gallbladder-benefiting traditional Chinese medicine composition samples are divided into 3 classes, and 7 main chemical markers which may cause mass difference are screened out, namely chromatographic peaks 2 and 6 (baicalin), chromatographic peaks 4, chromatographic peaks 8, chromatographic peaks 7, chromatographic peaks 9 (rhein) and chromatographic peaks 5 (hesperidin). The fingerprint detection method has the advantages of simplicity, feasibility, short detection time (about 25 minutes), good stability and good repeatability, can evaluate the inherent quality of the stone-eliminating and gallbladder-benefiting traditional Chinese medicine composition, further guarantees the stability of the inherent quality of the product, and provides a reference basis.

The invention discloses a method for detecting euonymus alatus based on thin-layer chromatography. According to the method, stigmas-4-ene-3-ketone is selected as a characteristic chemical marker, and a thin-layer chromatography identification system with toluene-ethyl acetate-formic acid (20: 1: 0.5) as a developing system is established. According to the method, consistent fluorescence quenching spots can be clearly detected on a silica gel GF254 thin-layer plate under an ultraviolet lamp (254nm) at a position (Rf value is 0.48 + / -0.03) corresponding to a reference substance. In addition, the invention further provides an efficient preparation process of the reference substance and a detection kit containing the key components, and the technical bottleneck that euonymus alatus medicinal materials and decoction pieces lack quality control of standardization, high specificity and good reproducibility for a long time is effectively solved.